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Lexicon Pharmaceuticals (LXRX) Competitors

Lexicon Pharmaceuticals logo
$2.22 -0.03 (-1.33%)
Closing price 07/10/2026 04:00 PM Eastern
Extended Trading
$2.24 +0.01 (+0.68%)
As of 07/10/2026 07:50 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.

LXRX vs. CLDX, BCRX, ZBIO, INVA, and NVAX

Should you buy Lexicon Pharmaceuticals stock or one of its competitors? MarketBeat compares Lexicon Pharmaceuticals with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Lexicon Pharmaceuticals include Celldex Therapeutics (CLDX), BioCryst Pharmaceuticals (BCRX), Zenas BioPharma (ZBIO), Innoviva (INVA), and Novavax (NVAX). These companies are all part of the "biotechnology" industry.

How does Lexicon Pharmaceuticals compare to Celldex Therapeutics?

Lexicon Pharmaceuticals (NASDAQ:LXRX) and Celldex Therapeutics (NASDAQ:CLDX) are both medical companies, but which is the superior investment? We will contrast the two companies based on the strength of their dividends, risk, valuation, media sentiment, analyst recommendations, profitability, institutional ownership and earnings.

Celldex Therapeutics has a net margin of 0.00% compared to Lexicon Pharmaceuticals' net margin of -37.46%. Lexicon Pharmaceuticals' return on equity of -18.64% beat Celldex Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Lexicon Pharmaceuticals-37.46% -18.64% -11.79%
Celldex Therapeutics N/A -50.72%-46.59%

Lexicon Pharmaceuticals presently has a consensus price target of $4.55, indicating a potential upside of 104.95%. Celldex Therapeutics has a consensus price target of $49.30, indicating a potential upside of 26.05%. Given Lexicon Pharmaceuticals' higher probable upside, analysts plainly believe Lexicon Pharmaceuticals is more favorable than Celldex Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Lexicon Pharmaceuticals
1 Sell rating(s)
0 Hold rating(s)
2 Buy rating(s)
1 Strong Buy rating(s)
2.75
Celldex Therapeutics
1 Sell rating(s)
1 Hold rating(s)
8 Buy rating(s)
1 Strong Buy rating(s)
2.82

74.7% of Lexicon Pharmaceuticals shares are held by institutional investors. 14.0% of Lexicon Pharmaceuticals shares are held by company insiders. Comparatively, 5.2% of Celldex Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company will outperform the market over the long term.

Lexicon Pharmaceuticals has a beta of 1.05, suggesting that its share price is 5% more volatile than the broader market. Comparatively, Celldex Therapeutics has a beta of 0.9, suggesting that its share price is 10% less volatile than the broader market.

Lexicon Pharmaceuticals has higher revenue and earnings than Celldex Therapeutics. Lexicon Pharmaceuticals is trading at a lower price-to-earnings ratio than Celldex Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Lexicon Pharmaceuticals$49.80M19.80-$50.34M-$0.07N/A
Celldex Therapeutics$1.54M1,993.34-$258.76M-$4.26N/A

In the previous week, Lexicon Pharmaceuticals had 1 more articles in the media than Celldex Therapeutics. MarketBeat recorded 2 mentions for Lexicon Pharmaceuticals and 1 mentions for Celldex Therapeutics. Lexicon Pharmaceuticals' average media sentiment score of 1.25 beat Celldex Therapeutics' score of 0.00 indicating that Lexicon Pharmaceuticals is being referred to more favorably in the media.

Company Overall Sentiment
Lexicon Pharmaceuticals Positive
Celldex Therapeutics Neutral

Summary

Lexicon Pharmaceuticals beats Celldex Therapeutics on 11 of the 16 factors compared between the two stocks.

How does Lexicon Pharmaceuticals compare to BioCryst Pharmaceuticals?

BioCryst Pharmaceuticals (NASDAQ:BCRX) and Lexicon Pharmaceuticals (NASDAQ:LXRX) are both medical companies, but which is the superior business? We will contrast the two businesses based on the strength of their earnings, valuation, profitability, analyst recommendations, dividends, media sentiment, institutional ownership and risk.

BioCryst Pharmaceuticals has a beta of 0.55, suggesting that its stock price is 45% less volatile than the broader market. Comparatively, Lexicon Pharmaceuticals has a beta of 1.05, suggesting that its stock price is 5% more volatile than the broader market.

Lexicon Pharmaceuticals has a net margin of -37.46% compared to BioCryst Pharmaceuticals' net margin of -51.71%. Lexicon Pharmaceuticals' return on equity of -18.64% beat BioCryst Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
BioCryst Pharmaceuticals-51.71% -76.36% 60.12%
Lexicon Pharmaceuticals -37.46%-18.64%-11.79%

BioCryst Pharmaceuticals currently has a consensus target price of $21.78, suggesting a potential upside of 108.40%. Lexicon Pharmaceuticals has a consensus target price of $4.55, suggesting a potential upside of 104.95%. Given BioCryst Pharmaceuticals' higher probable upside, equities research analysts clearly believe BioCryst Pharmaceuticals is more favorable than Lexicon Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
BioCryst Pharmaceuticals
0 Sell rating(s)
3 Hold rating(s)
8 Buy rating(s)
0 Strong Buy rating(s)
2.73
Lexicon Pharmaceuticals
1 Sell rating(s)
0 Hold rating(s)
2 Buy rating(s)
1 Strong Buy rating(s)
2.75

BioCryst Pharmaceuticals has higher revenue and earnings than Lexicon Pharmaceuticals. Lexicon Pharmaceuticals is trading at a lower price-to-earnings ratio than BioCryst Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
BioCryst Pharmaceuticals$874.84M3.04$263.86M-$1.78N/A
Lexicon Pharmaceuticals$49.80M19.80-$50.34M-$0.07N/A

85.9% of BioCryst Pharmaceuticals shares are owned by institutional investors. Comparatively, 74.7% of Lexicon Pharmaceuticals shares are owned by institutional investors. 3.8% of BioCryst Pharmaceuticals shares are owned by insiders. Comparatively, 14.0% of Lexicon Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company is poised for long-term growth.

In the previous week, BioCryst Pharmaceuticals had 2 more articles in the media than Lexicon Pharmaceuticals. MarketBeat recorded 4 mentions for BioCryst Pharmaceuticals and 2 mentions for Lexicon Pharmaceuticals. Lexicon Pharmaceuticals' average media sentiment score of 1.25 beat BioCryst Pharmaceuticals' score of 0.79 indicating that Lexicon Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
BioCryst Pharmaceuticals
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Lexicon Pharmaceuticals
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Lexicon Pharmaceuticals beats BioCryst Pharmaceuticals on 9 of the 17 factors compared between the two stocks.

How does Lexicon Pharmaceuticals compare to Zenas BioPharma?

Zenas BioPharma (NASDAQ:ZBIO) and Lexicon Pharmaceuticals (NASDAQ:LXRX) are both small-cap medical companies, but which is the superior business? We will contrast the two companies based on the strength of their profitability, earnings, analyst recommendations, media sentiment, institutional ownership, dividends, valuation and risk.

74.7% of Lexicon Pharmaceuticals shares are owned by institutional investors. 22.0% of Zenas BioPharma shares are owned by insiders. Comparatively, 14.0% of Lexicon Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock is poised for long-term growth.

In the previous week, Zenas BioPharma had 2 more articles in the media than Lexicon Pharmaceuticals. MarketBeat recorded 4 mentions for Zenas BioPharma and 2 mentions for Lexicon Pharmaceuticals. Lexicon Pharmaceuticals' average media sentiment score of 1.25 beat Zenas BioPharma's score of 0.00 indicating that Lexicon Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Zenas BioPharma
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Lexicon Pharmaceuticals
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Zenas BioPharma has a beta of -0.96, suggesting that its share price is 196% less volatile than the broader market. Comparatively, Lexicon Pharmaceuticals has a beta of 1.05, suggesting that its share price is 5% more volatile than the broader market.

Zenas BioPharma presently has a consensus target price of $44.29, suggesting a potential upside of 54.09%. Lexicon Pharmaceuticals has a consensus target price of $4.55, suggesting a potential upside of 104.95%. Given Lexicon Pharmaceuticals' stronger consensus rating and higher probable upside, analysts plainly believe Lexicon Pharmaceuticals is more favorable than Zenas BioPharma.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Zenas BioPharma
1 Sell rating(s)
2 Hold rating(s)
6 Buy rating(s)
0 Strong Buy rating(s)
2.56
Lexicon Pharmaceuticals
1 Sell rating(s)
0 Hold rating(s)
2 Buy rating(s)
1 Strong Buy rating(s)
2.75

Zenas BioPharma has a net margin of 0.00% compared to Lexicon Pharmaceuticals' net margin of -37.46%. Lexicon Pharmaceuticals' return on equity of -18.64% beat Zenas BioPharma's return on equity.

Company Net Margins Return on Equity Return on Assets
Zenas BioPharmaN/A -99.99% -58.06%
Lexicon Pharmaceuticals -37.46%-18.64%-11.79%

Lexicon Pharmaceuticals has higher revenue and earnings than Zenas BioPharma. Lexicon Pharmaceuticals is trading at a lower price-to-earnings ratio than Zenas BioPharma, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Zenas BioPharma$10M181.44-$377.74M-$8.47N/A
Lexicon Pharmaceuticals$49.80M19.80-$50.34M-$0.07N/A

Summary

Lexicon Pharmaceuticals beats Zenas BioPharma on 11 of the 17 factors compared between the two stocks.

How does Lexicon Pharmaceuticals compare to Innoviva?

Lexicon Pharmaceuticals (NASDAQ:LXRX) and Innoviva (NASDAQ:INVA) are both small-cap medical companies, but which is the superior stock? We will compare the two companies based on the strength of their profitability, valuation, dividends, earnings, institutional ownership, analyst recommendations, media sentiment and risk.

In the previous week, Innoviva had 1 more articles in the media than Lexicon Pharmaceuticals. MarketBeat recorded 3 mentions for Innoviva and 2 mentions for Lexicon Pharmaceuticals. Lexicon Pharmaceuticals' average media sentiment score of 1.25 beat Innoviva's score of 1.11 indicating that Lexicon Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Lexicon Pharmaceuticals
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Innoviva
1 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Lexicon Pharmaceuticals has a beta of 1.05, suggesting that its share price is 5% more volatile than the broader market. Comparatively, Innoviva has a beta of 0.34, suggesting that its share price is 66% less volatile than the broader market.

74.7% of Lexicon Pharmaceuticals shares are owned by institutional investors. Comparatively, 99.1% of Innoviva shares are owned by institutional investors. 14.0% of Lexicon Pharmaceuticals shares are owned by insiders. Comparatively, 2.0% of Innoviva shares are owned by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a stock is poised for long-term growth.

Lexicon Pharmaceuticals currently has a consensus target price of $4.55, indicating a potential upside of 104.95%. Innoviva has a consensus target price of $36.20, indicating a potential upside of 62.77%. Given Lexicon Pharmaceuticals' stronger consensus rating and higher probable upside, equities research analysts clearly believe Lexicon Pharmaceuticals is more favorable than Innoviva.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Lexicon Pharmaceuticals
1 Sell rating(s)
0 Hold rating(s)
2 Buy rating(s)
1 Strong Buy rating(s)
2.75
Innoviva
1 Sell rating(s)
1 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.57

Innoviva has higher revenue and earnings than Lexicon Pharmaceuticals. Lexicon Pharmaceuticals is trading at a lower price-to-earnings ratio than Innoviva, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Lexicon Pharmaceuticals$49.80M19.80-$50.34M-$0.07N/A
Innoviva$411.33M3.99$271.17M$6.013.70

Innoviva has a net margin of 119.89% compared to Lexicon Pharmaceuticals' net margin of -37.46%. Innoviva's return on equity of 33.33% beat Lexicon Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Lexicon Pharmaceuticals-37.46% -18.64% -11.79%
Innoviva 119.89%33.33%22.67%

Summary

Innoviva beats Lexicon Pharmaceuticals on 10 of the 17 factors compared between the two stocks.

How does Lexicon Pharmaceuticals compare to Novavax?

Lexicon Pharmaceuticals (NASDAQ:LXRX) and Novavax (NASDAQ:NVAX) are both small-cap medical companies, but which is the superior business? We will compare the two companies based on the strength of their profitability, media sentiment, valuation, earnings, institutional ownership, analyst recommendations, risk and dividends.

74.7% of Lexicon Pharmaceuticals shares are owned by institutional investors. Comparatively, 53.0% of Novavax shares are owned by institutional investors. 14.0% of Lexicon Pharmaceuticals shares are owned by insiders. Comparatively, 1.6% of Novavax shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company is poised for long-term growth.

Novavax has higher revenue and earnings than Lexicon Pharmaceuticals. Lexicon Pharmaceuticals is trading at a lower price-to-earnings ratio than Novavax, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Lexicon Pharmaceuticals$49.80M19.80-$50.34M-$0.07N/A
Novavax$1.12B1.37$440.30M-$0.58N/A

Lexicon Pharmaceuticals has a beta of 1.05, suggesting that its stock price is 5% more volatile than the broader market. Comparatively, Novavax has a beta of 2.43, suggesting that its stock price is 143% more volatile than the broader market.

Novavax has a net margin of -14.73% compared to Lexicon Pharmaceuticals' net margin of -37.46%. Novavax's return on equity of -14.82% beat Lexicon Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Lexicon Pharmaceuticals-37.46% -18.64% -11.79%
Novavax -14.73%-14.82%1.23%

Lexicon Pharmaceuticals presently has a consensus price target of $4.55, suggesting a potential upside of 104.95%. Novavax has a consensus price target of $13.00, suggesting a potential upside of 39.34%. Given Lexicon Pharmaceuticals' stronger consensus rating and higher probable upside, research analysts plainly believe Lexicon Pharmaceuticals is more favorable than Novavax.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Lexicon Pharmaceuticals
1 Sell rating(s)
0 Hold rating(s)
2 Buy rating(s)
1 Strong Buy rating(s)
2.75
Novavax
3 Sell rating(s)
1 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.40

In the previous week, Novavax had 20 more articles in the media than Lexicon Pharmaceuticals. MarketBeat recorded 22 mentions for Novavax and 2 mentions for Lexicon Pharmaceuticals. Lexicon Pharmaceuticals' average media sentiment score of 1.25 beat Novavax's score of 0.71 indicating that Lexicon Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Lexicon Pharmaceuticals
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Novavax
6 Very Positive mention(s)
2 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
2 Very Negative mention(s)
Positive

Summary

Novavax beats Lexicon Pharmaceuticals on 9 of the 16 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding LXRX and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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LXRX vs. The Competition

MetricLexicon PharmaceuticalsMED IndustryMedical SectorNASDAQ Exchange
Market Cap$999.44M$3.79B$7.12B$12.61B
Dividend YieldN/A2.17%2.68%7.83%
P/E Ratio-31.7121.2727.1924.56
Price / Sales19.80323.90590.19121.71
Price / CashN/A147.6449.3460.04
Price / Book7.408.4110.906.39
Net Income-$50.34M$23.85M$3.57B$331.44M
7 Day Performance-4.31%-0.76%-0.25%0.37%
1 Month Performance17.46%8.80%4.53%0.54%
1 Year Performance105.56%53.61%29.18%21.93%

Lexicon Pharmaceuticals Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
LXRX
Lexicon Pharmaceuticals
2.3989 of 5 stars
$2.22
-1.3%
$4.55
+105.0%
+96.5%$999.44M$49.80MN/A140
CLDX
Celldex Therapeutics
1.7976 of 5 stars
$37.95
-1.1%
$49.30
+29.9%
+72.4%$3.01B$1.54MN/A150
BCRX
BioCryst Pharmaceuticals
3.1318 of 5 stars
$10.17
+3.4%
$21.67
+113.0%
+17.7%$2.50B$874.84MN/A530
ZBIO
Zenas BioPharma
3.1653 of 5 stars
$26.45
-2.9%
$44.29
+67.4%
+138.1%$1.72B$10MN/AN/A
INVA
Innoviva
3.6625 of 5 stars
$21.82
-2.2%
$36.20
+65.9%
+16.7%$1.65B$411.33M3.63100

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This page (NASDAQ:LXRX) was last updated on 7/11/2026 by MarketBeat.com Staff.
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