Spyre Therapeutics (SYRE) News Today $12.71 +0.20 (+1.60%) Closing price 04:00 PM EasternExtended Trading$12.68 -0.04 (-0.28%) As of 07:49 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Headlines Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFinancialsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestTrendsBuy This Stock SYRE Latest News All Sources Trusted Sources MarketBeat Benzinga Bloomberg GuruFocus MarketWatch Motley Fool NASDAQ PR Newswire Reuters Seeking Alpha TalkMarkets The Street TipRanks The Wall Street Journal Wall Street Zen Yahoo Finance Source Sentiment refers to the positivity or negativity of each headline according to our language processing algorithm. Sentiment All Sentiments Very Positive Positive Neutral Negative Very Negative Most Recent May 2025 April 2025 March 2025 February 2025 January 2025 December 2024 November 2024 October 2024 September 2024 August 2024 July 2024 June 2024 May 2024 April 2024 March 2024 February 2024 January 2024 December 2023 November 2023 October 2023 September 2023 August 2023 July 2023 June 2023 May 2023 April 2023 March 2023 February 2023 January 2023 December 2022 November 2022 October 2022 September 2022 August 2022 July 2022 June 2022 Time Period Spyre Therapeutics (NASDAQ:SYRE) Trading Down 5.8% - Here's WhySpyre Therapeutics (NASDAQ:SYRE) Stock Price Down 5.8% - What's Next?May 7 at 1:16 PM | marketbeat.comSpyre Therapeutics (NASDAQ:SYRE) Receives "Outperform" Rating from WedbushWedbush reissued an "outperform" rating and issued a $65.00 price target on shares of Spyre Therapeutics in a research report on Monday.May 7 at 12:12 PM | marketbeat.comSpyre Therapeutics' (SYRE) "Outperform" Rating Reiterated at WedbushMay 7 at 1:23 AM | americanbankingnews.comInvesco Ltd. Sells 118,195 Shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE)Invesco Ltd. cut its stake in Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) by 85.7% in the 4th quarter, according to its most recent disclosure with the Securities and Exchange Commission (SEC). The firm owned 19,663 shares of the company's stock after selling 118,195 shares during the periMay 6 at 3:18 AM | marketbeat.comSpyre Therapeutics Announces Poster Presentations at Digestive Disease Week (DDW) 2025 Including Up to Eight months of Follow-up from an Ongoing Phase 1 Trial of SPY001May 5 at 8:00 AM | prnewswire.comSpyre Therapeutics, Inc. (NASDAQ:SYRE) Receives Average Recommendation of "Buy" from AnalystsSpyre Therapeutics, Inc. (NASDAQ:SYRE - Get Free Report) has been given an average rating of "Buy" by the ten brokerages that are currently covering the stock, MarketBeat reports. Eight research analysts have rated the stock with a buy recommendation and two have issued a strong buy recommendationMay 5 at 4:26 AM | marketbeat.comPrice T Rowe Associates Inc. MD Acquires 77,323 Shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE)Price T Rowe Associates Inc. MD grew its holdings in shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) by 18.0% in the fourth quarter, according to the company in its most recent 13F filing with the Securities and Exchange Commission (SEC). The firm owned 506,450 shares of the company'May 5 at 4:14 AM | marketbeat.comBoxer Capital Management LLC Takes Position in Spyre Therapeutics, Inc. (NASDAQ:SYRE)Boxer Capital Management LLC purchased a new position in shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) during the fourth quarter, according to its most recent filing with the Securities and Exchange Commission (SEC). The firm purchased 466,680 shares of the company's stock, valuedMay 4 at 6:25 AM | marketbeat.comAnalysts Have Conflicting Sentiments on These Healthcare Companies: Bausch + Lomb Corporation (BLCO), Spyre Therapeutics (SYRE) and Herbalife (HLF)May 3, 2025 | theglobeandmail.comSpyre Therapeutics (SYRE) to Release Earnings on ThursdaySpyre Therapeutics (NASDAQ:SYRE) will be releasing its Q1 2025 earnings before the market opens on Thursday, May 8. (View Earnings Report at https://www.marketbeat.com/earnings/reports/2025-5-8-spyre-therapeutics-inc-stock/)May 3, 2025 | marketbeat.comSpyre Therapeutics Announces Grants of Inducement AwardsMay 2, 2025 | prnewswire.comBarclays PLC Increases Position in Spyre Therapeutics, Inc. (NASDAQ:SYRE)Barclays PLC boosted its holdings in shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) by 16.7% during the fourth quarter, according to its most recent disclosure with the Securities and Exchange Commission. The institutional investor owned 123,071 shares of the company's stock afterMay 2, 2025 | marketbeat.comSoros Fund Management LLC Acquires 105,000 Shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE)Soros Fund Management LLC increased its holdings in shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) by 72.4% during the fourth quarter, according to the company in its most recent disclosure with the SEC. The institutional investor owned 250,000 shares of the company's stock after pMay 1, 2025 | marketbeat.comSpyre Therapeutics, Inc. (NASDAQ:SYRE) Shares Acquired by Emerald Mutual Fund Advisers TrustEmerald Mutual Fund Advisers Trust raised its position in Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) by 52.4% during the 4th quarter, according to its most recent filing with the Securities and Exchange Commission (SEC). The fund owned 386,384 shares of the company's stock after purchasinMay 1, 2025 | marketbeat.comSpyre Therapeutics (SYRE) Expected to Announce Quarterly Earnings on ThursdayMay 1, 2025 | americanbankingnews.comAdage Capital Partners GP L.L.C. Lowers Holdings in Spyre Therapeutics, Inc. (NASDAQ:SYRE)Adage Capital Partners GP L.L.C. reduced its stake in Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) by 2.4% during the fourth quarter, according to the company in its most recent Form 13F filing with the Securities and Exchange Commission. The fund owned 1,030,000 shares of the company's stoApril 28, 2025 | marketbeat.comSpyre Therapeutics (NASDAQ:SYRE) Trading Down 3.6% - Here's WhySpyre Therapeutics (NASDAQ:SYRE) Trading Down 3.6% - What's Next?April 24, 2025 | marketbeat.comCapital World Investors Invests $8.81 Million in Spyre Therapeutics, Inc. (NASDAQ:SYRE)Capital World Investors purchased a new position in Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) during the 4th quarter, according to its most recent Form 13F filing with the Securities and Exchange Commission (SEC). The firm purchased 378,573 shares of the company's stock, valued at approxApril 24, 2025 | marketbeat.comSpyre Therapeutics (NASDAQ:SYRE) Trading Up 6.3% - Still a Buy?Spyre Therapeutics (NASDAQ:SYRE) Stock Price Up 6.3% - What's Next?April 23, 2025 | marketbeat.comB Group Inc. Buys Shares of 50,000 Spyre Therapeutics, Inc. (NASDAQ:SYRE)B Group Inc. purchased a new position in shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) in the fourth quarter, according to the company in its most recent Form 13F filing with the Securities and Exchange Commission (SEC). The firm purchased 50,000 shares of the company's stock, valuApril 23, 2025 | marketbeat.comGeode Capital Management LLC Buys 75,081 Shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE)Geode Capital Management LLC raised its stake in shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) by 8.4% in the 4th quarter, according to its most recent 13F filing with the Securities & Exchange Commission. The fund owned 966,129 shares of the company's stock after purchasing anApril 21, 2025 | marketbeat.comAffinity Asset Advisors LLC Purchases 325,908 Shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE)Affinity Asset Advisors LLC increased its holdings in Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) by 65.4% in the fourth quarter, according to the company in its most recent Form 13F filing with the Securities and Exchange Commission. The institutional investor owned 824,328 shares of theApril 17, 2025 | marketbeat.comFmr LLC Grows Stock Holdings in Spyre Therapeutics, Inc. (NASDAQ:SYRE)Fmr LLC lifted its stake in Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) by 15.4% during the fourth quarter, according to its most recent disclosure with the Securities & Exchange Commission. The fund owned 8,801,266 shares of the company's stock after buying an additional 1,177,385 shaApril 15, 2025 | marketbeat.comF M Investments LLC Takes Position in Spyre Therapeutics, Inc. (NASDAQ:SYRE)F M Investments LLC purchased a new position in Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) during the fourth quarter, according to its most recent Form 13F filing with the SEC. The fund purchased 48,806 shares of the company's stock, valued at approximately $1,136,000. F M Investments LLCApril 14, 2025 | marketbeat.comVanguard Group Inc. Buys 330,553 Shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE)Vanguard Group Inc. raised its position in shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) by 13.1% during the fourth quarter, according to its most recent Form 13F filing with the Securities & Exchange Commission. The fund owned 2,846,473 shares of the company's stock after acquApril 13, 2025 | marketbeat.comWhat is Leerink Partnrs' Estimate for SYRE Q1 Earnings?Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) - Research analysts at Leerink Partnrs issued their Q1 2025 EPS estimates for Spyre Therapeutics in a research note issued on Tuesday, April 8th. Leerink Partnrs analyst F. Khurshid anticipates that the company will post earnings per share of (April 12, 2025 | marketbeat.comSpyre Therapeutics (NASDAQ:SYRE) Upgraded to "Strong-Buy" at Leerink PartnrsLeerink Partnrs upgraded shares of Spyre Therapeutics to a "strong-buy" rating in a research report on Tuesday.April 11, 2025 | marketbeat.comSpyre Therapeutics (NASDAQ:SYRE) Now Covered by Leerink PartnersLeerink Partners assumed coverage on Spyre Therapeutics in a report on Tuesday. They set an "outperform" rating and a $45.00 price objective for the company.April 10, 2025 | marketbeat.comSpyre Therapeutics Stock Price, Quotes and Forecasts | NASDAQ:SYRE | BenzingaApril 9, 2025 | benzinga.comSpyre Therapeutics (NASDAQ:SYRE) Reaches New 1-Year Low - Here's What HappenedSpyre Therapeutics (NASDAQ:SYRE) Reaches New 12-Month Low - Here's WhyApril 9, 2025 | marketbeat.comLeerink Partners Initiates Coverage of Spyre Therapeutics (SYRE) with Outperform RecommendationApril 8, 2025 | msn.comSpyre Therapeutics, Inc. (NASDAQ:SYRE) Shares Bought by Wellington Management Group LLPWellington Management Group LLP grew its stake in Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) by 6.5% during the fourth quarter, according to the company in its most recent 13F filing with the SEC. The institutional investor owned 1,604,508 shares of the company's stock after purchasing aApril 8, 2025 | marketbeat.comSchroder Investment Management Group Takes $2.56 Million Position in Spyre Therapeutics, Inc. (NASDAQ:SYRE)Schroder Investment Management Group bought a new position in Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) in the 4th quarter, according to the company in its most recent 13F filing with the SEC. The firm bought 113,620 shares of the company's stock, valued at approximately $2,561,000. SchrApril 8, 2025 | marketbeat.comSpyre Therapeutics, Inc. (NASDAQ:SYRE) Stock Holdings Lowered by Cinctive Capital Management LPCinctive Capital Management LP cut its position in Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) by 68.1% during the 4th quarter, according to the company in its most recent filing with the Securities & Exchange Commission. The fund owned 19,567 shares of the company's stock after sellinApril 6, 2025 | marketbeat.comSpyre Therapeutics Announces Grants of Inducement AwardsApril 4, 2025 | prnewswire.comPictet Asset Management Holding SA Buys 266,418 Shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE)Pictet Asset Management Holding SA lifted its stake in Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) by 32.3% in the 4th quarter, according to the company in its most recent filing with the Securities and Exchange Commission. The institutional investor owned 1,092,124 shares of the company'April 2, 2025 | marketbeat.comSpyre Therapeutics (NASDAQ:SYRE) Reaches New 52-Week Low - Time to Sell?Spyre Therapeutics (NASDAQ:SYRE) Reaches New 52-Week Low - Should You Sell?April 2, 2025 | marketbeat.comSpyre Therapeutics (NASDAQ:SYRE) Stock Price Down 7.7% - Here's What HappenedSpyre Therapeutics (NASDAQ:SYRE) Stock Price Down 7.7% - What's Next?April 1, 2025 | marketbeat.comSwiss National Bank Buys 19,000 Shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE)Swiss National Bank grew its position in shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) by 38.3% in the 4th quarter, according to the company in its most recent 13F filing with the SEC. The fund owned 68,600 shares of the company's stock after purchasing an additional 19,000 sharesMarch 30, 2025 | marketbeat.comSpyre Therapeutics (NASDAQ:SYRE) Shares Gap Up - Here's WhySpyre Therapeutics (NASDAQ:SYRE) Shares Gap Up - Here's What HappenedMarch 29, 2025 | marketbeat.comSpyre Therapeutics, Inc.: Spyre Therapeutics Announces First Participant Dosed in Phase 1 Trial of SPY003, its Novel Half-life Extended IL-23 AntibodyMarch 28, 2025 | finanznachrichten.deSpyre Therapeutics (NASDAQ:SYRE) Shares Up 5.2% - Still a Buy?Spyre Therapeutics (NASDAQ:SYRE) Shares Up 5.2% - Here's WhyMarch 28, 2025 | marketbeat.comNatixis Advisors LLC Purchases Shares of 17,300 Spyre Therapeutics, Inc. (NASDAQ:SYRE)Natixis Advisors LLC purchased a new position in shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) during the fourth quarter, according to the company in its most recent filing with the Securities and Exchange Commission (SEC). The fund purchased 17,300 shares of the company's stock, vMarch 28, 2025 | marketbeat.comSpyre Therapeutics says first patient dosed in Phase 1 trial of SPY003March 27, 2025 | markets.businessinsider.comSpyre Therapeutics (NASDAQ:SYRE) Reaches New 1-Year Low - Here's WhySpyre Therapeutics (NASDAQ:SYRE) Reaches New 52-Week Low - Should You Sell?March 27, 2025 | marketbeat.comSpyre Therapeutics Announces First Participant Dosed in Phase 1 Trial of SPY003, its Novel Half-life Extended IL-23 AntibodyMarch 27, 2025 | prnewswire.comEFG Asset Management North America Corp. Boosts Holdings in Spyre Therapeutics, Inc. (NASDAQ:SYRE)EFG Asset Management North America Corp. raised its holdings in shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) by 58.6% in the fourth quarter, according to the company in its most recent disclosure with the Securities and Exchange Commission. The fund owned 82,818 shares of the compMarch 27, 2025 | marketbeat.comSpyre Therapeutics (NASDAQ:SYRE) Stock Price Down 6.4% - Here's What HappenedSpyre Therapeutics (NASDAQ:SYRE) Stock Price Down 6.4% - What's Next?March 26, 2025 | marketbeat.comEmerald Advisers LLC Acquires 254,222 Shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE)Emerald Advisers LLC grew its stake in shares of Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) by 86.9% during the 4th quarter, according to its most recent Form 13F filing with the Securities and Exchange Commission. The firm owned 546,791 shares of the company's stock after purchasing an aMarch 24, 2025 | marketbeat.comCharles Schwab Investment Management Inc. Has $8.84 Million Position in Spyre Therapeutics, Inc. (NASDAQ:SYRE)Charles Schwab Investment Management Inc. boosted its position in Spyre Therapeutics, Inc. (NASDAQ:SYRE - Free Report) by 13.9% in the fourth quarter, according to the company in its most recent 13F filing with the Securities & Exchange Commission. The institutional investor owned 379,650 sharMarch 23, 2025 | marketbeat.com Get Spyre Therapeutics News Delivered to You Automatically Sign up to receive the latest news and ratings for SYRE and its competitors with MarketBeat's FREE daily newsletter. Email Address SYRE Media Mentions By Week SYRE Media Sentiment Learn about the media sentiment score. Each headline receives a score ranging from 2 (good news) to -2 (bad news). Our company news sentiment scores track the average news sentiment of articles about each company over the most recent 7 days in order to identify companies that are receiving positive press. SYRE News Sentiment▼0.830.64▲Average Medical News Sentiment SYRE News Coverage Learn about the media coverage comparison. We track news headlines from hundreds of news outlets and tag them by company. This chart compares the number of articles about this company in the last seven days compared with the average number of articles about this company on a typical week. SYRE Articles This Week▼164▲SYRE Articles Average Week Get Spyre Therapeutics News Delivered to You Automatically Sign up to receive the latest news and ratings for SYRE and its competitors with MarketBeat's FREE daily newsletter. Email Address Related Companies and Tools Related Companies SWTX News Today OGN News Today MRUS News Today CRNX News Today SRRK News Today AKRO News Today VKTX News Today XENE News Today CPRX News Today MOR News Today Headlines Tools Trending Media MentionsHigh Media Sentiment StocksLive News FeedMarketBeat OriginalsStock Ideas This page (NASDAQ:SYRE) was last updated on 5/7/2025 by MarketBeat.com Staff From Our Partners3..2..1.. AI 2.0 ignition (don’t sleep on this)I just put together an urgent new presentation that you need to see right away. 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