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Karyopharm Therapeutics (KPTI) Institutional Ownership

Karyopharm Therapeutics logo
$1.62 0.00 (0.00%)
Closing price 09/28/2026 04:00 PM Eastern
Extended Trading
$1.65 +0.03 (+1.85%)
As of 07:17 AM Eastern
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Institutional Ownership Changes (13F Filings) for Karyopharm Therapeutics (NASDAQ:KPTI)

Current
Institutional Ownership
Percentage
66.44%
Number of
Institutional Buyers
(last 12 months)
24
Total
Institutional Inflows
(last 12 months)
$29.55M
Number of
Institutional Sellers
(last 12 months)
12
Total
Institutional Outflows
(last 12 months)
$515.89M
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KPTI Institutional Buying and Selling by Quarter

Karyopharm Therapeutics Major Shareholders & Ownership History

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Reporting DateMajor Shareholder NameShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
9/9/2026Engineers Gate Manager LP33,966$332K0.0%-69.8%0.150%
9/9/2026Squarepoint Ops LLC63,801$623K0.0%N/A0.281%
8/20/2026Headlands Technologies LLC12,113$118K0.0%N/A0.053%
8/6/2026Bank of New York Mellon Corp57,262$559K0.0%N/A0.253%
5/28/2026Avidity Partners Management LP463,741$2.58M0.5%+244.6%2.047%
5/19/2026Bank of America Corp DE19,472$108K0.0%-59.5%0.086%
5/18/2026Royal Bank of Canada60,399$336K0.0%+4.1%0.267%
5/15/2026Commodore Capital LP1,950,000$10.86M0.6%N/A8.647%
5/15/2026OMERS ADMINISTRATION Corp19,400$108K0.0%N/A0.086%
5/15/2026Affinity Asset Advisors LLC500,000$2.79M0.1%-43.8%2.217%
5/14/2026Renaissance Technologies LLC105,414$587K0.0%+75.9%0.467%
4/30/2026Hsbc Holdings PLC11,495$66K0.0%N/A0.051%
3/9/2026Corient Private Wealth LLC10,039$74K0.0%N/A0.055%
2/19/2026T. Rowe Price Investment Management Inc.1,491,409$10.98M0.0%+112.8%8.132%
2/19/2026Corient Private Wealth LLC10,039$74K0.0%N/A0.055%
2/18/2026XTX Topco Ltd11,904$88K0.0%-17.3%0.065%
2/18/2026Ikarian Capital LLC544,554$4.01M0.3%+1,897.9%2.974%
2/18/2026Tudor Investment Corp ET AL12,922$95K0.0%N/A0.071%
2/18/2026Quadrature Capital Ltd59,708$439K0.0%N/A0.326%
2/18/2026Opaleye Management Inc.930,000$6.85M0.9%-84.5%5.079%
2/18/2026Bridgeway Capital Management LLC65,873$485K0.0%+88.9%0.360%
2/18/2026Boothbay Fund Management LLC144,628$1.06M0.0%N/A0.790%
2/17/2026ADAR1 Capital Management LLC50,000$368K0.0%+100.0%0.273%
2/17/2026Braidwell LP303,370$2.23M0.1%-99.4%1.657%
2/17/2026Trexquant Investment LP41,733$307K0.0%N/A0.228%
2/17/2026Jump Financial LLC53,816$396K0.0%N/A0.294%
2/17/2026T. Rowe Price Investment Management Inc.585,908$4.31M0.0%-16.4%3.200%
2/17/2026Royal Bank of Canada58,000$427K0.0%+761.3%0.317%
2/17/2026Persistent Asset Partners Ltd18,316$135K0.1%N/A0.100%
2/16/2026Context Capital Management LLC62,995$464K0.0%N/A0.344%
2/13/2026Walleye Capital LLC95,672$704K0.0%N/A0.523%
2/13/2026Affinity Asset Advisors LLC889,575$6.55M0.4%-94.2%4.858%
2/13/2026Exome Asset Management LLC295,541$2.18M1.0%-84.9%1.614%
2/13/2026State Street Corp58,942$434K0.0%+27.2%0.322%
2/12/2026Renaissance Technologies LLC59,914$441K0.0%-7.4%0.327%
2/9/2026Geode Capital Management LLC187,734$1.38M0.0%+101.2%1.025%
11/14/2025ADAR1 Capital Management LLC25,000$164K0.0%N/A0.147%
11/14/2025Bridgeway Capital Management LLC34,873$228K0.0%-7.8%0.205%
11/14/2025Silverback Asset Management LLC40,000$262K0.0%-42.9%0.235%
11/7/2025Vanguard Group Inc.408,222$2.67M0.0%-21.2%4.708%
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8/15/2025Bridgeway Capital Management LLC37,836$163K0.0%N/A0.436%
8/15/2025Bank of America Corp DE168,534$726K0.0%+26.8%1.944%
8/13/2025Baird Financial Group Inc.10,532$45K0.0%N/A0.122%
8/13/2025Silverback Asset Management LLC70,000$302K0.0%+40.0%0.810%
8/12/2025XTX Topco Ltd13,056$56K0.0%N/A0.151%
8/8/2025Geode Capital Management LLC91,841$396K0.0%-7.8%1.063%
6/27/2025Goldman Sachs Group Inc.85,410$319K0.0%-93.6%0.989%
5/19/2025Jane Street Group LLC11,420$43K0.0%-98.5%0.132%
5/16/2025Goldman Sachs Group Inc.85,410$319K0.0%-93.6%0.997%
5/16/2025Adage Capital Partners GP L.L.C.421,322$1.58M0.0%-93.3%4.916%
5/15/2025Birchview Capital LP27,985$105K0.1%-93.3%0.327%
5/15/2025Palo Alto Investors LP324,032$1.21M0.2%-93.4%3.781%
5/14/2025T. Rowe Price Investment Management Inc.139,646$523K0.0%N/A1.629%
5/13/2025Altium Capital Management LLC49,333$185K0.4%-93.3%0.576%
5/5/2025C WorldWide Group Holding A S100,000$374K0.0%-93.3%1.167%
4/29/2025Bank of New York Mellon Corp11,086$41K0.0%-93.3%0.129%
2/17/2025Velan Capital Investment Management LP40,000$27K0.0%N/A0.032%
2/17/2025Two Sigma Advisers LP76,600$52K0.0%+145.5%0.061%
2/17/2025Two Sigma Investments LP137,786$93K0.0%+60.3%0.109%
2/17/2025Shay Capital LLC172,153$116K0.0%N/A0.136%
2/17/2025Millennium Management LLC1,154,414$781K0.0%-8.0%0.915%
2/17/2025Focus Partners Wealth45,818$31K0.0%N/A0.036%
2/17/2025D. E. Shaw & Co. Inc.229,685$155K0.0%-78.1%0.182%
2/17/2025Cubist Systematic Strategies LLC328,807$222K0.0%-33.7%0.261%
2/17/2025Bank of America Corp DE161,708$109K0.0%-29.4%0.128%
2/17/2025BNP Paribas Financial Markets1,313,893$889K0.0%-33.7%1.041%
2/14/2025Jane Street Group LLC748,306$506K0.0%+265.5%0.593%
2/14/2025Northern Trust Corp283,729$192K0.0%+23.5%0.225%
2/14/2025Birchview Capital LP419,832$284K0.2%-10.6%0.333%
2/14/2025Opti Capital Management LP125,000$85K0.0%N/A0.099%
2/14/2025Adage Capital Partners GP L.L.C.6,319,842$4.27M0.0%+46.3%5.008%
2/14/2025Price T Rowe Associates Inc. MD64,300$44K0.0%-52.3%0.051%
2/14/2025Silverarc Capital Management LLC595,990$403K0.1%+6.7%0.472%
2/14/2025Eversept Partners LP2,088,757$1.41M0.1%-62.4%1.655%
2/14/2025TD Waterhouse Canada Inc.48,049$32K0.0%N/A0.038%
2/13/2025Marshall Wace LLP2,401,413$1.63M0.0%+15.3%1.903%
2/13/2025Renaissance Technologies LLC1,202,590$813K0.0%-3.1%0.953%
2/12/2025Geode Capital Management LLC1,392,314$942K0.0%+2.7%1.103%
11/19/2024Barclays PLC95,767$79K0.0%-89.0%0.076%
11/16/2024Geode Capital Management LLC1,355,392$1.13M0.0%+3.3%1.082%
11/15/2024Barclays PLC95,767$79K0.0%-89.0%0.076%
11/15/2024Jane Street Group LLC204,750$170K0.0%-86.8%0.163%
11/15/2024State Street Corp409,510$340K0.0%-9.8%0.327%
11/15/2024Point72 Asia Singapore Pte. Ltd.82,446$68K0.0%-50.1%0.066%
11/13/2024BNP Paribas Financial Markets1,982,354$1.65M0.0%-12.8%1.582%
11/13/2024FMR LLC369,723$307K0.0%+26.1%0.295%
11/5/2024GSA Capital Partners LLP1,775,700$1.47M0.1%+80.6%1.424%
10/10/2024Exchange Traded Concepts LLC218,791$182K0.0%+34.9%0.176%
9/16/2024Point72 DIFC Ltd35,939$31K0.0%N/A0.029%
9/16/2024Cubist Systematic Strategies LLC568,975$494K0.0%N/A0.456%
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9/16/2024Point72 Asia Singapore Pte. Ltd.165,318$143K0.0%N/A0.133%
8/15/2024AQR Capital Management LLC748,020$649K0.0%+494.5%0.600%
8/15/2024Point72 Asia Singapore Pte. Ltd.165,318$143K0.0%N/A0.133%
8/14/2024Cubist Systematic Strategies LLC568,975$494K0.0%N/A0.457%
8/14/2024Point72 DIFC Ltd35,939$31K0.0%N/A0.029%
8/14/2024Marshall Wace LLP2,580,863$2.25M0.0%-0.6%2.071%
8/12/2024XTX Topco Ltd140,576$122K0.0%-42.1%0.113%
8/9/2024Renaissance Technologies LLC756,227$656K0.0%-16.6%0.607%
8/6/2024Acadian Asset Management LLC194,168$167K0.0%N/A0.156%
8/6/2024Los Angeles Capital Management LLC354,020$307K0.0%-8.6%0.284%


KPTI Institutional Ownership - Frequently Asked Questions

During the previous two years, 62 institutional investors and hedge funds held shares of Karyopharm Therapeutics. The most heavily invested institutionals were T. Rowe Price Investment Management Inc. ($10.98M), Commodore Capital LP ($10.86M), Opaleye Management Inc. ($6.85M), Ikarian Capital LLC ($4.01M), Affinity Asset Advisors LLC ($2.79M), Vanguard Group Inc. ($2.67M), and Avidity Partners Management LP ($2.58M).Learn more on Karyopharm Therapeutics' institutional investors.

66.44% of Karyopharm Therapeutics' stock is owned by institutional investors. Learn more on KPTI's institutional investor holdings.

Of the 43 institutional investors that purchased Karyopharm Therapeutics' stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: Adage Capital Partners GP L.L.C. ($2M), Commodore Capital LP ($1.95M), T. Rowe Price Investment Management Inc. ($930.06K), GSA Capital Partners LLP ($792.28K), Jane Street Group LLC ($543.56K), Ikarian Capital LLC ($517.30K), and Avidity Partners Management LP ($329.18K).

Institutional investors have bought a total of 4,548,038 shares in the last 24 months. This purchase volume represents approximately $29.55M in transactions.

Of the 12 institutional investors that sold Karyopharm Therapeutics' stock in the last 24 months, the following investors and hedge funds have sold the highest volume of shares: Braidwell LP ($48.18M), Affinity Asset Advisors LLC ($14.91M), Opaleye Management Inc. ($5.07M), Exome Asset Management LLC ($1.66M), T. Rowe Price Investment Management Inc. ($115.08K), Vanguard Group Inc. ($110.05K), and Engineers Gate Manager LP ($78.47K).

Institutional investors have sold a total of 70,185,063 shares in the last 24 months. This volume of shares sold represents approximately $515.89M in transactions.


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Institutional ownership data for NASDAQ:KPTI is compiled from quarterly 13F filings submitted to the U.S. Securities and Exchange Commission (SEC), with the most recent received on 9/9/2026. New 13F filings are added each quarter as they're published.
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