Aprea Therapeutics (APRE) Stock Price, News & Analysis

Company Overview

Aprea Therapeutics is a clinical‐stage biopharmaceutical company dedicated to developing targeted therapies that restore tumor suppressor function in cancers driven by TP53 mutations. The company’s lead investigational agent, eprenetapopt (APR-246), is designed to convert mutant p53 protein into a form that induces programmed cell death in malignant cells. Aprea’s research focuses on hematologic malignancies, including myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), as well as solid tumors harboring TP53 mutations.

Eprenetapopt has advanced through multiple clinical trials, including pivotal studies assessing its efficacy in combination with hypomethylating agents for patients with MDS. In addition to its lead program, Aprea maintains a pipeline of early‐stage candidates and explores combination regimens intended to enhance response rates and overcome resistance mechanisms associated with TP53 dysfunction.

Aprea conducts global clinical development activities, collaborating with academic centers and biopharmaceutical partners in North America and Europe. These partnerships support Aprea’s efforts to accelerate trial enrollment, broaden access to investigational therapies and facilitate regulatory interactions across multiple jurisdictions.

Founded in 2013 and headquartered in San Francisco, California, Aprea is led by a management team with extensive experience in oncology drug development. The company’s scientific leadership combines expertise in molecular biology, translational research and clinical operations to advance its precision oncology approach for patients with high‐unmet‐need cancers.

Key Stats

• Today's Range: $1.50 to $1.57
• 50-Day Range: $1.42 to $1.71
• 52-Week Range: $1.37 to $5.01
• Volume: 60,569 shs
• Average Volume: 57,873 shs
• Market Capitalization: $8.98 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $15.50
• Consensus Rating: Hold

Aprea Therapeutics Stock Analysis - MarketRank™

Aprea Therapeutics scored higher than 50% of companies evaluated by MarketBeat. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 3.4 / 5
• Analyst Rating: Hold

Consensus Rating

Aprea Therapeutics has received a consensus rating of Hold. The company's average rating score is 2.33, and is based on 2 buy ratings, no hold ratings, and 1 sell rating.

Upside Potential

Aprea Therapeutics has a consensus price target of $15.50, representing about 906.5% upside from its current price of $1.54.

Amount of Analyst Coverage

Aprea Therapeutics has only been the subject of 1 research reports in the past 90 days.

Earnings and Valuation

• Score: 1.3 / 5
• Proj. Earnings Growth: Growing

Earnings Growth

Earnings for Aprea Therapeutics are expected to grow in the coming year, from ($2.55) to ($0.95) per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of Aprea Therapeutics is -0.66, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of Aprea Therapeutics is -0.66, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Book Value per Share Ratio

Aprea Therapeutics has a P/B Ratio of 0.43. P/B Ratios below 1 indicate that a company could be undervalued with respect to its assets and liabilities.

Short Interest

• Score: 3.0 / 5
• Short Interest Level: Healthy

Percentage of Shares Shorted

1.70% of the float of Aprea Therapeutics has been sold short.

Short Interest Ratio / Days to Cover

Aprea Therapeutics has a short interest ratio ("days to cover") of 1.8, which is generally considered an acceptable ratio of short interest to trading volume.

Change versus previous month

Short interest in Aprea Therapeutics has recently increased by 1.53%, indicating that investor sentiment is decreasing.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

Aprea Therapeutics does not currently pay a dividend.

Dividend Growth

Aprea Therapeutics does not have a long track record of dividend growth.

Sustainability and ESG

• Score: N/A
• Environmental Score: N/A

Percentage of Shares Shorted

1.70% of the float of Aprea Therapeutics has been sold short.

Short Interest Ratio / Days to Cover

Aprea Therapeutics has a short interest ratio ("days to cover") of 1.8, which is generally considered an acceptable ratio of short interest to trading volume.

Change versus previous month

Short interest in Aprea Therapeutics has recently increased by 1.53%, indicating that investor sentiment is decreasing.

News and Social Media

• Score: 2.4 / 5
• News Sentiment: 0.32

News Sentiment

Aprea Therapeutics has a news sentiment score of 0.32. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a lower news sentiment than the 0.72 average news sentiment score of Medical companies.

News Coverage This Week

MarketBeat has tracked 3 news articles for Aprea Therapeutics this week, compared to 1 article on an average week.

MarketBeat Follows

1 people have added Aprea Therapeutics to their MarketBeat watchlist in the last 30 days.

Company Ownership

• Score: 0.8 / 5
• Insider Trading: N/A

Insider Buying vs. Insider Selling

In the past three months, Aprea Therapeutics insiders have not sold or bought any company stock.

Percentage Held by Insiders

13.63% of the stock of Aprea Therapeutics is held by insiders. A high percentage of insider ownership can be a sign of company health.

Percentage Held by Institutions

Only 34.19% of the stock of Aprea Therapeutics is held by institutions.

APRE Stock Analysis - Frequently Asked Questions

How have APRE shares performed this year?

Aprea Therapeutics' stock was trading at $3.29 at the beginning of 2025. Since then, APRE shares have decreased by 53.2% and is now trading at $1.54.

How were Aprea Therapeutics' earnings last quarter?

Aprea Therapeutics, Inc. (NASDAQ:APRE) issued its quarterly earnings data on Tuesday, August, 12th. The company reported ($0.53) EPS for the quarter, topping analysts' consensus estimates of ($0.77) by $0.24. The firm had revenue of $0.12 million for the quarter. Aprea Therapeutics had a negative trailing twelve-month return on equity of 78.90% and a negative net margin of 1,645.01%.

When did Aprea Therapeutics' stock split?

Aprea Therapeutics shares reverse split before market open on Monday, February 13th 2023.The 1-20 reverse split was announced on Monday, February 13th 2023. The number of shares owned by shareholders was adjusted after the market closes on Monday, February 13th 2023. An investor that had 100 shares of stock prior to the reverse split would have 5 shares after the split.

When did Aprea Therapeutics IPO?

Aprea Therapeutics (APRE) raised $52 million in an initial public offering (IPO) on Thursday, October 3rd 2019. The company issued 5,000,000 shares at a price of $19.00-$2.00 per share. J.P. Morgan, Morgan Stanley and RBC Capital Markets acted as the underwriters for the IPO.

How do I buy shares of Aprea Therapeutics?

Shares of APRE stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of Aprea Therapeutics own?

Based on aggregate information from My MarketBeat watchlists, some other companies that Aprea Therapeutics investors own include Tesla (TSLA), HubSpot (HUBS), Netflix (NFLX), Adverum Biotechnologies (ADVM), Biogen (BIIB), Sarepta Therapeutics (SRPT) and Corbus Pharmaceuticals (CRBP).

Company Calendar

• Last Earnings: 8/12/2025
• Today: 10/16/2025
• Next Earnings (Estimated): 11/06/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: MED - BIOMED/GENE
• Sub-Industry: Pharmaceutical Products
• Current Symbol: NASDAQ:APRE
• CIK: 1781983
• Web: www.aprea.com
• Phone: 617-463-9385
• Fax: N/A
• Employees: 7
• Year Founded: N/A

Price Target and Rating

• Average Price Target for Aprea Therapeutics: $15.50
• High Price Target: $20.00
• Low Price Target: $11.00
• Potential Upside/Downside: +909.8%
• Consensus Rating: Hold
• Rating Score (0-4): 2.33
• Research Coverage: 3 Analysts

Profitability

• EPS (Trailing Twelve Months): ($2.32)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: -$12.96 million
• Net Margins: -1,645.01%
• Pretax Margin: -1,645.01%
• Return on Equity: -78.90%
• Return on Assets: -62.67%

Debt

• Debt-to-Equity Ratio: N/A
• Current Ratio: 5.34
• Quick Ratio: 5.34

Sales & Book Value

• Annual Sales: N/A
• Price / Sales: N/A
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: $3.55 per share
• Price / Book: 0.43

Miscellaneous

• Outstanding Shares: 5,825,000
• Free Float: 5,031,000
• Market Cap: $8.94 million
• Optionable: No Data
• Beta: 1.30