Trending NewsTrending NewsNYSE:ANRO Alto Neuroscience (ANRO) Stock Price, News & Analysis $3.91 +0.32 (+8.83%) Closing price 08/22/2025 03:59 PM EasternExtended Trading$3.90 -0.01 (-0.18%) As of 08/22/2025 06:35 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Stock Analysis Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOwnershipSEC FilingsShort InterestTrendsBuy This Stock About Alto Neuroscience Stock (NYSE:ANRO) 30 days 90 days 365 days Advanced Chart View Price History Chart DataSkip Price History Chart Get Alto Neuroscience alerts:Sign Up Key Stats Today's Range$3.61▼$3.9350-Day Range$2.21▼$3.9152-Week Range$1.60▼$15.04Volume157,542 shsAverage Volume102,544 shsMarket Capitalization$105.80 millionP/E RatioN/ADividend YieldN/APrice Target$8.50Consensus RatingModerate Buy Company Overview Alto Neuroscience, Inc. operates as a clinical-stage biopharmaceutical company in the United States. Its product pipeline comprising ALTO-100, which is in phase 2b clinical trial for the treatment of patients with major depressive disorder (MDD); and which is in phase 2a clinical trial for the treatment of post-traumatic stress disorder. The company develops ALTO-300, a small molecule melatonergic agonist and serotonergic antagonist with antidepressant properties which is in phase 2b clinical trial to treat patients with MDD; ALTO-101, a novel small molecule phosphodiesterase 4 inhibitor which is in phase 1 clinical trial for the treatment of cognitive impairment associated with schizophrenia; ALTO-203, a novel small-molecule histamine H3 receptor inverse agonist which is in phase 1 clinical trial to treat patients with MDD and higher levels of anhedonia; and ALTO-202, an investigational orally bioavailable antagonist of the GluN2B subunit of the NMDA receptor which is in phase 1 clinical trial for the treatment of MDD. In addition, it develops novel pharmacodynamically synergistic combination and biomarker platform that collects patient-specific data to identify biomarker-characterized patient. The company was incorporated in 2019 and is headquartered in Los Altos, California. Read More Alto Neuroscience Stock Analysis - MarketRank™See Top-Rated MarketRank™ Stocks35th Percentile Overall ScoreANRO MarketRank™: Alto Neuroscience scored higher than 35% of companies evaluated by MarketBeat, and ranked 751st out of 940 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation. Analyst's Opinion3.3 / 5Analyst RatingModerate Buy Consensus RatingAlto Neuroscience has received a consensus rating of Moderate Buy. The company's average rating score is 2.57, and is based on 4 buy ratings, 3 hold ratings, and no sell ratings.Amount of Analyst CoverageAlto Neuroscience has only been the subject of 1 research reports in the past 90 days.Read more about Alto Neuroscience's stock forecast and price target. Earnings and Valuation1.3 / 5Proj. Earnings GrowthGrowing Earnings GrowthEarnings for Alto Neuroscience are expected to grow in the coming year, from ($2.54) to ($2.39) per share.Price to Earnings Ratio vs. the MarketThe P/E ratio of Alto Neuroscience is -1.63, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Earnings Ratio vs. SectorThe P/E ratio of Alto Neuroscience is -1.63, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Book Value per Share RatioAlto Neuroscience has a P/B Ratio of 0.86. P/B Ratios below 1 indicate that a company could be undervalued with respect to its assets and liabilities.Read more about Alto Neuroscience's valuation and earnings. Short Interest1.0 / 5Short Interest LevelBearish Percentage of Shares Shorted10.00% of the float of Alto Neuroscience has been sold short.Short Interest Ratio / Days to CoverAlto Neuroscience has a short interest ratio ("days to cover") of 9.1.Change versus previous monthShort interest in Alto Neuroscience has recently increased by 4.88%, indicating that investor sentiment is decreasing. Dividend0.0 / 5Dividend StrengthN/A Dividend YieldAlto Neuroscience does not currently pay a dividend.Dividend GrowthAlto Neuroscience does not have a long track record of dividend growth. Sustainability and ESGN/AEnvironmental ScoreN/A Percentage of Shares Shorted10.00% of the float of Alto Neuroscience has been sold short.Short Interest Ratio / Days to CoverAlto Neuroscience has a short interest ratio ("days to cover") of 9.1.Change versus previous monthShort interest in Alto Neuroscience has recently increased by 4.88%, indicating that investor sentiment is decreasing. News and Social Media1.1 / 5News Sentiment-0.04 News SentimentAlto Neuroscience has a news sentiment score of -0.04. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a lower news sentiment than the 0.66 average news sentiment score of Medical companies.News Coverage This WeekMarketBeat has tracked 61 news articles for Alto Neuroscience this week, compared to 5 articles on an average week.Search InterestOnly 1 people have searched for ANRO on MarketBeat in the last 30 days. This is a decrease of -75% compared to the previous 30 days. Company Ownership0.8 / 5Insider TradingN/A Insider Buying vs. Insider SellingIn the past three months, Alto Neuroscience insiders have not sold or bought any company stock.Percentage Held by Insiders11.13% of the stock of Alto Neuroscience is held by insiders. A high percentage of insider ownership can be a sign of company health.Read more about Alto Neuroscience's insider trading history. Receive ANRO Stock News and Ratings via Email Sign-up to receive the latest news and ratings for Alto Neuroscience and its competitors with MarketBeat's FREE daily newsletter. Email Address ANRO Stock News HeadlinesANRO Investors Have Opportunity to Lead Alto Neuroscience, Inc. Securities Fraud LawsuitAugust 22 at 5:39 PM | prnewswire.comContact Levi & Korsinsky by September 19, 2025 Deadline to Join Class Action Against Alto Neuroscience, Inc.(ANRO)August 22 at 4:31 PM | globenewswire.comAlex’s “Next Magnificent Seven” stocksThe original “Magnificent Seven” turned $7K into $1.18 million. Now, Alex Green has identified AI’s Next Magnificent Seven—seven stocks he believes could deliver similar gains in under six years. His full breakdown is now live. | The Oxford Club (Ad)SHAREHOLDER REMINDER: Faruqi & Faruqi, LLP Investigates Claims on Behalf of Investors of Alto NeuroscienceAugust 22 at 10:15 AM | globenewswire.comPomerantz Law Firm Announces the Filing of a Class Action Against Alto Neuroscience, Inc. and Certain Officers - ANROAugust 22 at 10:00 AM | prnewswire.comLevi & Korsinsky Reminds Shareholders of a Lead Plaintiff Deadline of September 19, 2025 in Alto Neuroscience, Inc. Lawsuit - ANROAugust 22 at 8:45 AM | prnewswire.comInvestors in Alto Neuroscience, Inc. Should Contact Levi & Korsinsky Before September 19, 2025 to Discuss Your Rights - ANROAugust 22 at 2:48 AM | theglobeandmail.comROSEN, A LONGSTANDING LAW FIRM, Encourages Alto Neuroscience, Inc. Investors to Secure Counsel Before Important Deadline in Securities Class Action - ANROAugust 21 at 8:22 PM | globenewswire.comSee More Headlines ANRO Stock Analysis - Frequently Asked Questions How have ANRO shares performed this year? Alto Neuroscience's stock was trading at $4.23 at the beginning of the year. Since then, ANRO shares have decreased by 7.6% and is now trading at $3.9070. How were Alto Neuroscience's earnings last quarter? Alto Neuroscience, Inc. (NYSE:ANRO) issued its earnings results on Wednesday, August, 13th. The company reported ($0.65) earnings per share for the quarter, missing the consensus estimate of ($0.57) by $0.08. When did Alto Neuroscience IPO? Alto Neuroscience (ANRO) raised $129 million in an IPO on Friday, February 2nd 2024. The company issued 8,040,000 shares at $16.00 per share. Who are Alto Neuroscience's major shareholders? Alto Neuroscience's top institutional investors include Armistice Capital LLC (6.00%), Marshall Wace LLP (3.46%), AWM Investment Company Inc. (1.04%) and Peapod Lane Capital LLC (1.03%). Insiders that own company stock include Wave Global Lp Alpha, Adam Savitz and Nicholas Conrad Smith. View institutional ownership trends. How do I buy shares of Alto Neuroscience? Shares of ANRO stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. What other stocks do shareholders of Alto Neuroscience own? Based on aggregate information from My MarketBeat watchlists, some other companies that Alto Neuroscience investors own include JPMorgan Chase & Co. (JPM), Tesla (TSLA), Meta Platforms (META), NVIDIA (NVDA), Advanced Micro Devices (AMD), Netflix (NFLX) and Alphabet (GOOG). Company Calendar Last Earnings8/13/2025Today8/23/2025Next Earnings (Estimated)11/11/2025Fiscal Year End12/31/2025Get Stock AlertsIndustry, Sector and Symbol Stock ExchangeNYSE SectorMedical Industry MED - BIOMED/GENE Sub-IndustryPharmaceutical Products Current SymbolNYSE:ANRO Previous SymbolNYSE:ANRO CIK1999480 Webwww.altoneuroscience.com Phone(650) 200-0412FaxN/AEmployeesN/AYear FoundedN/APrice Target and Rating Average Price Target for Alto Neuroscience$8.50 High Price Target$10.00 Low Price Target$4.00 Potential Upside/Downside+117.6%Consensus RatingModerate Buy Rating Score (0-4)2.57 Research Coverage7 Analysts Profitability EPS (Trailing Twelve Months)($2.39) Trailing P/E RatioN/A Forward P/E RatioN/A P/E GrowthN/ANet Income-$61.43 million Net MarginsN/A Pretax MarginN/A Return on Equity-44.34% Return on Assets-36.73% Debt Debt-to-Equity Ratio0.18 Current Ratio18.43 Quick Ratio18.43 Sales & Book Value Annual SalesN/A Price / SalesN/A Cash FlowN/A Price / Cash FlowN/A Book Value$4.56 per share Price / Book0.86Miscellaneous Outstanding Shares27,080,000Free Float24,063,000Market Cap$105.80 million OptionableN/A Beta1.84 Social Links Beginner's Guide To Retirement StocksEnter your email address and we'll send you MarketBeat's list of seven best retirement stocks and why they should be in your portfolio. 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