Casdin Capital, LLC Top Holdings and 13F Report (2021) About Casdin Capital, LLCInvestment ActivityCasdin Capital, LLC has $2.00 billion in total holdings as of September 30, 2021.Casdin Capital, LLC owns shares of 43 different stocks, but just 12 companies or ETFs make up 80% of its holdings.Approximately 9.94% of the portfolio was purchased this quarter.About 6.97% of the portfolio was sold this quarter.This quarter, Casdin Capital, LLC has purchased 40 new stocks and bought additional shares in 9 stocks.Casdin Capital, LLC sold shares of 3 stocks and completely divested from 3 stocks this quarter.Largest Holdings Revolution Medicines $482,682,924Relay Therapeutics $300,019,340GeneDx $254,496,809BioLife Solutions $131,457,200Illumina $93,189,900 Largest New Holdings this Quarter 698955101 - PARABILIS MEDICINES INC $17,672,535 Holding829401108 - SIONNA THERAPEUTICS INC $17,596,000 Holding803607100 - Sarepta Therapeutics $8,445,900 HoldingN90064101 - uniQure $6,909,000 Holding28106W103 - Editas Medicine $1,441,800 Holding Largest Purchases this Quarter GeneDx 700,000 shares (about $48.06M)Relay Therapeutics 1,616,666 shares (about $30.25M)PARABILIS MEDICINES INC 645,690 shares (about $17.67M)SIONNA THERAPEUTICS INC 400,000 shares (about $17.60M)Scholar Rock 315,000 shares (about $17.33M) Largest Sales this Quarter 10x Genomics 1,225,000 shares (about $46.97M)BioLife Solutions 1,302,165 shares (about $36.77M)Guardant Health 130,000 shares (about $19.50M) Sector Allocation Over TimeMap of 500 Largest Holdings ofCasdin Capital, LLC Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorRVMDRevolution Medicines$482,682,9240.0%2,577,33324.2%HealthcareRLAYRelay Therapeutics$300,019,340$30,247,821 â–²11.2%16,035,24015.0%HealthcareWGSGeneDx$254,496,809$48,055,000 â–²23.3%3,707,16412.7%HealthcareBLFSBioLife Solutions$131,457,200$36,773,140 â–¼-21.9%4,655,0006.6%HealthcareILMNIllumina$93,189,9000.0%530,0004.7%HealthcareLABStandard BioTools$73,042,4780.0%88,783,8563.7%HealthcareGPCRStructure Therapeutics$63,062,2500.0%1,175,0003.2%HealthcareDNLIDenali Therapeutics$52,597,400$5,272,600 â–²11.1%2,045,0002.6%HealthcareNEUROGENE INC$48,601,603$3,931,250 â–²8.8%1,545,3612.4%COMBEAMBeam Therapeutics$46,332,0000.0%1,350,0002.3%HealthcareTXG10x Genomics$40,257,000$46,966,500 â–¼-53.8%1,050,0002.0%HealthcareSRRKScholar Rock$36,575,000$17,325,000 â–²90.0%665,0001.8%HealthcarePSNLPersonalis$34,170,000$12,730,000 â–²59.4%2,550,0001.7%HealthcareGRAIL INC$32,769,600$17,067,500 â–²108.7%480,0001.6%COMGHGuardant Health$27,755,550$19,503,900 â–¼-41.3%185,0001.4%HealthcareMAZE THERAPEUTICS INC$25,180,693$2,536,400 â–²11.2%843,8571.3%COMHIMSHims & Hers Health$24,269,0000.0%700,0001.2%HealthcareALNYAlnylam Pharmaceuticals$22,577,2500.0%75,0001.1%HealthcareTSHATaysha Gene Therapies$22,132,5000.0%3,250,0001.1%HealthcareAGOMAB THERAPEUTICS NV$20,119,0000.0%1,550,0001.0%SPONSORED ADSSEPTERNA INC$18,528,9450.0%553,2680.9%COMPARABILIS MEDICINES INC$17,672,535$17,672,535 â–²New Holding645,6900.9%COMSIONNA THERAPEUTICS INC$17,596,000$17,596,000 â–²New Holding400,0000.9%COMVCYTVeracyte$16,227,5690.0%276,3080.8%HealthcareADLAI NORTYE LTD$14,375,000$8,182,699 â–²132.1%1,250,0000.7%SPONSORED ADSPRIME MEDICINE INC$11,686,8760.0%3,167,1750.6%COMABSIAbsci$11,280,0830.0%973,2600.6%HealthcareDGXQuest Diagnostics$10,597,5000.0%50,0000.5%HealthcareSRPTSarepta Therapeutics$8,445,900$8,445,900 â–²New Holding470,0000.4%HealthcareQUREuniQure$6,909,000$6,909,000 â–²New Holding150,0000.3%HealthcareNTLAIntellia Therapeutics$6,006,6000.0%355,0000.3%HealthcareMRNAModerna$5,252,2500.0%75,0000.3%HealthcareIRONDisc Medicine$4,754,1000.0%65,0000.2%HealthcareGLUEMonte Rosa Therapeutics$4,501,5390.0%186,0140.2%HealthcareIPSCCentury Therapeutics$3,009,0660.0%1,228,1900.2%HealthcareCONTINEUM THERAPEUTICS INC$2,431,1780.0%148,3330.1%CL ABRIDGEBIO ONCOLOGY THERAPEUT$2,151,2170.0%282,3120.1%COM NEWEDITEditas Medicine$1,441,800$1,441,800 â–²New Holding445,0000.1%HealthcarePACBPacific Biosciences of California$1,215,9290.0%723,7670.1%HealthcareKARDIGAN INC$1,192,500$1,192,500 â–²New Holding50,0000.1%COMRXRXRecursion Pharmaceuticals$606,7350.0%165,3230.0%HealthcareGINKGO BIOWORKS HOLDINGS INC$361,6460.0%36,4930.0%CL A NEWTNYATenaya Therapeutics$267,5310.0%361,9690.0%HealthcareQIAGEN NV$0$14,414,400 â–¼-100.0%00.0%ORD SHARESTEMPUS AI INC$0$13,300,423 â–¼-100.0%00.0%CL AMLTXMoonLake Immunotherapeutics$0$8,388,000 â–¼-100.0%00.0%HealthcareShowing largest 100 holdings. 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