Spruce Biosciences (SPRB) Stock Price, News & Analysis

Company Overview

Spruce Biosciences, Inc., a biopharmaceutical company, focuses on developing and commercializing novel therapies for rare endocrine disorders. The company engages in developing tildacerfont, a non-steroidal therapy to enhance disease control and reduce steroid burden for patients suffering from congenital adrenal hyperplasia (CAH), which is in Phase 2b clinical trial; and to evaluate glucocorticoid reduction in adult patients with classic CAH that is Phase 2b clinical trial. It is also developing tildacerfont for the treatment of pediatric classic congenital adrenal hyperplasia in children that is in Phase 2 clinical trial; and for females with polycystic ovary syndrome, which is in Phase 2 clinical trial. Spruce Biosciences, Inc. has a license agreement with Eli Lilly and Company to research, develop, and commercialize compounds for various pharmaceutical uses; and collaboration and license agreement with Kaken Pharmaceutical Co. Ltd. to develop, manufacture, and commercialize tildacerfont for the treatment of CAH in Japan. The company was incorporated in 2014 and is headquartered in South San Francisco, California.

Key Stats

• Today's Range: $7.60 to $8.25
• 50-Day Range: $4.58 to $11.39
• 52-Week Range: $0.06 to $0.61
• Volume: 5,615 shs
• Average Volume: 802,052 shs
• Market Capitalization: $4.61 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $131.25
• Consensus Rating: Hold

Spruce Biosciences Stock Analysis - MarketRank™

Spruce Biosciences scored higher than 47% of companies evaluated by MarketBeat. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 3.0 / 5
• Analyst Rating: Hold

Consensus Rating

Spruce Biosciences has received a consensus rating of Hold. The company's average rating score is 2.00, and is based on no buy ratings, 6 hold ratings, and no sell ratings.

Amount of Analyst Coverage

Spruce Biosciences has received no research coverage in the past 90 days.

Earnings and Valuation

• Score: 0.6 / 5
• Proj. Earnings Growth: Growing

Earnings Growth

Earnings for Spruce Biosciences are expected to grow in the coming year, from ($1.00) to ($0.85) per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of Spruce Biosciences is -8.72, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of Spruce Biosciences is -8.72, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Book Value per Share Ratio

Spruce Biosciences has a P/B Ratio of 4.36. P/B Ratios above 3 indicate that a company could be overvalued with respect to its assets and liabilities.

Short Interest

• Score: 3.0 / 5
• Short Interest Level: Healthy

Percentage of Shares Shorted

0.22% of the float of Spruce Biosciences has been sold short.

Short Interest Ratio / Days to Cover

Spruce Biosciences has a short interest ratio ("days to cover") of 0.2, which is generally considered an acceptable ratio of short interest to trading volume.

Change versus previous month

Short interest in Spruce Biosciences has recently increased by 96.45%, indicating that investor sentiment is decreasing significantly.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

Spruce Biosciences does not currently pay a dividend.

Dividend Growth

Spruce Biosciences does not have a long track record of dividend growth.

Sustainability and ESG

• Score: N/A
• Environmental Score: N/A

Percentage of Shares Shorted

0.22% of the float of Spruce Biosciences has been sold short.

Short Interest Ratio / Days to Cover

Spruce Biosciences has a short interest ratio ("days to cover") of 0.2, which is generally considered an acceptable ratio of short interest to trading volume.

Change versus previous month

Short interest in Spruce Biosciences has recently increased by 96.45%, indicating that investor sentiment is decreasing significantly.

News and Social Media

• Score: 2.5 / 5
• News Sentiment: 0.42

News Sentiment

Spruce Biosciences has a news sentiment score of 0.42. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a lower news sentiment than the 0.66 average news sentiment score of Medical companies.

News Coverage This Week

MarketBeat has tracked 2 news articles for Spruce Biosciences this week, compared to 0 articles on an average week.

Search Interest

1 people have searched for SPRB on MarketBeat in the last 30 days.

Company Ownership

• Score: 1.7 / 5
• Insider Trading: N/A

Insider Buying vs. Insider Selling

In the past three months, Spruce Biosciences insiders have not sold or bought any company stock.

Percentage Held by Insiders

Only 6.90% of the stock of Spruce Biosciences is held by insiders.

Percentage Held by Institutions

91.71% of the stock of Spruce Biosciences is held by institutions. High institutional ownership can be a signal of strong market trust in this company.

SPRB Stock Analysis - Frequently Asked Questions

How have SPRB shares performed this year?

Spruce Biosciences' stock was trading at $31.50 at the beginning of 2025. Since then, SPRB stock has decreased by 74.0% and is now trading at $8.20.

How were Spruce Biosciences' earnings last quarter?

Spruce Biosciences, Inc. (NASDAQ:SPRB) posted its earnings results on Tuesday, April, 15th. The company reported ($42.75) EPS for the quarter, missing the consensus estimate of ($15.00) by $27.75. The firm earned $0.55 million during the quarter, compared to analysts' expectations of $0.50 million. Spruce Biosciences had a negative trailing twelve-month return on equity of 62.10% and a negative net margin of 555.23%.

When did Spruce Biosciences' stock split?

Spruce Biosciences's stock reverse split on Monday, August 4th 2025.The 1-75 reverse split was announced on Thursday, July 24th 2025. The number of shares owned by shareholders was adjusted after the closing bell on Friday, August 1st 2025. An investor that had 100 shares of stock prior to the reverse split would have 1 shares after the split.

When did Spruce Biosciences IPO?

Spruce Biosciences (SPRB) raised $75 million in an initial public offering (IPO) on Friday, October 9th 2020. The company issued 5,000,000 shares at a price of $14.00-$16.00 per share. Cowen, SVB Leerink, Credit Suisse and RBC Capital Markets acted as the underwriters for the IPO.

How do I buy shares of Spruce Biosciences?

Shares of SPRB stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of Spruce Biosciences own?

Based on aggregate information from My MarketBeat watchlists, some other companies that Spruce Biosciences investors own include NVIDIA (NVDA), Broadcom (AVGO), Arista Networks (ANET), Jabil (JBL), Adobe (ADBE), Meta Platforms (META) and Disc Medicine (IRON).

Company Calendar

• Last Earnings: 4/15/2025
• Today: 8/23/2025
• Next Earnings (Estimated): 11/10/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: Pharmaceutical preparations
• Sub-Industry: Pharmaceutical Products
• Current Symbol: NASDAQ:SPRB
• CIK: 1683553
• Web: www.sprucebiosciences.com
• Phone: 415-655-4168
• Fax: N/A
• Employees: 20
• Year Founded: N/A

Price Target and Rating

• Average Price Target for Spruce Biosciences: $131.25
• High Price Target: $225.00
• Low Price Target: $37.50
• Potential Upside/Downside: +1,444.1%
• Consensus Rating: Hold
• Rating Score (0-4): 2.00
• Research Coverage: 6 Analysts

Profitability

• EPS (Trailing Twelve Months): ($99.25)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: -$47.92 million
• Net Margins: -555.23%
• Pretax Margin: -555.23%
• Return on Equity: -62.10%
• Return on Assets: -47.49%

Debt

• Debt-to-Equity Ratio: 0.01
• Current Ratio: 5.36
• Quick Ratio: 5.36

Sales & Book Value

• Annual Sales: $4.91 million
• Price / Sales: 0.97
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: $1.88 per share
• Price / Book: 4.52

Miscellaneous

• Outstanding Shares: 562,000
• Free Float: 37,544,000
• Market Cap: $4.78 million
• Optionable: Optionable
• Beta: 2.43