Casdin Capital, LLC Top Holdings and 13F Report (2021)

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About Casdin Capital, LLC

Investment Activity

Casdin Capital, LLC has $1.35 billion in total holdings as of September 30, 2021.
Casdin Capital, LLC owns shares of 36 different stocks, but just 14 companies or ETFs make up 80% of its holdings.
Approximately 21.26% of the portfolio was purchased this quarter.
About 5.35% of the portfolio was sold this quarter.
This quarter, Casdin Capital, LLC has purchased 36 new stocks and bought additional shares in 12 stocks.
Casdin Capital, LLC sold shares of 4 stocks and completely divested from 3 stocks this quarter.

Largest Holdings

Revolution Medicines: $181,055,216
Standard BioTools: $167,769,610
BioLife Solutions: $161,517,911
Sarepta Therapeutics: $138,392,740
Relay Therapeutics: $61,615,664

Largest New Holdings this Quarter

Veracyte: $19,011,153 Holding
KYVERNA THERAPEUTICS INC: $3,726,000 Holding
Ginkgo Bioworks: $1,693,307 Holding

Largest Purchases this Quarter

Standard BioTools: 60,707,605 shares (about $164.52M)
Alnylam Pharmaceuticals: 163,000 shares (about $24.36M)
Avidity Biosciences: 909,091 shares (about $23.20M)
Veracyte: 857,904 shares (about $19.01M)
Exact Sciences: 230,000 shares (about $15.88M)

Largest Sales this Quarter

Illumina: 90,000 shares (about $12.36M)
Pliant Therapeutics: 577,108 shares (about $8.60M)
4D Molecular Therapeutics: 233,811 shares (about $7.45M)
Revolution Medicines: 97,176 shares (about $3.13M)

Sector Allocation Over Time

Selling

Neutral

Buying

Latest 13F Holdings and Changes Since Previous Quarterly Filing

Issuer Name	Holdings Value	Approximate Purchase/Sale	Change in Shares	Shares Held	% of Portfolio	Sector
RVMD Revolution Medicines	$181,055,216	$3,131,982 ▼	-1.7%	5,617,599	13.5%	Medical
LAB Standard BioTools	$167,769,610	$164,517,610 ▲	5,059.0%	61,907,605	12.5%	Medical
BLFS BioLife Solutions	$161,517,911		0.0%	8,707,165	12.0%	Medical
SRPT Sarepta Therapeutics	$138,392,740	$8,091,250 ▲	6.2%	1,069,000	10.3%	Medical
RLAY Relay Therapeutics	$61,615,664	$295,737 ▲	0.5%	7,423,574	4.6%	Medical
ALNY Alnylam Pharmaceuticals	$53,503,100	$24,360,350 ▲	83.6%	358,000	4.0%	Medical
RNA Avidity Biosciences	$53,205,142	$23,200,002 ▲	77.3%	2,084,841	4.0%	Medical
NTLA Intellia Therapeutics	$52,956,750	$13,067,250 ▲	32.8%	1,925,000	3.9%	Medical
GPCR Structure Therapeutics	$47,868,920		0.0%	1,116,867	3.6%	Medical
EXAS Exact Sciences	$44,889,000	$15,883,800 ▲	54.8%	650,000	3.3%	Medical
VERV Verve Therapeutics	$40,624,768	$664,000 ▲	1.7%	3,059,094	3.0%	Medical
TNYA Tenaya Therapeutics	$35,213,438	$1,838,837 ▲	5.5%	6,732,971	2.6%	Medical
ILMN Illumina	$34,055,360	$12,358,800 ▼	-26.6%	248,000	2.5%	Medical
BPMC Blueprint Medicines	$30,960,217		0.0%	326,378	2.3%	Medical
WGS GeneDx	$28,635,432	$373,417 ▲	1.3%	3,136,411	2.1%	Medical
NEUROGENE INC	$26,702,954		0.0%	524,616	2.0%	COM
DNLI Denali Therapeutics	$26,676,000		0.0%	1,300,000	2.0%	Medical
FDMT 4D Molecular Therapeutics	$25,488,000	$7,449,218 ▼	-22.6%	800,000	1.9%	Medical
BEAM Beam Therapeutics	$22,302,000	$4,856,880 ▲	27.8%	675,000	1.7%	Medical
VCYT Veracyte	$19,011,153	$19,011,153 ▲	New Holding	857,904	1.4%	Medical
PLRX Pliant Therapeutics	$14,900,000	$8,598,909 ▼	-36.6%	1,000,000	1.1%	Medical
IPSC Century Therapeutics	$13,402,668		0.0%	3,206,380	1.0%	Medical
TSVT 2seventy bio	$10,700,000	$4,372,967 ▲	69.1%	2,000,000	0.8%	Medical
ABCL AbCellera Biologics	$10,691,384		0.0%	2,360,129	0.8%	Medical
TNGX Tango Therapeutics	$9,435,491		0.0%	1,188,349	0.7%	Medical
CDXS Codexis	$6,980,000		0.0%	2,000,000	0.5%	Medical
ABSI Absci	$5,528,117		0.0%	973,260	0.4%	Medical
PACB Pacific Biosciences of California	$3,884,471		0.0%	1,035,859	0.3%	Medical
KYVERNA THERAPEUTICS INC	$3,726,000	$3,726,000 ▲	New Holding	150,000	0.3%	COM
GLUE Monte Rosa Therapeutics	$3,601,718		0.0%	510,882	0.3%	Medical
SNDX Syndax Pharmaceuticals	$3,570,000		0.0%	150,000	0.3%	Medical
PRME Prime Medicine	$2,570,225		0.0%	367,175	0.2%	Medical
DNA Ginkgo Bioworks	$1,693,307	$1,693,307 ▲	New Holding	1,459,747	0.1%	Medical
EXAI Exscientia	$1,223,508		0.0%	213,900	0.1%	Medical
OMIC Singular Genomics Systems	$680,742		0.0%	1,323,885	0.1%	Medical
KRON Kronos Bio	$160,991		0.0%	123,839	0.0%	Medical
SLGC Standard BioTools	$0	$31,888,816 ▼	-100.0%	0	0.0%	Business Services
FATE Fate Therapeutics	$0	$7,667,000 ▼	-100.0%	0	0.0%	Medical
LIAN LianBio	$0	$922,675 ▼	-100.0%	0	0.0%	Medical