Opaleye Management Inc. Top Holdings and 13F Report (2025) About Opaleye Management Inc.Investment ActivityOpaleye Management Inc. has $498.92 million in total holdings as of June 30, 2025.Opaleye Management Inc. owns shares of 41 different stocks, but just 14 companies or ETFs make up 80% of its holdings.Approximately 11.45% of the portfolio was purchased this quarter.About 9.00% of the portfolio was sold this quarter.This quarter, Opaleye Management Inc. has purchased 45 new stocks and bought additional shares in 15 stocks.Opaleye Management Inc. sold shares of 12 stocks and completely divested from 9 stocks this quarter.Largest Holdings Harrow $119,258,700Eton Pharmaceuticals $40,755,000Immunome $32,825,103SANUWAVE HEALTH INC $32,202,800Liquidia Technologies $30,838,500 Largest New Holdings this Quarter 803607100 - Sarepta Therapeutics $8,550,000 Holding92673K108 - Vigil Neuroscience $7,950,000 Holding76155X100 - Revolution Medicines $3,862,950 Holding022307102 - ALUMIS INC $2,325,000 Holding28623U101 - Elevation Oncology $529,381 Holding Largest Purchases this Quarter Sarepta Therapeutics 500,000 shares (about $8.55M)Vigil Neuroscience 1,000,000 shares (about $7.95M)Codexis 3,100,000 shares (about $7.56M)Larimar Therapeutics 2,195,923 shares (about $6.35M)Disc Medicine 101,418 shares (about $5.37M) Largest Sales this Quarter GINKGO BIOWORKS HOLDINGS 695,000 shares (about $7.82M)Protara Therapeutics 875,000 shares (about $7.54M)Trevi Therapeutics 405,000 shares (about $2.22M)Arvinas 295,000 shares (about $2.17M)Harrow 50,000 shares (about $1.53M) Sector Allocation Over TimeMap of 500 Largest Holdings ofOpaleye Management Inc. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorHROWHarrow$119,258,700$1,527,000 ▼-1.3%3,905,00023.9%MedicalETONEton Pharmaceuticals$40,755,000$113,003 ▲0.3%2,860,0008.2%MedicalIMNMImmunome$32,825,103$189,897 ▼-0.6%3,529,5816.6%MedicalSANUWAVE HEALTH INC$32,202,800$262,814 ▲0.8%980,0006.5%COMLQDALiquidia Technologies$30,838,500$2,678,900 ▲9.5%2,475,0006.2%MedicalCDXSCodexis$30,744,000$7,564,000 ▲32.6%12,600,0006.2%MedicalRYTMRhythm Pharmaceuticals$30,015,250$947,850 ▼-3.1%475,0006.0%MedicalTGTXTG Therapeutics$19,254,6500.0%535,0003.9%MedicalOCULOcular Therapeutix$14,801,6000.0%1,595,0003.0%MedicalARVNArvinas$12,364,800$2,171,200 ▼-14.9%1,680,0002.5%MedicalLRMRLarimar Therapeutics$11,877,900$6,346,217 ▲114.7%4,110,0002.4%MedicalIRONDisc Medicine$9,872,697$5,371,097 ▲119.3%186,4182.0%MedicalSRPTSarepta Therapeutics$8,550,000$8,550,000 ▲New Holding500,0001.7%MedicalVIGLVigil Neuroscience$7,950,000$7,950,000 ▲New Holding1,000,0001.6%MedicalTARAProtara Therapeutics$7,369,800$7,542,193 ▼-50.6%855,0001.5%MedicalCG ONCOLOGY INC$6,916,000$2,652,312 ▲62.2%266,0001.4%COMXOMAXOMA Royalty$6,428,192$51,509 ▲0.8%255,0871.3%MedicalEWTXEdgewise Therapeutics$6,423,900$1,245,450 ▲24.1%490,0001.3%MedicalSTOKStoke Therapeutics$6,380,062$2,975,062 ▲87.4%562,1201.3%MedicalANIKAnika Therapeutics$6,229,472$2,050,372 ▲49.1%588,7971.2%MedicalGOSSAMER BIO INC$5,948,9730.0%11,500,0001.2%NOTE 5.000% 6/0PTGXProtagonist Therapeutics$5,803,3500.0%105,0001.2%MedicalGINKGO BIOWORKS HOLDINGS$5,625,000$7,818,750 ▼-58.2%500,0001.1%Class A NewKARYOPHARM THERAPEUTICS INC$4,556,0520.0%6,000,0000.9%NOTE 3.000%10/1GOSSGossamer Bio$4,360,350$913,170 ▼-17.3%3,545,0000.9%MedicalRZLTRezolute$4,029,351$1,955,451 ▲94.3%903,4420.8%MedicalRVMDRevolution Medicines$3,862,950$3,862,950 ▲New Holding105,0000.8%MedicalEPIXESSA Pharma$3,756,9970.0%2,209,9980.8%MedicalCARGO THERAPEUTICS INC$2,745,9920.0%666,5030.6%COMMBX BIOSCIENCES INC$2,730,630$121,870 ▼-4.3%239,3190.5%COMZYMEZymeworks$2,635,500$439,250 ▲20.0%210,0000.5%MedicalALUMIS INC$2,325,000$2,325,000 ▲New Holding775,0000.5%COMZNTLZentalis Pharmaceuticals$2,232,188$70,412 ▼-3.1%1,924,3000.4%MedicalTRVITrevi Therapeutics$2,133,300$2,215,350 ▼-50.9%390,0000.4%MedicalRCELAvita Medical$2,060,556$267,045 ▼-11.5%389,5190.4%MedicalOCUPOcuphire Pharma$1,149,362$42,395 ▲3.8%1,220,0000.2%MedicalDERMJourney Medical$682,100$184,361 ▲37.0%95,0000.1%MedicalELEVElevation Oncology$529,381$529,381 ▲New Holding1,442,0610.1%MedicalIBIO INC$285,0000.0%375,0000.1%COM NEWPEPGPepGen$266,400$199,800 ▼-42.9%240,0000.1%MedicalADAGIO MED HLDGS INC$143,7420.0%110,5710.0%COMPALVELLA THERAPEUTICS INC$0$4,824,272 ▼-100.0%00.0%COMANABAnaptysBio$0$4,664,844 ▼-100.0%00.0%MedicalSLRNAcelyrin$0$3,989,050 ▼-100.0%00.0%MedicalBDSXBiodesix$0$2,016,270 ▼-100.0%00.0%MedicalOPTINOSE INC$0$1,770,168 ▼-100.0%00.0%COM NEWKINIKSA PHARMACEUTICALS INTL$0$1,388,147 ▼-100.0%00.0%ORD SHRS CL ANRIXNurix Therapeutics$0$1,366,200 ▼-100.0%00.0%MedicalSGMOSangamo Therapeutics$0$691,869 ▼-100.0%00.0%MedicalVTYXVentyx Biosciences$0$218,500 ▼-100.0%00.0%MedicalShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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