Lexicon Pharmaceuticals (LXRX) Short Interest Ratio & Short Volume $1.52 +0.10 (+6.69%) As of 03:01 PM Eastern This is a fair market value price provided by Polygon.io. Learn more. Add Compare Share Share Short Interest Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestTrendsBuy This Stock Lexicon Pharmaceuticals Short Interest DataLexicon Pharmaceuticals (LXRX) has a short interest of 27.30 million shares. This marks a -3.81% decrease in short interest from the previous month. The short interest ratio (days to cover) is 10.1, indicating that it would take 10.1 days of the average trading volume of 7.33 million shares to cover all short positions.Current Short Interest27,300,000 sharesPrevious Short Interest28,380,000 sharesChange Vs. Previous Month-3.81%Dollar Volume Sold Short$36.86 millionShort Interest Ratio10.1 Days to CoverLast Record DateSeptember 30, 2025Outstanding Shares363,400,000 sharesPercentage of Shares Shorted7.51%Today's Trading Volume1,298,836 sharesAverage Trading Volume7,330,974 sharesToday's Volume Vs. Average18% Short Selling Lexicon Pharmaceuticals? Sign up to receive the latest short interest report for Lexicon Pharmaceuticals and its competitors with MarketBeat's FREE newsletter. Email Address Get Report View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. 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Skip Charts & View Short Interest HistoryShort Interest ChartDays to Cover ChartShort Percent of Float ChartLXRX Short Interest Over TimeLXRX Days to Cover Over TimeLXRX Percentage of Float Shorted Over Time Lexicon Pharmaceuticals Short Interest History Export to ExcelReport DateTotal Shares Sold ShortDollar Volume Sold ShortChange from Previous ReportPercentage of Float ShortedDays to CoverPrice on Report Date 9/30/202527,300,000 shares $36.86 million -3.8%N/A10.1 $1.35 9/15/202528,380,000 shares $31.79 million -1.6%N/A8.8 $1.12 8/31/202528,840,000 shares $31.72 million +3.3%9.2%8.6 $1.10 8/15/202527,910,000 shares $34.61 million +3.1%N/A7.6 $1.24 7/31/202527,060,000 shares $28.95 million -7.4%8.6%6.6 $1.07 7/15/202529,210,000 shares $33.59 million -12.0%N/A6.2 $1.15 6/30/202533,210,000 shares $31.41 million -11.6%10.7%6.1 $0.95 6/15/202537,560,000 shares $25.22 million -3.3%12.1%2.8 $0.67 5/31/202538,830,000 shares $24.94 million -9.8%16.9%2.9 $0.64 5/15/202543,030,000 shares $22.81 million +15.5%18.8%2.9 $0.53 Get the Latest News and Ratings for LXRX and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Lexicon Pharmaceuticals and its competitors with MarketBeat's FREE daily newsletter. 4/30/202537,270,000 shares $27.24 million -9.8%N/A2.5 $0.73 4/15/202541,330,000 shares $21.17 million -5.8%18.0%2.8 $0.51 3/31/202543,880,000 shares $20.22 million +11.8%19.1%3 $0.46 3/15/202539,260,000 shares $14.39 million -17.3%17.1%6.3 $0.37 2/28/202547,460,000 shares $33.51 million +6.1%20.7%7.3 $0.71 2/15/202544,740,000 shares $35.12 million +4.0%19.5%9.3 $0.78 1/31/202543,030,000 shares $32.54 million +10.1%N/A9 $0.76 1/15/202539,100,000 shares $28.45 million +16.7%N/A8 $0.73 12/31/202433,500,000 shares $24.74 million +7.1%N/A7.8 $0.74 12/15/202431,280,000 shares $25.35 million -0.8%N/A7.6 $0.81 11/30/202431,530,000 shares $25.22 million +0.5%N/A9.6 $0.80 11/15/202431,380,000 shares $30.60 million +9.5%N/A9.7 $0.98 10/31/202428,650,000 shares $55.87 million +3.6%N/A9.5 $1.95 10/15/202427,650,000 shares $49.49 million +2.5%N/A10.1 $1.79 9/30/202426,970,000 shares $42.34 million +1.3%N/A9.4 $1.57 9/15/202426,630,000 shares $45.27 million +4.9%N/A9.5 $1.70 8/31/202425,390,000 shares $43.92 million +3.5%N/A8.8 $1.73 8/15/202424,530,000 shares $40.23 million +9.8%N/A8.5 $1.64 7/31/202422,350,000 shares $50.29 million +7.0%N/A8 $2.25 7/15/202420,880,000 shares $44.27 million +3.4%N/A7.6 $2.12 6/30/202420,200,000 shares $33.94 million -6.4%N/A7.8 $1.68 6/15/202421,570,000 shares $39.26 million -14.2%N/A7.7 $1.82 5/31/202425,140,000 shares $42.74 million +8.0%N/A7.3 $1.70 5/15/202423,270,000 shares $45.14 million -0.7%N/A6.3 $1.94 4/30/202423,440,000 shares $36.10 million +16.5%N/A5.3 $1.54 4/15/202420,120,000 shares $37.62 million -8.2%N/A4.2 $1.87 3/31/202421,910,000 shares $52.58 million +2.6%N/A4.7 $2.40 3/15/202421,350,000 shares $55.51 million +1.3%N/A4.6 $2.60 2/29/202421,070,000 shares $52.46 million -10.0%N/A4.9 $2.49 2/15/202423,410,000 shares $83.81 million +1.7%N/A6.4 $3.58 1/31/202423,030,000 shares $43.07 million -8.9%N/A8 $1.87 1/15/202425,270,000 shares $34.62 million +8.8%N/A10.3 $1.37 12/31/202323,220,000 shares $35.53 million -0.3%N/A8.6 $1.53 12/15/202323,280,000 shares $29.57 million -0.5%N/A9.1 $1.27 11/30/202323,400,000 shares $24.80 million +4.6%N/A9.3 $1.06 11/15/202322,370,000 shares $25.50 million +1.8%N/A9.3 $1.14 10/31/202321,980,000 shares $27.26 million +12.7%N/A9.9 $1.24 10/15/202319,500,000 shares $23.21 million -3.7%N/A9.1 $1.19 9/30/202320,240,000 shares $22.06 million +7.1%N/A11.2 $1.09 9/15/202318,900,000 shares $26.46 million +6.1%N/A11.5 $1.40 8/31/202317,810,000 shares $30.63 million +1.5%N/A9.5 $1.72 8/15/202317,550,000 shares $28.61 million -2.2%N/A6.6 $1.63 7/31/202317,950,000 shares $36.08 million +14.2%N/A6.9 $2.01 7/15/202315,720,000 shares $34.74 million +8.7%N/A6.3 $2.21 6/30/202314,460,000 shares $33.11 million +38.0%N/A6.1 $2.29 6/15/202310,480,000 shares $26.93 million -2.6%N/A4.9 $2.57 5/31/202310,760,000 shares $35.51 million +66.8%N/A6.3 $3.30 5/15/20236,450,000 shares $19.22 million +30.8%N/A8.5 $2.98 4/30/20234,930,000 shares $11.78 million +17.4%N/A8.1 $2.39 4/15/20234,200,000 shares $10.12 million +3.5%N/A9.5 $2.41 3/31/20234,060,000 shares $9.87 million +2.3%N/A10.3 $2.43 3/15/20233,970,000 shares $9.09 million +4.2%N/A9.3 $2.29 2/28/20233,810,000 shares $8.57 million -8.0%N/A9.3 $2.25 2/15/20234,140,000 shares $9.44 million +3.5%N/A11.3 $2.28 1/31/20234,000,000 shares $8.96 million +2.6%N/A10.6 $2.24 1/15/20233,900,000 shares $9.20 million +0.3%N/A9.8 $2.36 12/30/20223,890,000 shares $7.43 million +2.9%N/A9.3 $1.91 12/15/20223,780,000 shares $8.05 million +0.3%N/A8.6 $2.13 11/30/20223,770,000 shares $8.07 million -2.3%N/A7.8 $2.14 11/15/20223,860,000 shares $8.96 million -9.4%N/A7.5 $2.32 10/31/20224,260,000 shares $9.16 million -4.7%N/A6.4 $2.15 10/15/20224,470,000 shares $9.43 million -0.2%N/A4.4 $2.11 9/30/20224,480,000 shares $10.75 million +11.4%N/A4.3 $2.40 9/15/20224,020,000 shares $10.77 million +7.8%N/A2.4 $2.68 8/31/20223,730,000 shares $10.26 million +1.9%N/A2.2 $2.75 8/15/20223,660,000 shares $12.55 million -55.2%N/A2.2 $3.43 7/31/20228,170,000 shares $19.44 million -0.9%N/A5.3 $2.38 7/15/20228,240,000 shares $25.38 million +6.6%8.0%6.9 $3.08 6/30/20227,730,000 shares $14.38 million +34.4%7.5%6.6 $1.86 6/15/20225,750,000 shares $8.05 million +5.7%5.6%10.5 $1.40 5/31/20225,440,000 shares $9.63 million +1.3%N/A10.9 $1.77 5/15/20225,370,000 shares $9.29 million +0.9%N/A8.8 $1.73 4/30/20225,320,000 shares $9.63 million +11.5%N/A8.4 $1.81 4/15/20224,770,000 shares $11.11 million +2.8%N/A7.3 $2.33 3/31/20224,640,000 shares $9.70 million -2.1%N/A7.1 $2.09 3/15/20224,740,000 shares $9.24 million -2.1%N/A6.8 $1.95 2/28/20224,840,000 shares $10.02 million +8.3%N/A6.8 $2.07 2/15/20224,470,000 shares $13.50 million +17.6%N/A7 $3.02 1/31/20223,800,000 shares $12.05 million +5.3%N/A5.9 $3.17 1/15/20223,610,000 shares $12.45 million +1.4%N/A5.6 $3.45 12/31/20213,560,000 shares $14.03 million +10.9%N/A5 $3.94 12/15/20213,210,000 shares $12.78 million -10.6%N/A4.3 $3.98 11/30/20213,590,000 shares $16.44 million -0.6%N/A4.9 $4.58 11/15/20213,610,000 shares $18.59 million +8.4%N/A4.1 $5.15 10/29/20213,330,000 shares $17.62 million -2.4%2.4%3.5 $5.29 10/15/20213,410,000 shares $21.01 million -2.9%2.4%3.6 $6.16 9/30/20213,510,000 shares $16.88 million -4.6%2.5%3.8 $4.81 9/15/20213,680,000 shares $16.71 million -11.1%2.6%3.4 $4.54 8/31/20214,140,000 shares $19.54 million +16.6%3.0%4 $4.72 8/13/20213,550,000 shares $12.89 million -8.5%2.5%4 $3.63 7/30/20213,880,000 shares $13.74 million -3.2%2.8%4.7 $3.54 7/15/20214,010,000 shares $14.80 million -8.2%2.9%4.9 $3.69 6/30/20214,370,000 shares $20.06 million +24.2%3.1%5.2 $4.59 6/15/20213,520,000 shares $16.68 million -3.3%2.5%5.3 $4.74 5/28/20213,640,000 shares $15.98 million -9.0%2.6%4.7 $4.39 5/14/20214,000,000 shares $16.80 million -5.7%N/A4.5 $4.20 4/30/20214,240,000 shares $21.37 million -5.4%N/A3.9 $5.04 4/15/20214,480,000 shares $23.25 million +20.1%N/A2.9 $5.19 3/31/20213,730,000 shares $21.15 million -24.0%N/A0.8 $5.67 3/15/20214,910,000 shares $33.73 million +36.8%N/A0.9 $6.87 2/26/20213,590,000 shares $26.85 million -20.0%N/A0.4 $7.48 2/12/20214,490,000 shares $35.96 million -16.2%N/A0.5 $8.01 1/29/20215,360,000 shares $43.20 million -52.9%N/A0.5 $8.06 1/15/202111,380,000 shares $91.61 million -5.1%N/A1 $8.05 12/31/202011,990,000 shares $39.69 million -2.0%N/A1.6 $3.31 12/15/202012,240,000 shares $36.48 million +29.0%N/A1.7 $2.98 11/30/20209,490,000 shares $15.37 million -1.7%N/A1.6 $1.62 11/15/20209,650,000 shares $12.26 million -0.4%N/A3.7 $1.27 10/30/20209,690,000 shares $11.24 million +3.1%N/A11.7 $1.16 LXRX Short Interest - Frequently Asked Questions What is Lexicon Pharmaceuticals' current short interest? Short interest is the volume of Lexicon Pharmaceuticals shares that have been sold short but have not yet been covered or closed out. As of September 30th, investors have sold 27,300,000 shares of LXRX short. Learn More on Lexicon Pharmaceuticals' current short interest. What is a good short interest ratio for Lexicon Pharmaceuticals? The short interest ratio, also known as the "days to cover ratio", is calculated by dividing the number of shares of a stock sold short divided by its average trading volume. A short interest ratio ranging between 1 and 4 generally indicates strong positive sentiment about a stock and a lack of short sellers. A short interest ratio of 10 or greater indicates strong pessimism about a stock. LXRX shares currently have a short interest ratio of 10.0. Learn More on Lexicon Pharmaceuticals's short interest ratio. Which institutional investors are shorting Lexicon Pharmaceuticals? As of the most recent reporting period, the following institutional investors, funds, and major shareholders have reported short positions of Lexicon Pharmaceuticals: Group One Trading LLC, and Simplex Trading LLC. These positions are disclosed in Form 13F filings with the Securities and Exchange Commission. Is Lexicon Pharmaceuticals' short interest increasing or decreasing? Lexicon Pharmaceuticals saw a drop in short interest in September. As of September 30th, there was short interest totaling 27,300,000 shares, a drop of 3.8% from the previous total of 28,380,000 shares. Changes in short volume can be used to identify positive and negative investor sentiment. Investors that short sell a stock are betting that its price will decline in the future. An increase in short sale volume suggests bearish (negative) sentiment among investors. A decrease on short sale volume suggests bullish (positive) sentiment. How does Lexicon Pharmaceuticals' short interest compare to its competitors? Here is how the short interest of companies in the industry of "biotechnology" compare to Lexicon Pharmaceuticals: Celldex Therapeutics, Inc. (10.66%), MannKind Corporation (6.14%), BioCryst Pharmaceuticals, Inc. (13.13%), Novavax, Inc. (26.75%), OPKO Health, Inc. (9.46%), Dynavax Technologies Corporation (11.49%), Zenas BioPharma, Inc. (54.51%), Innoviva, Inc. (10.93%), Geron Corporation (14.07%), Myriad Genetics, Inc. (8.37%), Which stocks are the most shorted right now? As of the most recent reporting period, the following stocks had the largest short interest positions: AppLovin Corporation ($15.71 billion), Robinhood Markets, Inc. ($7.56 billion), Reddit Inc. ($4.55 billion), Coinbase Global, Inc. ($4.53 billion), CoreWeave Inc. ($4.43 billion), Charter Communications, Inc. ($4.07 billion), Seagate Technology Holdings PLC ($3.94 billion), IonQ, Inc. ($3.78 billion), TC Energy Corporation ($3.13 billion), and Live Nation Entertainment, Inc. ($3.12 billion). View all of the most shorted stocks. What does it mean to sell short Lexicon Pharmaceuticals stock? Short selling LXRX is an investing strategy that aims to generate trading profit from Lexicon Pharmaceuticals as its price is falling. LXRX shares are trading down $0.05 today. To short a stock, an investor borrows shares, sells them and buys the shares back on the public market later to return it to the lender. Short sellers are betting that a stock will decline in price. If the stock does drop after selling, the short seller buys it back at a lower price and returns it to the lender. The difference between the sell price and the buy price is the trader's profit. How does a short squeeze work against Lexicon Pharmaceuticals? A short squeeze for Lexicon Pharmaceuticals occurs when it has a large amount of short interest and its stock increases in price. This forces short sellers to cover their short interest positions by buying actual shares of LXRX, which in turn drives the price of the stock up even further. How often is Lexicon Pharmaceuticals' short interest reported? Short interest is typically published by a stock exchange once per month. However, NASDAQ publishes a report for U.S. stocks, including LXRX, twice per month. The most recent reporting period available is September, 30 2025. More Short Interest Resources from MarketBeat Related Companies CLDX Short Interest Data MNKD Short Interest Data BCRX Short Interest Data NVAX Short Interest Data OPK Short Interest Data DVAX Short Interest Data ZBIO Short Interest Data INVA Short Interest Data GERN Short Interest Data MYGN Short Interest Data Short Interest Tools Stocks to Short Largest Short Interest Positions Short Interest Increases Short Interest Decreases Short Interest Reporting Dates This page (NASDAQ:LXRX) was last updated on 10/20/2025 by MarketBeat.com Staff From Our PartnersYour Bank Account Is No Longer SafeWhat If Washington Declared That: YOUR Money ISN'T Actually Yours? 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