Adherex Technologies Q1 2026 Earnings Report

Adherex Technologies EPS Results

• Actual EPS: $0.01
• Consensus EPS: -$0.02
• Beat/Miss: Beat by +$0.03
• One Year Ago EPS: N/A

Adherex Technologies Revenue Results

• Actual Revenue: $15.11 million
• Expected Revenue: $13.90 million
• Beat/Miss: Beat by +$1.21 million
• YoY Revenue Growth: N/A

Adherex Technologies Announcement Details

• Quarter: Q1 2026
• Date: 5/14/2026
• Time: Before Market Opens
• Conference Call Date: Thursday, May 14, 2026
• Conference Call Time: 8:30AM ET

Fennec Pharmaceuticals Inc., a biopharmaceutical company, develops product candidates for use in the treatment of cancer in the United States. Its lead product candidate is the Sodium Thiosulfate, which has completed the Phase III clinical trial for the prevention of cisplatin induced hearing loss or ototoxicity in children. The company was formerly known as Adherex Technologies (NASDAQ:FENC) and changed its name to Fennec Pharmaceuticals Inc. in September 2014. Fennec Pharmaceuticals Inc. was founded in 1996 and is based in Research Triangle Park, North Carolina.

Adherex Technologies Q1 2026 Earnings Call Transcript

Key Takeaways

• Positive Sentiment: Fennec reported Q1 2026 net product sales of $15.1 million, up about 73% year over year, marking the sixth consecutive quarter of sales growth under the current commercial leadership.
• Positive Sentiment: The company said its commercial push is gaining traction after launching Project Ignite, expanding the field force to 14 new territories and 4 frontline managers and increasing target prescribers from about 1,300 to more than 5,000.
• Positive Sentiment: Operational metrics improved meaningfully, including a 48% quarter-over-quarter increase in completed infusions through Fennec HEARS, conversion rates reaching the company’s 80% benchmark, and adherence running around 80%.
• Positive Sentiment: Management highlighted growing clinical interest in PEDMARK beyond pediatrics, including three investigator-initiated studies and four ASCO abstracts, with potential expansion into AYA and adult patient populations and new tumor types.
• Neutral Sentiment: Fennec ended the quarter with $40.1 million in cash and said it generated positive cash flow in Q1, but it also expects Q2 ending cash to be lower and noted it does not anticipate receiving the German milestone payment from partner Norgine.

Presentation

[Operator]

Good morning, ladies and gentlemen, and welcome to the Fennec Pharmaceuticals First Quarter 2026 Earnings and Corporate Update Conference Call. At this time, all participants are in a listen-only mode. Later, we will conduct a question and answer session, and instructions on how to participate will be given at that time. As a reminder, today's conference call is being recorded. I would now like to turn the conference over to Fennec's Chief Financial Officer, Robert Andrade. Please begin.

[Robert Andrade, CFO at Fennec Pharmaceuticals]

Thank you, operator, and good morning, everyone. Thank you for joining us. We are pleased to host Fennec Pharmaceuticals First Quarter 2026 Earnings Conference Call today, during which we will review our financial results as well as provide a general business update. Joining me from Fennec this morning is our Chief Executive Officer and board member, Jeffrey S. Hackman. I am also pleased to welcome our Chief Commercial Officer, Terry Evans, who is joining our earnings call for the first time.

[Robert Andrade, CFO at Fennec Pharmaceuticals]

Terry is a seasoned commercial and operations leader with a proven track record for delivering significant revenue growth and leading high-performing teams. Terry's industry experience spans all facets of commercial operations, including sales management, operations, market access, trade, specialty pharmacy, and data analytics. He has more than 25 years of commercial leadership experience with companies including Currax Pharmaceuticals, Horizon Therapeutics, and Medesis.

[Robert Andrade, CFO at Fennec Pharmaceuticals]

Since joining Fennec in the fourth quarter of 2024, Terry has played a pivotal role in reshaping and strengthening our commercial organization. He has helped to sharpen our execution, enhance our field presence, and position the team to capitalize on the opportunities ahead.

[Robert Andrade, CFO at Fennec Pharmaceuticals]

Later in the call, Terry will speak to how recent efforts will support Fennec's next phase of growth. Our Chief Medical Officer, Dr. Pierre Sayad, will join us for the Q&A portion of today's call. Before we begin, I would like to remind you that during this call, the company will be making forward-looking statements that are subject to risks and uncertainties that may cause actual results to differ from the results discussed in the forward-looking statements.

[Robert Andrade, CFO at Fennec Pharmaceuticals]

References to these risks and uncertainties are made in today's press release and disclosed in the company's periodic and current event filings with the United States Securities and Exchange Commission. In addition, any forward-looking statements made on this call represent our views only as of today and should not be relied upon as representing our views as of any subsequent date.

[Robert Andrade, CFO at Fennec Pharmaceuticals]

We specifically disclaim any obligation to update or revise any forward-looking statements. This conference call is being recorded for audio rebroadcast on Fennec's website, www.fennecpharma.com, where it will be available for the next 30 days. I will now turn the call over to Jeff Hackman.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

Thank you, Robert. Good morning, everyone. Thanks for joining the call here today. We are encouraged by our strong start to the year and believe 2026 is a defining period for Fennec. Our conviction is rooted in the progress across many multiple fronts. We've made important strategic enhancements to our business for 2026 that are strengthening our execution across the organization and positions us to continue to build momentum as the year unfolds.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

On the commercial front, we're seeing encouraging early indicators, including positive experiences through our full-service patient support program, Fennec HEARS, as well as trends that support our confidence in the opportunity ahead. Terry will provide more color on those dynamics shortly. Beyond commercial execution, we continue to be encouraged by growing clinical interest in PEDMARK and its broader potential.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

We are pleased to have recently announced a third investigator-initiated study with the University of Arizona Cancer Center to evaluate PEDMARK in adolescent and young adults, or AYA, and adult patients in head and neck and testicular cancers receiving cisplatin. The news follows recent initiations of two other institution-led clinical studies with Tampa General Hospital Cancer Institute and City of Hope.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

We believe that the data insights generated through these studies and others to come will help support broader clinical adoption of PEDMARK to prevent ototoxicity in AYA and adult cancer patients receiving cisplatin-based treatments. Additionally, four abstracts from key opinion leaders evaluating the utility of PEDMARK in preventing cisplatin-induced ototoxicity or permanent hearing loss were accepted for the presentation at this year's ASCO annual meeting.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

Collectively, these studies are continuing to the momentum and the growing body of evidence supporting potential use of PEDMARK in new patient populations and tumor types. As a reminder, PEDMARK is currently approved for pediatric patients one month of age and older with localized non-metastatic solid tumors and is also recognized by the National Comprehensive Cancer Network with a 2A recommendation for use in AYA patients. With regards to Japan, we had a positive informal PMDA meeting earlier this quarter.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

We continue to be in conversations and to explore partnering opportunities in that region. In summary, we're making meaningful progress across the drivers that matters most to our long-term success, expanding clinical momentum, strengthening commercial execution, and maintaining a solid financial foundation. Taken together with what we are observing early in Q2, we believe we are well-positioned to deliver sustained growth throughout this year.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

With that, I will turn it over to Terry for a detailed commercial update.

[Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals]

Thank you, Jeff. As Jeff just noted, we're encouraged by the momentum we're seeing in the business and believe our first quarter performance reflects the benefits of the key strategic enhancements we've made across the commercial organization. In late Q4 2025, we launched an initiative called Project Ignite. This was a strategic decision based on successful cross-functional initiatives put in place at the start of 2025.

[Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals]

Building on the shared insights and strong commercial execution, we used data to evaluate opportunities to optimize both reach and frequency. Our Q1 investment in 14 new territories and four frontline managers expanded our ability to engage healthcare professionals, support adoption, and drive sustained momentum across priority markets. Much of the quarter involved the foundational work required to bring those investments fully online, recruiting and onboarding new talent, completing training, and integrating these team members into our commercial model.

[Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals]

The recruitment and onboarding process concluded at our national meeting in early March. This was an important milestone to align the expanded organization around our strategy, sharpen execution, and ensure the team entered the field equipped and ready to execute. There is a natural ramp period with any field force expansion, and we view much of Q1 as laying that groundwork.

[Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals]

The expansion of our customer-facing team has allowed us to reach with greater frequency a larger prescriber target base, increasing from 1,300 to now over 5,000 targets. We know the AYA market is promotionally sensitive and effectively communicating the unmet need around CIO is our number one priority. This creates a pathway for practices to help change the standard of care for all appropriate patients receiving cisplatin.

[Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals]

We believe we're executing in Q2 with a strengthened commercial footprint that is now positioned to drive greater impact through increased reach, frequency, and account penetration. Importantly, we're already seeing encouraging signs from these investments through our HCP targeting efforts. To bring our cross-functional model to life, one recent example illustrates how coordinated engagement can translate into adoption over time.

[Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals]

About a year ago, our medical team initiated engagement with a KOL from a leading academic center who was familiar with CIO, but not aware of PEDMARK as a preventative treatment option. Through multiple scientific exchanges and participation in a sponsored program at ASCO GU alongside the Testicular Cancer Awareness Foundation, awareness evolved into meaningful engagement. More recently, that relationship was transitioned from medical to field sales.

[Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals]

A newly deployed territory manager with our key account director introduced Fennec HEARS, which facilitated this KOL's identification and treatment of his first testicular cancer patient for home infusion. Since then, the engagement is actively expanding across the institution with multiple physicians across tumor types now positioned to prescribe and treat more than 20 patients with PEDMARK. In parallel, we're working collaboratively on order sets and EMR integration.

[Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals]

This example highlights a key principle. Durable growth stems from persistent cross-functional engagement across medical, sales, market access, and patient support services. Another example of significant progress is through our market access initiatives, specifically in terms of engaging with GPOs. One of the fastest-growing oncology aggregators in the U.S. has partnered with us to integrate PEDMARK throughout their network with order sets and site activations.

[Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals]

We have ongoing efforts with other organizations to replicate this model that supports a top-down adoption approach, complementing the expansion of our sales force focused on bottom-up activities. At the macro level, we continue to see a healthy mix of both new and existing prescribers. Many established accounts are becoming more comfortable with PEDMARK, contributing to deeper utilization and increased vials per account.

[Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals]

We view that continued adoption and growing depth of use as an important marker of durable demand. In fact, demand in the first quarter was driven by prescribing in three core tumor types: testicular, cervical, and head and neck cancers, and these remain foundational to our commercial opportunity.

[Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals]

Another area we would highlight is cross-functional collaboration across all parts of our organization to convert prescription demand into completed therapy. This collaboration comes together through Fennec HEARS, our full-service hub designed to simplify access and support continuity of care by guiding patients and providers through coverage, reimbursement, nurse-led administration, and at-home infusion services. This white glove support and education continue to be a meaningful differentiator as we change the standard of care.

[Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals]

That coordinated approach is reflected in the operational metrics we're seeing. We continue to see strength in infusion volume and vial utilization. This is reflected in a 48% quarter-over-quarter increase in completed infusions through Fennec HEARS and reinforces our ability to translate prescription demand into completed therapy. From a site of care perspective, we're maintaining a productive mix of approximately 50% from both in-office and at-home infusions, which supports access and flexibility for patients and providers.

[Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals]

Fennec continues to be an important contributor to momentum in the quarter. Through ongoing operational refinements, we're seeing more patients enter the funnel. Specifically, a higher share of patients are progressing to therapy, as reflected in encouraging conversion rates, which are hitting our benchmark of 80% for the first time. Once on treatment, we continue to see strong adherence trends of approximately 80%, which is a huge improvement from where we were one year ago today.

[Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals]

With our larger sales footprint, we're able to make substantially more sales calls each day versus previous quarters. Now, as I mentioned before, this is a promotionally sensitive market where reach and frequency make an impact on our business. Early indicators of this success include Fennec HEARS patient record monthly enrollments in April.

[Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals]

Demand through Fennec HEARS in April alone is more than 50% of the total Fennec HEARS demand for all of Q1. As a result, demand in Q2 is tracking to surpass Q1. Additionally, conversion rates remain above our target of 80%, and key community and academic relationships are opening up to our message of CIO prevention. We remain focused on disciplined execution as we build on this momentum throughout the year. With that, I will now turn the call over to Robert for our financial review.

[Robert Andrade, CFO at Fennec Pharmaceuticals]

Thank you, Terry. Our press release contains details of our financial results for the first quarter of 2026, which can be viewed on the Investors and Media section of our website. Rather than read through all of those details, my comments today will focus on some key financial results.

[Robert Andrade, CFO at Fennec Pharmaceuticals]

For the first quarter of 2026, the company recorded net product sales of $15.1 million, compared to $8.8 million in the first quarter of 2025, representing an increase of approximately 73% year-over-year compared with the first quarter of 2025. The first quarter demonstrated continued momentum in delivering PEDMARK to patients, with net product sales up for the sixth consecutive quarter since new commercial leadership took over.

[Robert Andrade, CFO at Fennec Pharmaceuticals]

We saw record new patient enrollments in the March quarter, and April was our highest demand month ever. On the OpEx side, which we define as R&D and SG&A, excluding stock-based compensation, it was approximately $14 million for the quarter, with a year-over-year increase of approximately $6 million.

[Robert Andrade, CFO at Fennec Pharmaceuticals]

The increase was on the SG&A with expanded marketing investment and increased commercial headcount supporting PEDMARK growth. Important to note, we expect approximately $50 million in cash OpEx in 2026, with over 60% of those expenses expected in the first half of 2026. Cash and cash equivalents were $40.1 million as of March 31st, 2026. For the quarter, there was an increase of $3.3 million in cash and cash equivalents.

[Robert Andrade, CFO at Fennec Pharmaceuticals]

The net increase in cash consisted of $2.3 million in operating cash flow and approximately $1 million in proceeds from option exercises. With regard to anticipated milestone payments from our partner, Norgine, we do not anticipate receiving the German milestone payment. We look forward to Norgine's expansion efforts in 2026 as they launch in multiple markets and the potential for the next milestone achievement by the end of 2026.

[Robert Andrade, CFO at Fennec Pharmaceuticals]

Importantly, we generated positive cash flow in the 1st quarter of 2026. As we grow the business, we anticipate select quarterly swings in the cash position based on collection cycles with customers, and as such, expect the 2nd quarter ending cash to be lower than the 1st quarter.

[Robert Andrade, CFO at Fennec Pharmaceuticals]

However, we expect the third quarter cash to be positive and to grow the cash the remainder of the year in the second half of 2026. We have tremendous leverage in the business with a predominantly fixed cost base. As our revenue growth continues, we anticipate operating income to grow meaningfully in the quarters to come. Lastly, as stated in our press release, we anticipate that our cash equivalents in investment securities as of March 31st 2026

[Robert Andrade, CFO at Fennec Pharmaceuticals]

Combined with projected revenues from PEDMARK, will be sufficient to fund our business based on our current operating plan. Operator, with that, we are now ready to open the call for questions.

[Operator]

Certainly. As a reminder, to ask a question, please press star one one on your telephone and wait for your name to be announced. To withdraw your question, please press star one one again, and please stand by while we compile our Q&A roster. Our first question will be coming from the line of Madison El-Saadi of B. Riley Securities. Your line is open, Madison.

[Madison El-Saadi, Healthcare Equity Research Analyst at B. Riley Securities]

Hey, guys. Thanks for taking our question, and, congrats on the quarter. It seems you gave some additional color this quarter on KPIs and performance. Maybe just help us break down really what drove the upside here, if this was predominantly new account adds in 1Q, if it was deepening utilization of your base accounts, or maybe just productivity from sales force, expansion that weren't fully onboarded, as of March. Afterwards, a follow-up.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

Sure. Sure. This is Jeff. Thanks for the question. Yeah, appreciate it, and I'll let Terry comment on a little bit. You know, we talked about execution early on, when I even first got here, a year and a half or so ago and going on. You know, we're starting to see it now. One of the things that we saw with Project Ignite was the ability for us to not only expand our reach, but expand our frequency. That's what we're seeing, and one of the reasons why you're seeing such, you know, significant uptake, especially in a month like April. You know, we can go into a little bit more detail.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

You know, Fennec HEARS is something that drives a lot of the growth here. We see, you know, we see demand all throughout Q1, growing through Fennec HEARS, so that's also exciting for us. You know, I'll let Terry comment a little bit more on some of the growth.

[Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals]

Yeah, for sure. Thank you for the question. What we're seeing is new starts in Q2 is balanced really between both academic and community. In that balanced approach, utilizing the additional folks that we have, our increased reach and frequency that Jeff mentioned. We're seeing that really present itself in academic and large community, small community practices. We're seeing a nice growth in both AYA and pediatrics. Yeah, we're encouraged by the balance of the year.

[Madison El-Saadi, Healthcare Equity Research Analyst at B. Riley Securities]

Got it. Thanks, Jeff.

[Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals]

Do you want to follow up, Madison?

[Madison El-Saadi, Healthcare Equity Research Analyst at B. Riley Securities]

Yeah. Yes, please. It seems like you've had multiple inbound interests regarding these ISTs. I'm just wondering, you know, why you guys decided to go with the ISTs and the tumor types you did. If we focus just on, say, the AYA adult testicular, you know, what can this practically mean for the company? Is it more of a means of entrenching PEDMARK, increasing awareness, or is it more in the context of tumor expansion? Just curious, if you can comment, if you've seen any revenue come out of these IST institutions. Seems that would be a really tremendous kind of leading indicator of kind of the awareness gap. Thanks.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

Oh, great question again, and I'll kick it over to Pierre, who's sitting here with us today. You know, ISTs are something that are important for a couple of reasons. Number one is it establishes, you know, our position in the space. One of the pushback you'll get from AYA physicians that talk is, "Let me see the data. Let me see some of the data that was generated in this population." As you know, you know, the trials that got PEDMARK approved were trials that were done with the Children's Oncology Group or in the pediatric space.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

That's one of the reasons why we're excited about the testicular data that we're generating through the as well as some of the adult data down the road that are gonna come from these. The second part is and I'll let Pierre talk a little bit more on how this happens inside the institutions. We not only the physicians who are participating in these studies are using the product, but also physicians that are surrounding those physicians. We're seeing that expansion throughout the institution. Pierre, maybe you can comment a little bit on that.

[Pierre Sayad, Chief Medical Officer at Fennec Pharmaceuticals]

Sure. Sure, Jeff. Thanks for the question. Yes, you know, as the medical team have the conversations around our two phase III clinical trials, as Jeff alluded, those were obviously in the pediatric setting. There's a very natural conversation that happens with our physicians where they say, "Okay, now that I'm really understanding how cisplatin is causing this damage in the cochlea and how PEDMARK can potentially prevent that," they're coming to us with these new and very creative ISTs to test this out in AYA and adult patients.

[Pierre Sayad, Chief Medical Officer at Fennec Pharmaceuticals]

we're as you know from previous press releases, at least on the three ISTs that have already been announced, these are across tumor types, AYA setting, adult setting, localized tumors, metastatic tumors, and all these ideas are coming directly from the KOLs. we're very excited about all this interest. I think your second question maybe was what do we do with this data? As you can imagine, as the data matures and our dataset expands, we're certainly thinking about potential regulatory conversations, NCCN guidelines submissions, so on and so forth.

[Pierre Sayad, Chief Medical Officer at Fennec Pharmaceuticals]

I think the third point, just to cover what Jeff said, we absolutely see this very interesting trend of once an IST is activated in a given academic institution, there's so much training, so much conversation that needs to happen that now you have the pharmacists, the nurses, other oncologists, all really on board with PEDMARK. I, you know, we begin to see a little bit of an uptick in commercial use in those institutions.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

Great. Thanks, Pierre.

[Madison El-Saadi, Healthcare Equity Research Analyst at B. Riley Securities]

Thanks, guys. That's very helpful.

[Operator]

Our next question will come from the line of Chase Knickerbocker of Craig-Hallum. Your line is open, Chase.

[Chase Knickerbocker, Analyst at Craig-Hallum]

Good morning. Thanks for taking the questions. Congrats on the nice quarter here. Could you maybe just share what percentage of your volume or, you know, just some kind of underlying demand metric was driven by the new rep hires over the last couple quarters? How is that productivity trending in Q2? Really just trying, you know, to get to the extent of kind of what to what magnitude those new hires are playing a role in this sequential growth and then when they can be fully productive.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

Yeah. I'll give this over to Terry, but Chase, thanks for the question. It's a good one. The things we're seeing early on April is new patients or I mean coming from new territories, which is exciting. You know, we see a healthy mix both coming from new and existing prescribers. I'm commenting now on, you know, the April numbers that we're seeing. These are established accounts, but which are becoming more comfortable with PEDMARK. Also we're seeing execution in accounts, in new accounts, which is really exciting in places where we've never seen patients before.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

we knew that once we expanded our reach and we expanded the frequency of this, you know, the PEDMARK message, we were gonna see continued adoption through these. Terry, maybe you can comment a little bit.

[Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals]

Yeah. A couple of things. Jeff's exactly right. There's a significant number of our new territories that had prescriptions or patients that have come through between the time that our national meeting occurred through the end of April. Part of the point that you made, Chase, we actually began the decision of Project Ignite in Q4, and it kinda happened all the way through Q1.

[Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals]

We trained everybody the first week of March, ended at our national meeting. The effectiveness of these salespeople, the new salespeople really began, you know, call it on March the ninth. As you know, and through years of experience, there's a ramp period of productivity for our sales team.

[Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals]

We've talked about we've talked about kind of the second half as we get these folks up and running and more productive. Early signs are good. You know. There's a good balance between new accounts and existing accounts and growing patients and prescriptions inside of both of those. You know, we're encouraged that the fact that with the strengthened commercial footprint, we're gonna drive reach and frequency and we're excited that we've been able to deliver six consecutive quarters of strong performance.

[Chase Knickerbocker, Analyst at Craig-Hallum]

Helpful. Thank you. Maybe just a couple smaller kinda details. Can you just speak to the kinda stability of the pediatric revenue? Just trying to get a sense for kind of underlying sequential AYA growth. Can you just remind us what percentage of your business at this point, either from a demand or revenue perspective, is flowing through Fennec HEARS? Thank you.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

Yeah. I'll take a couple of the beginning points of this, then I'll give it over to Terry. You know, Chase, we see, you know, We're excited about the business and how it's growing. The Fennec HEARS right now, what we're seeing is, in April alone, about 50% of our business and demand is going through Fennec HEARS.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

That's increasing every day. It increases as we get better at implementation. It increases as physicians wanna add more patients to this. We're continuing to see that. Our pediatric business is growing. It's growing, not at the pace, of course, of AYA, and we've said that before in the past.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

Pediatric business grows because we're getting now into institutions and places where we didn't have the ability to get to in the past with our pediatric business as well. When a pharmacist, for example, becomes comfortable in an academic institution with the product, for example, in the AYA space, we're seeing now uptake in the pediatric space as well because of that ability to be comfortable with the product. Whether we get in there through AYA or pediatric, for me, it doesn't really matter. It's the opportunity to be able to access these patients. Terry?

[Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals]

Yeah. Jeff, I agree. Chase, we're growing in both pediatrics and AYA. you know, Fennec's, as Jeff mentioned, is, roughly about 50%. it's important to note that even though we grow pediatrics and we're growing the AYA, PEDMARK is weight-based. just AYA represents, you know, 20-plus thousand patients with a high survival rate that take high-dose cisplatin. the AYA would be expected to outpace pediatrics even though the pediatric space is growing. you know, in both of those things, I think we, I think we're taking a balanced approach, which again, kinda leads us to six quarters of strong growth.

[Chase Knickerbocker, Analyst at Craig-Hallum]

Thanks, Dave.

[Operator]

Thank you. Our next question will come from the line of David Amsellem of Piper Sandler & Co. Your line is open, David.

[Alex von Riesemann, Analyst at Piper Sandler]

Hi. Good morning. This is Alex von Riesemann on for David. Thanks for taking our question. My first question is just, how are you thinking about life cycle management for PEDMARK? Secondly, what is your appetite for acquiring another asset? Thank you.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

Yeah, it's a great question. you know, I'll touch on it on the, you know, the life cycle and I can turn to Pierre on this. you know, you're starting to see a little bit of that life cycle management come into play with the ISTs. you know, we talk about three kind of groups of patients for our business. It's the pediatric, and we talk about AYA, but there's also adult.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

When you think of where cisplatin is given, it's given across not only these three areas, but it's also given to both localized and metastatic. now you're starting to see us start to grow the opportunity to develop data and expand it from a life cycle management standpoint into these other types of populations. The metastatic population, for example.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

Can this product be given there, and be effective in these patients? In the adult patients, in the head and neck space. You're starting to see all of this, and we have got more opportunities to be able to do that in other areas. Maybe, Pierre, you can touch on those.

[Pierre Sayad, Chief Medical Officer at Fennec Pharmaceuticals]

Sure. That's exactly right, Jeff. As I touched upon earlier, you know, the ISTs are beginning to mature, and we're seeing the data come through, so that obviously is going to open doors into metastatic indications. We've had a tremendous interest from multiple academic institutions putting forth very creative new ISTs in the head and neck space.

[Pierre Sayad, Chief Medical Officer at Fennec Pharmaceuticals]

As I mentioned, alluded to before, we have our sights set on possible NCCN designation criteria for head and neck, and cervical is also a very robust area in terms of interest. As the data matures, that'll define our strategy to expand, whether it's with regulatory meaningfulness or NCCN guidelines.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

Yeah. As related to the second part of your question, you know, looking at other products and bringing in, you know, other opportunities, we continue to be open to that. As you know now, we've expanded our commercial team significantly. We've expanded the organization and put resources in places now that you could start to expect a potential opportunity to be able to layer in some additional, you know, products, for example. Yeah, we continue to be open to that, and that's something that, you know, we're looking at as well. Thank you.

[Operator]

Our next question will be coming from the line of Ram Selvaraju of H.C. Wainwright. Your line is open, Ram.

[Katie Degen, Equity Research Associate at H.C. Wainwright]

Hi. Good morning. This is Katie on for Ram. I guess I'm wondering, what is the typical profile of a high-volume prescriber for PEDMARK at this point? Are those high-volume prescribers predominantly NCI cancer centers? Are they more community oncologists? how many of those physicians are there in the U.S.?

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

Yeah, we talked about. That's a good question. Appreciate it. Terry mentioned that we're targeting about 5,400 folks with our new team, expanded up from, you know, from just a little bit over 1,000. And those break out. Typically, we see the concentration of our uptake in both academic and community settings. Our strategy, you know, as we get into this, is designed to engage both academic centers and also community practices, and we're seeing a really good balance between both. Maybe, Terry, you can comment on that.

[Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals]

No, I think you're exactly right. With our greater region frequency, what we're seeing, we're seeing new starts from academic and community settings. One of the important things that I may or may not have said, which is PEDMARK's a long, it's a long play sometimes, where it takes medical, it takes sales, it takes market access, it takes, you know, patient support services, lots of these, you know, cross-functional teams to kind of pull it through. The need in academic is slightly different than the need in community. I'd mentioned this before, we're taking a nice balanced approach and activating both sides of them. Thank you.

[Katie Degen, Equity Research Associate at H.C. Wainwright]

Excellent. If I could sneak in one more question.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

Sure.

[Katie Degen, Equity Research Associate at H.C. Wainwright]

Do you guys have an idea of how many additional investigator-initiated trials you're gonna have starting this year? Could any of those outcomes give you avenues to label expansion?

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

Sure, it's a good question. You know, we get, soon as we put out, you know, your first press release, you know, you start to see, significant interest come in, right? Well, 'cause, you know, they see that we have, you know, our doors are open for partnerships. Let me let Pierre comment on that a little bit. You know, again, the doors, you know, there's a limit to how many we're gonna do, I can tell you that. You know, there are some really interesting ones that we've been talking about. Pierre, maybe you can comment on that.

[Pierre Sayad, Chief Medical Officer at Fennec Pharmaceuticals]

Sure, sure. I'm smiling a little bit at the question. I mean, the we're really excited, very encouraged. You know, when you have the amount of interest that we've had from the top academic institutions for new ISTs, it's always a great sign. In terms of how many are we expecting to see, I can't comment on that. There will hopefully be more press releases here soon. I think the point, though, that I wanna make is these are not, I'll use the word haphazard. You know, we have a very strong strategy as to which ones we're approving and which ones we are not.

[Pierre Sayad, Chief Medical Officer at Fennec Pharmaceuticals]

Ultimately, there will be efforts to combine data, et cetera, do some pooled analyses, with very specific purposes, again, as I mentioned, for regulatory enabling conversations.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

Perfect. Thanks, Pierre.

[Operator]

Our next question-

[Katie Degen, Equity Research Associate at H.C. Wainwright]

Thank you, guys

[Operator]

will be coming from the line of Sudan Loganathan of Stephens. Your line is open.

[Sudan Loganathan, Managing Director and Equity Research Analyst at Stephens]

Thanks. Good morning, and we appreciate the update and the great progress. My first question, I wanted to ask what your internal pipeline looks like to target new patient populations also treated with platinum-based chemotherapy, such as ovarian cancer, bladder cancer, colorectal cancer, and even non-small cell or small cell lung cancers. I believe those areas will start getting into more into the AYA population. I'm curious to see what you view out of those maybe or others, to be the next low-hanging fruit.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

Sure. Thanks, Sudan. That's a good question. You know, we, you know, we go where cisplatin is given, right? We know that there's certain tumor types that are obviously a target for us, and in that space of where, you know, these patients receive therapy, you know, with cisplatin. I'll let Pierre comment on the potential new ones. You know, we see as an opportunity, obviously, testicular, because cisplatin has done so. It is the gold standard. It's something that there's a lot of cisplatin that's given, and we see a big impact of CIO in that space.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

There are others that physicians have come to us throughout the, you know, our timeframe as we expand because they're using a lot of cisplatin in, you know, in cervical and head and neck and other places. We see that expansion in places like that. Maybe, Pierre, you can talk about why we see that.

[Pierre Sayad, Chief Medical Officer at Fennec Pharmaceuticals]

Yeah. As we've covered before, there's a strong foothold, if you will, interest that has come through for head and neck, testicular, cervical. We are absolutely having a lot of conversations in those additional areas that you mentioned as well, bladder, as well as lung. I think it's basically what Jeff said.

[Pierre Sayad, Chief Medical Officer at Fennec Pharmaceuticals]

The mechanism by which cisplatin, A, combats the tumor but then also defeats and kills these very sensitive cochlear hair cells is the same across all these tumors. Wherever cisplatin goes, PEDMARK absolutely has a strong potential of helping those patients. Yes, you're absolutely right? It's head and neck, cervical, testicular, lung, bladder, and there's probably a few more that we could rattle off here.

[Pierre Sayad, Chief Medical Officer at Fennec Pharmaceuticals]

those are all absolutely, big targets for PEDMARK.

[Sudan Loganathan, Managing Director and Equity Research Analyst at Stephens]

Great. Secondly, if I can squeeze one more in. You know, could we get more details on how the PEDMARK launches are going? What are the primary sticking points, and when do you anticipate revenues from there maybe to start actually moving the needle for the business? Thanks again for all the details.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

Yeah. You know, we're enthusiastic about what we're seeing with Norgine. It's, you know, this is the year we'll see significant growth in Norgine throughout their territories, and we're starting to see obviously many countries as Robert said. Maybe you can comment a little bit on some of the growth that we're seeing through Fennec here. I mean, through Norgine.

[Robert Andrade, CFO at Fennec Pharmaceuticals]

Yeah. PEDMARQCY for 2026 will be launched in multiple markets, almost double-digit type markets. This is the year where the foundation gets laid. I think an important point there is not only our royalties, which start in the mid-teens, as they grow those sales, but also the milestones. If you think of the over $200 million in milestones, at least half of those are tied purely to achieving certain sales. We look forward to giving you updates, but this is 2026 is the year where we see the ramp starting.

[Sudan Loganathan, Managing Director and Equity Research Analyst at Stephens]

Great. Thank you so much. Congrats again on a great quarter.

[Operator]

And now with that-

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

Thank you. Yep.

[Operator]

I would now like to turn the call back to Jeff for closing remarks.

[Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals]

Perfect. Well, thanks, and great questions and really appreciate everybody here, you know, attending today. In closing, we believe our first quarter performance reflects meaningful momentum across the business and reinforces our confidence in 2026 as an important year for Fennec. With strong execution underway in Q2 and multiple catalysts ahead, we remain focused on delivering sustained value. Thank you all again for your continued interest and support. We appreciate it. Take care.

[Operator]

This concludes today's conference. Thank you for your participation. You may now disconnect.

Participants

Analysts

• Alex von Riesemann, Analyst at Piper Sandler
• Chase Knickerbocker, Analyst at Craig-Hallum
• Jeffrey S. Hackman, CEO and Director at Fennec Pharmaceuticals
• Katie Degen, Equity Research Associate at H.C. Wainwright
• Madison El-Saadi, Healthcare Equity Research Analyst at B. Riley Securities
• Pierre Sayad, Chief Medical Officer at Fennec Pharmaceuticals
• Robert Andrade, CFO at Fennec Pharmaceuticals
• Sudan Loganathan, Managing Director and Equity Research Analyst at Stephens
• Terry Evans, Chief Commercial Officer at Fennec Pharmaceuticals