Most-Downgraded StocksMost-DowngradedNASDAQ:IONS Ionis Pharmaceuticals (IONS) Stock Price, News & Analysis $53.29 -0.92 (-1.69%) As of 12:37 PM Eastern This is a fair market value price provided by Massive. Learn more. Add Compare Share Share Stock Analysis Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsFinancialsInsider TradesNews and TrendsOptions ChainOwnershipSEC FilingsShort Interest About Ionis Pharmaceuticals Stock (NASDAQ:IONS) View Price History Chart DataSkip Price History Chart 1 Day 5 Days 30 Days 90 Days 1 Year Advanced 1 Day 1 Day 5 Days 30 Days 90 Days 1 Year Advanced Show volume Show extended hours Get Ionis Pharmaceuticals alerts:Sign Up Key Stats Today's Range$53.07▼$55.5050-Day Range$51.77▼$86.3352-Week Range$50.01▼$86.74Volume1.23 million shsAverage Volume2.46 million shsMarket Capitalization$8.86 billionP/E RatioN/ADividend YieldN/APrice Target$91.25Consensus RatingModerate Buy Company Overview Ionis Pharmaceuticals, Inc. is a biotechnology company that discovers and develops medicines using antisense technology, which is designed to target RNA and influence the production of disease-related proteins. The company focuses on neurological, cardiovascular, metabolic and other serious diseases for which there remains a significant unmet medical need. Ionis has developed several approved therapies, including SPINRAZA (nusinersen) for spinal muscular atrophy, QALSODY (tofersen) for a form of amyotrophic lateral sclerosis, TEGSEDI (inotersen) for hereditary transthyretin-mediated amyloidosis and WAYLIVRA (volanesorsen) for familial chylomicronemia syndrome in certain markets. Its pipeline also includes eplontersen, an antisense medicine developed with AstraZeneca for transthyretin amyloidosis. Founded in 1989, Ionis is headquartered in Carlsbad, California. The company develops medicines independently and through collaborations with pharmaceutical partners, supporting commercialization and distribution across international markets. Ionis is led by Chief Executive Officer Brett P. Monia.AI Generated. May Contain Errors. Read More Ionis Pharmaceuticals Stock Analysis - MarketRank™See Top-Rated MarketRank™ Stocks64th Percentile Overall ScoreIONS MarketRank™: Ionis Pharmaceuticals scored higher than 64% of companies evaluated by MarketBeat, and ranked 317th out of 904 stocks in the healthcare sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation. Analyst's Opinion4.4 / 5Analyst RatingModerate Buy Consensus RatingIonis Pharmaceuticals has received a consensus rating of Moderate Buy. The company's average rating score is 2.73, and is based on no strong buy ratings, 17 buy ratings, 4 hold ratings, and 1 sell rating.Upside PotentialIonis Pharmaceuticals has a consensus price target of $91.25, representing about 70.9% upside from its current price of $53.39.Amount of Analyst CoverageIonis Pharmaceuticals has been the subject of 18 research reports in the past 90 days, demonstrating strong analyst interest in this stock.Read more about Ionis Pharmaceuticals' stock forecast and price target. Earnings and Valuation0.6 / 5Proj. Earnings GrowthGrowing Earnings GrowthEarnings for Ionis Pharmaceuticals are expected to grow in the coming year, from ($3.57) to ($2.36) per share.Price to Earnings Ratio vs. the MarketThe P/E ratio of Ionis Pharmaceuticals is -15.48, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Earnings Ratio vs. SectorThe P/E ratio of Ionis Pharmaceuticals is -15.48, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Book Value per Share RatioIonis Pharmaceuticals has a P/B Ratio of 17.68. P/B Ratios above 3 indicate that a company could be overvalued with respect to its assets and liabilities.Read more about Ionis Pharmaceuticals' valuation and earnings. Short Interest1.0 / 5Short Interest LevelBearish Percentage of Shares Shorted12.82% of the float of Ionis Pharmaceuticals has been sold short.Short Interest Ratio / Days to CoverIonis Pharmaceuticals has a short interest ratio ("days to cover") of 9.18.Change versus previous monthShort interest in Ionis Pharmaceuticals has recently increased by 0.07%, indicating that investor sentiment is decreasing. Dividend0.0 / 5Dividend StrengthN/A Dividend YieldIonis Pharmaceuticals does not currently pay a dividend.Dividend GrowthIonis Pharmaceuticals does not have a long track record of dividend growth. News and Social Media2.7 / 5News Sentiment0.32 News SentimentIonis Pharmaceuticals has a news sentiment score of 0.32. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a lower news sentiment than the 0.89 average news sentiment score of Healthcare companies.News Coverage This WeekMarketBeat has tracked 26 news articles for Ionis Pharmaceuticals this week, compared to 10 articles on an average week.Search InterestOnly 17 people have searched for IONS on MarketBeat in the last 30 days. This is a decrease of -32% compared to the previous 30 days.MarketBeat Follows10 people have added Ionis Pharmaceuticals to their MarketBeat watchlist in the last 30 days. This is an increase of 67% compared to the previous 30 days. Company Ownership2.2 / 5Insider TradingSelling Shares Insider Buying vs. Insider SellingIn the past three months, Ionis Pharmaceuticals insiders have sold 1,151.01% more of their company's stock than they have bought. Specifically, they have bought $1,058,700.00 in company stock and sold $13,244,486.00 in company stock.Percentage Held by Insiders1.81% of the stock of Ionis Pharmaceuticals is held by insiders.Percentage Held by Institutions93.86% of the stock of Ionis Pharmaceuticals is held by institutions. High institutional ownership can be a signal of strong market trust in this company.Read more about Ionis Pharmaceuticals' insider trading history. Receive IONS Stock News and Ratings via Email Sign-up to receive the latest news and ratings for Ionis Pharmaceuticals and its competitors with MarketBeat's FREE daily newsletter. Submit View SMS TermsSMS is currently available in Australia, Belgium, Canada, France, Germany, Ireland, Italy, New Zealand, the Netherlands, Singapore, South Africa, Spain, Switzerland, the United Kingdom, and the United States. 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IONS Stock News HeadlinesIonis Has Its First Neurology Launch, But Can Zanvastro Justify Its $285,000 Price?September 11 at 7:10 PM | insidermonkey.comEquities Analysts Offer Predictions for IONS Q4 EarningsSeptember 11 at 1:12 AM | americanbankingnews.comDOJ Admits It In Court—Your Cash Can Be Seized Without WarningThe Department of Justice recently argued in court that cash may not be legally your property - raising concerns about government authority to freeze or seize private accounts. Greece raided pensions. Cyprus drained bank accounts. Poland seized retirement funds. Priority Gold has put together a free Wealth Defense Guide for Americans looking to move assets beyond potential government reach.September 14 at 1:00 AM | Priority Gold (Ad)Ionis Pharmaceuticals, Inc. (IONS) Presents at Wells Fargo 21st Annual Healthcare Conference TranscriptSeptember 10, 2026 | seekingalpha.comCanaccord Genuity Group Issues Pessimistic Forecast for Ionis Pharmaceuticals (NASDAQ:IONS) Stock PriceSeptember 10, 2026 | americanbankingnews.comHC Wainwright Issues Pessimistic Forecast for Ionis Pharmaceuticals (NASDAQ:IONS) Stock PriceSeptember 10, 2026 | americanbankingnews.comIonis Pharmaceuticals (NASDAQ:IONS) Shares Gap Down After Analyst DowngradeSeptember 10, 2026 | americanbankingnews.comBank of America Securities Keeps Their Buy Rating on Ionis Pharmaceuticals (IONS)September 9, 2026 | theglobeandmail.comSee More Headlines IONS Stock Analysis - Frequently Asked Questions How have IONS shares performed this year? Ionis Pharmaceuticals' stock was trading at $79.11 on January 1st, 2026. Since then, IONS shares have decreased by 32.5% and is now trading at $53.3850. How were Ionis Pharmaceuticals' earnings last quarter? Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) posted its quarterly earnings results on Wednesday, April, 29th. The company reported ($0.56) earnings per share (EPS) for the quarter, topping analysts' consensus estimates of ($0.85) by $0.29. The firm's quarterly revenue was up 86.4% compared to the same quarter last year. Read the conference call transcript. Who are Ionis Pharmaceuticals' major shareholders? Ionis Pharmaceuticals' top institutional shareholders include California State Teachers Retirement System (8.63%), Alyeska Investment Group L.P. (0.85%), Bank of America Corp DE (0.48%) and Connor Clark & Lunn Investment Management Ltd. (0.41%). Insiders that own company stock include Brett P Monia, Spencer R Berthelsen, Elizabeth L Hougen, Eugene Schneider, C Frank Bennett, Brian Birchler, Patrick R O'neil, Richard S Geary, B Lynne Parshall, Joseph H Wender, Onaiza Cadoret-Manier, Michael R Hayden, Kyle Jenne, Holly B Kordasiewicz, Eric Swayze, Joseph Baroldi, Shannon L Devers, Joseph Klein III and Allene M Diaz. View institutional ownership trends. How do I buy shares of Ionis Pharmaceuticals? Shares of IONS stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. What other stocks do shareholders of Ionis Pharmaceuticals own? Based on aggregate information from My MarketBeat watchlists, some other companies that Ionis Pharmaceuticals investors own include NVIDIA (NVDA), Meta Platforms (META), Broadcom (AVGO), Advanced Micro Devices (AMD), Arista Networks (ANET), Adobe (ADBE) and CrowdStrike (CRWD). Company Calendar Last Earnings4/29/2026Today9/14/2026Morgan Stanley 24th Annual Global Healthcare Conference9/16/2026Next Earnings (Estimated)11/04/2026Fiscal Year End12/31/2026Get Stock Alerts Health Indicator TradeSmith's Health IndicatorA long-term volatility-based measure designed for securities held 12 months or longer.Green: Strong and healthy uptrend with normal pullbacks.Yellow: Significant pullback but still within expected volatility.Red: Dropped beyond expected volatility; considered unhealthy. Red Zone (2m+) 1-Year History Sep 25 Dec 25 Mar 26 Jun 26 Sep 26 IONS's financial health is in the Red zone, according to TradeSmith. IONS has been in this zone for over 2 months. Industry, Sector and Symbol Stock ExchangeNASDAQ SectorHealthcare Industry Biotechnology Sub-IndustryBiotechnology Current SymbolNASDAQ:IONS CIK874015 Webwww.ionis.com Phone(760) 931-9200Fax760-603-2700Employees1,402Year Founded1989Price Target and Rating Average Price Target for Ionis Pharmaceuticals$91.25 High Price Target$129.00 Low Price Target$54.00 Potential Upside/Downside+71.2%Consensus RatingModerate Buy Rating Score (0-4)2.73 Research Coverage22 Analysts Profitability EPS (Trailing Twelve Months)($3.46) Trailing P/E RatioN/A Forward P/E RatioN/A P/E GrowthN/ANet Income-$381.39 million Net Margins-64.76% Pretax Margin-64.30% Return on Equity-111.08% Return on Assets-17.41% Debt Debt-to-Equity Ratio3.07 Current Ratio7.89 Quick Ratio7.73 Sales & Book Value Annual Sales$944 million Price / Sales9.38 Cash FlowN/A Price / Cash FlowN/A Book Value$3.02 per share Price / Book17.65Miscellaneous Outstanding Shares166,180,000Free Float163,176,000Market Cap$8.86 billion OptionableOptionable Beta0.42 Social Links (Almost) Everything You Need To Know About The EV MarketLooking to profit from the electric vehicle mega-trend? 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