NASDAQ:KPTI Karyopharm Therapeutics (KPTI) Stock Price, News & Analysis $0.35 -0.04 (-11.30%) Closing price 10/19/2026 04:00 PM EasternExtended Trading$0.35 0.00 (0.00%) As of 05:21 AM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more. Add Compare Share Share Stock Analysis Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsFinancialsInsider TradesNews and TrendsOptions ChainOwnershipSEC Filings About Karyopharm Therapeutics Stock (NASDAQ:KPTI) View Price History Chart DataSkip Price History Chart 1 Day 5 Days 30 Days 90 Days 1 Year Advanced 1 Day 1 Day 5 Days 30 Days 90 Days 1 Year Advanced Show volume Show extended hours Get KPTI alerts:Sign Up Key Stats Today's Range$0.33▼$0.4050-Day Range$0.32▼$2.1052-Week Range$0.31▼$10.99Volume1.25 million shsAverage Volume1.46 million shsMarket Capitalization$7.85 millionP/E RatioN/ADividend YieldN/APrice Target$11.50Consensus RatingModerate Buy Company Overview Karyopharm Therapeutics Inc. is a commercial-stage biopharmaceutical company focused on discovering and developing medicines that target nuclear transport proteins involved in cancer and other serious diseases. The company’s technology platform centers on selective inhibitors of nuclear export, particularly exportin 1 (XPO1), a protein that helps regulate the movement of key molecules between a cell’s nucleus and cytoplasm. Karyopharm’s primary product is XPOVIO (selinexor), an oral XPO1 inhibitor. In the United States, XPOVIO is used in combination regimens for certain adults with relapsed or refractory multiple myeloma and relapsed or refractory diffuse large B-cell lymphoma. The company has also evaluated selinexor in additional hematologic and solid-tumor cancers and continues to develop other investigational compounds based on its nuclear export platform. Founded in 2008 and headquartered in Newton, Massachusetts, Karyopharm serves patients through commercial and development activities in the United States and international markets, supported by regulatory approvals and partnerships in selected regions. Its work is primarily focused on oncology, with research aimed at expanding the use of XPO1 inhibition and developing potential treatments for diseases with limited therapeutic options.AI Generated. May Contain Errors. Read More Karyopharm Therapeutics Stock Analysis - MarketRank™See Top-Rated MarketRank™ Stocks54th Percentile Overall ScoreKPTI MarketRank™: 2.698890225965 of 5 starsKaryopharm Therapeutics scored higher than 54% of companies evaluated by MarketBeat. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation. Analyst's Opinion4.1 / 5Analyst RatingModerate Buy Consensus RatingKaryopharm Therapeutics has received a consensus rating of Moderate Buy. The company's average rating score is 2.57, and is based on 1 strong buy rating, 3 buy ratings, 2 hold ratings, and 1 sell rating.Upside PotentialKaryopharm Therapeutics has a consensus price target of $11.50, representing about 3,223.7% upside from its current price of $0.35.Amount of Analyst CoverageKaryopharm Therapeutics has only been the subject of 4 research reports in the past 90 days.Read more about Karyopharm Therapeutics' stock forecast and price target. Earnings and Valuation0.6 / 5Proj. Earnings GrowthGrowing Earnings GrowthEarnings for Karyopharm Therapeutics are expected to grow in the coming year, from ($4.70) to ($2.33) per share.Price to Earnings Ratio vs. the MarketThe P/E ratio of Karyopharm Therapeutics is -0.03, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Earnings Ratio vs. SectorThe P/E ratio of Karyopharm Therapeutics is -0.03, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Read more about Karyopharm Therapeutics' valuation and earnings. Short Interest3.0 / 5Short Interest LevelHealthy Percentage of Shares Shorted27.16% of the float of Karyopharm Therapeutics has been sold short.Short Interest Ratio / Days to CoverKaryopharm Therapeutics has a short interest ratio ("days to cover") of 4.79.Change versus previous monthShort interest in Karyopharm Therapeutics has recently decreased by 23.00%, indicating that investor sentiment is improving significantly. Dividend0.0 / 5Dividend StrengthN/A Dividend YieldKaryopharm Therapeutics does not currently pay a dividend.Dividend GrowthKaryopharm Therapeutics does not have a long track record of dividend growth. News and Social Media0.6 / 5News Sentiment0.00 News Coverage This WeekMarketBeat has tracked 2 news articles for Karyopharm Therapeutics this week, compared to 3 articles on an average week.Search Interest2 people have searched for KPTI on MarketBeat in the last 30 days. This is an increase of 100% compared to the previous 30 days. Company Ownership1.5 / 5Insider TradingSelling Shares Insider Buying vs. Insider SellingIn the past three months, Karyopharm Therapeutics insiders have sold more of their company's stock than they have bought. Specifically, they have bought $0.00 in company stock and sold $2,116.00 in company stock.Percentage Held by Insiders1.68% of the stock of Karyopharm Therapeutics is held by insiders.Percentage Held by Institutions66.44% of the stock of Karyopharm Therapeutics is held by institutions. High institutional ownership can be a signal of strong market trust in this company.Read more about Karyopharm Therapeutics' insider trading history. Receive KPTI Stock News and Ratings via Email Sign-up to receive the latest news and ratings for Karyopharm Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 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(NYSE:MRK) & Karyopharm Therapeutics (NASDAQ:KPTI) Head to Head ComparisonOctober 18 at 4:29 AM | americanbankingnews.comKaryopharm Therapeutics Reports Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)October 1, 2026 | prnewswire.comYour book is insideBlane Markham and the Markham Trading Team are giving readers a limited window to download their options strategy guide, titled How To Turn 100 Into 1000 Gains, before it moves behind a paywall. The guide walks through options trading concepts the team uses in its own research and education materials. Once the paywall goes up, free access ends for good. | TradeWins (Ad)Karyopharm Therapeutics (KPTI) Stock Fair Value Falls After Split Analyst Views On Trial UpdatesSeptember 4, 2026 | finance.yahoo.comAnalysts Offer Insights on Healthcare Companies: IDEAYA Biosciences (IDYA), BioMarin Pharmaceutical (BMRN) and Karyopharm Therapeutics (KPTI)September 3, 2026 | theglobeandmail.comKaryopharm Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)September 1, 2026 | prnewswire.comKaryopharm Therapeutics Inc.: Karyopharm Submits Supplemental New Drug Application to the FDA for XPOVIO (selinexor) Plus Ruxolitinib for Patients with MyelofibrosisAugust 31, 2026 | finanznachrichten.deKaryopharm Submits SNDA Seeking Accelerated Approval For XPOVIO In Combination With RuxolitinibAugust 31, 2026 | rttnews.comSee More Headlines KPTI Stock Analysis - Frequently Asked Questions How have KPTI shares performed this year? Karyopharm Therapeutics' stock was trading at $7.36 at the start of the year. Since then, KPTI stock has decreased by 95.3% and is now trading at $0.3460. How were Karyopharm Therapeutics' earnings last quarter? Karyopharm Therapeutics Inc. (NASDAQ:KPTI) released its quarterly earnings data on Thursday, August, 13th. The company reported ($2.32) EPS for the quarter, missing analysts' consensus estimates of ($1.37) by $0.95. The firm had revenue of $33.43 million for the quarter, compared to analyst estimates of $32.19 million. Read the conference call transcript. When did Karyopharm Therapeutics' stock split? Karyopharm Therapeutics's stock reverse split on Wednesday, February 26th 2025.The 1-15 reverse split was announced on Monday, February 24th 2025. The number of shares owned by shareholders was adjusted after the market closes on Tuesday, February 25th 2025. An investor that had 100 shares of stock prior to the reverse split would have 7 shares after the split. When did Karyopharm Therapeutics IPO? Karyopharm Therapeutics (KPTI) raised $102 million in an initial public offering on Wednesday, November 6th 2013. The company issued 6,800,000 shares at a price of $14.00-$16.00 per share. How do I buy shares of Karyopharm Therapeutics? Shares of KPTI stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. What other stocks do shareholders of Karyopharm Therapeutics own? Based on aggregate information from My MarketBeat watchlists, some other companies that Karyopharm Therapeutics investors own include NVIDIA (NVDA), Bristol Myers Squibb (BMY), Alibaba Group (BABA), Tesla (TSLA), Gilead Sciences (GILD), Advanced Micro Devices (AMD) and Pfizer (PFE). Company Calendar Last Earnings8/13/2026Today10/19/2026Next Earnings (Estimated)11/02/2026Fiscal Year End12/31/2026Get Stock Alerts Health Indicator TradeSmith's Health IndicatorA long-term volatility-based measure designed for securities held 12 months or longer.Green: Strong and healthy uptrend with normal pullbacks.Yellow: Significant pullback but still within expected volatility.Red: Dropped beyond expected volatility; considered unhealthy. Red Zone (2m+) 1-Year History Oct 25 Jan 26 Apr 26 Jul 26 Oct 26 KPTI's financial health is in the Red zone, according to TradeSmith. KPTI has been in this zone for over 2 months. Industry, Sector and Symbol Stock ExchangeNASDAQ SectorHealthcare Industry Pharmaceuticals Sub-IndustryPharmaceuticals Current SymbolNASDAQ:KPTI CIK1503802 Webwww.karyopharm.com Phone(617) 658-0600FaxN/AEmployees228Year Founded2008Price Target and Rating Average Price Target for Karyopharm Therapeutics$11.50 High Price Target$28.00 Low Price Target$3.00 Potential Upside/Downside+3,223.7%Consensus RatingModerate Buy Rating Score (0-4)2.57 Research Coverage7 Analysts Profitability EPS (Trailing Twelve Months)($13.09) Trailing P/E RatioN/A Forward P/E RatioN/A P/E GrowthN/ANet Income-$196.04 million Net Margins-153.28% Pretax Margin-153.30% Return on EquityN/A Return on Assets-145.18% Debt Debt-to-Equity RatioN/A Current Ratio0.79 Quick Ratio0.76 Sales & Book Value Annual Sales$146.07 million Price / Sales0.05 Cash FlowN/A Price / Cash FlowN/A Book Value($16.00) per share Price / Book-0.02Miscellaneous Outstanding Shares22,680,000Free Float22,300,000Market Cap$7.85 million OptionableOptionable Beta1.04 Social Links 7 Stocks to Buy Before the Robotics RevolutionRobotics and automation are rapidly becoming essential infrastructure across healthcare, manufacturing, logistics, and many other industries. 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