Zymeworks (ZYME) Stock Price, News & Analysis

Company Overview

Zymeworks Inc. (NASDAQ: ZYME) is a biopharmaceutical company focused on discovering, developing and commercializing engineered antibody-based therapeutics for cancer and other serious diseases. The company’s technologies are designed to create bispecific and multispecific antibodies, as well as antibody-drug conjugates that can target tumor cells and deliver therapeutic payloads.

Zymeworks’ leading product is zanidatamab, marketed in the United States as Ziihera. The bispecific antibody targets two separate sites on the HER2 protein and received U.S. Food and Drug Administration accelerated approval in 2024 for previously treated, unresectable, locally advanced or metastatic HER2-positive biliary tract cancer. The company continues to study zanidatamab in additional HER2-expressing cancers and treatment settings.

The company’s research is supported by its proprietary Azymetric bispecific antibody and ZymeLink antibody-drug conjugate platforms. Founded in Vancouver, British Columbia, Zymeworks conducts research and development activities in North America and works with pharmaceutical partners to advance and commercialize its therapies in international markets. Its development portfolio has included additional antibody-based candidates for oncology applications.

Key Stats

• Today's Range: $25.28 to $26.34
• 50-Day Range: $21.81 to $31.05
• 52-Week Range: $16.00 to $31.34
• Volume: 491,135 shs
• Average Volume: 1.00 million shs
• Market Capitalization: $1.83 billion
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $40.64
• Consensus Rating: Moderate Buy

Zymeworks Stock Analysis - MarketRank™

Zymeworks scored higher than 53% of companies evaluated by MarketBeat, and ranked 474th out of 883 stocks in the healthcare sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 4.4 / 5
• Analyst Rating: Moderate Buy

Consensus Rating

Zymeworks has received a consensus rating of Moderate Buy. The company's average rating score is 2.77, and is based on no strong buy ratings, 11 buy ratings, 1 hold rating, and 1 sell rating.

Upside Potential

Zymeworks has a consensus price target of $40.64, representing about 57.6% upside from its current price of $25.79.

Amount of Analyst Coverage

Zymeworks has been the subject of 10 research reports in the past 90 days, demonstrating strong analyst interest in this stock.

Earnings and Valuation

• Score: 0.0 / 5
• Proj. Earnings Growth: -15.83%

Earnings Growth

Earnings for Zymeworks are expected to decrease by -15.83% in the coming year, from $1.20 to $1.01 per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of Zymeworks is -12.77, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of Zymeworks is -12.77, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Book Value per Share Ratio

Zymeworks has a P/B Ratio of 7.18. P/B Ratios above 3 indicate that a company could be overvalued with respect to its assets and liabilities.

Short Interest

• Score: 1.0 / 5
• Short Interest Level: Bearish

Percentage of Shares Shorted

11.21% of the float of Zymeworks has been sold short.

Short Interest Ratio / Days to Cover

Zymeworks has a short interest ratio ("days to cover") of 5.55.

Change versus previous month

Short interest in Zymeworks has recently increased by 7.13%, indicating that investor sentiment is decreasing significantly.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

Zymeworks does not currently pay a dividend.

Dividend Growth

Zymeworks does not have a long track record of dividend growth.

News and Social Media

• Score: 2.3 / 5
• News Sentiment: 0.61

News Sentiment

Zymeworks has a news sentiment score of 0.61. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This news sentiment score is similar to the average news sentiment of Healthcare companies.

News Coverage This Week

MarketBeat has tracked 6 news articles for Zymeworks this week, compared to 6 articles on an average week.

Search Interest

Only 3 people have searched for ZYME on MarketBeat in the last 30 days. This is a decrease of 0% compared to the previous 30 days.

MarketBeat Follows

7 people have added Zymeworks to their MarketBeat watchlist in the last 30 days. This is an increase of 600% compared to the previous 30 days.

Company Ownership

• Score: 2.1 / 5
• Insider Trading: Selling Shares

Insider Buying vs. Insider Selling

In the past three months, Zymeworks insiders have sold more of their company's stock than they have bought. Specifically, they have bought $0.00 in company stock and sold $357,557.00 in company stock.

Percentage Held by Insiders

33.51% of the stock of Zymeworks is held by insiders. A high percentage of insider ownership can be a sign of company health.

Percentage Held by Institutions

92.89% of the stock of Zymeworks is held by institutions. High institutional ownership can be a signal of strong market trust in this company.

Company Calendar

• Last Earnings: 8/07/2026
• Today: 10/10/2026
• Next Earnings (Estimated): 11/05/2026
• Fiscal Year End: 12/31/2026

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Healthcare
• Industry: Biotechnology
• Sub-Industry: Biotechnology
• Current Symbol: NASDAQ:ZYME
• Previous Symbol: NASDAQ:ZYME
• CIK: 1937653
• Web: zymeworks.com
• Phone: (302) 274-8744
• Fax: 604-737-7077
• Employees: 264
• Year Founded: 2003

Price Target and Rating

• Average Price Target for Zymeworks: $40.64
• High Price Target: $58.00
• Low Price Target: $32.00
• Potential Upside/Downside: +57.6%
• Consensus Rating: Moderate Buy
• Rating Score (0-4): 2.77
• Research Coverage: 13 Analysts

Profitability

• EPS (Trailing Twelve Months): ($2.02)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: 21.49
• P/E Growth: N/A
• Net Income: -$81.13 million
• Net Margins: -405.31%
• Pretax Margin: -407.76%
• Return on Equity: -72.30%
• Return on Assets: -37.18%

Debt

• Debt-to-Equity Ratio: N/A
• Current Ratio: 6.32
• Quick Ratio: 6.32

Sales & Book Value

• Annual Sales: $105.96 million
• Price / Sales: 17.27
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: $3.59 per share
• Price / Book: 7.18

Miscellaneous

• Outstanding Shares: 70,960,000
• Free Float: 47,181,000
• Market Cap: $1.83 billion
• Optionable: N/A
• Beta: 1.17