Spero Therapeutics (SPRO) Stock Price, News & Analysis

Company Overview

Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying, developing, and commercializing novel treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include tebipenem pivoxil hydrobromide (HBr), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adults; SPR206, an intravenous-administered antibiotic against MDR Gram-negative pathogens comprising carbapenem-resistant enterobacterales (CRE), acinetobacter baumannii, and pseudomonas aeruginosa, as well as negative bacterial infections in the hospital setting; and SPR720, a novel oral antibiotic agent for the treatment of non-tuberculous mycobacterial pulmonary disease. It has license agreement with Meiji Seika Pharma Co., Ltd. to support the development of tebipenem HBr; Everest Medicines to develop, manufacture, and commercialize SPR206 in Greater China, South Korea, and Southeast Asian countries; and Vertex Pharmaceuticals Incorporated for patents relating to SPR720, as well as SPR719, an active metabolite. Spero Therapeutics, Inc. was founded in 2013 and is headquartered in Cambridge, Massachusetts.

Key Stats

• Today's Range: $1.85 to $2.01
• 50-Day Range: $1.83 to $3.04
• 52-Week Range: $0.51 to $3.22
• Volume: 554,715 shs
• Average Volume: 757,155 shs
• Market Capitalization: $111.43 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $5.00
• Consensus Rating: Moderate Buy

Spero Therapeutics Stock Analysis - MarketRank™

Spero Therapeutics scored higher than 82% of companies evaluated by MarketBeat, and ranked 200th out of 945 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 3.3 / 5
• Analyst Rating: Moderate Buy

Consensus Rating

Spero Therapeutics has received a consensus rating of Moderate Buy. The company's average rating score is 2.50, and is based on 2 buy ratings, 2 hold ratings, and no sell ratings.

Amount of Analyst Coverage

Spero Therapeutics has received no research coverage in the past 90 days.

Earnings and Valuation

• Score: 0.6 / 5
• Proj. Earnings Growth: Growing

Earnings Growth

Earnings for Spero Therapeutics are expected to grow in the coming year, from ($1.20) to ($0.79) per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of Spero Therapeutics is -2.02, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of Spero Therapeutics is -2.02, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Book Value per Share Ratio

Spero Therapeutics has a P/B Ratio of 3.41. P/B Ratios above 3 indicate that a company could be overvalued with respect to its assets and liabilities.

Short Interest

• Score: 3.0 / 5
• Short Interest Level: Healthy

Percentage of Shares Shorted

2.61% of the float of Spero Therapeutics has been sold short.

Short Interest Ratio / Days to Cover

Spero Therapeutics has a short interest ratio ("days to cover") of 0.3, which is generally considered an acceptable ratio of short interest to trading volume.

Change versus previous month

Short interest in Spero Therapeutics has recently increased by 13.11%, indicating that investor sentiment is decreasing significantly.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

Spero Therapeutics does not currently pay a dividend.

Dividend Growth

Spero Therapeutics does not have a long track record of dividend growth.

Sustainability and ESG

• Score: 4.7 / 5
• Environmental Score: -0.80

Percentage of Shares Shorted

2.61% of the float of Spero Therapeutics has been sold short.

Short Interest Ratio / Days to Cover

Spero Therapeutics has a short interest ratio ("days to cover") of 0.3, which is generally considered an acceptable ratio of short interest to trading volume.

Change versus previous month

Short interest in Spero Therapeutics has recently increased by 13.11%, indicating that investor sentiment is decreasing significantly.

News and Social Media

• Score: 3.5 / 5
• News Sentiment: 1.30

News Sentiment

Spero Therapeutics has a news sentiment score of 1.30. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a higher news sentiment than the 0.99 average news sentiment score of Medical companies.

News Coverage This Week

MarketBeat has tracked 3 news articles for Spero Therapeutics this week, compared to 1 article on an average week.

Search Interest

Only 1 people have searched for SPRO on MarketBeat in the last 30 days. This is a decrease of 0% compared to the previous 30 days.

MarketBeat Follows

2 people have added Spero Therapeutics to their MarketBeat watchlist in the last 30 days.

Company Ownership

• Score: 0.0 / 5
• Insider Trading: N/A

Insider Buying vs. Insider Selling

In the past three months, Spero Therapeutics insiders have not sold or bought any company stock.

Percentage Held by Insiders

Only 5.50% of the stock of Spero Therapeutics is held by insiders.

Percentage Held by Institutions

Only 25.60% of the stock of Spero Therapeutics is held by institutions.

SPRO Stock Analysis - Frequently Asked Questions

How have SPRO shares performed this year?

Spero Therapeutics' stock was trading at $1.03 at the beginning of 2025. Since then, SPRO shares have increased by 92.2% and is now trading at $1.98.

How were Spero Therapeutics' earnings last quarter?

Spero Therapeutics, Inc. (NASDAQ:SPRO) released its quarterly earnings results on Tuesday, August, 12th. The company reported ($0.03) earnings per share (EPS) for the quarter, topping analysts' consensus estimates of ($0.38) by $0.35. The firm earned $14.19 million during the quarter, compared to analysts' expectations of $11 million. Spero Therapeutics had a negative net margin of 110.35% and a negative trailing twelve-month return on equity of 120.27%.
Read the conference call transcript.

When did Spero Therapeutics IPO?

Spero Therapeutics (SPRO) raised $75 million in an IPO on Thursday, November 2nd 2017. The company issued 5,000,000 shares at a price of $14.00-$16.00 per share. BofA Merrill Lynch, Cowen and Stifel acted as the underwriters for the IPO and Oppenheimer & Co. was co-manager.

Who are Spero Therapeutics' major shareholders?

Top institutional investors of Spero Therapeutics include Geode Capital Management LLC (0.91%), Stonepine Capital Management LLC (0.28%), Group One Trading LLC and Bridgeway Capital Management LLC (0.20%). Insiders that own company stock include Aquilo Capital Management, Llc, Sath Shukla, Esther Rajavelu, Ankit Mahadevia, Kamal Hamed and Timothy Keutzer.
View institutional ownership trends.

How do I buy shares of Spero Therapeutics?

Shares of SPRO stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of Spero Therapeutics own?

Based on aggregate information from My MarketBeat watchlists, some other companies that Spero Therapeutics investors own include Invesco QQQ (QQQ), SPDR S&P 500 ETF Trust (SPY), SPDR Dow Jones Industrial Average ETF Trust (DIA), Meta Platforms (META), NVIDIA (NVDA), Editas Medicine (EDIT) and Advanced Micro Devices (AMD).

Company Calendar

• Last Earnings: 8/12/2025
• Today: 8/27/2025
• Next Earnings (Estimated): 11/13/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: MED - BIOMED/GENE
• Sub-Industry: Pharmaceutical Products
• Current Symbol: NASDAQ:SPRO
• CIK: 1701108
• Web: sperotherapeutics.com
• Phone: (857) 242-1600
• Fax: N/A
• Employees: 150
• Year Founded: 2013

Price Target and Rating

• Average Price Target for Spero Therapeutics: $5.00
• High Price Target: $5.00
• Low Price Target: $5.00
• Potential Upside/Downside: +152.5%
• Consensus Rating: Moderate Buy
• Rating Score (0-4): 2.50
• Research Coverage: 4 Analysts

Profitability

• EPS (Trailing Twelve Months): ($0.98)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: -$68.57 million
• Net Margins: -110.35%
• Pretax Margin: -110.35%
• Return on Equity: -120.27%
• Return on Assets: -55.61%

Debt

• Debt-to-Equity Ratio: N/A
• Current Ratio: 3.97
• Quick Ratio: 3.97

Sales & Book Value

• Annual Sales: $47.98 million
• Price / Sales: 2.32
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: $0.58 per share
• Price / Book: 3.41

Miscellaneous

• Outstanding Shares: 56,280,000
• Free Float: 53,180,000
• Market Cap: $111.43 million
• Optionable: Optionable
• Beta: 1.39