Crinetics Pharmaceuticals (CRNX) Stock Price, News & Analysis

Company Overview

Crinetics Pharmaceuticals, Inc., a clinical-stage pharmaceutical company, focuses on the discovery, development, and commercialization of novel therapeutics for rare endocrine diseases and endocrine-related tumors. The company's lead product candidate is paltusotine, an oral selective nonpeptide somatostatin receptor type 2 agonist, which is in Phase 3 trial for the treatment of acromegaly; and Phase 2 trial for treating carcinoid syndrome associated with neuroendocrine tumors. It is also developing CRN04894, an investigational oral nonpeptide product candidate to antagonize the adrenocorticotrophic hormone (ACTH) receptor that has completed a Phase 1 study for the treatment of diseases caused by excess ACTH, including congenital adrenal hyperplasia and Cushing's disease. In addition, the company is developing antagonists of the parathyroid hormone (PTH) receptor for the treatment of primary hyperparathyroidism and humoral hypercalcemia of malignancy, and other diseases of excess PTH; identified investigational orally available somatostatin receptor type 3 targeted nonpeptide agonists for the treatment of autosomal dominant polycystic kidney disease; and developing thyroid-stimulating hormone receptor antagonists for the treatment of graves' disease and thyroid eye disease, as well as Oral GLP-1 and GIP nonpeptides for the treatment of diabetes and obesity. Crinetics Pharmaceuticals, Inc. was incorporated in 2008 and is headquartered in San Diego, California.

Key Stats

• Today's Range: $30.27 to $31.45
• 50-Day Range: $26.85 to $33.02
• 52-Week Range: $24.10 to $62.53
• Volume: 382,072 shs
• Average Volume: 939,193 shs
• Market Capitalization: $2.92 billion
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $68.86
• Consensus Rating: Moderate Buy

Crinetics Pharmaceuticals Stock Analysis - MarketRank™

Crinetics Pharmaceuticals scored higher than 73% of companies evaluated by MarketBeat, and ranked 277th out of 949 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 3.4 / 5
• Analyst Rating: Moderate Buy

Consensus Rating

Crinetics Pharmaceuticals has received a consensus rating of Moderate Buy. The company's average rating score is 2.78, and is based on 7 buy ratings, 2 hold ratings, and no sell ratings.

Amount of Analyst Coverage

Crinetics Pharmaceuticals has only been the subject of 3 research reports in the past 90 days.

Earnings and Valuation

• Score: 0.0 / 5
• Proj. Earnings Growth: Decreasing

Earnings Growth

Earnings for Crinetics Pharmaceuticals are expected to decrease in the coming year, from ($3.73) to ($4.11) per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of Crinetics Pharmaceuticals is -7.54, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of Crinetics Pharmaceuticals is -7.54, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Book Value per Share Ratio

Crinetics Pharmaceuticals has a P/B Ratio of 2.49. P/B Ratios below 3 indicates that a company is reasonably valued with respect to its assets and liabilities.

Short Interest

• Score: 0.0 / 5
• Short Interest Level: Bearish

Percentage of Shares Shorted

14.66% of the float of Crinetics Pharmaceuticals has been sold short.

Short Interest Ratio / Days to Cover

Crinetics Pharmaceuticals has a short interest ratio ("days to cover") of 15.7, which indicates bearish sentiment.

Change versus previous month

Short interest in Crinetics Pharmaceuticals has recently increased by 7.60%, indicating that investor sentiment is decreasing significantly.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

Crinetics Pharmaceuticals does not currently pay a dividend.

Dividend Growth

Crinetics Pharmaceuticals does not have a long track record of dividend growth.

Sustainability and ESG

• Score: 3.7 / 5
• Environmental Score: -0.62

Percentage of Shares Shorted

14.66% of the float of Crinetics Pharmaceuticals has been sold short.

Short Interest Ratio / Days to Cover

Crinetics Pharmaceuticals has a short interest ratio ("days to cover") of 15.7, which indicates bearish sentiment.

Change versus previous month

Short interest in Crinetics Pharmaceuticals has recently increased by 7.60%, indicating that investor sentiment is decreasing significantly.

News and Social Media

• Score: 3.4 / 5
• News Sentiment: 1.20

News Sentiment

Crinetics Pharmaceuticals has a news sentiment score of 1.20. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a higher news sentiment than the 0.99 average news sentiment score of Medical companies.

News Coverage This Week

MarketBeat has tracked 16 news articles for Crinetics Pharmaceuticals this week, compared to 6 articles on an average week.

Search Interest

12 people have searched for CRNX on MarketBeat in the last 30 days. This is an increase of 200% compared to the previous 30 days.

Company Ownership

• Score: 2.5 / 5
• Insider Trading: Selling Shares

Insider Buying vs. Insider Selling

In the past three months, Crinetics Pharmaceuticals insiders have sold more of their company's stock than they have bought. Specifically, they have bought $0.00 in company stock and sold $4,244,214.00 in company stock.

Percentage Held by Insiders

Only 4.60% of the stock of Crinetics Pharmaceuticals is held by insiders.

Percentage Held by Institutions

98.51% of the stock of Crinetics Pharmaceuticals is held by institutions. High institutional ownership can be a signal of strong market trust in this company.

CRNX Stock Analysis - Frequently Asked Questions

How have CRNX shares performed this year?

Crinetics Pharmaceuticals' stock was trading at $51.13 at the beginning of 2025. Since then, CRNX shares have decreased by 39.4% and is now trading at $30.9990.

How were Crinetics Pharmaceuticals' earnings last quarter?

Crinetics Pharmaceuticals, Inc. (NASDAQ:CRNX) released its quarterly earnings results on Thursday, August, 7th. The company reported ($1.23) earnings per share for the quarter, missing the consensus estimate of ($1.13) by $0.10. The company's quarterly revenue was up 158.4% compared to the same quarter last year.
Read the conference call transcript.

When did Crinetics Pharmaceuticals IPO?

Crinetics Pharmaceuticals (CRNX) raised $80 million in an initial public offering on Wednesday, July 18th 2018. The company issued 5,000,000 shares at $15.00-$17.00 per share. J.P. Morgan, Leerink Partners and Piper Jaffray acted as the underwriters for the IPO.

Who are Crinetics Pharmaceuticals' major shareholders?

Crinetics Pharmaceuticals' top institutional shareholders include State Street Corp (3.42%), Geode Capital Management LLC (2.36%), Jennison Associates LLC (2.12%) and Orbimed Advisors LLC (1.22%). Insiders that own company stock include Richard Scott Struthers, Marc Wilson, Stephen F Betz, Jeff E Knight, Dana Pizzuti, Alan Seth Krasner, James Hassard, Matthew K Fust, Stephanie Okey and Coelho Rogerio Vivaldi.
View institutional ownership trends.

How do I buy shares of Crinetics Pharmaceuticals?

Shares of CRNX stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of Crinetics Pharmaceuticals own?

Based on aggregate information from My MarketBeat watchlists, some other companies that Crinetics Pharmaceuticals investors own include NVIDIA (NVDA), Broadcom (AVGO), Meta Platforms (META), Arista Networks (ANET), Adobe (ADBE), ServiceNow (NOW) and Advanced Micro Devices (AMD).

Company Calendar

• Last Earnings: 8/07/2025
• Today: 8/28/2025
• Next Earnings (Estimated): 11/11/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: MED - DRUGS
• Sub-Industry: Pharmaceutical Products
• Current Symbol: NASDAQ:CRNX
• CIK: 1658247
• Web: www.crinetics.com
• Phone: (858) 450-6464
• Fax: N/A
• Employees: 210
• Year Founded: N/A

Price Target and Rating

• Average Price Target for Crinetics Pharmaceuticals: $68.86
• High Price Target: $90.00
• Low Price Target: $36.00
• Potential Upside/Downside: +122.6%
• Consensus Rating: Moderate Buy
• Rating Score (0-4): 2.78
• Research Coverage: 9 Analysts

Profitability

• EPS (Trailing Twelve Months): ($4.11)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: -$298.41 million
• Net Margins: N/A
• Pretax Margin: -26,568.53%
• Return on Equity: -32.28%
• Return on Assets: -29.45%

Debt

• Debt-to-Equity Ratio: N/A
• Current Ratio: 17.80
• Quick Ratio: 17.80

Sales & Book Value

• Annual Sales: $1.04 million
• Price / Sales: 2,800.95
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: $12.44 per share
• Price / Book: 2.49

Miscellaneous

• Outstanding Shares: 94,180,000
• Free Float: 89,844,000
• Market Cap: $2.91 billion
• Optionable: Optionable
• Beta: 0.33