| 5/5/2026 | Bank of New York Mellon Corp | 28,358 | $31K | 0.0% | -6.9% | 0.208% | |
| 4/27/2026 | Simplify Asset Management Inc. | 438,932 | $487K | 0.0% | N/A | 0.322% | |
| 2/26/2026 | Seven Fleet Capital Management LP | 155,223 | $83K | 0.1% | N/A | 0.119% | |
| 2/19/2026 | Connective Capital Management LLC | 301,296 | $161K | 0.1% | N/A | 0.250% | |
| 2/18/2026 | XTX Topco Ltd | 225,271 | $120K | 0.0% | N/A | 0.187% | |
| 2/18/2026 | Ikarian Capital LLC | 674,662 | $360K | 0.0% | -26.2% | 0.561% | |
| 2/18/2026 | Millennium Management LLC | 3,419,299 | $1.83M | 0.0% | +544.6% | 2.843% | |
| 2/18/2026 | Boothbay Fund Management LLC | 130,585 | $70K | 0.0% | -45.8% | 0.109% | |
| 2/17/2026 | Laurion Capital Management LP | 3,882,162 | $2.07M | 0.1% | +106.3% | 3.227% | |
| 2/16/2026 | Squarepoint Ops LLC | 352,875 | $188K | 0.0% | +29.9% | 0.293% | |
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| 2/13/2026 | Nantahala Capital Management LLC | 4,378,406 | $2.34M | 0.1% | N/A | 3.640% | |
| 2/13/2026 | Marshall Wace LLP | 1,019,983 | $541K | 0.0% | +91.2% | 0.848% | |
| 2/12/2026 | Jane Street Group LLC | 286,677 | $153K | 0.0% | +46.8% | 0.238% | |
| 2/9/2026 | Geode Capital Management LLC | 1,176,285 | $628K | 0.0% | +13.8% | 0.978% | |
| 11/17/2025 | Laurion Capital Management LP | 1,882,162 | $1.66M | 0.0% | -1.2% | 1.908% | |
| 11/17/2025 | Qube Research & Technologies Ltd | 32,669 | $29K | 0.0% | N/A | 0.033% | |
| 11/17/2025 | Millennium Management LLC | 530,470 | $468K | 0.0% | +414.5% | 0.538% | |
| 11/17/2025 | Focus Partners Wealth | 2,581,587 | $2.28M | 0.0% | +1.5% | 2.617% | |
| 11/14/2025 | Virtu Financial LLC | 112,287 | $99K | 0.0% | N/A | 0.114% | |
| 11/14/2025 | Two Sigma Investments LP | 58,681 | $52K | 0.0% | N/A | 0.059% | |
| 11/14/2025 | Squarepoint Ops LLC | 271,574 | $239K | 0.0% | N/A | 0.275% | |
| 11/7/2025 | GSA Capital Partners LLP | 192,923 | $170K | 0.0% | N/A | 0.196% | |
| 11/7/2025 | Vanguard Group Inc. | 4,345,105 | $3.83M | 0.0% | +5.3% | 4.405% | |
| 10/23/2025 | HB Wealth Management LLC | 91,450 | $81K | 0.0% | N/A | 0.093% | |
| 8/15/2025 | Boothbay Fund Management LLC | 240,873 | $168K | 0.0% | -43.3% | 0.244% | |
| 8/15/2025 | BVF Inc. IL | 7,652,972 | $5.34M | 0.2% | -14.0% | 7.758% | |
| 8/15/2025 | 683 Capital Management LLC | 62,458 | $44K | 0.0% | -93.1% | 0.063% | |
| 8/13/2025 | Marshall Wace LLP | 49,991 | $35K | 0.0% | -91.1% | 0.051% | |
| 7/24/2025 | Aberdeen Group plc | 8,243,941 | $5.75M | 0.0% | +678.1% | 8.604% | |
| 5/20/2025 | Focus Partners Wealth | 2,583,457 | $2.82M | 0.0% | +19.1% | 2.696% | |
| 5/19/2025 | Jane Street Group LLC | 207,401 | $226K | 0.0% | +279.3% | 0.216% | |
| 5/16/2025 | 683 Capital Management LLC | 900,000 | $981K | 0.1% | +28.6% | 0.939% | |
| 5/13/2025 | Aberdeen Group plc | 1,059,484 | $1.16M | 0.0% | N/A | 1.106% | |
| 5/12/2025 | Connor Clark & Lunn Investment Management Ltd. | 120,027 | $131K | 0.0% | -24.6% | 0.125% | |
| 5/7/2025 | HB Wealth Management LLC | 52,400 | $57K | 0.0% | -33.2% | 0.055% | |
| 2/17/2025 | Two Sigma Investments LP | 157,204 | $157K | 0.0% | -40.2% | 0.175% | |
| 2/17/2025 | OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC | 204,579 | $205K | 0.0% | +90.0% | 0.227% | |
| 2/17/2025 | Millennium Management LLC | 579,683 | $580K | 0.0% | +480.6% | 0.644% | |
| 2/17/2025 | Janus Henderson Group PLC | 2,689,082 | $2.69M | 0.0% | -47.3% | 2.985% | |
| 2/17/2025 | Focus Partners Wealth | 2,168,353 | $2.17M | 0.0% | +1.1% | 2.407% | |
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| 2/17/2025 | Bridgeway Capital Management LLC | 215,000 | $215K | 0.0% | +11.5% | 0.239% | |
| 2/17/2025 | 683 Capital Management LLC | 700,000 | $700K | 0.0% | +2.2% | 0.777% | |
| 2/14/2025 | Jane Street Group LLC | 54,675 | $55K | 0.0% | -22.2% | 0.061% | |
| 2/14/2025 | Adage Capital Partners GP L.L.C. | 1,398,600 | $1.40M | 0.0% | -75.0% | 1.553% | |
| 2/13/2025 | Marshall Wace LLP | 417,883 | $418K | 0.0% | -10.4% | 0.464% | |
| 2/13/2025 | Barclays PLC | 84,299 | $84K | 0.0% | N/A | 0.094% | |
| 2/13/2025 | Renaissance Technologies LLC | 566,623 | $567K | 0.0% | +45.6% | 0.629% | |
| 2/13/2025 | Invesco Ltd. | 36,811 | $37K | 0.0% | N/A | 0.041% | |
| 1/15/2025 | HB Wealth Management LLC | 78,400 | $81K | 0.0% | N/A | 0.087% | |
| 11/20/2024 | Virtu Financial LLC | 30,359 | $50K | 0.0% | N/A | 0.034% | |
| 11/15/2024 | XTX Topco Ltd | 28,957 | $48K | 0.0% | -53.4% | 0.032% | |
| 11/15/2024 | Jane Street Group LLC | 70,299 | $116K | 0.0% | +121.4% | 0.078% | |
| 11/15/2024 | State Street Corp | 167,145 | $276K | 0.0% | +7.5% | 0.186% | |
| 11/15/2024 | Janus Henderson Group PLC | 5,099,278 | $8.44M | 0.0% | -27.9% | 5.661% | |
| 11/8/2024 | Connor Clark & Lunn Investment Management Ltd. | 102,257 | $169K | 0.0% | +70.8% | 0.114% | |
| 11/5/2024 | GSA Capital Partners LLP | 32,766 | $54K | 0.0% | -71.9% | 0.036% | |
| 8/14/2024 | Marshall Wace LLP | 39,621 | $44K | 0.0% | -20.0% | 0.044% | |
| 8/9/2024 | Renaissance Technologies LLC | 291,087 | $323K | 0.0% | -61.0% | 0.323% | |
| 5/20/2024 | Virtu Financial LLC | 19,088 | $25K | 0.0% | N/A | 0.021% | |
| 5/17/2024 | Ikarian Capital LLC | 1,612,378 | $2.13M | 0.2% | +258.3% | 1.790% | |
| 5/16/2024 | Janus Henderson Group PLC | 6,993,007 | $9.27M | 0.0% | N/A | 7.763% | |
| 5/16/2024 | BVF Inc. IL | 8,902,972 | $11.75M | 0.3% | N/A | 9.884% | |
| 5/10/2024 | Acadian Asset Management LLC | 239,962 | $316K | 0.0% | -57.1% | 0.266% | |
| 5/10/2024 | Vanguard Group Inc. | 3,394,047 | $4.48M | 0.0% | +100.7% | 3.768% | |
| 4/23/2024 | Summit Trail Advisors LLC | 18,600 | $25K | 0.0% | N/A | 0.021% | |
| 2/22/2024 | Sierra Summit Advisors LLC | 324,829 | $487K | 0.1% | N/A | 0.719% | |
| 2/7/2024 | Gratus Capital LLC | 1,941,454 | $2.91M | 0.2% | +15.1% | 4.300% | |
| 1/12/2024 | Sweet Financial Partners LLC | 29,829 | $45K | 0.0% | N/A | 0.066% | |
| 11/15/2023 | RTW Investments LP | 4,335,255 | $6.37M | 0.1% | +0.9% | 9.720% | |
| 11/13/2023 | Connor Clark & Lunn Investment Management Ltd. | 24,773 | $36K | 0.0% | -77.0% | 0.056% | |
| 11/13/2023 | Acadian Asset Management LLC | 757,250 | $1.11M | 0.0% | +26.8% | 1.698% | |
| 11/9/2023 | Cowen AND Company LLC | 317,059 | $466K | 0.0% | -11.4% | 0.711% | |
| 11/9/2023 | Innovis Asset Management LLC | 272,457 | $401K | 0.2% | +46.3% | 0.611% | |
| 8/14/2023 | Deep Track Capital LP | 308,314 | $774K | 0.0% | -87.8% | 0.691% | |
| 8/8/2023 | Balboa Wealth Partners | 12,000 | $30K | 0.0% | N/A | 0.027% | |
| 8/7/2023 | Acadian Asset Management LLC | 597,277 | $1.50M | 0.0% | +439.2% | 1.339% | |
| 8/3/2023 | Innovis Asset Management LLC | 186,240 | $467K | 0.2% | +130.6% | 0.419% | |
| 8/3/2023 | Gratus Capital LLC | 1,678,793 | $4.21M | 0.3% | +1.4% | 3.781% | |
| 7/27/2023 | Virtu Financial LLC | 67,424 | $169K | 0.0% | N/A | 0.152% | |
| 7/24/2023 | Vontobel Holding Ltd. | 10,000 | $25K | 0.0% | N/A | 0.023% | |
| 5/15/2023 | Logos Global Management LP | 421,184 | $628K | 0.1% | N/A | 0.949% | |
| 5/15/2023 | RTW Investments LP | 4,294,459 | $6.40M | 0.1% | +11.2% | 9.671% | |
| 5/10/2023 | Innovis Asset Management LLC | 80,773 | $120K | 0.0% | N/A | 0.182% | |
| 5/10/2023 | Connor Clark & Lunn Investment Management Ltd. | 86,907 | $129K | 0.0% | N/A | 0.196% | |
| 5/9/2023 | Cowen AND Company LLC | 357,855 | $533K | 0.1% | -54.8% | 0.806% | |
| 4/20/2023 | Gratus Capital LLC | 1,655,405 | $2.47M | 0.2% | -0.8% | 3.728% | |
| 2/14/2023 | RA Capital Management L.P. | 632,184 | $885K | 0.0% | N/A | 1.425% | |
| 2/13/2023 | Vivo Capital LLC | 632,184 | $833K | 0.1% | N/A | 1.425% | |
| 2/13/2023 | Artal Group S.A. | 1,274,713 | $1.79M | 0.1% | +82.1% | 2.874% | |
| 2/9/2023 | Cowen AND Company LLC | 791,024 | $1.11M | 0.1% | -34.1% | 1.783% | |
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| 1/27/2023 | Gratus Capital LLC | 1,668,294 | $2.34M | 0.2% | +121.5% | 3.761% | |
| 11/15/2022 | Parkman Healthcare Partners LLC | 657,643 | $2.08M | 0.6% | +1.2% | 1.675% | |
| 11/14/2022 | Lynx1 Capital Management LP | 1,072,288 | $3.39M | 3.1% | -2.9% | 2.731% | |
| 11/14/2022 | Verition Fund Management LLC | 698,934 | $2.21M | 0.0% | +14.6% | 1.780% | |
| 11/14/2022 | Ergoteles LLC | 24,725 | $78K | 0.0% | -72.6% | 0.063% | |
| 11/14/2022 | UBS Oconnor LLC | 197,988 | $626K | 0.0% | -14.9% | 0.504% | |
| 11/4/2022 | Gratus Capital LLC | 753,190 | $2.38M | 0.3% | N/A | 2.464% | |
| 10/25/2022 | Denali Advisors LLC | 17,000 | $54K | 0.0% | N/A | 0.056% | |
| 8/30/2022 | Verition Fund Management LLC | 609,765 | $2.12M | 0.0% | +331.5% | 1.995% | |
| 8/16/2022 | Corton Capital Inc. | 12,142 | $42K | 0.0% | N/A | 0.040% | |