| 2/14/2020 | Point72 Asset Management L.P. | 855,800 | $11.22M | 0.1% | -7.5% | 3.308% | |
| 2/14/2020 | BVF Inc. IL | 1,949,075 | $25.55M | 1.9% | +11.9% | 7.534% | |
| 2/14/2020 | Cubist Systematic Strategies LLC | 25,515 | $0.34M | 0.0% | +1,452.0% | 0.099% | |
| 2/14/2020 | Schonfeld Strategic Advisors LLC | 69,400 | $0.91M | 0.0% | N/A | 0.268% | |
| 2/14/2020 | Bank of America Corp DE | 2,618 | $34K | 0.0% | N/A | 0.010% | |
| 2/14/2020 | Marshall Wace LLP | 48,606 | $0.64M | 0.0% | N/A | 0.188% | |
| 2/14/2020 | Bank of New York Mellon Corp | 246,263 | $3.23M | 0.0% | -1.6% | 0.952% | |
| 2/14/2020 | Marshall Wace North America L.P. | 14,939 | $0.20M | 0.0% | N/A | 0.058% | |
| 2/14/2020 | Goldman Sachs Group Inc. | 12,937 | $0.17M | 0.0% | +22.9% | 0.050% | |
| 2/13/2020 | Parkman Healthcare Partners LLC | 588,059 | $7.71M | 2.2% | N/A | 2.273% | |
| 2/13/2020 | Oxford Asset Management LLP | 12,553 | $0.17M | 0.0% | N/A | 0.049% | |
| 2/13/2020 | Renaissance Technologies LLC | 595,677 | $7.81M | 0.0% | +21.9% | 2.303% | |
| 2/10/2020 | Granite Point Capital Management L.P. | 272,543 | $3.57M | 0.6% | -8.1% | 1.054% | |
| 2/10/2020 | Bank of Montreal Can | 5,000 | $66K | 0.0% | -19.3% | 0.019% | |
| 2/7/2020 | Tower Research Capital LLC TRC | 5,006 | $65K | 0.0% | +66.8% | 0.019% | |
| 1/31/2020 | Ikarian Capital LLC | 243,470 | $3.19M | 0.5% | N/A | 0.941% | |
| 1/29/2020 | Russell Investments Group Ltd. | 24,460 | $0.32M | 0.0% | -33.9% | 0.095% | |
| 1/27/2020 | California Public Employees Retirement System | 58,555 | $0.77M | 0.0% | -5.9% | 0.226% | |
| 1/24/2020 | NEA Management Company LLC | 992,107 | $13.01M | 0.6% | +64.6% | 3.835% | |
| 11/27/2019 | Squarepoint Ops LLC | 87,100 | $0.79M | 0.0% | -6.3% | 0.337% | |
| 11/27/2019 | Granahan Investment Management Inc. MA | 106,459 | $0.96M | 0.1% | +8.3% | 0.412% | |
| 11/5/2019 | Tower Research Capital LLC TRC | 3,002 | $27K | 0.0% | N/A | 0.012% | |
| 11/4/2019 | Alps Advisors Inc. | 51,356 | $0.46M | 0.0% | -4.7% | 0.199% | |
| 11/1/2019 | Russell Investments Group Ltd. | 37,004 | $0.33M | 0.0% | -55.6% | 0.144% | |
| 10/31/2019 | California Public Employees Retirement System | 62,255 | $0.56M | 0.0% | +11.0% | 0.242% | |
| 10/30/2019 | Granite Point Capital Management L.P. | 296,500 | $2.67M | 0.4% | -2.2% | 1.150% | |
| 10/18/2019 | Supplemental Annuity Collective Trust of NJ | 11,000 | $99K | 0.0% | N/A | 0.043% | |
| 10/11/2019 | NEA Management Company LLC | 602,663 | $5.43M | 0.4% | +229.8% | 2.339% | |
| 8/17/2019 | Royal Bank of Canada | 60,340 | $0.60M | 0.0% | +5.8% | 0.234% | |
| 8/16/2019 | United Services Automobile Association | 101,039 | $1M | 0.0% | +2.4% | 0.392% | |
| 8/14/2019 | Citadel Advisors LLC | 437,580 | $4.32M | 0.0% | -32.9% | 1.698% | |
| 8/14/2019 | D. E. Shaw & Co. Inc. | 30,766 | $0.30M | 0.0% | -44.7% | 0.119% | |
| 8/14/2019 | Cubist Systematic Strategies LLC | 4,470 | $44K | 0.0% | -37.6% | 0.017% | |
| 8/14/2019 | Point72 Asset Management L.P. | 925,000 | $9.12M | 0.0% | +8.8% | 3.589% | |
| 8/14/2019 | Morgan Stanley | 6,148 | $61K | 0.0% | +25.3% | 0.024% | |
| 8/14/2019 | Invesco Ltd. | 13,858 | $0.14M | 0.0% | N/A | 0.054% | |
| 8/14/2019 | A.R.T. Advisors LLC | 10,760 | $0.11M | 0.0% | N/A | 0.042% | |
| 8/13/2019 | BlackRock Inc. | 258,614 | $2.55M | 0.0% | -3.3% | 1.003% | |
| 8/13/2019 | Athanor Capital LP | 10,100 | $100K | 0.0% | N/A | 0.039% | |
| 8/13/2019 | Northern Trust Corp | 37,636 | $0.37M | 0.0% | +55.5% | 0.146% | |
| 8/12/2019 | Renaissance Technologies LLC | 475,500 | $4.69M | 0.0% | +0.7% | 1.845% | |
| 8/12/2019 | Bank of New York Mellon Corp | 227,539 | $2.24M | 0.0% | N/A | 0.883% | |
| 8/9/2019 | Russell Investments Group Ltd. | 83,280 | $0.82M | 0.0% | +1,710.0% | 0.323% | |
| 8/7/2019 | Alps Advisors Inc. | 53,888 | $0.53M | 0.0% | -11.6% | 0.209% | |
| 8/7/2019 | NEA Management Company LLC | 182,754 | $1.80M | 0.1% | N/A | 0.709% | |
| 8/7/2019 | JPMorgan Chase & Co. | 33,594 | $0.33M | 0.0% | -65.2% | 0.130% | |
| 8/6/2019 | Altshuler Shaham Ltd | 149,758 | $1.48M | 0.1% | +4.3% | 0.581% | |
| 6/30/2019 | Falcon Point Capital LLC | 25,608 | $0.25M | 0.1% | N/A | 0.099% | |
| 6/20/2019 | Sphera Funds Management LTD. | 533,655 | $5.42M | 0.5% | +18.7% | 2.071% | |
| 5/14/2019 | Altrinsic Global Advisors LLC | 160,000 | $1.63M | 0.1% | +6.7% | 0.621% | |
| 5/13/2019 | Knott David M | 179,390 | $1.82M | 0.7% | +3.5% | 0.696% | |
| 5/1/2019 | Alps Advisors Inc. | 60,964 | $0.62M | 0.0% | +5.5% | 0.242% | |
| 4/1/2019 | Deutsche Bank AG | 73,200 | $0.46M | 0.0% | +39.6% | 0.290% | |
| 2/15/2019 | Millennium Management LLC | 145,382 | $0.92M | 0.0% | +75.4% | 0.576% | |
| 2/14/2019 | D. E. Shaw & Co. Inc. | 131,220 | $0.83M | 0.0% | N/A | 0.520% | |
| 2/14/2019 | Two Sigma Advisers LP | 36,200 | $0.23M | 0.0% | N/A | 0.143% | |
| 2/14/2019 | Two Sigma Investments LP | 200,261 | $1.26M | 0.0% | +161.5% | 0.793% | |
| 2/14/2019 | venBio Select Advisor LLC | 2,400,000 | $15.14M | 0.9% | +1.4% | 9.509% | |
| 2/14/2019 | Sphera Funds Management LTD. | 449,484 | $2.84M | 0.3% | +18.4% | 1.781% | |
| 2/13/2019 | Geode Capital Management LLC | 14,084 | $88K | 0.0% | N/A | 0.056% | |
| 2/13/2019 | Eversept Partners LP | 205,104 | $1.29M | 0.7% | -2.2% | 0.813% | |
| 2/12/2019 | Northern Trust Corp | 12,246 | $77K | 0.0% | +18.9% | 0.049% | |
| 2/11/2019 | Scotia Capital Inc. | 66,704 | $0.42M | 0.0% | +16.8% | 0.264% | |
| 2/11/2019 | Altshuler Shaham Ltd | 98,007 | $0.62M | 0.0% | N/A | 0.388% | |
| 2/8/2019 | BlackRock Inc. | 283,708 | $1.79M | 0.0% | N/A | 1.124% | |
| 2/5/2019 | Granite Point Capital Management L.P. | 253,300 | $1.60M | 0.3% | -45.4% | 1.004% | |
| 2/4/2019 | Alps Advisors Inc. | 57,796 | $0.37M | 0.0% | N/A | 0.229% | |
| 1/16/2019 | Virtu Financial LLC | 12,696 | $80K | 0.0% | N/A | 0.050% | |
| 11/15/2018 | Point72 Asset Management L.P. | 400,000 | $5.28M | 0.0% | +412.2% | 2.077% | |
| 11/15/2018 | Opaleye Management Inc. | 465,200 | $7.01M | 1.8% | N/A | 2.415% | |
| 11/14/2018 | Capital World Investors | 963,500 | $12.72M | 0.0% | -32.6% | 5.003% | |
| 11/14/2018 | Capital International Investors | 937,400 | $12.37M | 0.0% | N/A | 4.867% | |
| 11/14/2018 | Sphera Funds Management LTD. | 379,484 | $5.01M | 0.6% | -13.6% | 1.970% | |
| 11/14/2018 | Jefferies Group LLC | 325,630 | $4.30M | 0.0% | N/A | 1.691% | |
| 11/13/2018 | Renaissance Technologies LLC | 527,337 | $6.96M | 0.0% | +7.7% | 2.738% | |
| 11/13/2018 | Stonepine Capital Management LLC | 100,000 | $1.32M | 0.8% | N/A | 0.396% | |
| 11/13/2018 | Citadel Advisors LLC | 753,935 | $9.95M | 0.0% | N/A | 3.915% | |
| 11/13/2018 | Vivo Capital LLC | 1,405,476 | $18.55M | 1.9% | N/A | 7.297% | |
| 11/13/2018 | Foresite Capital Management IV LLC | 385,714 | $5.09M | 1.7% | N/A | 2.003% | |
| 11/13/2018 | Monashee Investment Management LLC | 80,000 | $1.06M | 0.2% | N/A | 0.415% | |
| 11/13/2018 | Granite Point Capital Management L.P. | 464,300 | $6.13M | 0.4% | -3.7% | 2.411% | |
| 11/9/2018 | Trexquant Investment LP | 11,198 | $0.15M | 0.0% | N/A | 0.058% | |
| 11/9/2018 | Artal Group S.A. | 250,000 | $3.30M | 0.1% | +66.7% | 1.298% | |
| 11/7/2018 | JPMorgan Chase & Co. | 8,430 | $0.11M | 0.0% | N/A | 0.044% | |
| 11/7/2018 | Acuta Capital Partners LLC | 482,500 | $6.37M | 2.3% | +7.2% | 2.505% | |
| 10/16/2018 | NJ State Employees Deferred Compensation Plan | 25,000 | $0.33M | 0.1% | -50.0% | 0.130% | |
| 10/12/2018 | Bank of Montreal Can | 11,721 | $0.16M | 0.0% | +433.3% | 0.061% | |
| 10/11/2018 | Elmwood Wealth Management Inc. | 18,729 | $0.25M | 0.2% | -50.0% | 0.097% | |
| 8/22/2018 | Elmwood Wealth Management Inc. | 37,458 | $0.26M | 0.2% | +100.0% | 0.194% | |
| 8/15/2018 | Acuta Capital Partners LLC | 450,000 | $4.14M | 0.7% | N/A | 3.176% | |
| 8/14/2018 | Point72 Asset Management L.P. | 78,100 | $0.72M | 0.0% | -74.6% | 0.551% | |
| 8/13/2018 | OppenheimerFunds Inc. | 22,481 | $0.21M | 0.0% | +104.3% | 0.159% | |
| 8/13/2018 | Renaissance Technologies LLC | 489,500 | $4.50M | 0.0% | +70.0% | 3.454% | |
| 8/13/2018 | DAFNA Capital Management LLC | 294,362 | $2.71M | 1.3% | -22.1% | 2.077% | |
| 8/9/2018 | JBF Capital Inc. | 40,000 | $0.37M | 0.1% | N/A | 0.282% | |
| 8/8/2018 | Spark Investment Management LLC | 26,100 | $0.24M | 0.0% | +105.5% | 0.184% | |
| 8/2/2018 | NJ State Employees Deferred Compensation Plan | 50,000 | $0.46M | 0.1% | +150.0% | 0.353% | |
| 8/1/2018 | Kovack Advisors Inc. | 12,300 | $0.11M | 0.0% | N/A | 0.087% | |
| 7/30/2018 | State of New Jersey Common Pension Fund D | 155,100 | $1.43M | 0.0% | +138.6% | 1.095% | |
| 5/16/2018 | Nexthera Capital LP | 379,071 | $1.86M | 0.3% | N/A | 2.675% | |
