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Xenon Pharmaceuticals (XENE) Competitors

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$36.44 +0.28 (+0.77%)
Closing price 10/9/2026 04:00 PM Eastern
Extended Trading
$36.48 +0.04 (+0.11%)
As of 10/9/2026 07:30 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.

XENE vs. EXEL, ASND, SMMT, BBIO, and HALO

Should you buy Xenon Pharmaceuticals stock or one of its competitors? Xenon Pharmaceuticals's main competitors and comparable companies include Exelixis (EXEL), Ascendis Pharma A/S (ASND), Summit Therapeutics (SMMT), BridgeBio Pharma (BBIO), and Halozyme Therapeutics (HALO). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Xenon Pharmaceuticals compare to Exelixis?

Xenon Pharmaceuticals (NASDAQ:XENE) and Exelixis (NASDAQ:EXEL) are both healthcare companies, but which is the better investment? We will contrast the two businesses based on the strength of their institutional ownership, media sentiment, risk, valuation, analyst recommendations, dividends, earnings and profitability.

Xenon Pharmaceuticals has a beta of 0.6, indicating that its share price is 40% less volatile than the broader market. Comparatively, Exelixis has a beta of 0.47, indicating that its share price is 53% less volatile than the broader market.

95.5% of Xenon Pharmaceuticals shares are held by institutional investors. Comparatively, 85.3% of Exelixis shares are held by institutional investors. 2.9% of Xenon Pharmaceuticals shares are held by company insiders. Comparatively, 2.6% of Exelixis shares are held by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company is poised for long-term growth.

In the previous week, Xenon Pharmaceuticals had 1 more articles in the media than Exelixis. MarketBeat recorded 15 mentions for Xenon Pharmaceuticals and 14 mentions for Exelixis. Exelixis' average media sentiment score of 0.54 beat Xenon Pharmaceuticals' score of 0.46 indicating that Exelixis is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Xenon Pharmaceuticals
2 Very Positive mention(s)
2 Positive mention(s)
8 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Neutral
Exelixis
5 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
2 Negative mention(s)
0 Very Negative mention(s)
Positive

Exelixis has higher revenue and earnings than Xenon Pharmaceuticals. Xenon Pharmaceuticals is trading at a lower price-to-earnings ratio than Exelixis, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Xenon Pharmaceuticals$7.50M469.69-$345.91M-$4.74N/A
Exelixis$2.32B6.39$782.57M$3.1818.82

Xenon Pharmaceuticals currently has a consensus price target of $70.14, indicating a potential upside of 92.49%. Exelixis has a consensus price target of $50.79, indicating a potential downside of 15.16%. Given Xenon Pharmaceuticals' stronger consensus rating and higher probable upside, equities research analysts clearly believe Xenon Pharmaceuticals is more favorable than Exelixis.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Xenon Pharmaceuticals
1 Sell rating(s)
1 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.87
Exelixis
1 Sell rating(s)
12 Hold rating(s)
6 Buy rating(s)
1 Strong Buy rating(s)
2.35

Exelixis has a net margin of 35.33% compared to Xenon Pharmaceuticals' net margin of 0.00%. Exelixis' return on equity of 42.17% beat Xenon Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Xenon PharmaceuticalsN/A -43.98% -41.72%
Exelixis 35.33%42.17%31.76%

Summary

Xenon Pharmaceuticals and Exelixis tied by winning 8 of the 16 factors compared between the two stocks.

How does Xenon Pharmaceuticals compare to Ascendis Pharma A/S?

Xenon Pharmaceuticals (NASDAQ:XENE) and Ascendis Pharma A/S (NASDAQ:ASND) are both healthcare companies, but which is the superior business? We will compare the two companies based on the strength of their profitability, media sentiment, dividends, earnings, risk, analyst recommendations, valuation and institutional ownership.

Ascendis Pharma A/S has higher revenue and earnings than Xenon Pharmaceuticals. Xenon Pharmaceuticals is trading at a lower price-to-earnings ratio than Ascendis Pharma A/S, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Xenon Pharmaceuticals$7.50M469.69-$345.91M-$4.74N/A
Ascendis Pharma A/S$814.57M17.55-$258M$12.8917.78

In the previous week, Xenon Pharmaceuticals had 10 more articles in the media than Ascendis Pharma A/S. MarketBeat recorded 15 mentions for Xenon Pharmaceuticals and 5 mentions for Ascendis Pharma A/S. Xenon Pharmaceuticals' average media sentiment score of 0.46 beat Ascendis Pharma A/S's score of 0.33 indicating that Xenon Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Xenon Pharmaceuticals
2 Very Positive mention(s)
2 Positive mention(s)
8 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Neutral
Ascendis Pharma A/S
0 Very Positive mention(s)
0 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Xenon Pharmaceuticals currently has a consensus price target of $70.14, suggesting a potential upside of 92.49%. Ascendis Pharma A/S has a consensus price target of $313.21, suggesting a potential upside of 36.64%. Given Xenon Pharmaceuticals' higher probable upside, equities research analysts plainly believe Xenon Pharmaceuticals is more favorable than Ascendis Pharma A/S.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Xenon Pharmaceuticals
1 Sell rating(s)
1 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.87
Ascendis Pharma A/S
0 Sell rating(s)
1 Hold rating(s)
18 Buy rating(s)
1 Strong Buy rating(s)
3.00

Ascendis Pharma A/S has a net margin of 70.99% compared to Xenon Pharmaceuticals' net margin of 0.00%. Ascendis Pharma A/S's return on equity of 32.54% beat Xenon Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Xenon PharmaceuticalsN/A -43.98% -41.72%
Ascendis Pharma A/S 70.99%32.54%7.71%

95.5% of Xenon Pharmaceuticals shares are held by institutional investors. 2.9% of Xenon Pharmaceuticals shares are held by insiders. Comparatively, 40.0% of Ascendis Pharma A/S shares are held by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock is poised for long-term growth.

Xenon Pharmaceuticals has a beta of 0.6, suggesting that its stock price is 40% less volatile than the broader market. Comparatively, Ascendis Pharma A/S has a beta of 0.38, suggesting that its stock price is 62% less volatile than the broader market.

Summary

Ascendis Pharma A/S beats Xenon Pharmaceuticals on 10 of the 16 factors compared between the two stocks.

How does Xenon Pharmaceuticals compare to Summit Therapeutics?

Summit Therapeutics (NASDAQ:SMMT) and Xenon Pharmaceuticals (NASDAQ:XENE) are both healthcare companies, but which is the better stock? We will contrast the two companies based on the strength of their institutional ownership, analyst recommendations, media sentiment, earnings, dividends, profitability, valuation and risk.

Summit Therapeutics has a beta of -1.51, meaning that its stock price is 251% less volatile than the broader market. Comparatively, Xenon Pharmaceuticals has a beta of 0.6, meaning that its stock price is 40% less volatile than the broader market.

Xenon Pharmaceuticals has higher revenue and earnings than Summit Therapeutics. Summit Therapeutics is trading at a lower price-to-earnings ratio than Xenon Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Summit TherapeuticsN/AN/A-$1.08B-$1.12N/A
Xenon Pharmaceuticals$7.50M469.69-$345.91M-$4.74N/A

Summit Therapeutics presently has a consensus price target of $28.61, indicating a potential upside of 62.64%. Xenon Pharmaceuticals has a consensus price target of $70.14, indicating a potential upside of 92.49%. Given Xenon Pharmaceuticals' stronger consensus rating and higher possible upside, analysts clearly believe Xenon Pharmaceuticals is more favorable than Summit Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Summit Therapeutics
1 Sell rating(s)
8 Hold rating(s)
9 Buy rating(s)
1 Strong Buy rating(s)
2.53
Xenon Pharmaceuticals
1 Sell rating(s)
1 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.87

4.6% of Summit Therapeutics shares are held by institutional investors. Comparatively, 95.5% of Xenon Pharmaceuticals shares are held by institutional investors. 83.5% of Summit Therapeutics shares are held by insiders. Comparatively, 2.9% of Xenon Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company is poised for long-term growth.

Xenon Pharmaceuticals' return on equity of -43.98% beat Summit Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Summit TherapeuticsN/A -168.94% -141.92%
Xenon Pharmaceuticals N/A -43.98%-41.72%

In the previous week, Xenon Pharmaceuticals had 13 more articles in the media than Summit Therapeutics. MarketBeat recorded 15 mentions for Xenon Pharmaceuticals and 2 mentions for Summit Therapeutics. Xenon Pharmaceuticals' average media sentiment score of 0.46 beat Summit Therapeutics' score of 0.36 indicating that Xenon Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Summit Therapeutics
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Xenon Pharmaceuticals
2 Very Positive mention(s)
2 Positive mention(s)
8 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Neutral

Summary

Xenon Pharmaceuticals beats Summit Therapeutics on 12 of the 14 factors compared between the two stocks.

How does Xenon Pharmaceuticals compare to BridgeBio Pharma?

BridgeBio Pharma (NASDAQ:BBIO) and Xenon Pharmaceuticals (NASDAQ:XENE) are both healthcare companies, but which is the better investment? We will compare the two companies based on the strength of their earnings, institutional ownership, analyst recommendations, risk, valuation, media sentiment, dividends and profitability.

In the previous week, Xenon Pharmaceuticals had 2 more articles in the media than BridgeBio Pharma. MarketBeat recorded 15 mentions for Xenon Pharmaceuticals and 13 mentions for BridgeBio Pharma. BridgeBio Pharma's average media sentiment score of 0.49 beat Xenon Pharmaceuticals' score of 0.46 indicating that BridgeBio Pharma is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
BridgeBio Pharma
3 Very Positive mention(s)
2 Positive mention(s)
7 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Xenon Pharmaceuticals
2 Very Positive mention(s)
2 Positive mention(s)
8 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Neutral

BridgeBio Pharma currently has a consensus target price of $105.42, indicating a potential upside of 61.32%. Xenon Pharmaceuticals has a consensus target price of $70.14, indicating a potential upside of 92.49%. Given Xenon Pharmaceuticals' stronger consensus rating and higher possible upside, analysts plainly believe Xenon Pharmaceuticals is more favorable than BridgeBio Pharma.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
BridgeBio Pharma
1 Sell rating(s)
2 Hold rating(s)
21 Buy rating(s)
0 Strong Buy rating(s)
2.83
Xenon Pharmaceuticals
1 Sell rating(s)
1 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.87

Xenon Pharmaceuticals has lower revenue, but higher earnings than BridgeBio Pharma. BridgeBio Pharma is trading at a lower price-to-earnings ratio than Xenon Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
BridgeBio Pharma$502.08M25.44-$724.93M-$3.57N/A
Xenon Pharmaceuticals$7.50M469.69-$345.91M-$4.74N/A

99.9% of BridgeBio Pharma shares are held by institutional investors. Comparatively, 95.5% of Xenon Pharmaceuticals shares are held by institutional investors. 14.2% of BridgeBio Pharma shares are held by company insiders. Comparatively, 2.9% of Xenon Pharmaceuticals shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company will outperform the market over the long term.

Xenon Pharmaceuticals has a net margin of 0.00% compared to BridgeBio Pharma's net margin of -97.03%. BridgeBio Pharma's return on equity of 0.00% beat Xenon Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
BridgeBio Pharma-97.03% N/A -61.19%
Xenon Pharmaceuticals N/A -43.98%-41.72%

BridgeBio Pharma has a beta of 0.97, suggesting that its stock price is 3% less volatile than the broader market. Comparatively, Xenon Pharmaceuticals has a beta of 0.6, suggesting that its stock price is 40% less volatile than the broader market.

Summary

Xenon Pharmaceuticals beats BridgeBio Pharma on 9 of the 17 factors compared between the two stocks.

How does Xenon Pharmaceuticals compare to Halozyme Therapeutics?

Halozyme Therapeutics (NASDAQ:HALO) and Xenon Pharmaceuticals (NASDAQ:XENE) are both healthcare companies, but which is the superior investment? We will contrast the two businesses based on the strength of their risk, analyst recommendations, profitability, institutional ownership, valuation, earnings, dividends and media sentiment.

Halozyme Therapeutics presently has a consensus price target of $94.00, indicating a potential downside of 14.87%. Xenon Pharmaceuticals has a consensus price target of $70.14, indicating a potential upside of 92.49%. Given Xenon Pharmaceuticals' stronger consensus rating and higher possible upside, analysts clearly believe Xenon Pharmaceuticals is more favorable than Halozyme Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Halozyme Therapeutics
1 Sell rating(s)
2 Hold rating(s)
9 Buy rating(s)
0 Strong Buy rating(s)
2.67
Xenon Pharmaceuticals
1 Sell rating(s)
1 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.87

In the previous week, Halozyme Therapeutics had 10 more articles in the media than Xenon Pharmaceuticals. MarketBeat recorded 25 mentions for Halozyme Therapeutics and 15 mentions for Xenon Pharmaceuticals. Halozyme Therapeutics' average media sentiment score of 0.64 beat Xenon Pharmaceuticals' score of 0.46 indicating that Halozyme Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Halozyme Therapeutics
10 Very Positive mention(s)
8 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Xenon Pharmaceuticals
2 Very Positive mention(s)
2 Positive mention(s)
8 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Neutral

97.8% of Halozyme Therapeutics shares are owned by institutional investors. Comparatively, 95.5% of Xenon Pharmaceuticals shares are owned by institutional investors. 2.5% of Halozyme Therapeutics shares are owned by insiders. Comparatively, 2.9% of Xenon Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company will outperform the market over the long term.

Halozyme Therapeutics has a beta of 0.88, meaning that its share price is 12% less volatile than the broader market. Comparatively, Xenon Pharmaceuticals has a beta of 0.6, meaning that its share price is 40% less volatile than the broader market.

Halozyme Therapeutics has a net margin of 24.86% compared to Xenon Pharmaceuticals' net margin of 0.00%. Halozyme Therapeutics' return on equity of 260.98% beat Xenon Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Halozyme Therapeutics24.86% 260.98% 23.91%
Xenon Pharmaceuticals N/A -43.98%-41.72%

Halozyme Therapeutics has higher revenue and earnings than Xenon Pharmaceuticals. Xenon Pharmaceuticals is trading at a lower price-to-earnings ratio than Halozyme Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Halozyme Therapeutics$1.40B8.97$316.89M$3.3532.96
Xenon Pharmaceuticals$7.50M469.69-$345.91M-$4.74N/A

Summary

Halozyme Therapeutics beats Xenon Pharmaceuticals on 11 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding XENE and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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XENE vs. The Competition

MetricXenon PharmaceuticalsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$3.50B$3.84B$7.16B$13.21B
Dividend YieldN/A3.66%2.53%16.36%
P/E Ratio-7.6913.42274.1326.16
Price / Sales469.691,240.95590.4494.78
Price / CashN/A116.5676.3853.09
Price / Book4.8417.1711.216.34
Net Income-$345.91M-$22.69M$3.50B$381.90M
7 Day Performance-4.16%-1.33%-0.92%-1.41%
1 Month Performance-38.03%-8.44%-4.46%-3.48%
1 Year Performance-8.07%14.02%6.94%1.16%

Xenon Pharmaceuticals Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
XENE
Xenon Pharmaceuticals
4.3972 of 5 stars
$36.44
+0.8%
$70.14
+92.5%
-11.7%$3.50B$7.50MN/A364
EXEL
Exelixis
2.6907 of 5 stars
$58.85
+0.8%
$50.29
-14.6%
+55.2%$14.58B$2.44B18.511,077
ASND
Ascendis Pharma A/S
4.7883 of 5 stars
$228.03
+0.1%
$310.75
+36.3%
+6.7%$14.21B$814.57M17.691,189
SMMT
Summit Therapeutics
2.3654 of 5 stars
$17.27
+3.1%
$28.61
+65.6%
-22.3%$13.37BN/AN/A265
BBIO
BridgeBio Pharma
3.9361 of 5 stars
$66.14
-1.7%
$102.61
+55.1%
+19.3%$13.15B$713.07MN/A839

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This page (NASDAQ:XENE) was last updated on 10/10/2026 by MarketBeat.com Staff.
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