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Zymeworks (ZYME) Competitors

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$26.57 -0.91 (-3.31%)
Closing price 09/18/2026 04:00 PM Eastern
Extended Trading
$26.58 +0.00 (+0.02%)
As of 09/18/2026 07:30 PM Eastern
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ZYME vs. RYTM, SRRK, MIRM, CGON, and TVTX

Should you buy Zymeworks stock or one of its competitors? Zymeworks's main competitors and comparable companies include Rhythm Pharmaceuticals (RYTM), Scholar Rock (SRRK), Mirum Pharmaceuticals (MIRM), CG Oncology (CGON), and Travere Therapeutics (TVTX). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Zymeworks compare to Rhythm Pharmaceuticals?

Zymeworks (NASDAQ:ZYME) and Rhythm Pharmaceuticals (NASDAQ:RYTM) are both healthcare companies, but which is the superior investment? We will contrast the two companies based on the strength of their media sentiment, risk, valuation, profitability, analyst recommendations, dividends, earnings and institutional ownership.

Zymeworks has a beta of 1.19, indicating that its share price is 19% more volatile than the broader market. Comparatively, Rhythm Pharmaceuticals has a beta of 1.97, indicating that its share price is 97% more volatile than the broader market.

In the previous week, Rhythm Pharmaceuticals had 13 more articles in the media than Zymeworks. MarketBeat recorded 17 mentions for Rhythm Pharmaceuticals and 4 mentions for Zymeworks. Zymeworks' average media sentiment score of 0.69 beat Rhythm Pharmaceuticals' score of 0.38 indicating that Zymeworks is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Zymeworks
0 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Rhythm Pharmaceuticals
3 Very Positive mention(s)
3 Positive mention(s)
8 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Rhythm Pharmaceuticals has a net margin of -85.59% compared to Zymeworks' net margin of -405.31%. Zymeworks' return on equity of -72.30% beat Rhythm Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Zymeworks-405.31% -72.30% -37.18%
Rhythm Pharmaceuticals -85.59%-159.87%-44.00%

Zymeworks currently has a consensus price target of $41.00, suggesting a potential upside of 54.31%. Rhythm Pharmaceuticals has a consensus price target of $140.67, suggesting a potential upside of 43.96%. Given Zymeworks' higher possible upside, equities analysts clearly believe Zymeworks is more favorable than Rhythm Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Zymeworks
1 Sell rating(s)
1 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.75
Rhythm Pharmaceuticals
1 Sell rating(s)
3 Hold rating(s)
17 Buy rating(s)
0 Strong Buy rating(s)
2.76

92.9% of Zymeworks shares are owned by institutional investors. 33.5% of Zymeworks shares are owned by company insiders. Comparatively, 5.9% of Rhythm Pharmaceuticals shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company is poised for long-term growth.

Zymeworks has higher earnings, but lower revenue than Rhythm Pharmaceuticals. Rhythm Pharmaceuticals is trading at a lower price-to-earnings ratio than Zymeworks, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Zymeworks$105.96M17.79-$81.13M-$2.02N/A
Rhythm Pharmaceuticals$189.76M35.29-$196.54M-$3.11N/A

Summary

Zymeworks beats Rhythm Pharmaceuticals on 9 of the 16 factors compared between the two stocks.

How does Zymeworks compare to Scholar Rock?

Scholar Rock (NASDAQ:SRRK) and Zymeworks (NASDAQ:ZYME) are both healthcare companies, but which is the better stock? We will contrast the two companies based on the strength of their analyst recommendations, institutional ownership, valuation, profitability, risk, earnings, dividends and media sentiment.

Scholar Rock has a net margin of 0.00% compared to Zymeworks' net margin of -405.31%. Zymeworks' return on equity of -72.30% beat Scholar Rock's return on equity.

Company Net Margins Return on Equity Return on Assets
Scholar RockN/A -160.19% -87.18%
Zymeworks -405.31%-72.30%-37.18%

91.1% of Scholar Rock shares are owned by institutional investors. Comparatively, 92.9% of Zymeworks shares are owned by institutional investors. 10.3% of Scholar Rock shares are owned by insiders. Comparatively, 33.5% of Zymeworks shares are owned by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.

Scholar Rock has a beta of 0.67, indicating that its stock price is 33% less volatile than the broader market. Comparatively, Zymeworks has a beta of 1.19, indicating that its stock price is 19% more volatile than the broader market.

Scholar Rock currently has a consensus target price of $66.00, indicating a potential upside of 41.48%. Zymeworks has a consensus target price of $41.00, indicating a potential upside of 54.31%. Given Zymeworks' higher possible upside, analysts plainly believe Zymeworks is more favorable than Scholar Rock.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Scholar Rock
2 Sell rating(s)
0 Hold rating(s)
12 Buy rating(s)
4 Strong Buy rating(s)
3.00
Zymeworks
1 Sell rating(s)
1 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.75

Zymeworks has higher revenue and earnings than Scholar Rock. Scholar Rock is trading at a lower price-to-earnings ratio than Zymeworks, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Scholar RockN/AN/A-$377.94M-$3.45N/A
Zymeworks$105.96M17.79-$81.13M-$2.02N/A

In the previous week, Scholar Rock had 29 more articles in the media than Zymeworks. MarketBeat recorded 33 mentions for Scholar Rock and 4 mentions for Zymeworks. Scholar Rock's average media sentiment score of 0.77 beat Zymeworks' score of 0.69 indicating that Scholar Rock is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Scholar Rock
14 Very Positive mention(s)
5 Positive mention(s)
5 Neutral mention(s)
2 Negative mention(s)
0 Very Negative mention(s)
Positive
Zymeworks
0 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Zymeworks beats Scholar Rock on 10 of the 16 factors compared between the two stocks.

How does Zymeworks compare to Mirum Pharmaceuticals?

Zymeworks (NASDAQ:ZYME) and Mirum Pharmaceuticals (NASDAQ:MIRM) are both healthcare companies, but which is the better stock? We will compare the two businesses based on the strength of their risk, dividends, valuation, analyst recommendations, media sentiment, earnings, profitability and institutional ownership.

In the previous week, Mirum Pharmaceuticals had 4 more articles in the media than Zymeworks. MarketBeat recorded 8 mentions for Mirum Pharmaceuticals and 4 mentions for Zymeworks. Zymeworks' average media sentiment score of 0.69 beat Mirum Pharmaceuticals' score of 0.62 indicating that Zymeworks is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Zymeworks
0 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Mirum Pharmaceuticals
4 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive

92.9% of Zymeworks shares are held by institutional investors. 33.5% of Zymeworks shares are held by insiders. Comparatively, 8.3% of Mirum Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company is poised for long-term growth.

Zymeworks presently has a consensus target price of $41.00, suggesting a potential upside of 54.31%. Mirum Pharmaceuticals has a consensus target price of $137.31, suggesting a potential upside of 49.53%. Given Zymeworks' higher possible upside, analysts clearly believe Zymeworks is more favorable than Mirum Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Zymeworks
1 Sell rating(s)
1 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.75
Mirum Pharmaceuticals
1 Sell rating(s)
0 Hold rating(s)
13 Buy rating(s)
1 Strong Buy rating(s)
2.93

Zymeworks has a beta of 1.19, meaning that its stock price is 19% more volatile than the broader market. Comparatively, Mirum Pharmaceuticals has a beta of 0.49, meaning that its stock price is 51% less volatile than the broader market.

Mirum Pharmaceuticals has higher revenue and earnings than Zymeworks. Zymeworks is trading at a lower price-to-earnings ratio than Mirum Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Zymeworks$105.96M17.79-$81.13M-$2.02N/A
Mirum Pharmaceuticals$521.31M11.44-$23.36M-$14.55N/A

Mirum Pharmaceuticals has a net margin of -139.18% compared to Zymeworks' net margin of -405.31%. Mirum Pharmaceuticals' return on equity of -36.28% beat Zymeworks' return on equity.

Company Net Margins Return on Equity Return on Assets
Zymeworks-405.31% -72.30% -37.18%
Mirum Pharmaceuticals -139.18%-36.28%-8.54%

Summary

Mirum Pharmaceuticals beats Zymeworks on 10 of the 17 factors compared between the two stocks.

How does Zymeworks compare to CG Oncology?

Zymeworks (NASDAQ:ZYME) and CG Oncology (NASDAQ:CGON) are both healthcare companies, but which is the superior business? We will contrast the two businesses based on the strength of their institutional ownership, profitability, analyst recommendations, media sentiment, earnings, risk, valuation and dividends.

In the previous week, CG Oncology had 3 more articles in the media than Zymeworks. MarketBeat recorded 7 mentions for CG Oncology and 4 mentions for Zymeworks. CG Oncology's average media sentiment score of 0.82 beat Zymeworks' score of 0.69 indicating that CG Oncology is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Zymeworks
0 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
CG Oncology
4 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Zymeworks has a net margin of -405.31% compared to CG Oncology's net margin of -3,602.68%. CG Oncology's return on equity of -25.20% beat Zymeworks' return on equity.

Company Net Margins Return on Equity Return on Assets
Zymeworks-405.31% -72.30% -37.18%
CG Oncology -3,602.68%-25.20%-23.98%

Zymeworks presently has a consensus target price of $41.00, suggesting a potential upside of 54.31%. CG Oncology has a consensus target price of $87.78, suggesting a potential upside of 17.63%. Given Zymeworks' stronger consensus rating and higher probable upside, analysts plainly believe Zymeworks is more favorable than CG Oncology.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Zymeworks
1 Sell rating(s)
1 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.75
CG Oncology
1 Sell rating(s)
1 Hold rating(s)
9 Buy rating(s)
0 Strong Buy rating(s)
2.73

Zymeworks has a beta of 1.19, indicating that its share price is 19% more volatile than the broader market. Comparatively, CG Oncology has a beta of 0.24, indicating that its share price is 76% less volatile than the broader market.

92.9% of Zymeworks shares are held by institutional investors. Comparatively, 26.6% of CG Oncology shares are held by institutional investors. 33.5% of Zymeworks shares are held by insiders. Comparatively, 4.8% of CG Oncology shares are held by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock is poised for long-term growth.

Zymeworks has higher revenue and earnings than CG Oncology. CG Oncology is trading at a lower price-to-earnings ratio than Zymeworks, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Zymeworks$105.96M17.79-$81.13M-$2.02N/A
CG Oncology$4.04M1,637.21-$160.99M-$2.69N/A

Summary

Zymeworks beats CG Oncology on 11 of the 16 factors compared between the two stocks.

How does Zymeworks compare to Travere Therapeutics?

Zymeworks (NASDAQ:ZYME) and Travere Therapeutics (NASDAQ:TVTX) are both healthcare companies, but which is the better stock? We will compare the two businesses based on the strength of their dividends, analyst recommendations, valuation, earnings, risk, institutional ownership, profitability and media sentiment.

Travere Therapeutics has higher revenue and earnings than Zymeworks. Travere Therapeutics is trading at a lower price-to-earnings ratio than Zymeworks, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Zymeworks$105.96M17.79-$81.13M-$2.02N/A
Travere Therapeutics$490.73M12.06-$25.55M-$0.46N/A

Zymeworks has a beta of 1.19, suggesting that its stock price is 19% more volatile than the broader market. Comparatively, Travere Therapeutics has a beta of 1.05, suggesting that its stock price is 5% more volatile than the broader market.

Travere Therapeutics has a net margin of -7.35% compared to Zymeworks' net margin of -405.31%. Travere Therapeutics' return on equity of -55.15% beat Zymeworks' return on equity.

Company Net Margins Return on Equity Return on Assets
Zymeworks-405.31% -72.30% -37.18%
Travere Therapeutics -7.35%-55.15%-6.88%

In the previous week, Travere Therapeutics had 33 more articles in the media than Zymeworks. MarketBeat recorded 37 mentions for Travere Therapeutics and 4 mentions for Zymeworks. Zymeworks' average media sentiment score of 0.69 beat Travere Therapeutics' score of 0.25 indicating that Zymeworks is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Zymeworks
0 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Travere Therapeutics
16 Very Positive mention(s)
7 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

92.9% of Zymeworks shares are owned by institutional investors. 33.5% of Zymeworks shares are owned by company insiders. Comparatively, 4.4% of Travere Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock will outperform the market over the long term.

Zymeworks presently has a consensus price target of $41.00, indicating a potential upside of 54.31%. Travere Therapeutics has a consensus price target of $68.00, indicating a potential upside of 8.35%. Given Zymeworks' higher possible upside, equities analysts plainly believe Zymeworks is more favorable than Travere Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Zymeworks
1 Sell rating(s)
1 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.75
Travere Therapeutics
1 Sell rating(s)
1 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.75

Summary

Zymeworks and Travere Therapeutics tied by winning 7 of the 14 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding ZYME and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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ZYME vs. The Competition

MetricZymeworksBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$1.95B$3.92B$7.25B$13.14B
Dividend YieldN/A3.65%2.57%12.30%
P/E Ratio-13.1514.30275.7925.40
Price / Sales17.791,415.50695.58114.44
Price / CashN/A110.7577.4251.66
Price / Book7.4015.4510.466.33
Net Income-$81.13M-$22.86M$3.49B$358.33M
7 Day Performance1.26%-1.21%0.59%1.12%
1 Month Performance-2.35%-4.42%-2.01%-2.67%
1 Year Performance63.51%37.81%18.09%6.01%

Zymeworks Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
ZYME
Zymeworks
2.9098 of 5 stars
$26.57
-3.3%
$41.00
+54.3%
+61.1%$1.95B$105.96MN/A264
RYTM
Rhythm Pharmaceuticals
2.7793 of 5 stars
$104.71
+2.5%
$141.12
+34.8%
-0.8%$7.00B$189.76MN/A414
SRRK
Scholar Rock
3.6695 of 5 stars
$55.41
-0.5%
$58.77
+6.1%
+43.6%$6.78BN/AN/A289
MIRM
Mirum Pharmaceuticals
3.0443 of 5 stars
$98.22
-2.4%
$137.31
+39.8%
+21.9%$6.53B$618.07MN/A433
CGON
CG Oncology
2.852 of 5 stars
$72.35
+0.5%
$87.78
+21.3%
+92.2%$6.38B$6.23MN/A142

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This page (NASDAQ:ZYME) was last updated on 9/19/2026 by MarketBeat.com Staff.
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