Amylyx Pharmaceuticals (AMLX) Stock Price, News & Analysis

Company Overview

Amylyx Pharmaceuticals, Inc., a commercial-stage biotechnology company, engages in the discovery and development of treatment for amyotrophic lateral sclerosis (ALS) and neurodegenerative diseases. The company's products include RELYVRIO, a dual UPR-Bax apoptosis inhibitor composed of sodium phenylbutyrate and taurursodiol for the treatment of ALS in adults in the United States and marketed as ALBRIOZA for the treatment of ALS in Canada. It is also developing AMX0114 for other neurodegenerative diseases. Amylyx Pharmaceuticals, Inc. was founded in 2013 and is headquartered in Cambridge, Massachusetts.

Key Stats

• Today's Range: $9.29 to $9.72
• 50-Day Range: $5.02 to $9.45
• 52-Week Range: $2.08 to $9.72
• Volume: 1.49 million shs
• Average Volume: 1.18 million shs
• Market Capitalization: $839.98 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $12.25
• Consensus Rating: Buy

Amylyx Pharmaceuticals Stock Analysis - MarketRank™

Amylyx Pharmaceuticals scored higher than 70% of companies evaluated by MarketBeat, and ranked 295th out of 949 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 4.5 / 5
• Analyst Rating: Buy

Consensus Rating

Amylyx Pharmaceuticals has received a consensus rating of Buy. The company's average rating score is 3.00, and is based on 9 buy ratings, 2 hold ratings, and no sell ratings.

Amount of Analyst Coverage

Amylyx Pharmaceuticals has been the subject of 6 research reports in the past 90 days, demonstrating strong analyst interest in this stock.

Earnings and Valuation

• Score: 0.6 / 5
• Proj. Earnings Growth: Growing

Earnings Growth

Earnings for Amylyx Pharmaceuticals are expected to grow in the coming year, from ($2.20) to ($1.36) per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of Amylyx Pharmaceuticals is -3.77, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of Amylyx Pharmaceuticals is -3.77, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Book Value per Share Ratio

Amylyx Pharmaceuticals has a P/B Ratio of 5.01. P/B Ratios above 3 indicate that a company could be overvalued with respect to its assets and liabilities.

Short Interest

• Score: 2.0 / 5
• Short Interest Level: Bearish

Percentage of Shares Shorted

10.82% of the float of Amylyx Pharmaceuticals has been sold short.

Short Interest Ratio / Days to Cover

Amylyx Pharmaceuticals has a short interest ratio ("days to cover") of 5.

Change versus previous month

Short interest in Amylyx Pharmaceuticals has recently decreased by 3.75%, indicating that investor sentiment is improving.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

Amylyx Pharmaceuticals does not currently pay a dividend.

Dividend Growth

Amylyx Pharmaceuticals does not have a long track record of dividend growth.

Sustainability and ESG

• Score: N/A
• Environmental Score: N/A

Percentage of Shares Shorted

10.82% of the float of Amylyx Pharmaceuticals has been sold short.

Short Interest Ratio / Days to Cover

Amylyx Pharmaceuticals has a short interest ratio ("days to cover") of 5.

Change versus previous month

Short interest in Amylyx Pharmaceuticals has recently decreased by 3.75%, indicating that investor sentiment is improving.

News and Social Media

• Score: 2.7 / 5
• News Sentiment: 0.88

News Sentiment

Amylyx Pharmaceuticals has a news sentiment score of 0.88. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a lower news sentiment than the 1.03 average news sentiment score of Medical companies.

News Coverage This Week

MarketBeat has tracked 8 news articles for Amylyx Pharmaceuticals this week, compared to 4 articles on an average week.

Search Interest

Only 7 people have searched for AMLX on MarketBeat in the last 30 days. This is a decrease of -13% compared to the previous 30 days.

MarketBeat Follows

2 people have added Amylyx Pharmaceuticals to their MarketBeat watchlist in the last 30 days.

Company Ownership

• Score: 2.5 / 5
• Insider Trading: N/A

Insider Buying vs. Insider Selling

In the past three months, Amylyx Pharmaceuticals insiders have not sold or bought any company stock.

Percentage Held by Insiders

12.30% of the stock of Amylyx Pharmaceuticals is held by insiders. A high percentage of insider ownership can be a sign of company health.

Percentage Held by Institutions

95.84% of the stock of Amylyx Pharmaceuticals is held by institutions. High institutional ownership can be a signal of strong market trust in this company.

AMLX Stock Analysis - Frequently Asked Questions

How have AMLX shares performed this year?

Amylyx Pharmaceuticals' stock was trading at $3.78 at the beginning of 2025. Since then, AMLX stock has increased by 149.2% and is now trading at $9.42.

How were Amylyx Pharmaceuticals' earnings last quarter?

Amylyx Pharmaceuticals, Inc. (NASDAQ:AMLX) posted its quarterly earnings results on Thursday, August, 7th. The company reported ($0.46) EPS for the quarter, missing analysts' consensus estimates of ($0.44) by $0.02.
Read the conference call transcript.

When did Amylyx Pharmaceuticals IPO?

Amylyx Pharmaceuticals (AMLX) raised $190 million in an IPO on Friday, January 7th 2022. The company issued 10,000,000 shares at $18.00-$20.00 per share.

Who are Amylyx Pharmaceuticals' major shareholders?

Amylyx Pharmaceuticals' top institutional shareholders include Adage Capital Partners GP L.L.C. (9.87%), Perceptive Advisors LLC (8.86%), Saturn V Capital Management LP (3.66%) and 683 Capital Management LLC (2.42%). Insiders that own company stock include Morningside Venture Investment, Joshua B Cohen, Justin B Klee, Global Investors Lp Viking, George M Milne Jr, James M Frates, Patrick D Yeramian, Camille L Bedrosian, Gina Mazzariello, Bernhardt G Zeiher and Daphne Quimi.
View institutional ownership trends.

How do I buy shares of Amylyx Pharmaceuticals?

Shares of AMLX stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of Amylyx Pharmaceuticals own?

Based on aggregate information from My MarketBeat watchlists, some other companies that Amylyx Pharmaceuticals investors own include Waste Connections (WCN), American Water Works (AWK), AU Optronics (AUOTY), DiamondRock Hospitality (DRH), The RMR Group (RMR), iShares Micro-Cap ETF (IWC) and Triple Flag Precious Metals (TFPM).

Company Calendar

• Last Earnings: 8/07/2025
• Today: 8/29/2025
• Next Earnings (Estimated): 11/06/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: MED - DRUGS
• Sub-Industry: Pharmaceutical Products
• Current Symbol: NASDAQ:AMLX
• CIK: 1658551
• Web: amylyx.com
• Phone: 617-682-0917
• Fax: N/A
• Employees: 200
• Year Founded: N/A

Price Target and Rating

• Average Price Target for Amylyx Pharmaceuticals: $12.25
• High Price Target: $17.00
• Low Price Target: $8.00
• Potential Upside/Downside: +30.0%
• Consensus Rating: Buy
• Rating Score (0-4): 3.00
• Research Coverage: 13 Analysts

Profitability

• EPS (Trailing Twelve Months): ($2.50)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: -$301.74 million
• Net Margins: N/A
• Pretax Margin: -345.81%
• Return on Equity: -82.48%
• Return on Assets: -70.15%

Debt

• Debt-to-Equity Ratio: N/A
• Current Ratio: 8.72
• Quick Ratio: 8.72

Sales & Book Value

• Annual Sales: $87.37 million
• Price / Sales: 9.61
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: $1.88 per share
• Price / Book: 5.01

Miscellaneous

• Outstanding Shares: 89,170,000
• Free Float: 78,199,000
• Market Cap: $839.98 million
• Optionable: Optionable
• Beta: -0.46