| 05/01/2026 3:35 PM | MANE (1827635) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 04/30/2026 4:28 PM | MANE (1827635) Filer | Form 424B4 | |
| 04/29/2026 8:58 PM | MANE (1827635) Subject | Form FWP | |
| 04/29/2026 11:15 PM | MANE (1827635) Filer | Form EFFECT | |
| 04/29/2026 8:44 PM | MANE (1827635) Filer | Form S-1MEF | |
| 04/27/2026 4:28 PM | MANE (1827635) Subject | Form FWP | |
| 04/27/2026 4:16 PM | MANE (1827635) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 04/27/2026 4:18 PM | MANE (1827635) Filer | Form S-1 Registration statement under Securities Act of 1933 | |
| 04/27/2026 8:10 AM | MANE (1827635) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 03/30/2026 7:44 AM | MANE (1827635) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 02/12/2026 5:11 PM | Longitude Capital Partners V, LLC (2018312) Filed by MANE (1827635) Subject | Form SCHEDULE 13D | |
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| 02/11/2026 4:22 PM | SUVRETTA CAPITAL MANAGEMENT, LLC (1569064) Filed by MANE (1827635) Subject | Form SCHEDULE 13D | |
| 02/09/2026 5:28 PM | Averill Madison Master Fund, Ltd. (2021243) Reporting Averill Master Fund, Ltd. (1939329) Reporting Cowen Aaron (1869640) Reporting SUVRETTA CAPITAL MANAGEMENT, LLC (1569064) Reporting MANE (1827635) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/09/2026 5:13 PM | Averill Madison Master Fund, Ltd. (2021243) Reporting Averill Master Fund, Ltd. (1939329) Reporting Cowen Aaron (1869640) Reporting SUVRETTA CAPITAL MANAGEMENT, LLC (1569064) Reporting MANE (1827635) Issuer | Form 3 Initial statement of beneficial ownership of securities | |
| 02/05/2026 6:12 PM | Pance Katarina (2105096) Reporting MANE (1827635) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/05/2026 6:00 PM | MANE (1827635) Issuer Waldman Reid Alexander (2107415) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/05/2026 6:00 PM | Durso Timothy August (2107508) Reporting MANE (1827635) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/05/2026 6:01 PM | Carrano Dominic Gabriel (2107420) Reporting MANE (1827635) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/05/2026 6:02 PM | Neumann Mark (1756211) Reporting MANE (1827635) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/05/2026 6:02 PM | Greco Michael V. (1786766) Reporting MANE (1827635) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/05/2026 6:03 PM | ENRIGHT PATRICK G (1253886) Reporting MANE (1827635) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/05/2026 6:03 PM | Longitude 103.8 East Partners, LLC (2094273) Reporting Longitude 103.8 East, L.P. (2094269) Reporting Longitude Capital Partners V, LLC (2018312) Reporting Longitude Venture Partners V, L.P. (1935964) Reporting MANE (1827635) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/05/2026 6:04 PM | CHILDS JOHN W (1027035) Reporting MANE (1827635) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/05/2026 6:04 PM | Coric Vlad (1704317) Reporting MANE (1827635) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/05/2026 6:04 PM | Friedman David Matthew (2108980) Reporting MANE (1827635) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/05/2026 6:05 PM | Grant-Kels Jane M. (2108622) Reporting MANE (1827635) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/04/2026 4:17 PM | MANE (1827635) Filer | Form 424B4 | |
| 02/04/2026 5:07 AM | MANE (1827635) Filer | Form CERT | |
| 02/03/2026 8:13 PM | Pance Katarina (2105096) Reporting MANE (1827635) Issuer | Form 3 Initial statement of beneficial ownership of securities | |
| 02/03/2026 8:05 PM | MANE (1827635) Issuer Waldman Reid Alexander (2107415) Reporting | Form 3 Initial statement of beneficial ownership of securities | |
| 02/03/2026 8:05 PM | Durso Timothy August (2107508) Reporting MANE (1827635) Issuer | Form 3 Initial statement of beneficial ownership of securities | |
| 02/03/2026 8:05 PM | Carrano Dominic Gabriel (2107420) Reporting MANE (1827635) Issuer | Form 3 Initial statement of beneficial ownership of securities | |
| 02/03/2026 8:05 PM | Neumann Mark (1756211) Reporting MANE (1827635) Issuer | Form 3 Initial statement of beneficial ownership of securities | |
| 02/03/2026 8:05 PM | Greco Michael V. (1786766) Reporting MANE (1827635) Issuer | Form 3 Initial statement of beneficial ownership of securities | |
| 02/03/2026 8:05 PM | ENRIGHT PATRICK G (1253886) Reporting MANE (1827635) Issuer | Form 3 Initial statement of beneficial ownership of securities | |
| 02/03/2026 8:05 PM | Longitude 103.8 East Partners, LLC (2094273) Reporting Longitude 103.8 East, L.P. (2094269) Reporting Longitude Capital Partners V, LLC (2018312) Reporting Longitude Venture Partners V, L.P. (1935964) Reporting MANE (1827635) Issuer | Form 3 Initial statement of beneficial ownership of securities | |
| 02/03/2026 8:05 PM | CHILDS JOHN W (1027035) Reporting MANE (1827635) Issuer | Form 3 Initial statement of beneficial ownership of securities | |
| 02/03/2026 8:05 PM | Coric Vlad (1704317) Reporting MANE (1827635) Issuer | Form 3 Initial statement of beneficial ownership of securities | |
| 02/03/2026 8:06 PM | Friedman David Matthew (2108980) Reporting MANE (1827635) Issuer | Form 3 Initial statement of beneficial ownership of securities | |
| 02/03/2026 8:06 PM | Grant-Kels Jane M. (2108622) Reporting MANE (1827635) Issuer | Form 3 Initial statement of beneficial ownership of securities | |
| 02/03/2026 7:21 PM | MANE (1827635) Filer | Form S-1MEF | |
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| 02/02/2026 8:24 PM | MANE (1827635) Subject | Form FWP | |
| 02/01/2026 11:15 PM | MANE (1827635) Filer | Form EFFECT | |
| 01/28/2026 10:52 AM | MANE (1827635) Filer | Form S-1/A | |
| 01/09/2026 4:04 PM | MANE (1827635) Filer | Form S-1 Registration statement under Securities Act of 1933 | |
| 10/28/2025 2:19 PM | MANE (1827635) Filer | Form D Notice of Exempt Offering of Securities | |