Alexandria Real Estate Equities Q4 2025 Earnings Results & Report

Alexandria Real Estate Equities EPS Results

• Actual EPS: $2.16
• Consensus EPS: $2.15
• Beat/Miss: Beat by +$0.01
• One Year Ago EPS: $2.39
• EPS Beat Rate: 4 of last 8 quarters

Alexandria Real Estate Equities Revenue Results

• Actual Revenue: $754.41 million
• Expected Revenue: $742.64 million
• Beat/Miss: Beat by +$11.77 million
• YoY Revenue Growth: -4.40%

Alexandria Real Estate Equities (NYSE:ARE) is a real estate investment trust specializing in life science, technology and other knowledge-based industries. Founded in 1994, the company develops, owns and operates collaborative campuses that bring together companies, researchers and institutions.

Its properties include laboratory, office and manufacturing space, as well as related facilities and amenities designed to support research and innovation. Alexandria also makes strategic investments in companies in the life science and technology sectors through its venture investment platform.

The company serves major U.S. innovation hubs, including Greater Boston, the San Francisco Bay Area, New York City, San Diego, Seattle and the Research Triangle region. Its portfolio is concentrated in locations with established research institutions and industry clusters.

Alexandria Real Estate Equities Q4 2025 Earnings Call Transcript

Key Takeaways

• Positive Sentiment: Completed $1.5 billion of dispositions in 4Q across 26 transactions and is executing a larger ~$2.9 billion 2026 disposition plan (majority non‑core/land) to reduce the pipeline and shore up funding needs.
• Positive Sentiment: Strong leasing momentum with 1.2 million sq ft in Q4 (highest quarter in the year), including ~900k sq ft of signed leases expected to commence in Q3 2026 that should add about $52 million of annual revenue.
• Negative Sentiment: Near‑term occupancy and cash‑flow headwinds — company expects occupancy to dip in 1Q26 due to ~1.2 million sq ft of expirations, a terminated 171k sq ft lease, and an assumed ~$6 million/quarter revenue reduction from tenant wind‑downs; same‑property NOI guidance midpoint is down ~8.5% for 2026.
• Negative Sentiment: Recognized a $1.45 billion share of impairments in 4Q (50%–60% land), led by write‑downs at 88 Bluxome and the Gateway campus, reflecting weaker submarket demand and weighing on reported asset values.
• Positive Sentiment: Reaffirmed 2026 FFO guidance (Q4 2026 trough FFO per share of $1.40–$1.60), and highlights a strong balance sheet with $5.3 billion liquidity, ~12‑year average debt maturity, and net debt/adjusted EBITDA of ~5.7x.

Presentation

[Operator]

Good afternoon, everyone, and welcome to the Alexandria Real Estate Equities fourth quarter and year-end 2025 conference call. All participants will be in a listen-only mode. Should you need assistance, please signal a conference specialist by pressing the star key followed by zero. After today's presentation, there will be an opportunity to ask questions. To ask a question, you may press star and then one on your touch-tone telephones. To withdraw your questions, you may press star and two. Please also note today's event is being recorded. At this time, I would like to turn the floor over to Paula Schwartz with Investor Relations. Ma'am, please go ahead.

[Paula Schwartz, Managing Director at Rx Communications Group]

Thank you, and good afternoon, everyone. This conference call contains forward-looking statements within the meaning of the federal securities laws. The company's actual results might differ materially from those projected in the forward-looking statement. Additional information concerning factors that could cause actual results to differ materially from those in the forward-looking statement is contained in the company's periodic reports filed with the Securities and Exchange Commission. Now I'd like to turn the call over to Joel Marcus, Executive Chairman and Founder. Please go ahead, Joel.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Thank you, Paula, and welcome everybody to our Fourth Quarter and Year End 2025 conference call. With me today are Peter, Marc, and Hallie, and I want to wish everybody a Happy New Year and remember, most importantly, health is wealth. I want to thank our family team for their exceptional efforts during 2025, and particularly a very busy fourth quarter. In 2025, we witnessed the fifth year of a life science bear market. Our 2025 timeline clearly evidences that no one could have predicted with the February 2025 nomination of HHS Secretary, the intense cascade of events from February 2025 on to the numerous key departures toward year-end at the FDA. And in fact, sadly, measles and polio may be back to some extent. We have been navigating a fast-changing life science industry landscape throughout 2025, which has been front and center for our team.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Our Investor Day path forward is our North Star for 2026. As the industry begins to adapt to the fast-changing landscape, 2026 is all about timely execution of our plan, heavily focused on dispositions and maintaining a strong and flexible balance sheet, driving occupancy with intense leasing focus on vacant space, rollover space, and redevelopment and development space, and meeting the marketplace. We also plan to continue to significantly reduce CapEx. With that, let me turn it over to Marc to highlight Q4 in 2025 briefly, and then we'll turn it over to everybody for questions since we had Investor Day less than 60 days ago, and we just reported yesterday. We'll try to make our comments brief. So, Marc.

[Marc Binda, CFO at Alexandria Real Estate Equities]

Thank you, Joel. This is Marc Binda, Chief Financial Officer. Good afternoon, everyone. First, a congratulations to the entire Alexandria team for that outstanding operational execution during the fourth quarter, including the completion of $1.5 billion of dispositions spread across 26 transactions and 1.2 million sq ft of total leasing volume for the fourth quarter, which was the highest quarter in the last year. We are focused on taking all the seven steps to our path forward that we outlined at our recent Investor Day and are also included on page four of the press release. Our team continues to navigate a challenging macro industry and regulatory environment. Please refer to our earnings release for our EPS results. FFO per share diluted as adjusted was $2.16 for Q4 2025 and $9.01 for the year, which represents the midpoint of our prior guidance provided on our last quarterly call.

[Marc Binda, CFO at Alexandria Real Estate Equities]

Leasing volume for the quarter of 1.2 million sq ft was up 14% over the prior four quarter average and up 10% over the prior eight quarter average. An important takeaway for the quarter is that the leasing of vacant space completed during the fourth quarter of 393,000 rentable sq ft was almost double the quarterly average over the last five quarters. Free rent and rental rate changes on renewed and re-leased space were under pressure this quarter, which reflects the market realities and included two large deals, one in Canada and one in our Sorrento Mesa submarket. Lease terms for the quarter of just over seven and a half years were consistent with the prior three-year average of right around eight years.

[Marc Binda, CFO at Alexandria Real Estate Equities]

Occupancy at the end of 2025 was 90.9%, which was up 30 basis points from the prior quarter and was up 10 basis points over the midpoint of our prior guidance. In addition, we've signed leases of almost 900,000 rentable sq ft, or about 2.5% of the portfolio, that are expected to commence in the third quarter of 2026 on average upon completion of construction and will generate incremental annual rental revenue of $52 million. It's important to emphasize that our asset quality, location, best-in-class operations, sponsorship, and brand trust continue to be a major distinguishing factor for tenants, as our Mega Campuses, which represent about 78% of our annual rental revenue, outperform the total market occupancy in our largest three markets by 19% for occupancy. We reiterated our year-end 2026 occupancy range of 87.7%-89.3% that was provided at our Investor Day this past December.

[Marc Binda, CFO at Alexandria Real Estate Equities]

A key takeaway on our outlook for 2026 is that we expect occupancy to dip in the first quarter of 2026, and we expect occupancy growth in the second half of 2026. The projected decline in occupancy for the first quarter is primarily driven by the 1.2 million sq ft of key lease expirations with expected downtime that we highlighted on page 22 of our supplemental package, consistent with our outlook from Investor Day. We're making good progress across these spaces with 13% that's either lease negotiating, and we've identified prospects or in early negotiations on another approximately 40% of these spaces. Same property net operating income was down 6% and 1.7% on a cash basis for the fourth quarter, and down 3.5% and up 0.9% on a cash basis for 2025.

[Marc Binda, CFO at Alexandria Real Estate Equities]

The results for the year were at or better than the guidance midpoint we provided on our last earnings call. The full year 2025 results were primarily driven by a decline in occupancy, which occurred in early 2025, and the cash results had a boost from the burn-off of free rent in the first half of 2025. We reiterated our outlook for same property performance for 2026 of down 8.5% at the midpoint of our guidance range, which is expected to be driven by lower occupancy.

[Marc Binda, CFO at Alexandria Real Estate Equities]

Despite the anticipated decline in occupancy in Q1 2026 I previously mentioned, we continue to benefit from a very high-quality tenant base with 53% of our annual rental revenue coming from investment-grade or publicly traded large-cap tenants, long remaining lease terms of 7.5 years, average rent steps approaching 3% on 97% of our leases, and strong adjusted EBITDA margins of 70% for the fourth quarter. We expect same property NOI performance to be weaker in the first half of 2026, driven by lower occupancy and stronger performance in the back half of 2026.

[Marc Binda, CFO at Alexandria Real Estate Equities]

Our guidance assumes the delivery of the nearly 900,000 sq ft of signed leases commencing in the third quarter of 2026 on average, as well as about a 2%-3% assumed benefit from a range of assets that could be sold or designated as held for sale in the second half of 2026. We highlighted several considerations for the first quarter of 2026 on page five of our supplemental package, including the following three items that we expect to impact same property performance. First, the 1.2 million sq ft of key lease expirations with expected downtime, of which around 60% expired mid-January on average. Second, we terminated one lease for nearly 171,000 rentable sq ft in South San Francisco in Q4 2025 that had annual rental revenue of $11.4 million.

[Marc Binda, CFO at Alexandria Real Estate Equities]

We are announcing that we re-leased 100% of the space to a new tenant, but the new lease isn't expected to commence until beginning in the second half of 2026, so there will be some additional temporary vacancy in the first half of 2026. And third, our guidance assumes a reduction of rent of approximately $6 million per quarter starting in the first quarter of 2026 related to potential tenant wind-downs. During 2025, we achieved tremendous general and administrative cost savings of $51.3 million, or 30% compared to the prior year, and our G&A cost as a percentage of NOI was about half the average for other S&P 500 REITs at 5.6% for 2025. As we've guided in the past, we expect those annual savings in 2026 relative to 2024 to be cut roughly in half given the temporary nature of some of the 2025 savings.

[Marc Binda, CFO at Alexandria Real Estate Equities]

We reiterated our guidance for capitalized interest for 2026 of $250 million, down 24% from 2025. With projects under construction and expected to generate significant NOI over the next few years and other earlier stage projects undergoing important entitlement design and site work necessary to be ready for future ground-up development, we were required to capitalize a portion of our gross interest cost. Part of our strategic path forward includes goals to reduce the size of our pipeline and construction spending needs and to substantially complete our large-scale non-core disposition plan in 2026. During December 2025, we sold or designated for held-for-sale projects with more than $1 billion of basis that had previously been subject to interest capitalization.

[Marc Binda, CFO at Alexandria Real Estate Equities]

As a result, we expect a decline in capitalized interest headed into the first quarter of 2026, and we have a number of projects under construction where we are evaluating the business strategy and a number of future pipeline projects undergoing pre-construction activities with milestones in May 2026 on average. To the extent that we decide in the future to either pause or sell any of those projects, capitalization of interest and other costs would cease. While those ultimate decisions have not yet been made, we would like our disposition program for 2026 to include a significant component of land, which will also help us achieve one of our strategic objectives to significantly reduce the size of our land bank. During the fourth quarter, realized gains from our venture investments was $21 million, down from the approximate $32 million quarterly average for the preceding three quarters.

[Marc Binda, CFO at Alexandria Real Estate Equities]

For 2026, we reiterated our guidance range for realized investment gains of $60 million-$90 million, or approximately $19 million per quarter at the midpoint. We continue to have one of the strongest balance sheets among all publicly traded U.S. REITs. Our corporate credit ratings continue to rank in the top 15% of all publicly traded U.S. REITs. We have tremendous liquidity of $5.3 billion, the longest average remaining debt maturity among all S&P 500 REITs at just over 12 years, and modest leverage of 5.7x for net debt to Adjusted EBITDA for the fourth quarter annualized. We reiterated our guidance range for Q4 2026 net debt to annualized adjusted EBITDA of 5.6x-6.2x.

[Marc Binda, CFO at Alexandria Real Estate Equities]

While we remain on track to achieve our leverage goals for year-end 2026 leverage, we expect leverage in the first quarter of 2026 measured on a quarterly annualized basis to temporarily increase by 1x-1.5x higher, driven by a reduction in quarterly Adjusted EBITDA. Please refer to page five of our supplemental package for detailed assumptions specific to the first quarter. We expect Q1 2026 leverage to significantly improve over the balance of 2026 as we make progress on our dispositions and sales of partial interest. As we announced at our Investor Day, we sold one of our campuses in South San Francisco. We expect to sell two redevelopment projects in 2026, and we pivoted to office on one project in The Fenway. These changes reduced our future funding needs by more than $300 million.

[Marc Binda, CFO at Alexandria Real Estate Equities]

In addition, we are evaluating the go-forward business strategy for four additional projects that are currently under construction and have significant remaining capital needs. Again, a huge congratulations to the Alexandria team for the tremendous execution during the fourth quarter with $1.5 billion of dispositions completed across 26 different transactions, which allowed us to achieve our leverage target of 5.7x for the fourth quarter. Over the course of 2025, we also made significant progress in reducing our investment in non-income producing assets as a percentage of gross assets from 20% at the end of 2024 to 17% at the end of 2025, and we expect that ratio to continue to decline by the end of 2026. In connection with our disposition program, we recognized our share of impairments of $1.45 billion in the fourth quarter. Five important items to highlight here.

[Marc Binda, CFO at Alexandria Real Estate Equities]

First, approximately 90% of that number was previously announced with our 8-K on December 3rd, and the remaining 10% was primarily related to one land parcel located in Greater Boston, which was designated as held for sale later in December. Second, 50%-60% of our share of the real estate impairments recognized in the fourth quarter was related to land, which is notable given the oversupply in numerous sub-markets. Third, the two largest impairments comprised 37% of the total and included our future development project at 88 Bluxome Street in SoMa, located in San Francisco, and our Gateway Campus in South San Francisco, which was owned through a consolidated joint venture. Fourth, we sold our interest in the Gateway Campus in South San Francisco in December.

[Marc Binda, CFO at Alexandria Real Estate Equities]

Ultimately, we decided to exit this investment given the challenging supply and demand dynamics in South San Francisco and the very significant capital required over time to redevelop the campus. And fifth, we expect to complete the sale of 88 Bluxome Street, our only asset located in SoMa, over the next few quarters. We originally acquired this site in 2017 with the intent to expand the Mission Bay cluster. However, Pinterest terminated their lease with us in 2020 and paid us an $89.5 million fee, and we ultimately decided the sale proceeds from this project would be better recycled into our Mega Campus platform and to address our current funding needs. We continue to focus on our disciplined strategy to recycle capital from dispositions and partial interest sales to support our funding needs, with a focus on the substantial completion of the large-scale non-core asset program in 2026.

[Marc Binda, CFO at Alexandria Real Estate Equities]

We expect non-core assets and land to comprise around 65%-75% of the $2.9 billion midpoint of our guidance for 2026 dispositions and sales of partial interest. We expect most of our dispositions and partial interest sales to close in the second, third, and fourth quarters, with a weighted average closing date in the third quarter. In early December, our board also authorized a reload and extension of the common stock repurchase program of up to $500 million, and our guidance does not assume any common stock repurchase in 2026 based upon current market conditions. Lastly, we reaffirmed our guidance for 2026 FFO per share diluted as adjusted, as well as the key components of guidance. Now I'll turn it back to Joel.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

So can we go to questions, operator, please?

[Operator]

At this time, we'll begin the question-and-answer session. To ask a question, you may press star and then one on your touch-tone telephones. If you are using a speakerphone, we do ask that you please pick up the handset prior to pressing the keys to ensure the best sound quality. To withdraw your questions, you may press star and two at any time. Once again, that is star and then one to join the question queue. Our first question today comes from Farrell Granath from Bank of America. Please go ahead with your question.

[Farrell Granath, Equity Research Associate at Bank of America]

Hello, this is Farrell Granath. Thank you for taking my question. I wanted to start it off. I know that we spoke about a month ago, but just given the sustained and slightly up quarter-over-quarter leasing that you've seen and recent commentary around better VC funding that we've seen in the broader biotech market, has that changed your outlook at all on expectations into 2026, or are you at least receiving greater inbounds in terms of sentiment as people are potentially making more decisions?

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Okay, so Farrell, is your question aimed broadly at leasing, or is it aimed at venture-backed private? So I'm not sure how broad or narrow your question is.

[Farrell Granath, Equity Research Associate at Bank of America]

I want to just connect the dots between what we've seen as positive headlines for broader VC funding and how that may be connecting to leasing and sentiment towards leasing.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Okay, because that's one segment of a very broad market. So Hallie, maybe take her through a little bit of venture and the private side, but then maybe overall.

[Hallie Kuhn, SVP of Life Science and Capital Markets at Alexandria Real Estate Equities]

Yeah, thanks. And hi, Farrell, this is Hallie. As Joel mentioned, when we think about VC dollars going into this industry, it's very much tied to a specific segment, our private biotechnology segment. And we have seen over the course of this year sustained funding. Numbers are similar, if not slightly higher, to the last couple of years. This is money that is going into new companies. On the other hand, venture funds have raised the lowest amount of dollars in the last decade. So this is LPs investing in these funds. And so we have this kind of interesting dynamic going on here where it's certainly not back to a healthy, robust environment that we would fully like to see.

[Hallie Kuhn, SVP of Life Science and Capital Markets at Alexandria Real Estate Equities]

What we see that manifesting in is that VCs and these companies continue to be very conservative. So we certainly are seeing demand. Peter can talk to tours increasing. There's some great companies out there. I do think by and large, decision-making is still taking longer, and companies are very cautious in terms of how they think about taking on new space or expanding. So while we're cautiously optimistic, we are monitoring it closely because we don't necessarily think that we're back to a fully robust environment that we may have been in in the past. More broadly speaking on headlines, the other big one is the XBI has certainly performed incredibly well over the past year, outperformed broader indices. As mentioned in Investor Day, the majority of those companies are commercial or near-commercial companies, which don't typically drive lab space needs.

[Hallie Kuhn, SVP of Life Science and Capital Markets at Alexandria Real Estate Equities]

So we're not seeing the immediate translation of that activity to leasing. So altogether, while we do feel that we're moving in the right direction in terms of positive sentiment, we still have a lot more work to do. There's still a lot of volatility on the regulatory and pricing side of things. And so we just continue to monitor and for the demand that is out in the market, meet the market and really capture our outside share of leasing.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Yeah, let me put one footnote on that, Farrell. If you look at the pie chart of our leasing for the year and the fourth quarter, you'll see in the fourth quarter a notable, very small amount of leasing for public biotech. That's something that we're hoping turns around in 2026 because that's a critical mainstay of this industry. And much of that has to do with the lack of availability of secondary offerings except on data or the lack of a real, robust, open IPO market. Okay.

[Farrell Granath, Equity Research Associate at Bank of America]

Thank you for the color on that. And I also wanted to ask about your strategy of retaining The Fenway office property and looking to lease as an office. Was that a one-off transaction that you're looking to maintain, or is that something that you could see doing across other properties as well?

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Well, yeah, I'll have Peter comment on that, but they have to remember that The Fenway is made up of multiple buildings. The one we're speaking about is, in fact, an office building and, in fact, has multiple long-term leases with some of the best institutions in LMA and The Fenway.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

And so sometimes you think about, would you create lab space or other things out of vacant space or stick with what makes sense and the demand there? We think we'll, on a go-forward basis, be pretty good office-wise. But Peter, do you want to comment on that, I think, 401?

[Peter Moglia, CEO and CIO at Alexandria Real Estate Equities]

Yeah, I mean, I would agree exactly with what you just said. We have seen an increase in demand for office space. And given the availability we have elsewhere in the Fenway for lab, it made more sense to just go ahead and follow a business plan to lease it as office and not create any more lab space in the near future.

[Farrell Granath, Equity Research Associate at Bank of America]

Okay, thank you very much.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Yeah, so that's more building and sub-market specific as opposed to something much broader.

[Operator]

Our next question comes from Ronald Kamdem from Morgan Stanley. Please go ahead with your question.

[Ronald Kamdem, Managing Director at Morgan Stanley]

Hey, two quick ones. Just starting with the dispositions, I saw some of the cap rates on the stabilized assets and the supplemental, which was helpful. But as you're sort of thinking about that $2.9 billion, I appreciate a lot of it is going to be land, but any sort of commentary on cap rate trends, sort of the interest price discovery, how that's been going relative to your expectations? Thanks.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Yeah, yeah, Peter?

[Peter Moglia, CEO and CIO at Alexandria Real Estate Equities]

Yeah, I mean, there's still going to be a considerable amount of non-core assets that we're selling. And you've seen cap rates for those in the mid-sixes all the way up to the mid-nines. A lot has to do with what markets they're in, how much leasing, or what the WALT is. The lower the WALT, the higher the cap rate. We do plan on a couple of executions during the year that would involve more core assets. So you should be able to get more discovery on what our NAV could be for what we're holding on to. But I'm not going to speculate on those cap rates yet. We have talked in the past and mentioned at Investor Day that we do think our top end properties should have a five-handle.

[Peter Moglia, CEO and CIO at Alexandria Real Estate Equities]

And one or two of those types of properties could be involved in this execution, and we'll report on that when it happens.

[Ronald Kamdem, Managing Director at Morgan Stanley]

Great. Just my follow-up. I had sort of a similar question on the leasing chart, but maybe asking it a different way. Can you just comment on the leasing pipeline in terms of how it's rebuilt after the quarter? And if any sort of notable groups are in the pipeline or are not in the pipeline, that'd be helpful. Thanks.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Well, yeah, that's kind of secret sauce. I'm not sure I want to say much, but Peter, do you have any overall comments?

[Peter Moglia, CEO and CIO at Alexandria Real Estate Equities]

Well, yeah, look, in practically all of our markets, the smaller spaces under 50,000 sq ft are still hot as moving. Most of the tours are in that range. There is, as Joel mentioned and Hallie mentioned, there is a bit of a dearth of biotech, public biotech type of companies, which are usually the middle of the barbell, 50,000-150,000 sq ft. We're not seeing a lot of that, but we do have in certain markets some good activity in the 100,000 sq ft+ range. So we're pleased to see that.

[Peter Moglia, CEO and CIO at Alexandria Real Estate Equities]

But as Joel mentioned, we really need to see the public biotech sector contribute to the leasing pipeline in order for it to really start to turn around. There are some good green shoots. We're very cautiously optimistic, but one example is that the Greater Boston region did see an 11% increase in tenants in the market, and that was really the first time we've seen an increase in a number of quarters. So we're happy to see that, and we'll keep you informed as we go.

[Ronald Kamdem, Managing Director at Morgan Stanley]

Really helpful. Thanks so much.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Thank you.

[Operator]

Our next question comes from John Kim from BMO Capital Markets. Please go ahead with your question.

[John Kim, Managing Director at BMO Capital Markets]

Thank you. I was wondering if you still felt comfortable with the previous guidance you gave for the fourth quarter, 2026 FFO of $1.40-$1.60 stated at your Investor Day and whether or not you believe this would represent trough earnings. I think in that presentation, you mentioned that earnings will be flattening out in the second half of the year, but there are some dispositions that look like that's falling into the fourth quarter.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Yep. So Marc?

[Marc Binda, CFO at Alexandria Real Estate Equities]

Yeah. Hey, John. Yeah, we're still tracking within that range that we gave for the fourth quarter of 2026, which I think was $1.40-$1.60. And that does represent kind of the trough for the year, at least for 2026. But as far as 2027, I know you don't want to give guidance for that, but.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Yeah, we haven't and can't give guidance at this point for 2027. But that was the point of saying that's a good run rate to think about as a base.

[John Kim, Managing Director at BMO Capital Markets]

And then can you comment on the dispositions you've completed year to date and what you've planned for the year in terms of the type of buyers you're talking to as far as owner users, other REITs, developers looking to convert some of that space potentially, or other buyers?

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Yeah. So maybe, Marc, do you want to just talk about the percentages of dispositions through the year and then maybe ask Peter to comment on the buyer pool?

[Marc Binda, CFO at Alexandria Real Estate Equities]

Yeah, sure. Yeah, the mix of dispositions was pretty consistent with what we kind of set out at Investor Day. So about 20% stabilized, 21% land, and then 59% non-stabilized.

[Marc Binda, CFO at Alexandria Real Estate Equities]

So I mean, obviously, the biggest pot or portion was the non-stabilized properties, which is going to attract a certain type of buyer. Maybe I'll hand it over to Peter to kind of get a little bit more point.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Yeah, before you do, talk about timing quarter by quarter because I think that's.

[Marc Binda, CFO at Alexandria Real Estate Equities]

Oh, sure. Yeah, yeah. So as we look forward to 2026, we've got just under $200 million of stuff that were under contract or under PSA negotiations. We've got about $580 million of assets on balance sheet today that have been designated as held for sale. And so I think that the first quarter closings will be pretty small. We expect the bulk of the closings to occur over Q2, Q3, Q4. And again, I think on a weighted average basis, it's probably closer to third quarter as a kind of a blended average for the closings for 2026.

[John Kim, Managing Director at BMO Capital Markets]

Yep. Thanks.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Yeah, Peter.

[Peter Moglia, CEO and CIO at Alexandria Real Estate Equities]

Yeah, hey. So on our guidance page, we did indicate that we've got about $180 million under contract or in negotiations that we expect to close in the near term. That's essentially three assets. One is a portfolio that is being purchased by what we would classify as an investment fund. Investment fund buyers have been our fourth largest over the last couple of years, taking down about 12%-15% of our inventory. An investment fund is someone who's buying it to hold long-term and is usually private capital. The other two assets are residential conversions.

[Peter Moglia, CEO and CIO at Alexandria Real Estate Equities]

They're land or assets that are at the end of their useful life that will be demolished and turned into a residential type of use. And that was another one of our largest segments of buyers last year. And we anticipate that will continue this year. More than 55% of our available land is either zoned or could have an allowable residential use and is in urban environments that could use the housing. So we expect that out of the $2.9 billion midpoint this year, as Marc said, there'll be a considerable amount of land, 25%-35%. And we do expect the majority of that to go to residential developers. But there has not been a problem getting assets sold. There's a number of buyers. The biggest issue is just the yields that these buyers are looking for. And that has created some impairments.

[Peter Moglia, CEO and CIO at Alexandria Real Estate Equities]

But the good news is when we need to get things sold, we do. And we fully are confident we'll do the same thing this year, even though it's a larger amount that we have to execute on.

[John Kim, Managing Director at BMO Capital Markets]

Thank you.

[Operator]

And our next question comes from Vikram Malhotra from Mizuho. Please go ahead with your question.

[Vikram Malhotra, Managing Director at Mizuho]

Morning. I just wanted to clarify kind of the earnings, I guess, trajectory through the year. With the vacancies or the move-outs you mentioned, some of the fees, etc., one-time items in Q4 2025, I'm just wondering sort of the cadence that you showed at Investor Day trending down to that $1.40-$1.60. Is that cadence still intact?

[Marc Binda, CFO at Alexandria Real Estate Equities]

Yeah. Hi, Vikram. Yeah. We still expect the fourth quarter to kind of be the low point in earnings for the year for 2026. We did. I think there was some question around where the first quarter goes and how steep of a decline that is coming off the fourth quarter. And so we tried to give a lot of color about the components that go in there. But the general trajectory that fourth quarter, things will even out in the back half of the year. And the fourth quarter being in that $1.40-$1.60 range still holds.

[Vikram Malhotra, Managing Director at Mizuho]

Okay. Great. And then I guess maybe Joel or Hallie, from a broader perspective, I understand it takes a while for all the changes on the macro front to translate to leasing. But I don't know if you've had any recent conversations with FDA officials or any larger VCs in terms of the shifts that you may be hearing as a precursor to new company formation and hopefully then leasing down the pike.

[Vikram Malhotra, Managing Director at Mizuho]

So maybe you can just update us any thoughts around the FDA and early-stage Series A, B type funding. Thanks.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Yeah. So maybe let me make a couple of comments and ask Hallie to fill in the blanks. So I think it's fair to say that the FDA Commissioner has been active. He's out a lot. He's certainly trying to head in the right direction and do the right things given speed of approvals, looking at trying to get products into the clinic much quicker than otherwise. Remember, we talked about it at Investor Day. The things that the market really wants to see is a substantial compression of the 10-12-year billion-dollar-plus cycle of bringing up a compound from discovery to the market. And he's, I think, very much focused on that now.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

With defections, top firings, resignations, and all that stuff at the FDA, how much does that practically impede the ability of the agency to do what they want to do, which I think they've got their mindset in the right place? I think is a big question for this year. Last year, they did end up approvals at 46, which was a very, very respectable number, but a lot of that was in the pipeline. This year is going to be a much more telling result. But Hallie, other thoughts, comments?

[Hallie Kuhn, SVP of Life Science and Capital Markets at Alexandria Real Estate Equities]

Sure. So maybe Vikram could take a step back on this question as it continues to come up. On page 21 of the Supp, we break out our leasing volume by business type, both for the fourth quarter and for the full year, 2025.

[Hallie Kuhn, SVP of Life Science and Capital Markets at Alexandria Real Estate Equities]

And if you look at private biotechnology, in the last quarter, it made up about a fifth of all leasing volume. So to be clear, we still continue to see demand from this segment. Whether that's going to pick up and how long that takes, I wish we could give you a specific time frame. These things take a while, right? And I think generally we need a lot more confidence in terms of the broader landscape, being able to return capital to LPs, the IPO window opening up, which is a really important source of capital for private companies. But where we've really seen the drop-off, as Joel mentioned, is in that public biotechnology cohort. So in terms of overall impact to our leasing going forward, we think that segment in particular is critical. And we are seeing some demand out there from some really good companies.

[Hallie Kuhn, SVP of Life Science and Capital Markets at Alexandria Real Estate Equities]

They still are tending to be more capital conservative, more commercial, near commercial. And without that next bolus of new companies that are IPOing, that tend to be earlier stage, they still seem to be on the back burner right now. At JPMorgan, there was a lot of, I would say, positive sentiment around the potential for some really strong companies to go public and raise capital. We haven't seen that yet. But that is really top of mind as we think about the next, I would say, 12-18 months.

[Vikram Malhotra, Managing Director at Mizuho]

Okay. Great. And then can I just clarify? The new leasing was really good this quarter. And hopefully, the pipeline supports sort of that continuation. But where are we today in terms of incentive packages, TIs, free rents to achieve that leasing?

[Vikram Malhotra, Managing Director at Mizuho]

I ask just because there have been a couple of leases in, say, South San Francisco where we've heard very big TI numbers. So I'm just wondering if you can give us a bit more granular color on the TI and free rents. Thanks.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Yeah. Peter?

[Peter Moglia, CEO and CIO at Alexandria Real Estate Equities]

Yeah. I mean, tenant improvements haven't changed. They're still elevated for anything that's from shell. It's got to really be either you get an allowance to build the whole thing out or you have to spec build it. So on renewals and releasing, the TIs are also stable. The fact that the space is already built out and the fact that people tend not to change much in the generic labs that we build, that's an advantage to us. So really where we continue to see weakening in fundamentals is in the free rent category. And it's continued to elevate.

[Peter Moglia, CEO and CIO at Alexandria Real Estate Equities]

We did have a couple of leases this quarter that really had a significant amount of free rent in order to win the deal. Joel mentioned in his comments that we're meeting the market. It's in our best interest to meet the market, but keep rental rates as stable as possible. Because as free rent burns off, then you get the income that you can build upon. Hopefully, the next generation of leasing, you can increase it from there. When you start taking rents down, then you're starting to destruct value. Alexandria and others that are competing in the market, free rent is the tool that we're using. Tenants really appreciate it because obviously, it's good for their cash flow.

[Peter Moglia, CEO and CIO at Alexandria Real Estate Equities]

As long as we continue to have availability in the mid-20s to low-30s in the major markets, free rent is going to be the tool that people need to use in order to execute on deals. But outside of that, we are pretty happy to see that rental rates are stable. In certain cases, growing. And we just got to get the net effect is to improve. But that'll take a decrease in supply over time in order to start seeing that.

[Operator]

Our next question comes from Jim Kammert from Evercore. Please go ahead with your question.

[Jim Kammert, Managing Director at Evercore]

Thank you very much. Just trying to triangulate on Peter and Hallie's comments regarding the public biotech. Is there any concern? I mean, you said they're both critical to sort of kickstarting demand again.

[Jim Kammert, Managing Director at Evercore]

But is it possible that some of these public biotechs, even if they raise more capital, already have sufficient space? Or do you really think there's expansion space need there?

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Well, yeah. Let me maybe give you an overarching comment, Jim. I think number one, historically, public biotech has been the mainstay of, I mean, the broader industry is obviously institutional, pharma, product, tools, services, all that. But when you get to biotech itself, the public market has been the mainstay of this industry going back 50 years this year to Genentech. And one would assume that it would continue to be the mainstay. And it's made up of really three things. One, you get a good start at the venture level. You can get public through an IPO window that's reasonable. And you can continue to finance the company even if you don't have immediately actionable data.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

That's how it's worked over the last several decades. That's what we're hoping to see a return to. Now, in any given case, it's hard to say. Some will need more space. Some will need less space. Some will be able to keep the same. I don't know. Hallie, thoughts there?

[Hallie Kuhn, SVP of Life Science and Capital Markets at Alexandria Real Estate Equities]

Yeah. Jim, I think that is in a way what we have been seeing. If you look at the XBI this past year and follow-on financings, which on an absolute numbers basis have been pretty strong, most of those have been for particularly commercial-stage companies, which is great in terms of sentiment for the industry. But these are by and large not companies that are driving a lot of R&D expansion. So to Joel's point, we need to see the earlier funnel fill up.

[Hallie Kuhn, SVP of Life Science and Capital Markets at Alexandria Real Estate Equities]

We need to see the venture-stage companies go public, gain more liquidity, expand their investor base. Those are more likely at that stage to drive additional R&D needs, which is what we've seen historically. I think Peter did mention we have seen some requirements hit the market. Things take a while. But not to say that it's a complete desert. But it is few and far between than it has been in years past.

[Jim Kammert, Managing Director at Evercore]

That's a very great color. And then one quick clarification. Peter Moglia, I think said that it's possible we might see a five handle on some of the core asset capital recycling in 2026. Would that be potentially, I mean, if it happens, a JV? Or would that also be for an outright sale? I'm just trying to think about NAV implications, sale versus JV. Thank you.

[Peter Moglia, CEO and CIO at Alexandria Real Estate Equities]

Yeah. Very likely a JV that would happen.

[Peter Moglia, CEO and CIO at Alexandria Real Estate Equities]

We are not planning on selling any core assets outright unless there's a special situation.

[Jim Kammert, Managing Director at Evercore]

Great. Thank you all.

[Operator]

Our next question comes from Ray Zhong from JPMorgan. Please go ahead with your question.

[Ray Zhong, VP of REIT Equity Research at JPMorgan]

Hi. Thank you for taking my question. My first one is on the capital allocation side. It seems like you guys did above midpoint of your guidance on dispo this year. And you guys, I think Marc mentioned, buyback is still not on the table at this point. But with the excess cash, is the thinking that the priority is on the debt side? Or how should we think about that? And when would buyback be on the table with the excess cash?

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Yeah. So Marc?

[Marc Binda, CFO at Alexandria Real Estate Equities]

Yeah. Hi, Ray.

[Marc Binda, CFO at Alexandria Real Estate Equities]

I think in terms of the buyback, we'd like to get farther along on the disposition program, which is going to involve paying down debt to keep the balance sheet in check before we consider buybacks. Now, I say that given the current market conditions and will remain flexible. But as we sit here today, that's kind of our current thinking.

[Ray Zhong, VP of REIT Equity Research at JPMorgan]

Got it. And a follow-up question on uses of funding then. You guys disclose how much you historically spend on the non-real estate investments in the 10-K. If I'm looking at it correctly, I think between $200-$250 a year. How should we think about that moving forward? Yeah. Any help on that front would be appreciated. Thank you.

[Marc Binda, CFO at Alexandria Real Estate Equities]

Yeah. Sure. So we really look at the fund kind of net of the inflows and outflows.

[Marc Binda, CFO at Alexandria Real Estate Equities]

So I think if you look at the cash that came in, it was maybe a net outflow of somewhere between $60 million-$70 million for the year. And that's been, I mean, I think it was a similar number in the prior year. So I think we'd like to see that the fund be as close to neutral as possible so that we're not putting a ton of capital in there, but still continuing to be very active in the space.

[Ray Zhong, VP of REIT Equity Research at JPMorgan]

Got it. So the net will, the expectation is hopefully get to a net neutral on that front.

[Marc Binda, CFO at Alexandria Real Estate Equities]

That's right. Or at least a small number. Like I said, it's been $60 million-$70 million in the last couple of years.

[Ray Zhong, VP of REIT Equity Research at JPMorgan]

Got it. Thank you so much.

[Operator]

And our next question comes from Rich Anderson from Cantor Fitzgerald. Please go ahead with your question.

[Rich Anderson, Managing Director at Cantor Fitzgerald]

Hey, thanks.

[Rich Anderson, Managing Director at Cantor Fitzgerald]

Still good morning out there. The elephant in the room is, I guess, stocks up 20% this year. It's great. Or 19%. Yeah, it still feels like pricing power is quite a ways off still with everything that's going on. Do you have any sense on the people that you're talking to, a different type of investor that's showing interest in the stock? Do you think it's just pure rotation, people sort of profit-taking, looking for a bottom in life science? Do you have any sense of what's driving stock performance so far this year?

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Well, I think it's all of the above. I think it's pretty clear that the slide that we showed at Investor Day, when you looked at stock price versus consensus NAV, certainly tells the story in many respects.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

I think if one believes in this industry, 50 years after Genentech was founded this year, back in 1976, again, we've only addressed 10% of diseases. 90% are left. And if the public is willing to pay for therapies and addressable cures to the extent we can have that, that's one has to believe the industry has a promising future. We are making some we're slipping back, as I said, when you look at some of the vaccine policy stuff, which is a little distressing to a lot of people. But I think if you set that kind of mentality aside and you look at what the FDA is trying to do, I think they're trying to do exactly the right thing to compress the time to go from discovery into the clinic, through the clinic, and out of the clinic into the commercial side.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Assuming the policymakers and executive and legislative branches don't get too crazy to pay a fair return on these innovative therapies. I mean, just look at anybody who's been the beneficiary of any real therapy that saved somebody's life and made that more a ongoing chronic condition as opposed to life-threatening, if you will. I think that's where the great promise is here, Rich. And so I think that when you look at our locations, quality of assets, quality of sponsorship, I mean, it's not surprising that the selloff after the third quarter was, I think, pretty radical.

[Rich Anderson, Managing Director at Cantor Fitzgerald]

And those are all good color. But do you think you're attracting a different investor? Do you think you're attracting a non-REIT investor, a biotech investor, a generalist investor to the name?

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

I think the nature of investors change over time. I mean, think about when we went public.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

There are a lot of long-term investors today. There's very few long-term investors, a lot of ETF investors. But there's a large cohort of value-driven investors that don't look at quarterly, day-to-day, monthly, year-to-year earnings. They look at quality of assets generating quality of cash flows, obviously, people interested in the industry. So I think it's a whole bunch of sets of different interests that have come to bear because the selloff just was, I think, foolishness.

[Rich Anderson, Managing Director at Cantor Fitzgerald]

I thought Hallie was going to jump in there, but maybe I misheard that. So okay.

[Hallie Kuhn, SVP of Life Science and Capital Markets at Alexandria Real Estate Equities]

No problem. Keep going. I just covered it really well.

[Rich Anderson, Managing Director at Cantor Fitzgerald]

Okay. Perfect. Okay. Second question for me is, let's say your development exposure as a percentage, just to use a simple way of looking at it, as a percentage of total assets goes from 20%-ish to 15%-ish this year.

[Rich Anderson, Managing Director at Cantor Fitzgerald]

I'm assuming that that's sort of a step in the process. I'm curious, Joel, Peter, whoever, what do you think the appropriate run rate is for development exposure, financing risk, need to access capital, all those things? What is new Alexandria going to look like from a development exposure point of view, call it two, three years from now in your mind?

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Yeah. I think we kind of articulated that at Investor Day. There's a slide there that talked about we think we don't know precisely because we're still in a, I think, a how shall I say, a phase of trying to get used to a new reality with the industry.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

But I think we've hypothesized that we think 10%, some more 10%+ as a percentage of non-productive or non-income-producing land as a percentage of overall gross assets is probably where we want to be, very different than GFC where there were no supply issues. The prospects were kind of unlimited because there was no supply constraint issue, oversupply issue, if you will. So I think this is just a new reality. But we've got great opportunities on many or most of our Mega Campuses. And so those will be the instruments of future development and external growth. And we're excited about that. And there isn't just biotech. There is a whole host of other interested parties, both in our current pie charts and pie charts beyond, that view those locations as top of mind.

[Rich Anderson, Managing Director at Cantor Fitzgerald]

Yeah. Okay. Great. Thanks very much.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Yep. Thank you.

[Operator]

Our next question comes from Seth Berge from Citi. Please go ahead with your question.

[Nick Joseph, Analyst at Citi]

Thanks. It's Nick Joseph here with Seth. I guess last month at the Investor Day, you talked about a four to five year recovery for life science broadly. And I recognize it's only been about two months. But you've been busy over those two months. So has anything changed that timeline, either moving it up or delaying it from what you've seen?

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Yeah. So that's actually I'm glad you teed this up because Peter, I think, addressed this. But a lot of people came away reporting it a little bit unclear.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

He basically said that he thought that the timeframe for recovery in our markets where we were very active would be in the two to threeyear range and that it may be as much as four to five in submarkets where we were not particularly involved or active. But Peter, you want to comment on that?

[Peter Moglia, CEO and CIO at Alexandria Real Estate Equities]

Yeah. Thanks for clarifying that. Exactly. If you look at Greater Boston, for example, there's a significant amount of inventory in an area like Somerville and other tertiary areas, and Alewife where we're not at, which that's where we think that it's going to take four to five years for that to resolve.

[Peter Moglia, CEO and CIO at Alexandria Real Estate Equities]

But Cambridge and Watertown, Seaport, where we're heavily invested, that's probably more like two to three years and maybe even less, depending on the trend of a lot of people are starting to realize that they should probably go a different path in life science. And we're hoping to continue to see that. So if we obviously, demand is going to be needed to take a lot of the lab space. But as a lot of it decides to change use, even that four to five estimate could be reduced. But Joel's exactly on point. Four to five years for the areas that are the new markets that really didn't ever need to be lab markets, those will need a long time to resolve because it's not going to get resolved through lab demand. It's going to get resolved by changing use.

[Peter Moglia, CEO and CIO at Alexandria Real Estate Equities]

But the lab markets that we're in that have been functional lab markets for decades, there has been some oversupply. And it'll take two to three years for that to resolve.

[Nick Joseph, Analyst at Citi]

That's very helpful. Thank you.

[Operator]

Our next question comes from Tayo Okusanya from Deutsche Bank. Please go ahead with your question.

[Tayo Okusanya, Managing Director at Deutsche Bank]

Hi. Yes. Good afternoon out there. In terms of the guidance, you talked a little bit about $6.25 million revenue headwinds from tenant wind down. Could you talk a little bit just about what's happening with that pool of tenants? Is it just they didn't get their drug trials failed, or they run out of cash? Or just kind of thematically, what's happening with that group? Just kind of understand what that headwind is.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Yeah. So I'll ask Marc to comment there.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

But I would say in this environment over the last handful of years, again, we're in the fifth year of a bear market, hopefully turning that around. And when you find that happening, obviously, more companies at the earlier stage or less companies are formed, and more companies may be wound down. Some companies merged in the public markets. The bankers, certainly during the heyday of the last decade, let too many companies go public. So there has been a shakeout there over the last handful of years of companies that probably shouldn't have gone public. So this is a natural outgrowth of that given where we are today. But Marc, you could comment more specifically.

[Marc Binda, CFO at Alexandria Real Estate Equities]

Yeah. The thing I would add is it's public and private biotech comprises the majority of it for the reasons that Joel and Hallie have mentioned.

[Marc Binda, CFO at Alexandria Real Estate Equities]

And some of it is kind of failures in their clinical milestones, which is normal in any market. That'll happen. But a lot of it is also ability to attract capital and just the kind of shorter runway that investors have given these companies that has caused part of the issue.

[Tayo Okusanya, Managing Director at Deutsche Bank]

Gotcha. That's helpful. And if I may ask one more, the four development assets that are still under strategic evaluation, does it all basically boil down to just leasing around these assets to determine whether you kind of proceed or you go through strategic alternatives?

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

No. I think it's much more granular than that. It's what is the prospect broadly in the submarket, the nature of the asset, any competitive product that we may have with that asset. I mean, there's a whole set of variability or analysis that you go through.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Leasing is clearly important, but it's not the sole determinant.

[Tayo Okusanya, Managing Director at Deutsche Bank]

Gotcha. Thank you very much. All the best.

[Operator]

Our next question comes from Michael Carroll from RBC Capital Markets. Please go ahead with your question.

[Michael Carroll, Managing Director at RBC Capital Markets]

Yep. Thanks. Joel or Peter, can you guys provide some color on the 400,000 sq ft of leases that were signed at previously vacant space? I mean, I would imagine a good chunk of that relates to the backfill at 259 East Grand Avenue. I guess if that's true, where were the other leases signed within that bucket?

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Yeah. Peter, I don't know if you want to give any color there.

[Peter Moglia, CEO and CIO at Alexandria Real Estate Equities]

I don't have the specific leases. But you are right that a significant amount of leasing was done at East Grand.

[Peter Moglia, CEO and CIO at Alexandria Real Estate Equities]

I will say that one thing that we were asked about and did some investigation on is that a significant amount of that leasing was absolutely new tenancy, not tenants relocating from one place to another, but new tenants actually coming into our portfolio, which we really love to see.

[Hallie Kuhn, SVP of Life Science and Capital Markets at Alexandria Real Estate Equities]

This is Hallie. I do have that list in front of me. So just to say, it was pretty diverse from a regional perspective, leasing in Cambridge. We have RT, Seattle, some in San Francisco. So in terms of just generally seeing positive momentum, backfilling that vacant space across the board, we think that diversity across the regions is healthy.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Yeah. And broader-based than you might otherwise guess.

[Michael Carroll, Managing Director at RBC Capital Markets]

And is there any common themes on why those tenants were willing to lease space, I guess, today in the fourth quarter?

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Yes. Because we're great sponsors.

[Michael Carroll, Managing Director at RBC Capital Markets]

Do they have funding agreements where they just got funding? Or is there?

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Yeah. Mike, it's so episodic in a sense because if a company hits a clinical milestone, a data milestone, and they need to do something, I mean, we've seen that with a couple of companies where they've doubled their space just on that one event. So it is very episodically driven. And I'm not sure I'd read anything into was the fourth quarter substantially different than the second quarter vis-à-vis leasing trends because it tends to be very case-specific.

[Michael Carroll, Managing Director at RBC Capital Markets]

Okay. Great. That's helpful. And then just one last one for me. On 401 Park, and I think I caught this earlier in the call. I just wanted to confirm to make sure I'm right. It's not necessarily that you have office tenants ready to lease that space. I don't know what type of interest.

[Michael Carroll, Managing Director at RBC Capital Markets]

It's just that you had lab space available in that marketplace, and you didn't need to decide, "Okay. We have this building that could be lab or could be office. Let's kind of diversify our approach and kind of go office with this specific property." Is that the right way to think about it? Or is there a vibrant office market ready for that asset?

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Yeah. I think that is the answer. It's an iconic office building that's been known for a long time. The mainstay is primarily anchor Boston institutions, brand names that you would know that have very, very specific uses there. Some are pure office. Some are more clinical-like or whatever. But fundamentally, this is part of and kind of adjacent to the LMA, Longwood Medical Area.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

So this is a big, big market for those institutions and their office and other adjacent or other kinds of uses other than, say, traditional wet lab space. So it's not so much that it's a hard call. The call was, given the NIH's move on the 15% limitation on indirect costs in a variety of ways, we saw a big decline of demand and immediate decision-making by a lot of medical institutions. And we've seen that across the country. We did put in the Supp. There is a court decision that has overruled that. That may start to move institutions in a different direction. But at some point, institutions still need to get space. And both Fenway and the LMA are the best locations for that. So it actually is a pretty easy decision.

[Michael Carroll, Managing Director at RBC Capital Markets]

Okay. Great. Thank you. I appreciate it.

[Operator]

Our final question today comes from Mason Guell from Baird. Please go ahead with your question.

[Mason Guell, Equity Research Associate at Baird]

Hi, everyone. Thanks for the time. You had previously talked about San Carlos, San Bruno, Seattle, and Campus Point as Mega Campuses with large shadow pipelines and that you may look to reevaluate some of these in the future. I guess, do you have any updates? Or do you expect to have any updates on any of these over the next few quarters?

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

You're talking about the expansion?

[Mason Guell, Equity Research Associate at Baird]

Yeah. The future shadow pipeline for.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Yeah. I think those are all under pretty deep study in each market. And probably at this point, don't want to get into that.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

But we clearly are looking to reduce our non-income-producing assets, as we've said, as a percentage of the gross assets and where we can carve off land that we have for other uses or move into a monetization path at a much faster rate. We're trying to do that. And so I would say stay tuned there, certainly for the Bay Area ones and Seattle.

[Mason Guell, Equity Research Associate at Baird]

Great. That's it for me.

[Operator]

And ladies and gentlemen, with that, we'll be concluding today's question and answer session. I'd like to turn the floor back over to Joel Marcus for closing remarks.

[Joel Marcus, Executive Chairman and Founder at Alexandria Real Estate Equities]

Okay. Well, thank you, everybody. We appreciate it and look forward to talking to everybody next quarter. Thank you. And stay safe.

[Operator]

And with that, ladies and gentlemen, we'll conclude today's conference call and presentation. We thank you for joining. You may now disconnect your lines.

Participants

Executives

• Hallie Kuhn, SVP of Life Science and Capital Markets
• Joel Marcus, Executive Chairman and Founder
• Marc Binda, CFO
• Peter Moglia, CEO and CIO

Analysts

• Farrell Granath, Equity Research Associate at Bank of America
• Jim Kammert, Managing Director at Evercore
• John Kim, Managing Director at BMO Capital Markets
• Mason Guell, Equity Research Associate at Baird
• Michael Carroll, Managing Director at RBC Capital Markets
• Nick Joseph, Analyst at Citi
• Paula Schwartz, Managing Director at Rx Communications Group
• Ray Zhong, VP of REIT Equity Research at JPMorgan
• Rich Anderson, Managing Director at Cantor Fitzgerald
• Ronald Kamdem, Managing Director at Morgan Stanley
• Tayo Okusanya, Managing Director at Deutsche Bank
• Vikram Malhotra, Managing Director at Mizuho