Twist Bioscience Q3 2026 Earnings Report

Twist Bioscience EPS Results

• Actual EPS: -$0.56
• Consensus EPS: -$0.51
• Beat/Miss: Missed by -$0.05
• One Year Ago EPS: $0.33

Twist Bioscience Revenue Results

• Actual Revenue: $118.38 million
• Expected Revenue: $114.55 million
• Beat/Miss: Beat by +$3.83 million
• YoY Revenue Growth: +23.20%

Twist Bioscience Announcement Details

• Quarter: Q3 2026
• Date: 8/3/2026
• Time: Before Market Opens
• Conference Call Date: Monday, August 3, 2026
• Conference Call Time: 8:00AM ET

Twist Bioscience (NASDAQ:TWST) is a synthetic biology company specializing in the development and commercialization of DNA-based products and solutions. Founded in 2013 and headquartered in South San Francisco, California, the company has pioneered a proprietary silicon-based DNA synthesis platform designed for high-throughput production of synthetic genes and oligonucleotides. Twist leverages semiconductor manufacturing techniques to enable precise, scalable synthesis of DNA at speeds and volumes unattainable with traditional methods.

At the core of Twist’s offering is its proprietary platform that automates the synthesis of custom DNA fragments, gene libraries, and long oligonucleotides. These products support applications across research, drug discovery, diagnostic development, and synthetic biology. By combining microfluidics, proprietary software, and chip-based synthesis, the company claims enhanced accuracy and uniformity while driving down per-base costs. Twist also offers next-generation sequencing services and bioinformatics support to accelerate customer workflows.

Twist Bioscience serves a global customer base spanning pharmaceutical and biotechnology companies, academic and government research institutions, agricultural and industrial biotechnology firms, and emerging data-storage ventures exploring DNA as a long-term archival medium. In addition to its primary manufacturing facility in California, the company has expanded operations to Europe, enabling faster delivery and localized support in key markets.

Leadership at Twist is anchored by co-founder and Chief Executive Officer Dr. Emily Leproust, whose background in chemistry and experience at leading genomics organizations helped shape the company’s technology strategy. Under her guidance, Twist has grown from a single R&D lab to a public company focused on scaling DNA synthesis for a wide range of commercial applications.

Twist Bioscience Q3 2026 Earnings Call Transcript

Key Takeaways

• Record revenue and raised guidance: Fiscal Q3 revenue rose 23% year over year to $118.4 million, marking 14 consecutive quarters of growth. Management raised fiscal 2026 revenue guidance to $456–$457 million and expects Q4 revenue of $123–$124 million, up approximately 25% year over year.
• AI-enabled drug discovery is accelerating: Twist expects to meet or exceed its target for triple-digit order growth in AI-enabled discovery in fiscal 2026 and believes it can deliver triple-digit growth again in fiscal 2027. Executives cited repeat orders, new customers, expanding modalities, and better visibility from larger, more collaborative customer programs.
• Strong therapeutics and NGS momentum: Therapeutics revenue grew 49% year over year, driven largely by pharma, biotech, and technology companies using AI-supported discovery, while NGS Applications revenue increased 12%. Management highlighted growing diagnostic demand, especially for molecular residual disease testing and proprietary enzyme-enabled workflows.
• Operational improvements are strengthening margins and product capabilities: Gross margin expanded to 52.8%, while the company reported major three-year reductions in manufacturing costs, waste, and turnaround time. Early access customers ordered more than 1,800 Complex Genes, and the offering has now been broadly launched.
• Profitability remains a near-term execution item: Adjusted EBITDA was negative $11.3 million in Q3, although management reiterated its expectation to reach adjusted EBITDA breakeven in Q4 and continue improving profitability in fiscal 2027. Cash and short-term investments declined to $166.8 million from $171.7 million at the end of the prior quarter.

Presentation

[Operator]

Welcome to Twist Bioscience's 2026 third quarter financial results conference call. At this time, all participants are in listen only mode. After the speaker's presentation, there'll be a question-and-answer session. To ask a question, you will need to press star one one on your touchtone telephone. Please note this call is being recorded. I would like to turn the call over to Angela Bitting, SVP of Corporate Affairs. Please go ahead.

[Angela Bitting, SVP of Corporate Affairs at Twist Bioscience]

Thank you, operator. Good morning, everyone. I'd like to thank you for joining us for Twist Bioscience's conference call to review our fiscal 2026 third quarter financial results and business progress. We issued our financial results press release before the market, and it is available at our website at www.twistbioscience.com. With me on the call today are Dr. Emily Leproust, CEO and Co-Founder of Twist, Adam Laponis, CFO of Twist, and Dr. Patrick Finn, President and COO of Twist.

[Angela Bitting, SVP of Corporate Affairs at Twist Bioscience]

Today, we will discuss our business progress, financial and operational performance, as well as growth opportunities. We'll then open the call for questions. We ask that you limit your questions to only one and then re-queue as a courtesy to others on the call. This call is being recorded and the audio portion will be archived in the investor section of our website and will be available for two weeks. During today's presentation, we will make forward-looking statements within the meaning of the U.S. Federal Securities laws. Forward-looking statements generally relate to future events or future financial or operating performance.

[Angela Bitting, SVP of Corporate Affairs at Twist Bioscience]

Our expectations and beliefs regarding these matters may not materialize. Actual results in financial periods are subject to risks and uncertainties that could cause actual results to differ materially from those projected. These risks include those set forth in the press release we issued earlier today, as well as those more fully described in our filings with the Securities and Exchange Commission. The forward-looking statements in this presentation are based on information available to us as of the date hereof. We disclaim any obligation to update any forward-looking statements except as required by law.

[Angela Bitting, SVP of Corporate Affairs at Twist Bioscience]

We'll also discuss adjusted EBITDA, a financial measure that does not conform with generally accepted accounting principles. Information may be calculated differently than similar non-GAAP data presented by other companies. When reported, a reconciliation between GAAP and non-GAAP financial measures will be included in our earnings documents, which can be found on the investor section of our website. With that, I will now turn the call over to our CEO and Co-Founder, Emily Leproust.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

Thank you, Angela, and good morning, everyone. On slide three, you will see that this morning we reported our 14th quarter of consecutive growth with record revenue of $118.4 million, growth of 23% year-over-year. This growth reflects the diligence and execution we have employed over the last several years, building for opportunities we see ahead. Sometimes those opportunities are clearly visible many years in advance. Others require us to be nimble and engage with our customers in real time to ensure we build and deliver what they need to be successful.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

On slide four, you'll see that at Twist, we sit at a unique junction where we have spent the last decade building the infrastructure to enable our customers to advance their therapeutics, diagnostics, and industrial breakthroughs resulting from their innovation. As biology becomes increasingly computational, our ability to deliver precision and speed at scale becomes even more valuable. On slide five, I'm sure you agree that AI is shifting workflows across multiple industries.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

We see an inflection point in drug discovery with more and more groups leveraging AI as their first antibody discovery screen. Where one year ago, just a handful of organizations were pursuing this path, now we have seen large pharma, dry lab biotech, traditional biotech, and even major technology companies all employ AI through ML/AI approaches following the pattern of design, build, test loop. Our customer can now design more sequences, test more hypotheses, and iterate faster than ever before. In parallel, we also see the benefit of data and genetic information resulting in diagnostic assays that monitor, select, and determine next steps for a wide variety of diseases.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

Turning to our product groups, over the past year, we've talked about AI-enabled discovery as an important emerging opportunity. Today, we are seeing that opportunity mature into a durable growth engine. We continue to support customers in building new models, while others are using Twist to conduct discovery for specific therapeutic targets and to iterate models. This combination of repeat business, new customer acquisition, and new organizations forming or expanding into the life sciences area gives us increasing confidence in the durability and longevity of AI-enabled discovery as a growth driver for the short, medium, and long term.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

On slide six, the promise of AI-enabled drug discovery is straightforward. Identify better drug candidates faster, reduce the cost of bringing new medicines to market, and improve the probability that candidates entering development ultimately succeed. On slide seven, you'll see the workflow where our customers use AI to computationally generate thousands to millions of potential DNA sequences and iteratively refine those designs to identify the most promising therapeutic candidates for a specific disease.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

Twist quickly translates those digital designs into physical biology through high-throughput DNA synthesis of individual or pooled DNA, followed by protein expression. Many customers then leverage our downstream capabilities to evaluate those proteins across assays, measuring binding, developability, characterization, and other properties associated with successful drug candidates. We enable rapid design, build, test, and learn cycles at the earliest stage of discovery, supporting our customers' ultimate objectives.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

When seeking a partner for this work, every customer needs a trusted provider capable of manufacturing increasingly Complex sequences, expressing proteins, generating high-quality characterization data, and delivering consistent results at the speed modern drug discovery requires. This combination of capabilities has become one of Twist's most important competitive advantages. At our Investor Day in May, we guided to triple-digit percentage order growth for AI-enabled discovery in fiscal 2026 versus fiscal 2025. Now that we are through the third quarter of the year, we are increasingly confident that we will meet or exceed that target.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

Our confidence reflects durable demand signals as existing customers return for iterative design, build, test, learn cycles, reflecting growing recognition that our platform is well-suited to support AI-enabled drug discovery programs, as well as traditional drug discovery. Importantly, our funnel of opportunities continues to expand meaningfully, and we believe that we have the potential to again post triple-digit percentage order growth for AI-enabled drug discovery in fiscal 2027 when compared to fiscal 2026. Turning to slide eight. During the quarter, our platform again demonstrated its importance in supporting global public health.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

On May 15, 2026, public health officials in the Democratic Republic of Congo announced a developing outbreak of hemorrhagic fever. The outbreak went undetected for at least a month, escaping standard PCR assays, a gap that allowed the virus to spread further before it could be identified and contained. As of July 1st, the virus has been confirmed in both the DRC and Uganda, with an estimated spread to 7,000 people and at least 399 confirmed deaths.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

Approximately one month into the outbreak, researchers used Twist Comprehensive Viral Research Panel to identify the pathogen as the Bundibugyo ebolavirus, underscoring the value of whole viral genome enrichment to catch emerging infectious diseases that standard testing missed. Separately, we also synthesized hantavirus material in less than 24 hours to support rapid response efforts during the cruise ship outbreak in May.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

These are powerful examples of the breadth, speed and reliability of our platform and of our role in the global research and public health communities. On slide nine, we continue to see strong accelerating momentum for our NGS Applications group, driven primarily by diagnostic customers, many of whom are focused on growing their commercial volumes, with others advancing towards commercialization.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

We have our eyes on several new opportunities as the pipeline remains rich for next-generation assays to inform molecular residual disease tests, optimize workflows using proprietary enzymes, and more. During the quarter, we increased customer adoption, strengthened our commercial pipeline, and continued to execute on new product introductions to reinforce our position as a trusted partner for next-generation sequencing workflows. As sequencing volumes continues to grow globally, we believe our differentiated technology and expanding portfolio positions us well for continued growth.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

We continue to see customers turn to Twist when scientific precision and rapid execution matter most. This holds true when we are supporting academic research, cancer diagnostic, agricultural biotech, responding to emerging infectious diseases, or myriad other work streams. On slide 10, one of the highlights of the quarter was hosting our Investor Day at our fab in Wilsonville, Oregon. Many of our customers shared how Twist products and services play a critical role in their internal workflows, providing tangible examples across multiple markets and applications.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

In addition, several Twist leaders showcased their expertise and leadership throughout the different areas of the business. As Twist has grown, we have built an organization designed to repeatedly convert scientific innovation into commercial success. Great science creates opportunity. Operational excellence turn that opportunity to durable revenue growth, expanding profitability and long-term value creation.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

That requires manufacturing discipline, commercial execution, digital capabilities, and above all, an exceptional team. Investor Day gave us the opportunity to demonstrate the strength of that foundation through our leadership bench, differentiated technology, highly automated manufacturing, expanding capacity, and the proprietary software that powers our business. The consistent feedback we received was that investors left with a broader appreciation of the scale of our opportunities, the strength of our execution, and the depth of our organization we have built, as well as the reality of the growth opportunities that lie ahead to drive confidence in our long-term trajectory.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

For me, Investor Day reinforced something I've believed since founding Twist. We do things the Twist way, and this is not the easy path. When someone says it's hard, I say, "Yes, that's the point." If it were easy, everyone would be doing it. Building what has never existed before requires relentless innovation, disciplined execution, and clear communication. What began as a founding principle has become how Twist operates.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

It's embedded in our systems, our processes, and most importantly, our people. That's how we scale innovation consistently, build trust with customers and investors, strengthen our competitive advantage, and create long-term shareholder value. With that, I'd like to turn the call over to Paddy, who will discuss our competitive moat, how we are executing against our priorities, and why we believe the operational foundation we've built positions Twist for its next phase of growth.

[Patrick Finn, President and COO at Twist Bioscience]

Thanks, Emily. Good morning, everyone. One of the things I enjoyed most about Investor Day is that people got to see Twist from the inside. They didn't just see the products, they saw how we operate. Twist's core technology differentiation is a semiconductor-based DNA synthesis platform that provides a structural advantage in cost, scale, and speed that feeds into every product and service we offer. The same platform also enables a highly efficient new product introduction engine, allowing us to rapidly translate customer demand into scalable offerings and continuously expand our portfolio.

[Patrick Finn, President and COO at Twist Bioscience]

As we increase volume on the silicon chip, we expand our wallet share, accelerate product innovation, and further strengthen our competitive advantage. As Twist has grown, one thing has become increasingly clear to me. You'll see on slide 11, our competitive moat expands well beyond our robust IP position around the chip into a complex infrastructure where manufacturing, automation, software, commercial execution, product development, customer engagement, scientific innovation, and critically, the customer experience, all reinforce one another.

[Patrick Finn, President and COO at Twist Bioscience]

Every improvement we make strengthens the platform. Every new capability benefits multiple parts of the business. Every automation project improves quality, productivity, and throughput, and every customer we add helps make the platform stronger. It's something we've been building deliberately for years. It's also why I believe our advantage continues to expand. Customers are looking for a partner that can help them move faster, and we're becoming more deeply embedded in our customers' research and development activities. That creates more durable relationships, and over time, a stronger business, and that doesn't happen without exceptional and consistent execution.

[Patrick Finn, President and COO at Twist Bioscience]

Every day, our teams are focused on delivering exceptional quality, increasing productivity, expanding capacity, and reducing turnaround times. These priorities don't change. There's no finish line. We measure ourselves by how consistently we improve. On slide 12, I talked earlier about our silicon chip, shown on the left. It's been the foundation of our commercial manufacturing platform since 2015. By miniaturizing known phosphoramidite chemistry and dramatically reducing reagent consumption, our economics have always been strong as we've created structural advantages in cost, scale, and throughput that extend across our entire portfolio.

[Patrick Finn, President and COO at Twist Bioscience]

Just as importantly, we continue to improve that platform, as shown on the right side of the slide. Over the last three years alone, we've reduced manufacturing costs by 60%, reduced waste by 70%, reduced turnaround time by roughly 73%, and increased oligonucleotide capacity four-fold. Those gains improve our economics, strengthen our competitive position, and create additional capacity to support future growth. Over the past several years, VC firms invested heavily in alternative DNA synthesis technologies. The marketing is compelling, but commercial success depends upon much more than chemistry.

[Patrick Finn, President and COO at Twist Bioscience]

It requires molecular quality, reproducibility, manufacturing scale, and continuous operational improvement. We believe our platform and our track record continue to set the standard. Our leadership in the field is one of the many things that gives us confidence in the long-term opportunity. Our investments aren't tied to one product cycle. They're strengthening the foundation for everything we build next. That's how we think about creating long-term value. We do not optimize for a single quarter. We focus on building a stronger company every quarter. On slide 13, another tangible example of continued improvement leading to a specific product launch.

[Patrick Finn, President and COO at Twist Bioscience]

Last quarter, I talked about an early access launch of our Complex Genes offering, extending the range of DNA sequences researchers can order from Twist. Complex Genes are highly challenging constructs that have historically been out of reach for most platforms to synthesize consistently because of high GC content, repetitive elements, or other complex characteristics. Today, we manufacture these sequences with the same automation, the same manufacturing line as part of our standard and Express Genes production workflow with the consistent speed, scale, and quality customers expect from Twist.

[Patrick Finn, President and COO at Twist Bioscience]

Early customer adoption has been very encouraging. During early access, we've worked with a select handful of customers who've ordered more than 1,800 Complex Genes across well over 100 orders. The execution has been superb. We've completed the overwhelming majority of these highly complex constructs in 12 days, within our expected delivery window. That matters because it's one thing to produce a complex sequence once in an R&D environment. It's something entirely different to manufacture thousands of highly complex constructs repeatedly at commercial scale with consistent quality.

[Patrick Finn, President and COO at Twist Bioscience]

While Complex Genes represent a relatively specialized market today, our execution demonstrates that we continue to expand the boundaries of what customers can manufacture on the Twist platform using the same highly automated production infrastructure. Each new capability increases the value of our platform, expands wallet share with existing customers, and further differentiates Twist from competitors. At Twist, we focus on automating and operationalizing any new product offering within our manufacturing workflow so that what we can do for one customer, we can deliver for thousands of customers with consistent quality, speed, and precision at scale.

[Patrick Finn, President and COO at Twist Bioscience]

Two weeks ago, we launched our complex offering formally, expanding availability broadly across the market. In summary, we believe our silicon platform, automation, software, and manufacturing infrastructure uniquely position us to serve a wide range of customers across industries, creating a competitive moat that would be exceptionally difficult to replicate. With that, I'll turn the call over to Adam Laponis to review our financial results.

[Adam Laponis, CFO at Twist Bioscience]

Thank you, Paddy. Turning to slide 14, Q3 was another quarter of consistent execution against the financial model we've laid out. Revenue grew 23% year-over-year to $118.4 million, our 14th consecutive quarter of sequential growth. We focused on growing the top line while maintaining our commitment to adjusted EBITDA breakeven for the fourth quarter of fiscal 2026. We understand that growth of 20% or more significantly differentiates Twist among our peers. Gross margin was 52.8%, growth of 120 basis points sequentially, with 70% of incremental revenue dropping to the gross margin line. Let me walk you through the details.

[Adam Laponis, CFO at Twist Bioscience]

On slide 15, you'll see DNA Synthesis and Protein Solutions revenue increased to $56.6 million compared to $40.8 million in the third quarter of fiscal 2025, growth of 39% year-over-year at 6% sequentially. We shipped 369,000 genes in the third quarter, plus consecutive quarter-over-quarter growth in genes manufactured for data characterization. On slide 16, we show NGS Applications revenue for the third quarter grew to approximately $61.8 million, compared to $55.3 million in the third quarter of fiscal 2025, an increase of 12% year-over-year and up 8% sequentially, driven by growth in top accounts.

[Adam Laponis, CFO at Twist Bioscience]

For the quarter, revenue from our top 10 NGS Applications customers accounted for approximately 48% of NGS Applications revenue. We served 657 NGS Applications customers in the quarter, with 182 having adopted our products. Looking geographically on slide 17, Americas revenue increased to approximately $77.3 million in the third quarter compared to $59.4 million in the same period of fiscal 2025, growth of 30% year-over-year. EMEA revenue rose to $33.6 million in the third quarter versus $30.7 million in the same period of fiscal 2025, growth of 9% year-over-year.

[Adam Laponis, CFO at Twist Bioscience]

APAC revenue increased to $7.5 million in the third quarter compared to $5.9 million in the same period of fiscal 2025, an increase of 26% year-over-year. On slide 18, looking at revenue by industry, therapeutic revenue was $40.4 million for the third quarter of 2026 compared to $27 million in the same period of fiscal 2025, growth of 49%, reflecting the increased uptake of our products by pharma, dry lab biotech, and large tech companies in their efforts on therapeutic discovery and including AI-enabled drug discovery. Diagnostics revenue was $43.8 million in the third quarter of 2026 compared to $38.1 million in the same period of fiscal 2025, an increase of 15%.

[Adam Laponis, CFO at Twist Bioscience]

Diagnostics revenue grew 10% sequentially based on strong growth from top accounts. Industry and applied revenue were $5.7 million in the third quarter of 2026 compared to $6.1 million in the same period of fiscal 2025. Academic and government revenue were $15.5 million in the third quarter of fiscal 2026, an increase of 32% year-over-year and 21% sequentially, driven by strength in U.S. accounts where we saw several large customers return during the quarter. Importantly, our outperformance this quarter for academic and government demonstrates the resilience of our business, the depth of our customer engagement, and the growth of this customer group.

[Adam Laponis, CFO at Twist Bioscience]

Global Supply Partner revenue was $12.9 million in the third quarter of 2026 compared to $13 million in the same period of fiscal 2025. This revenue stream continues to provide a stable reoccurring revenue base while our faster-growing therapeutics and diagnostics product groups drive overall company growth. Moving down the P&L to slide 19. You'll see our key financial metrics. Our gross margin for the third quarter was 52.8%, up sequentially and driven by strong revenue growth, even as we continue to make deliberate investments in new product offerings and manufacturing capacity that we expect to result in future margin gains as we accelerate growth and implement continuous process improvements.

[Adam Laponis, CFO at Twist Bioscience]

Operating expenses excluding cost to revenues were $98.7 million for the quarter compared to $81.4 million in the prior year, which includes approximately $2 million in employee transition costs as well as other one-time expenses that will result in more than $5 million reduction in OpEx in the fourth quarter. Looking at our progress and our path to profitability and progress towards breakeven on slide 20. For the third quarter of fiscal 2026, adjusted EBITDA was a loss of approximately $11.3 million, reflecting planned one-time investment.

[Adam Laponis, CFO at Twist Bioscience]

We ended Q3 with $166.8 million in cash equivalents, and short-term investments versus $171.7 million as of March 31st, 2026. On slide 21, turning to guidance. For fiscal 2026, we are increasing our revenue guidance and now expect total revenue of $456 million to $457 million, up $12 million at the midpoint, representing growth of approximately 21% year-over-year. In the third quarter, total revenue growth reflected above 20%. Based on customer demand, our current funnel, and order growth, we expect momentum to continue and look forward to sharing full year guidance for fiscal 2027 in November.

[Adam Laponis, CFO at Twist Bioscience]

For Q4 fiscal 2026, we expect total revenue of $123 million-$124 million, growth of approximately 25% year-over-year at the midpoint. We expect sequential growth from both DSPS and NGS. We expect DSPS sequential growth to be driven by therapeutics and NGS to return to growth above 20% year-over-year. Well into our final quarter of the fiscal year, we remain confident in our trajectory and continue to expect to achieve adjusted EBITDA breakeven this quarter. Our focus is now on sustaining that performance and continuing to execute against long-term financial objectives throughout fiscal 2027. With that, I'll turn the call back to Emily.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

Thank you, Adam. I'd like to leave you with one final thought. When Twist was founded more than 13 years ago, our goal wasn't simply to build a better way to synthesize DNA. It was to remove barriers that slow scientific discovery. That vision is working. Today, our platform is enabling advances across cancer diagnostic, AI-enabled drug discovery, synthetic biology, and academic research. We have translated the innovation into durable business performance, delivering 14 consecutive quarters of revenue growth, expanding gross margin, and remaining on track to achieve adjusted EBITDA breakeven this quarter.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

Yet, I believe we are still in the early chapters. Biology is becoming increasingly digital, data-driven, and AI-enabled. Scientists are asking bigger questions, designing more complex molecules, and moving faster than ever before. Those trends play directly to Twist's strength and reinforce our confidence that the opportunity ahead is substantially larger than the one we set out to address 13 years ago. Importantly, we continue to execute against our plan to deliver sustainable, profitable growth.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

As we look ahead, we are confident not only because of the opportunities in front of us, but because of the foundation we have built to capture them. We continue to see multiple durable drivers of growth, as you'll see on slide 22. AI-enabled drug discovery continues to expand. Molecular residual disease continues to grow in application within a reimbursement environment expanding. We see opportunity to introduce proprietary enzyme in our workflows and our internal processes to optimize performance and cost, as well as reduce our dependence on suppliers.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

In the longer term, we believe Nucleic Acid Therapeutics provides a personalized diagnostic and therapeutic approach that will improve patient outcomes and positively impact the healthcare system. With the growth across the market we serve expanding, our serviceable addressable market is projected to be $13 billion by 2030. In addition, our innovation engine will continue introducing new capabilities that we haven't mentioned here today, expanding that upside opportunity. On slide 24, you'll see that we feel confident in our ability to drive continued growth moving forward. Specifically, we've just delivered our 14th consecutive quarter of revenue growth at 23% growth year-over-year.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

We believe we have a strong growth trajectory to more than double revenue from organic growth in 2031. We guided to $123 million-$124 million for the fourth quarter of fiscal 2026, growth of approximately 25% year-over-year. Based on customer demand, our current funnel, and other growth, we expect momentum to continue. We expect to meet or exceed our guidance of triple-digit percent order growth for AI-enabled drug discovery in fiscal 2026.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

Based on our robust funnel, we expect to again deliver triple-digit percent growth for orders from AI-enabled drug discovery in fiscal 2027. We expect gross margin above [52%] for fiscal 2026, with a goal of margins of more than 60% as the business matures. We expect to achieve adjusted EBITDA breakeven for the fourth quarter of fiscal 2026. We expect to maintain this commitment for fiscal 2027. We will continue to meet our customers where they are, enabling them to truly change the world for the better. At this time, let's open the call for questions.

[Operator]

Thank you. As a reminder, if you'd like to ask a question, please press star one one. If your question has been answered and you'd like to remove yourself from the queue, press star one one again. Our first question comes from Brendan Smith with TD Cowen. Your line is open.

[Brendan Smith, Analyst at TD Cowen]

Great. Thanks for taking the questions, guys, and congrats on the quarter. Wanted to first ask actually just about the relative breakdown of F Q3 revenues. I know you talked a little bit about this already, but it looks like therapeutics revenues were incrementally down sequentially. The volumes do look good. I guess just any additional color there on some of the ordering dynamics we should maybe be aware of.

[Brendan Smith, Analyst at TD Cowen]

On the new FY 2027 outlook of repeating triple-digit AI growth next year, I appreciate all that as well. I guess, is that based on, I know you said the funnel, but is this kind of based on some visibility into orders already coming in? Is this kind of reflective of ongoing conversations you're having? Any particular inflections in the type of quality of orders over the next year or so? Just kind of any color you can give us to support durability on that scale would be great. Thanks.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

Thank you, Brendan. We're very excited about this quarter. We're seeing a lot of strength from existing customers as well as new customers coming in. Obviously, we had a growth of more than 20%, and we are guiding growth of more than 20%, actually almost 25% for people. Things are going really well. In AI-enabled discovery in particular, we had a few things happening. First, customers that have built their models are turning the crank. We are seeing new customers coming on top of that. Even the existing customers that have been turning the crank now are starting to look at new modalities.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

You might see people coming in with just a VHH and then expanding to a full IgG. People are not quite broadly talking about AI for bispecific, but we know it's coming. Talking to customers, looking at the quotes we're giving them, the number of sequences that they have in mind that they want to build either as full DNA or as array DNA Give us very strong confidence that triple-digit percentage growth that we've seen in AI-enabled drug discovery that we know we're going to be able to deliver in 2026. We see it continuing, again, from this conversation with

[Operator]

Thank you. Our next question comes from Puneet Souda with Leerink Partners. Your line is open.

[Puneet Souda, Analyst at Leerink Partners]

Hi, guys. Thanks for the question here. I'll wrap my questions in one. Look, on the gene shipped, you're seeing quite a bit of acceleration here, 56% growth. Wondering why is the protein segment growing only at 39%? Just wondering if there is any pricing or ASP compression that you're seeing. I think the bigger question here is that you're pointing out triple-digit growth this year, next year, triple-digit order growth again for AI. How is the AI order-to-revenue conversion? I think that's a key question we're getting. For Adam, on adjusted EBITDA, if you could you double-click on that and provide us how do we get to adjusted EBITDA breakeven in fourth quarter and keep that sustained or higher in fiscal 2027? Thank you.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

Thanks, Puneet, for the great question. The number of genes is growing massively, which is great, right? I think, for us, we can process them easily on our automated system, and it should be very hard for anybody else to absorb that kind of revenue growth. The therapeutics business grew 49% year-over-year, very much in line with the growth of genes. It's correct that the DSPS "only grew" 36%. I think that as the volume growth comes primarily from antibody type sequences. As you know, those sequences are shorter than maybe plant genes.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

As we see the growth coming primarily from human therapeutics, there's maybe a shift to smaller genes, which is totally fine with us. The key is, AI is doing exactly what we thought it would do. It just creates more sequences. The third part I mentioned is that biology now is becoming more digital, more data-driven, and more AI-enabled, and that just brings more demand for more N, more sequences, and we are absolutely seeing it in our data. Adam you want to take the second question?

[Adam Laponis, CFO at Twist Bioscience]

No, absolutely. Thanks for the question, Puneet. In terms of order-to-revenue recognition, we're noticing, particularly with AI drug discovery, that the timelines for projects are usually measured in weeks. At the end of last year when we had a pretty significant order step-up towards the end of the fiscal year, we saw there was some separation there. As we go into 2026 and look towards 2027, the two metrics converge pretty nicely. The other question, in terms of adjusted EBITDA and the path and the bridge to Q4 and beyond. No, great question, and we've been very disciplined over the last number of years with how we've managed the business and our investments, and we continue to do so.

[Adam Laponis, CFO at Twist Bioscience]

As we look into Q4, we had the one-timers associated with some of the employee transitions in Q3, as well as some continued investment in our new digital capabilities that we've here launched in Q4. We expect to see sequential improvements in the OpEx moving forward, starting in Q4. Said, we see that the path to adjusted EBITDA positive in Q4 and then being able to continue to make progress on that in 2027 and beyond. Thank you very much.

[Operator]

Thank you. Our next question comes from David Westenberg with Piper Sandler. Your line is open.

[David Westenberg, Analyst at Piper Sandler]

Thank you so much. Maybe I'll just add on to Puneet's question on the EBITDA bridge. I appreciate the color there. Do you expect continued momentum in 2027 with that EBITDA bridge, i.e., do you think that you could stay EBITDA positive throughout, or do you think it's going to be quarter-on-quarter, but the year you're really focusing on that EBITDA?

[David Westenberg, Analyst at Piper Sandler]

For a second question, I was hoping you could give maybe some color on the new product mix in NGS, particularly around some of your new whole genome offering and then maybe some of the more expansive or faster-growing new products from customers in NGS. I'm thinking about Shield, but any other ones like that could be just incredibly high-growth potential and how they did. Thank you.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

Thanks, David. Great to have you. Thanks for initiating and for your first double question. I'll start to Adam for your first one on the adjusted EBITDA momentum and then Paddy for the new work in NGS.

[Adam Laponis, CFO at Twist Bioscience]

David, great to hear you on the call. In terms of our commitment, we said we're going to give full-year guidance in November, and we plan to give a robust outlook. We're not in the business typically of going backwards, that being said. We look at our full-year adjusted EBITDA this year, improving year-on-year to being positive for the year.

[Adam Laponis, CFO at Twist Bioscience]

We look to make sequential improvements wherever possible. We also recognize we love our employees and give them a raise at the beginning of every fiscal year. We're going to balance that. We'll give a full guidance as we approach November. Also in terms of how we look at the business long term, very positive progress on both the growth trajectory, as well as the commitment on continued progress and profitability.

[Patrick Finn, President and COO at Twist Bioscience]

Dave, yeah, just building off of what Adam was saying, just coming over to your questions on products in the NGS space. From a workflow standpoint, it's a good time just as a reminder on how we've built out some really well-differentiated enzymes using AI-driven discovery and development methods. They're critical in whole genome and other workflows. It's high-performing ligase and high fidelity, high-performing polymerase, both of which are featuring in our kits, which are benchmarking incredibly well, both internally and in our customers' hands.

[Patrick Finn, President and COO at Twist Bioscience]

That's a long-term commitment to enhance our customers' success in their experiments, it's just going to be an ongoing drive into the market. If I move across into the emerging applications that we're very excited about, I'll just call out MRD again, so molecular residual disease. Obviously, we have workflows for any approach, but in particular, maybe just spend 30 seconds on the tumor informed platform. What you're seeing there obviously is a correlation between increasing probe count derived from knowledge gained from sequencing the patient's tumor, leading to higher sensitivity tests, and therefore better patient outcome.

[Patrick Finn, President and COO at Twist Bioscience]

We see demand continue to increase. If I just go way back to talking about something like our current capacity for something like 72 million oligos per day, if you can imagine a situation of hundreds of thousands to millions of tests in the future, all demanding thousands of probes, tumor informed, delivered to a patient in, or sorry, delivered to a service lab or to hospital or wherever a customer is in a very, very short period of time. By that I mean a couple of days max. We're pretty excited about where that segment's going. It's another beautiful application of our synthesis platform.

[Operator]

Thank you. Our next question comes from Subbu Nambi with Guggenheim. Your line is open.

[Subbu Nambi, Analyst at Guggenheim]

Hey, guys. Thank you for taking my question. Good morning. As we get closer to 2027 fiscal year, do you have any preliminary thoughts on 2027 growth outlook? I know you said you'll provide us full guidance, but then you touched on this a little bit about 20% growth for both NGS and DSPS. Is that reasonable? If yes, this would be above your LRP of mid-teens growth. I had a clarifying question. You had $25 million AI-related orders in 2025, even assuming 100% as bare minimum triple digit, that would be $50 million. Now you're confident that $50 million growing to $100 million. Did I get that right? Thank you so much.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

Thank you, Subbu. Yes, you got that right. That's some sort of clarifying comment. In terms of long-term growth, I think that overall the trends are in our favor. Paddy just mentioned the trends in MRD where I won't fully repeat his comment, but basically, what we're hearing is for high sensitivity, people want more probes. In order to be able to be fit there, the window, for the specific, it needs to be delivered fast.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

That's basically what we've built is the speed of delivering thousands of probes with another expression. We think that trend there is going to be a very, very strong sell into new win. In terms of AI story, it's just incredible the business is peaking through on all the cylinders. What last year or a year ago was a big order in DSPS and now, they're a regular model.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

Really, we've seen a change in the order pattern, where we are seeing just big chunky orders and then sticking to customers in what they need going forward. We've heard about the model for those AI bots needing more and more data points. It's the same for every story. There's a growing number of data points are needed, we can feel that hunger for data points. That's great for us to deliver.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

We deliver high throughput synthesis, expression, and characterization, we're going to be there to serve our customers. Overall, again, we're not guiding to 2027, but Q4, we're guiding to a very, very strong Q4. We're guiding to a fiscal 2026 above 20% growth. We're trying to just see the value given in Q4, we couldn't be more excited about what's to come. Again, the Twist platform is really meeting the moment of what our current [inaudible] need, both on the NGS and the DNA Synthesis and Protein Solutions side.

[Operator]

Thank you. Our next question comes from Kyle Mikson with Canaccord Genuity. Your line is open.

[Kyle Mikson, Analyst at Canaccord Genuity]

Hey, guys. Thanks for the questions. Congrats on the 49% growth in therapeutics. Very impressive. As was mentioned earlier, the revenues were down or kind of flat quarter-over-quarter. There was some competitive actions taken by other vendors in the field. There was some discounting, I believe. Is that having any impact on the therapeutics and the AI for discovery business at all? Secondly, Adam, you raised the guidance by $10 million or so. The beat was $4 million. Where are you expecting this outperformance in the fiscal first quarter to come through among the different industries and the products? Thanks.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

Thanks, Kyle, for initiating and the question. 49% growth quarter-over-quarter is outstanding. We are raising the guide by $12 million, which is three times the beat. Obviously, there's a lot of confidence. Maybe I'll step back to one sentence that Paddy said in his remarks, which really encompasses the Twist, which is that we do not optimize for a single quarter. Instead, what we're doing is we are focusing on building a stronger company every quarter. We have our eyes firmly looking ahead. Frankly, no worries about competition at all.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

The kinds of numbers in terms of thousands of sequences that people need in an array format, or the millions that people need in a pool format, I don't know if there's any other platform that actually can deliver that kind of numbers. For us, we're not really worried about competition. It's about being there for our customers, hearing what they need, and meeting their flexible data point target. We think we're doing really well.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

As people start to expand to new modalities, again, a lot of the AI so far has been done for VHHs, and we're starting to see IgGs. As people are going to new modalities, as more customers that maybe a year ago were on the sideline, now squarely engaged. Again, we would not guide to a triple-digit percentage growth on AI-driven discovery for 2027 again, as I've leaned on in 2026, without very strong comparable customers. Full speed ahead.

[Operator]

Thank you. Our next question comes from Matt Larew with William Blair. Your line is open.

[Matt Larew, Analyst at William Blair]

Hi, good morning. You provided some details on customers who have sort of progressed from model building to crank turning, and then the expansion of their overall work. I'm curious if you can maybe speak more to the new customer activity that you've seen over the last 12 months, and if there's any way you can help us put a number or a direction on the number of customers still sort of just starting or getting into AI-driven discovery as a part of their workflow today.

[Matt Larew, Analyst at William Blair]

That's the first part. The second is related, which is when we were at the Investor Day, it was clear that one area of physical investment you were making was broadening the data capability or the capability to serve data characterization. Would just be curious if you could, again, sort of put any numbers on how that business is growing, demand, what kind of services you're being asked for there. That would be helpful, again, just to contextualize the order growth for next year. Thanks.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

Yeah, thank you. Thank you, Matt. The growth for next year is anticipated to be very broad-based. We are actually adding capacity now ahead of the demand in the data characterization. As you know, the capacity that we have on the DNA Synthesis and protein expression is really outstanding and ahead of what people need. We know that the data piece is very exciting for our customers. They don't have to be the lab.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

They don't have to worry about maintenance, about calibration, about machine-to-machine reproducibility. We take care of all of that. Being able to have a one-stop shop where you give sequences, thousands of sequences, and the target that you're interested in, and being able to get data is very appealing. At the same time, we are a custom business.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

Our customers want different things, different blend of tests, different conditions, different buffer, different solution. Our platform is built for that as well. To your question in terms of where will the growth come from, frankly, it doesn't really matter. We don't really care. We will be there for wherever the science takes our customer. At the same time, we anticipate that a lot of it will come from the data side.

[Operator]

Thank you. Our next question comes from Mac Etoch with Stephens. Your line is open.

[Mac Etoch, Analyst at Stephens]

Hey, good morning, and thank you for taking my questions. Maybe just to clarify, sorry my connection's maybe a little bit spotty, so if you answer this, I apologize already, but the change in expectations from 3Q-4Q implying a sequential step up in DSPS now. Can you just double tap on the drivers that you're looking at there and what's changed in how you're looking at that from the past quarter and now in 3Q? Thank you.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

Adam?

[Adam Laponis, CFO at Twist Bioscience]

Paddy, thanks for the question. In terms of the guide for Q4, we are expecting sequential growth in both DSPS and NGS Applications. We continue to see both strength continuing in the diagnostic space sequentially as well as in the therapeutics, often driven by the AI drug discovery. As we look at that strength continuing, it's really a testament to the pipeline of the opportunities we see. We see growth both in terms of the new customers coming in as well as in the repeat business across the DSPS and the AI drug discovery space.

[Operator]

Thank you. Our next question comes from Vijay Kumar with Evercore ISI. Your line is open.

[Vijay Kumar, Analyst at Evercore ISI]

Hi, Emily. My first question was, getting back to those AI orders, I think in the past Twist has necessarily had its short order cycle, right? Shorter duration order cycle. I'm curious on commenting on fiscal 2027 triple-led AI orders. That implies a lot of visibility. Maybe could you elaborate what is different about AI that gives you this longer-term visibility versus the typical order book, which seems to be more shorter cycle?

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

Thank you. That's a great comment. It's true that, you're 100% correct, that in the past we talked to pharma companies, they would send us some sequences, we would ship them very quickly, we'd get paid. We didn't always have visibility as to when the next batch would be. I think for AI, it's a little bit different, because now we are thinking about very, very big numbers. Now we have all from the DNA Synthesis and Protein Solutions side that's similar from what we are getting in the NGS side.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

When you're thinking about big numbers, millions of dollar, now you need [MSA] and there's some discussion up front of what do they need, in a way it's more our customers making sure that convincing themselves that we have the capacity to do. They are a lot more transparent in what they need. Once the order comes in, again, those are our big numbers. There's a lot more engagement and transparency on their side with what they're going to do with it, what the next batch is coming in.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

In some ways, we have been much more engaged in the science of what our customers are doing than we were before, where we were, quote-unquote, "Just a DNA provider or just a sequence provider." Now we've moved to the next level of providing a solution. They're talking to our CSO, Colby Souders, who is a drug discoverer, right? It's a much higher level of engagement, and that's why we have more visibility than we had before.

[Operator]

Thank you. Our next question comes from Luke Sergott with Barclays. Your line is open.

[Luke Sergott, Analyst at Barclays]

Great. Thanks, guys. Just a couple cleanups. Did you already call out the amount of AI revs you guys had in the quarter, or what's embedded for the full-year guide? That's my first one. The second one is more, we're getting more, I guess more, not pushback from the market, but just more interest in the market from GenScript TurboCHO.

[Luke Sergott, Analyst at Barclays]

We're hearing about that side as we're doing more work on the AI labs and what this could mean for you guys, but we're also hearing them come up more in conversations given the cost. They have a different scale than you guys. Talk about where you see the competitive dynamic shaking out, what you would need to do from a scale or turnaround time, anything that you guys can do there to continue to win share and own the market.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

I'll start and then I'll pass the question to Adam on the financial question. We don't worry too much about the competition, frankly. We try to hear what customers want and then do that. At the same time, having a healthy paranoia and looking over the shoulder is important. I think in this case, it's a bit different. We started as a DNA company, 18 months ago, we didn't have a big presence in protein. Through the engagement with customers, we understood that they needed protein and data.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

Over the last 18 months, we built something that we think is pretty unique. In some ways, we are leaping ahead of GenScript, because we don't believe they have the same data capacity and capabilities as we are. In some ways, we are the disruptor, not the other way around. TurboCHO has been around for a long time, frankly, our customers don't care which view you use. They want to know what data capability we have, what capacities we have, and what speed we can deliver that data. The differentiation is not around the tool that you're using.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

The differentiation is around the breadth of the menu, the flexibility in the condition that those sets are being produced. Very importantly, the end. How many sequence can I test? If you're talking about millions of data points in a pool asset, I think we are unbeatable there. If you're talking about tens of thousands of sequences, in an array format, I think we're also pretty unbeatable. If you want five, 10 sequences, you may have a choice of supplier. For large numbers, I think we're in a very good position. Adam?

[Adam Laponis, CFO at Twist Bioscience]

No, Luke, thanks. Good question. In terms of AI orders and revenue, I hit on it earlier, if you looked at back a year ago at this time, in Q4 of 2025, we had a record order from an AI drug discovery project, that really made the cutover at the end of the fiscal year. Some of that order dripped into revenue recognition into Q1 fiscal 2026. Looking at 2026, the timelines are much more lined up, just that the progress has been smoother, we've had a broader base of customers upon which to grow on, we're seeing that the orders and the revenue are much more lined up with each other.

[Adam Laponis, CFO at Twist Bioscience]

Although we haven't given specific breakouts for AI drug discovery quarter-on-quarter, I point everybody to the progress in therapeutics, and really the outsized growth in therapeutics primarily being driven by AI drug discovery. Looking forward into 2027 and beyond, we'd expect the revenue and the orders to be more lined up like they are in 2026.

[Operator]

Thank you. Our next question comes from Robert Bamberger with Baird. Your line is open.

[Robert Bamberger, Analyst at Baird]

Thanks for taking my question. Academic and government went from 3% growth last quarter to 32% this quarter, and up pretty nicely sequentially. Any change in what you're seeing in academic, and I guess what caused those outsized gains? Any commentary on the academic promotions as well?

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

Paddy?

[Patrick Finn, President and COO at Twist Bioscience]

Good question. Thanks for that. The academic segment, good quarter. Team executed well. It remains a dynamic environment, and we'll continue to execute well into that segment. Our value proposition continues to resonate. You imagine a budget-constrained environment, cost, speed, quality tends to more shots on goal for your budget and resonates well. It's something that it's a segment we've underserved through the history of Twist.

[Patrick Finn, President and COO at Twist Bioscience]

Express Genes and promotions into the segment continue, and we're just focused on, like all of our customers, delivering a really fantastic customer experience, because once you're on the platform, you're not going to go back to pay more for slower product. We'll continue to execute day by day, and we'll look to continue our strength in that segment.

[Operator]

Thank you. I'm showing no further questions at this time. I'd like to turn the call over to Emily Leproust for closing remarks.

[Emily Leproust, CEO and Co-Founder at Twist Bioscience]

Thank you for your question. The story this quarter is simple. Customer demand continues to strengthen. Our execution continues to deliver, and the platform we've built over the more than 10 years that we've been doing this is creating an advantage that continues to widen. We remain confident in our trajectory and excited about the opportunities ahead. Thank you.

[Operator]

Thank you for your participation. This does conclude the program. You may now disconnect. Everyone, have a great day.

Participants

Executives

• Angela Bitting, SVP of Corporate Affairs
• Emily Leproust, CEO and Co-Founder
• Patrick Finn, President and COO
• Adam Laponis, CFO

Analysts

• Brendan Smith, Analyst at TD Cowen
• Puneet Souda, Analyst at Leerink Partners
• David Westenberg, Analyst at Piper Sandler
• Subbu Nambi, Analyst at Guggenheim
• Kyle Mikson, Analyst at Canaccord Genuity
• Matt Larew, Analyst at William Blair
• Mac Etoch, Analyst at Stephens
• Vijay Kumar, Analyst at Evercore ISI
• Luke Sergott, Analyst at Barclays
• Robert Bamberger, Analyst at Baird