Free Trial
→ Everyone’s watching Nvidia right now. Here’s why I’m excited. (From Timothy Sykes) (Ad) Buy KPTI Stock  Free KPTI Stock Alerts

Karyopharm Therapeutics (KPTI) Institutional Ownership

Karyopharm Therapeutics logo
$4.53 +0.05 (+1.12%)
Closing price 04:00 PM Eastern
Extended Trading
$4.53 0.00 (-0.11%)
As of 04:04 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.
Compare

Institutional Ownership Changes (13F Filings) for Karyopharm Therapeutics (NASDAQ:KPTI)

Current
Institutional Ownership
Percentage
66.44%
Number of
Institutional Buyers
(last 12 months)
22
Total
Institutional Inflows
(last 12 months)
$78.97M
Number of
Institutional Sellers
(last 12 months)
22
Total
Institutional Outflows
(last 12 months)
$161.10M
Get KPTI Insider Trade Alerts

Want to know when executives and insiders are buying or selling Karyopharm Therapeutics stock? Sign up for InsiderTrades.com's daily newsletter to get the latest insider transactions delivered to your inbox daily.

Skip Chart & View Institutional Buying and Selling Data

KPTI Institutional Buying and Selling by Quarter

Karyopharm Therapeutics Major Shareholders & Ownership History

Export to Excel
Reporting DateMajor Shareholder NameShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
5/19/2025 Jane Street Group LLC11,420$43K0.0%-98.5%0.132%
5/16/2025 Goldman Sachs Group Inc.85,410$319K0.0%-93.6%0.997%
5/16/2025 Adage Capital Partners GP L.L.C.421,322$1.58M0.0%-93.3%4.916%
5/15/2025 Birchview Capital LP27,985$105K0.1%-93.3%0.327%
5/15/2025 Palo Alto Investors LP324,032$1.21M0.2%-93.4%3.781%
5/14/2025 T. Rowe Price Investment Management Inc.139,646$523K0.0%N/A1.629%
5/13/2025 Altium Capital Management LLC49,333$185K0.4%-93.3%0.576%
5/5/2025 C WorldWide Group Holding A S100,000$374K0.0%-93.3%1.167%
4/29/2025 Bank of New York Mellon Corp11,086$41K0.0%-93.3%0.129%
2/17/2025 Velan Capital Investment Management LP40,000$27K0.0%N/A0.032%
2/17/2025 Two Sigma Advisers LP76,600$52K0.0%+145.5%0.061%
2/17/2025 Two Sigma Investments LP137,786$93K0.0%+60.3%0.109%
2/17/2025 Shay Capital LLC172,153$116K0.0%N/A0.136%
2/17/2025 Millennium Management LLC1,154,414$781K0.0%-8.0%0.915%
2/17/2025 Focus Partners Wealth45,818$31K0.0%N/A0.036%
2/17/2025 D. E. Shaw & Co. Inc.229,685$155K0.0%-78.1%0.182%
2/17/2025 Cubist Systematic Strategies LLC328,807$222K0.0%-33.7%0.261%
2/17/2025 Bank of America Corp DE161,708$109K0.0%-29.4%0.128%
2/17/2025 BNP Paribas Financial Markets1,313,893$889K0.0%-33.7%1.041%
2/14/2025 Jane Street Group LLC748,306$506K0.0%+265.5%0.593%
2/14/2025 Northern Trust Corp283,729$192K0.0%+23.5%0.225%
2/14/2025 Birchview Capital LP419,832$284K0.2%-10.6%0.333%
2/14/2025 Opti Capital Management LP125,000$85K0.0%N/A0.099%
2/14/2025 Adage Capital Partners GP L.L.C.6,319,842$4.27M0.0%+46.3%5.008%
2/14/2025 Price T Rowe Associates Inc. MD64,300$44K0.0%-52.3%0.051%
2/14/2025 Silverarc Capital Management LLC595,990$403K0.1%+6.7%0.472%
2/14/2025 Eversept Partners LP2,088,757$1.41M0.1%-62.4%1.655%
2/14/2025 TD Waterhouse Canada Inc.48,049$32K0.0%N/A0.038%
2/13/2025 Marshall Wace LLP2,401,413$1.63M0.0%+15.3%1.903%
2/13/2025 Renaissance Technologies LLC1,202,590$813K0.0%-3.1%0.953%
2/12/2025 Geode Capital Management LLC1,392,314$942K0.0%+2.7%1.103%
11/19/2024 Barclays PLC95,767$79K0.0%-89.0%0.076%
11/16/2024 Geode Capital Management LLC1,355,392$1.13M0.0%+3.3%1.082%
11/15/2024 Barclays PLC95,767$79K0.0%-89.0%0.076%
11/15/2024 Jane Street Group LLC204,750$170K0.0%-86.8%0.163%
11/15/2024 State Street Corp409,510$340K0.0%-9.8%0.327%
11/15/2024 Point72 Asia Singapore Pte. Ltd.82,446$68K0.0%-50.1%0.066%
11/13/2024 BNP Paribas Financial Markets1,982,354$1.65M0.0%-12.8%1.582%
11/13/2024 FMR LLC369,723$307K0.0%+26.1%0.295%
11/5/2024 GSA Capital Partners LLP1,775,700$1.47M0.1%+80.6%1.424%
Missed Nvidia? Trump’s Trade War Could Create a Bigger Winner (Ad)

Missed out on Nvidia? Don’t worry — a bigger AI opportunity may be emerging right now, thanks to Trump’s newly announced tariffs. One under-the-radar U.S. semiconductor stock just gained a major edge over its foreign rivals. With demand poised to skyrocket, this chipmaker could be perfectly positioned to ride the next wave of AI growth. Shares are still flying low — but not for long.

Trump’s new tariffs could spark the next AI boom — here’s the chip stock set to soar.
10/10/2024 Exchange Traded Concepts LLC218,791$182K0.0%+34.9%0.176%
9/16/2024 Point72 DIFC Ltd35,939$31K0.0%N/A0.029%
9/16/2024 Cubist Systematic Strategies LLC568,975$494K0.0%N/A0.456%
9/16/2024 Point72 Asia Singapore Pte. Ltd.165,318$143K0.0%N/A0.133%
8/15/2024 AQR Capital Management LLC748,020$649K0.0%+494.5%0.600%
8/15/2024 Point72 Asia Singapore Pte. Ltd.165,318$143K0.0%N/A0.133%
8/14/2024 Cubist Systematic Strategies LLC568,975$494K0.0%N/A0.457%
8/14/2024 Point72 DIFC Ltd35,939$31K0.0%N/A0.029%
8/14/2024 Marshall Wace LLP2,580,863$2.25M0.0%-0.6%2.071%
8/12/2024 XTX Topco Ltd140,576$122K0.0%-42.1%0.113%
8/9/2024 Renaissance Technologies LLC756,227$656K0.0%-16.6%0.607%
8/6/2024 Acadian Asset Management LLC194,168$167K0.0%N/A0.156%
8/6/2024 Los Angeles Capital Management LLC354,020$307K0.0%-8.6%0.284%
7/26/2024 Bank of New York Mellon Corp166,315$144K0.0%-65.9%0.133%
5/17/2024 Ikarian Capital LLC409,355$618K0.1%+2.3%0.348%
5/10/2024 Vanguard Group Inc.8,338,401$12.59M0.0%-4.3%7.160%
5/3/2024 GSA Capital Partners LLP1,299,151$1.96M0.2%-44.4%1.115%
4/24/2024 Simplicity Wealth LLC44,011$66K0.0%N/A0.038%
2/15/2024 Birchview Capital LP469,832$406K0.3%-17.8%0.410%
2/12/2024 Monashee Investment Management LLC132,435$115K0.0%N/A0.116%
2/8/2024 Panagora Asset Management Inc.227,445$197K0.0%N/A0.199%
2/7/2024 BNP Paribas Financial Markets1,769,184$1.53M0.0%+6.5%1.545%
2/6/2024 Los Angeles Capital Management LLC391,540$339K0.0%N/A0.342%
1/29/2024Simplicity Solutions LLC37,938$33K0.0%N/A0.033%
1/25/2024 Bleakley Financial Group LLC37,938$33K0.0%N/A0.033%
1/12/2024 SG Americas Securities LLC73,430$64K0.0%+295.0%0.064%
1/5/2024 Exchange Traded Concepts LLC115,864$100K0.0%+34.0%0.101%
11/15/2023 Tejara Capital Ltd1,077,388$1.44M0.8%-5.8%0.941%
11/15/2023 GSA Capital Partners LLP568,298$762K0.1%N/A0.496%
11/14/2023 Avidity Partners Management LP8,298,570$11.12M0.4%-0.9%7.246%
11/13/2023 Silverarc Capital Management LLC561,955$753K0.2%+8.3%0.491%
11/13/2023 Tejara Capital Ltd1,077,388$1.44M1.1%-5.8%0.941%
11/8/2023Wade G W & Inc.45,140$60K0.0%N/A0.039%
11/7/2023 Quantbot Technologies LP21,699$29K0.0%-60.1%0.019%
11/7/2023 Barclays PLC1,152,298$1.54M0.0%+4.2%1.008%
10/18/2023 Exchange Traded Concepts LLC86,484$116K0.0%+30.2%0.076%
8/15/2023 Silverarc Capital Management LLC518,985$929K0.3%-66.3%0.454%
8/14/2023 Prelude Capital Management LLC15,933$29K0.0%-62.4%0.014%
8/14/2023 Graham Capital Management L.P.62,414$112K0.0%N/A0.055%
8/11/2023 Rubric Capital Management LP919,196$1.65M0.1%-79.3%0.804%
8/11/2023 Tejara Capital Ltd1,143,991$2.05M1.0%+128.1%1.000%
8/11/2023 Platinum Investment Management Ltd.500,000$895K0.0%N/A0.437%
8/11/2023 ExodusPoint Capital Management LP2,382,451$4.27M0.0%N/A2.083%
8/9/2023 BNP Paribas Arbitrage SNC461,096$825K0.0%+24.8%0.403%
8/8/2023AlphaCentric Advisors LLC810,000$1.45M0.8%+237.5%0.708%
8/8/2023 Candriam S.C.A.1,435,694$2.57M0.0%-6.5%1.255%
8/7/2023 Principal Financial Group Inc.32,838$59K0.0%-32.8%0.029%
8/7/2023 Acadian Asset Management LLC98,946$177K0.0%N/A0.087%
8/4/2023 American International Group Inc.54,514$98K0.0%+45.1%0.048%
7/26/2023Simplicity Solutions LLC15,966$29K0.0%N/A0.014%
Is President Trump Lying To You With This? (Ad)

President Trump’s economic transition isn’t without hardship. But what if there were a smart, tax-free way to protect your 401(k), IRA, or pension from market chaos and currency collapse? The 2025 Wealth Protection Guide reveals a legal IRS strategy that may let you keep more of your retirement—regardless of what happens next. Trump’s warning was real. So is this opportunity.

Protect your IRA—Trump’s warning was real
7/20/2023 Exchange Traded Concepts LLC66,422$119K0.0%N/A0.058%
7/19/2023 Kennedy Investment Group35,000$63K0.0%+75.0%0.031%
7/10/2023 SG Americas Securities LLC14,868$27K0.0%-58.5%0.013%
6/1/2023 Prelude Capital Management LLC42,427$165K0.0%-27.5%0.037%
6/1/2023 Kennedy Investment Group20,000$78K0.0%N/A0.018%
5/16/2023 Altium Capital Management LP505,781$1.97M1.1%N/A0.444%
5/15/2023 Affinity Asset Advisors LLC460,979$1.79M0.6%-30.3%0.404%
5/15/2023 Rubric Capital Management LP4,441,056$17.28M0.4%-46.5%3.895%
5/12/2023AlphaCentric Advisors LLC240,000$934K0.6%N/A0.211%
5/12/2023 Profund Advisors LLC167,517$652K0.0%N/A0.147%
(Data available from 1/1/2016 forward)

KPTI Institutional Ownership - Frequently Asked Questions

Who are the largest shareholders of KPTI shares?

During the previous two years, 62 institutional investors and hedge funds held shares of Karyopharm Therapeutics. The most heavily invested institutionals were Vanguard Group Inc. ($12.59M), Avidity Partners Management LP ($11.12M), ExodusPoint Capital Management LP ($4.27M), Candriam S.C.A. ($2.57M), Rubric Capital Management LP ($1.65M), Marshall Wace LLP ($1.63M), and Adage Capital Partners GP L.L.C. ($1.58M).Learn more on KPTI's institutional investors.

What percentage of Karyopharm Therapeutics stock is owned by institutional investors?

66.44% of Karyopharm Therapeutics stock is owned by institutional investors. Learn more on KPTI's institutional investor holdings.

Which institutional investors have been buying Karyopharm Therapeutics stock?

Of the 41 institutional investors that purchased Karyopharm Therapeutics stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: ExodusPoint Capital Management LP ($2.38M), Adage Capital Partners GP L.L.C. ($2M), GSA Capital Partners LLP ($1.36M), Cubist Systematic Strategies LLC ($1.14M), Tejara Capital Ltd ($642.43K), AQR Capital Management LLC ($622.19K), and AlphaCentric Advisors LLC ($570K).

How much institutional buying is happening at Karyopharm Therapeutics?

Institutional investors have bought a total of 13,262,891 shares in the last 24 months. This purchase volume represents approximately $228.90M in transactions.

Which Karyopharm Therapeutics major shareholders have been selling company stock?

Of the 33 institutional investors that sold Karyopharm Therapeutics stock in the last 24 months, the following investors and hedge funds have sold the highest volume of shares: Adage Capital Partners GP L.L.C. ($5.90M), Palo Alto Investors LP ($4.58M), Rubric Capital Management LP ($3.52M), Eversept Partners LP ($3.46M), Jane Street Group LLC ($2.08M), Barclays PLC ($1.56M), and C WorldWide Group Holding A S ($1.40M).

How much institutional selling is happening at Karyopharm Therapeutics?

Institutional investors have sold a total of 30,960,856 shares in the last 24 months. This volume of shares sold represents approximately $326.47M in transactions.


Related Companies

This page (NASDAQ:KPTI) was last updated on 5/29/2025 by MarketBeat.com Staff
From Our Partners
Market Panic: Trump Just Dropped a Bomb on Your Stocks
tock Market Panic: Trump Just Dropped a Bomb on Your Stocks The market is in freefall—and Trump's new tarif...
American Alternative | Sponsored
White House to reset Social Security?
Elon Musk's parting DOGE gift looks set to shock America... A single announcement by July 22nd could soon b...
Altimetry | Sponsored
Is President Trump Lying To You With This?
President Trump’s economic transition isn’t without hardship. But what if there were a smart, tax-free way to ...
Colonial Metals | Sponsored
A grave, grave error.
I thought what happened 25 years ago was a once- in-a-lifetime event… but how wrong I was. Because here we...
Porter & Company | Sponsored
Silicon Valley Gold Rush
A new technology has sparked a modern-day gold rush in Silicon Valley. OpenAI’s Sam Altman invested $375M. Bil...
Stansberry Research | Sponsored
Buffett’s favorite chart just hit 209% – here’s what that means for gold
A Historic Gold Announcement Is About to Rock Wall Street For months, sharp-eyed analysts have watched the ...
Golden Portfolio | Sponsored
Trump Exec Order 14179 is wealth “gift” to good Americans?
Is President Trump’s Executive Order 14179… A secret way to restore wealth for good citizens? If you’ve ...
Paradigm Press | Sponsored
As Bitcoin supply vanishes, this Trump-aligned token could explode
Bitcoin's supply is being drained at unprecedented rates, but while most investors focus solely on Bitcoin, th...
Crypto 101 Media | Sponsored