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Agenus (AGEN) Competitors

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$3.22 -0.16 (-4.73%)
Closing price 06/3/2026 04:00 PM Eastern
Extended Trading
$3.24 +0.02 (+0.78%)
As of 06/3/2026 07:49 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.

AGEN vs. IRWD, CBIO, RIGL, ACHV, and XOMA

Should you buy Agenus stock or one of its competitors? MarketBeat compares Agenus with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Agenus include Ironwood Pharmaceuticals (IRWD), Crescent Biopharma (CBIO), Rigel Pharmaceuticals (RIGL), Achieve Life Sciences (ACHV), and XOMA Royalty (XOMA). These companies are all part of the "biotechnology" industry.

How does Agenus compare to Ironwood Pharmaceuticals?

Ironwood Pharmaceuticals (NASDAQ:IRWD) and Agenus (NASDAQ:AGEN) are both small-cap medical companies, but which is the better investment? We will compare the two companies based on the strength of their risk, institutional ownership, analyst recommendations, media sentiment, earnings, profitability, valuation and dividends.

Ironwood Pharmaceuticals presently has a consensus price target of $6.23, suggesting a potential upside of 92.39%. Agenus has a consensus price target of $23.00, suggesting a potential upside of 614.29%. Given Agenus' higher possible upside, analysts plainly believe Agenus is more favorable than Ironwood Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Ironwood Pharmaceuticals
1 Sell rating(s)
3 Hold rating(s)
2 Buy rating(s)
1 Strong Buy rating(s)
2.43
Agenus
1 Sell rating(s)
1 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.00

In the previous week, Ironwood Pharmaceuticals had 7 more articles in the media than Agenus. MarketBeat recorded 9 mentions for Ironwood Pharmaceuticals and 2 mentions for Agenus. Agenus' average media sentiment score of 1.26 beat Ironwood Pharmaceuticals' score of 0.78 indicating that Agenus is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Ironwood Pharmaceuticals
2 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Agenus
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Ironwood Pharmaceuticals has a beta of 0.25, meaning that its share price is 75% less volatile than the broader market. Comparatively, Agenus has a beta of 1.57, meaning that its share price is 57% more volatile than the broader market.

61.5% of Agenus shares are owned by institutional investors. 9.3% of Ironwood Pharmaceuticals shares are owned by company insiders. Comparatively, 5.5% of Agenus shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company is poised for long-term growth.

Ironwood Pharmaceuticals has higher revenue and earnings than Agenus. Agenus is trading at a lower price-to-earnings ratio than Ironwood Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Ironwood Pharmaceuticals$296.15M1.78$24.02M$0.605.40
Agenus$114.20M1.17$120K$1.592.03

Agenus has a net margin of 50.49% compared to Ironwood Pharmaceuticals' net margin of 28.26%. Agenus' return on equity of -31.66% beat Ironwood Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Ironwood Pharmaceuticals28.26% -39.65% 26.54%
Agenus 50.49%-31.66%42.71%

Summary

Ironwood Pharmaceuticals beats Agenus on 9 of the 17 factors compared between the two stocks.

How does Agenus compare to Crescent Biopharma?

Agenus (NASDAQ:AGEN) and Crescent Biopharma (NASDAQ:CBIO) are both small-cap medical companies, but which is the superior stock? We will contrast the two companies based on the strength of their media sentiment, dividends, profitability, valuation, institutional ownership, risk, earnings and analyst recommendations.

Agenus has a net margin of 50.49% compared to Crescent Biopharma's net margin of 0.00%. Agenus' return on equity of -31.66% beat Crescent Biopharma's return on equity.

Company Net Margins Return on Equity Return on Assets
Agenus50.49% -31.66% 42.71%
Crescent Biopharma N/A -103.44%-88.19%

Agenus presently has a consensus target price of $23.00, suggesting a potential upside of 614.29%. Crescent Biopharma has a consensus target price of $28.00, suggesting a potential upside of 55.73%. Given Agenus' higher possible upside, equities analysts clearly believe Agenus is more favorable than Crescent Biopharma.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Agenus
1 Sell rating(s)
1 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.00
Crescent Biopharma
1 Sell rating(s)
0 Hold rating(s)
5 Buy rating(s)
3 Strong Buy rating(s)
3.11

Agenus has higher revenue and earnings than Crescent Biopharma. Crescent Biopharma is trading at a lower price-to-earnings ratio than Agenus, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Agenus$114.20M1.17$120K$1.592.03
Crescent Biopharma$10.84M45.71-$153.94M-$10.91N/A

In the previous week, Crescent Biopharma had 2 more articles in the media than Agenus. MarketBeat recorded 4 mentions for Crescent Biopharma and 2 mentions for Agenus. Agenus' average media sentiment score of 1.26 beat Crescent Biopharma's score of 0.96 indicating that Agenus is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Agenus
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Crescent Biopharma
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Agenus has a beta of 1.57, suggesting that its stock price is 57% more volatile than the broader market. Comparatively, Crescent Biopharma has a beta of 1.16, suggesting that its stock price is 16% more volatile than the broader market.

61.5% of Agenus shares are held by institutional investors. Comparatively, 75.2% of Crescent Biopharma shares are held by institutional investors. 5.5% of Agenus shares are held by company insiders. Comparatively, 4.0% of Crescent Biopharma shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company is poised for long-term growth.

Summary

Agenus beats Crescent Biopharma on 11 of the 17 factors compared between the two stocks.

How does Agenus compare to Rigel Pharmaceuticals?

Rigel Pharmaceuticals (NASDAQ:RIGL) and Agenus (NASDAQ:AGEN) are both small-cap medical companies, but which is the better business? We will contrast the two businesses based on the strength of their valuation, earnings, dividends, institutional ownership, analyst recommendations, risk, media sentiment and profitability.

66.2% of Rigel Pharmaceuticals shares are owned by institutional investors. Comparatively, 61.5% of Agenus shares are owned by institutional investors. 10.5% of Rigel Pharmaceuticals shares are owned by insiders. Comparatively, 5.5% of Agenus shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.

Rigel Pharmaceuticals has a beta of 1.2, meaning that its stock price is 20% more volatile than the broader market. Comparatively, Agenus has a beta of 1.57, meaning that its stock price is 57% more volatile than the broader market.

In the previous week, Rigel Pharmaceuticals had 3 more articles in the media than Agenus. MarketBeat recorded 5 mentions for Rigel Pharmaceuticals and 2 mentions for Agenus. Agenus' average media sentiment score of 1.26 beat Rigel Pharmaceuticals' score of 0.54 indicating that Agenus is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Rigel Pharmaceuticals
2 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Agenus
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Rigel Pharmaceuticals presently has a consensus target price of $54.50, indicating a potential upside of 79.87%. Agenus has a consensus target price of $23.00, indicating a potential upside of 614.29%. Given Agenus' higher possible upside, analysts clearly believe Agenus is more favorable than Rigel Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Rigel Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
3 Buy rating(s)
0 Strong Buy rating(s)
2.33
Agenus
1 Sell rating(s)
1 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.00

Rigel Pharmaceuticals has higher revenue and earnings than Agenus. Rigel Pharmaceuticals is trading at a lower price-to-earnings ratio than Agenus, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Rigel Pharmaceuticals$294.28M1.90$367.02M$18.721.62
Agenus$114.20M1.17$120K$1.592.03

Rigel Pharmaceuticals has a net margin of 121.50% compared to Agenus' net margin of 50.49%. Rigel Pharmaceuticals' return on equity of 47.99% beat Agenus' return on equity.

Company Net Margins Return on Equity Return on Assets
Rigel Pharmaceuticals121.50% 47.99% 32.40%
Agenus 50.49%-31.66%42.71%

Summary

Rigel Pharmaceuticals beats Agenus on 11 of the 16 factors compared between the two stocks.

How does Agenus compare to Achieve Life Sciences?

Achieve Life Sciences (NASDAQ:ACHV) and Agenus (NASDAQ:AGEN) are both small-cap medical companies, but which is the better business? We will compare the two companies based on the strength of their risk, institutional ownership, valuation, media sentiment, dividends, analyst recommendations, profitability and earnings.

Achieve Life Sciences currently has a consensus target price of $14.67, suggesting a potential upside of 198.41%. Agenus has a consensus target price of $23.00, suggesting a potential upside of 614.29%. Given Agenus' higher possible upside, analysts plainly believe Agenus is more favorable than Achieve Life Sciences.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Achieve Life Sciences
1 Sell rating(s)
0 Hold rating(s)
3 Buy rating(s)
2 Strong Buy rating(s)
3.00
Agenus
1 Sell rating(s)
1 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.00

In the previous week, Achieve Life Sciences had 2 more articles in the media than Agenus. MarketBeat recorded 4 mentions for Achieve Life Sciences and 2 mentions for Agenus. Agenus' average media sentiment score of 1.26 beat Achieve Life Sciences' score of 0.80 indicating that Agenus is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Achieve Life Sciences
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Agenus
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Agenus has a net margin of 50.49% compared to Achieve Life Sciences' net margin of 0.00%. Agenus' return on equity of -31.66% beat Achieve Life Sciences' return on equity.

Company Net Margins Return on Equity Return on Assets
Achieve Life SciencesN/A -193.49% -111.88%
Agenus 50.49%-31.66%42.71%

33.5% of Achieve Life Sciences shares are held by institutional investors. Comparatively, 61.5% of Agenus shares are held by institutional investors. 3.0% of Achieve Life Sciences shares are held by company insiders. Comparatively, 5.5% of Agenus shares are held by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock will outperform the market over the long term.

Agenus has higher revenue and earnings than Achieve Life Sciences. Achieve Life Sciences is trading at a lower price-to-earnings ratio than Agenus, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Achieve Life SciencesN/AN/A-$54.65M-$1.12N/A
Agenus$114.20M1.17$120K$1.592.03

Achieve Life Sciences has a beta of 2.27, meaning that its stock price is 127% more volatile than the broader market. Comparatively, Agenus has a beta of 1.57, meaning that its stock price is 57% more volatile than the broader market.

Summary

Agenus beats Achieve Life Sciences on 11 of the 16 factors compared between the two stocks.

How does Agenus compare to XOMA Royalty?

XOMA Royalty (NASDAQ:XOMA) and Agenus (NASDAQ:AGEN) are both small-cap medical companies, but which is the better business? We will compare the two companies based on the strength of their media sentiment, valuation, dividends, institutional ownership, analyst recommendations, risk, earnings and profitability.

95.9% of XOMA Royalty shares are held by institutional investors. Comparatively, 61.5% of Agenus shares are held by institutional investors. 8.9% of XOMA Royalty shares are held by company insiders. Comparatively, 5.5% of Agenus shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term.

XOMA Royalty has a beta of 0.88, indicating that its share price is 12% less volatile than the broader market. Comparatively, Agenus has a beta of 1.57, indicating that its share price is 57% more volatile than the broader market.

In the previous week, XOMA Royalty and XOMA Royalty both had 2 articles in the media. Agenus' average media sentiment score of 1.26 beat XOMA Royalty's score of 0.94 indicating that Agenus is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
XOMA Royalty
0 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Agenus
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

XOMA Royalty has higher earnings, but lower revenue than Agenus. Agenus is trading at a lower price-to-earnings ratio than XOMA Royalty, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
XOMA Royalty$52.15M10.03$31.71M$1.5726.56
Agenus$114.20M1.17$120K$1.592.03

XOMA Royalty has a net margin of 53.46% compared to Agenus' net margin of 50.49%. XOMA Royalty's return on equity of 12.56% beat Agenus' return on equity.

Company Net Margins Return on Equity Return on Assets
XOMA Royalty53.46% 12.56% 4.11%
Agenus 50.49%-31.66%42.71%

XOMA Royalty currently has a consensus price target of $53.75, suggesting a potential upside of 28.90%. Agenus has a consensus price target of $23.00, suggesting a potential upside of 614.29%. Given Agenus' higher probable upside, analysts plainly believe Agenus is more favorable than XOMA Royalty.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
XOMA Royalty
0 Sell rating(s)
6 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.14
Agenus
1 Sell rating(s)
1 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.00

Summary

XOMA Royalty beats Agenus on 8 of the 14 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding AGEN and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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AGEN vs. The Competition

MetricAgenusMED IndustryMedical SectorNASDAQ Exchange
Market Cap$140.75M$3.24B$6.47B$12.54B
Dividend YieldN/A2.38%2.69%5.22%
P/E Ratio2.0317.7822.1724.18
Price / Sales1.17315.63520.79112.26
Price / CashN/A111.6441.3457.13
Price / Book-0.396.639.846.72
Net Income$120K$24.20M$3.57B$337.19M
7 Day Performance-5.29%-4.39%-2.46%-0.74%
1 Month PerformanceN/AN/AN/A-1.69%
1 Year Performance-42.81%45.50%26.49%33.10%

Agenus Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
AGEN
Agenus
2.3308 of 5 stars
$3.22
-4.7%
$23.00
+614.3%
-35.6%$140.75M$114.20M2.03440
IRWD
Ironwood Pharmaceuticals
2.4608 of 5 stars
$3.46
-3.1%
$6.23
+80.2%
+431.2%$582.12M$296.15M5.77220
CBIO
Crescent Biopharma
2.069 of 5 stars
$19.72
-4.5%
$28.00
+42.0%
N/A$569.05M$10.84MN/A50
RIGL
Rigel Pharmaceuticals
3.1831 of 5 stars
$29.86
-2.1%
$54.50
+82.5%
+48.6%$564.13M$294.28M1.60160
ACHV
Achieve Life Sciences
2.5568 of 5 stars
$5.30
+1.1%
$14.67
+176.7%
+16.7%$537.93MN/AN/A20

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This page (NASDAQ:AGEN) was last updated on 6/4/2026 by MarketBeat.com Staff.
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