Opaleye Management Inc. Top Holdings and 13F Report (2025)

About Opaleye Management Inc.

Investment Activity

Opaleye Management Inc. has $449.15 million in total holdings as of March 31, 2025.
Opaleye Management Inc. owns shares of 45 different stocks, but just 14 companies or ETFs make up 80% of its holdings.
Approximately 22.45% of the portfolio was purchased this quarter.
About 31.71% of the portfolio was sold this quarter.
This quarter, Opaleye Management Inc. has purchased 39 new stocks and bought additional shares in 8 stocks.
Opaleye Management Inc. sold shares of 14 stocks and completely divested from 9 stocks this quarter.

Largest Holdings

Harrow: $105,203,000
Eton Pharmaceuticals: $37,019,869
SANUWAVE HEALTH INC: $34,379,711
Liquidia: $33,335,000
Rhythm Pharmaceuticals: $25,955,300

Largest New Holdings this Quarter

80303D305 - SANUWAVE HEALTH INC: $34,379,711 Holding
035255108 - Anika Therapeutics: $5,936,850 Holding
697947109 - PALVELLA THERAPEUTICS INC: $4,824,272 Holding
032724106 - AnaptysBio: $4,664,844 Holding
254604101 - Disc Medicine: $4,219,400 Holding

Largest Purchases this Quarter

SANUWAVE HEALTH INC: 972,002 shares (about $34.38M)
Immunome: 1,510,000 shares (about $10.16M)
Liquidia: 561,858 shares (about $8.29M)
Anika Therapeutics: 395,000 shares (about $5.94M)
PALVELLA THERAPEUTICS INC: 172,357 shares (about $4.82M)

Largest Sales this Quarter

TG Therapeutics: 1,725,000 shares (about $68.02M)
Ocular Therapeutix: 2,747,500 shares (about $20.14M)
Trevi Therapeutics: 1,522,500 shares (about $9.58M)
Nurix Therapeutics: 263,500 shares (about $3.13M)
Edgewise Therapeutics: 85,000 shares (about $1.87M)

Sector Allocation Over Time

Selling

Neutral

Buying

Latest 13F Holdings and Changes Since Previous Quarterly Filing

Issuer Name	Holdings Value	Approximate Purchase/Sale	Change in Shares	Shares Held	% of Portfolio	Sector
HROW Harrow	$105,203,000	$931,000 ▼	-0.9%	3,955,000	23.4%	Medical
ETON Eton Pharmaceuticals	$37,019,869		0.0%	2,852,070	8.2%	Medical
SANUWAVE HEALTH INC	$34,379,711	$34,379,711 ▲	New Holding	972,002	7.7%	COM
LQDA Liquidia	$33,335,000	$8,287,406 ▲	33.1%	2,260,000	7.4%	Medical
RYTM Rhythm Pharmaceuticals	$25,955,300	$529,700 ▼	-2.0%	490,000	5.8%	Medical
CDXS Codexis	$25,555,000	$1,775,400 ▲	7.5%	9,500,000	5.7%	Medical
IMNM Immunome	$23,891,500	$10,162,300 ▲	74.0%	3,550,000	5.3%	Medical
TGTX TG Therapeutics	$21,095,050	$68,016,750 ▼	-76.3%	535,000	4.7%	Medical
ARVN Arvinas	$13,864,500	$2,457,000 ▲	21.5%	1,975,000	3.1%	Medical
OCUL Ocular Therapeutix	$11,691,350	$20,139,175 ▼	-63.3%	1,595,000	2.6%	Medical
EWTX Edgewise Therapeutics	$8,690,000	$1,870,000 ▼	-17.7%	395,000	1.9%	Medical
TARA Protara Therapeutics	$7,369,800	$404,700 ▼	-5.2%	1,730,000	1.6%	Medical
GINKGO BIOWORKS HOLDINGS	$6,811,500	$28,500 ▼	-0.4%	1,195,000	1.5%	Class A New
GOSSAMER BIO INC	$6,319,331		0.0%	11,500,000	1.4%	NOTE 5.000% 6/0
ANIK Anika Therapeutics	$5,936,850	$5,936,850 ▲	New Holding	395,000	1.3%	Medical
PTGX Protagonist Therapeutics	$5,077,800		0.0%	105,000	1.1%	Medical
XOMA XOMA	$5,043,147	$60,647 ▲	1.2%	253,043	1.1%	Medical
TRVI Trevi Therapeutics	$5,000,550	$9,576,525 ▼	-65.7%	795,000	1.1%	Medical
PALVELLA THERAPEUTICS INC	$4,824,272	$4,824,272 ▲	New Holding	172,357	1.1%	COM
GOSS Gossamer Bio	$4,716,157	$222,844 ▼	-4.5%	4,287,415	1.1%	Medical
ANAB AnaptysBio	$4,664,844	$4,664,844 ▲	New Holding	250,933	1.0%	Medical
KARYOPHARM THERAPEUTICS INC	$4,556,892		0.0%	6,000,000	1.0%	NOTE 3.000%10/1
IRON Disc Medicine	$4,219,400	$4,219,400 ▲	New Holding	85,000	0.9%	Medical
LRMR Larimar Therapeutics	$4,115,266	$4,115,266 ▲	New Holding	1,914,077	0.9%	Medical
CG ONCOLOGY INC	$4,016,066	$4,016,066 ▲	New Holding	163,988	0.9%	COM
SLRN Acelyrin	$3,989,050	$1,531,400 ▼	-27.7%	1,615,000	0.9%	Medical
RCEL AVITA Medical	$3,581,600	$3,581,600 ▲	New Holding	440,000	0.8%	Medical
EPIX ESSA Pharma	$3,491,797		0.0%	2,209,998	0.8%	Medical
ZNTL Zentalis Pharmaceuticals	$3,156,150	$345,825 ▲	12.3%	1,985,000	0.7%	Medical
CARGO THERAPEUTICS INC	$2,712,667	$339,833 ▼	-11.1%	666,503	0.6%	COM
ZYME Zymeworks	$2,084,250	$2,084,250 ▲	New Holding	175,000	0.5%	Medical
BDSX Biodesix	$2,016,270	$150,048 ▼	-6.9%	3,225,000	0.4%	Medical
STOK Stoke Therapeutics	$1,995,000	$1,828,750 ▲	1,100.0%	300,000	0.4%	Medical
MBX BIOSCIENCES INC	$1,845,000	$1,845,000 ▲	New Holding	250,000	0.4%	COM
OPTINOSE INC	$1,770,168	$1,770,168 ▲	New Holding	193,039	0.4%	COM NEW
OCUP Ocuphire Pharma	$1,546,335	$1,546,335 ▲	New Holding	1,175,000	0.3%	Medical
IBIO INC	$1,507,500		0.0%	375,000	0.3%	COM NEW
KINIKSA PHARMACEUTICALS INTL	$1,388,147	$1,388,147 ▲	New Holding	62,501	0.3%	ORD SHRS CL A
NRIX Nurix Therapeutics	$1,366,200	$3,130,380 ▼	-69.6%	115,000	0.3%	Medical
RZLT Rezolute	$1,348,500		0.0%	465,000	0.3%	Medical
SGMO Sangamo Therapeutics	$691,869	$691,869 ▲	New Holding	1,055,000	0.2%	Medical
PEPG PepGen	$590,100	$435,550 ▲	281.8%	420,000	0.1%	Medical
DERM Journey Medical	$409,006	$409,006 ▲	New Holding	69,323	0.1%	Medical
VTYX Ventyx Biosciences	$218,500	$103,500 ▼	-32.1%	190,000	0.0%	Medical
ADAGIO MED HLDGS INC	$92,106		0.0%	110,571	0.0%	COM
JASPER THERAPEUTICS INC	$0	$8,552,000 ▼	-100.0%	0	0.0%	COM NEW
NAMS NewAmsterdam Pharma	$0	$8,352,500 ▼	-100.0%	0	0.0%	Medical
PCVX Vaxcyte	$0	$6,139,500 ▼	-100.0%	0	0.0%	Medical
NUVL Nuvalent	$0	$4,579,380 ▼	-100.0%	0	0.0%	Medical
ABCL AbCellera Biologics	$0	$2,827,450 ▼	-100.0%	0	0.0%	Medical
URGN UroGen Pharma	$0	$2,343,000 ▼	-100.0%	0	0.0%	Medical
IMTX Immatics	$0	$1,173,150 ▼	-100.0%	0	0.0%	Medical
LEXEO THERAPEUTICS INC	$0	$855,400 ▼	-100.0%	0	0.0%	COM
RGNX REGENXBIO	$0	$618,400 ▼	-100.0%	0	0.0%	Medical

Showing largest 100 holdings. View all holdings.

More Institutional Buying and Selling Information

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Opaleye Management Inc. Top Holdings and 13F Report (2025)

About Opaleye Management Inc.

Investment Activity

Largest Holdings

Largest New Holdings this Quarter

Largest Purchases this Quarter

Largest Sales this Quarter

Sector Allocation Over Time

Latest 13F Holdings and Changes Since Previous Quarterly Filing

More Institutional Buying and Selling Information

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Opaleye Management Inc. Top Holdings and 13F Report (2025)

About Opaleye Management Inc.

Investment Activity

Largest Holdings

Largest New Holdings this Quarter

Largest Purchases this Quarter

Largest Sales this Quarter

Sector Allocation Over Time

Map of 500 Largest Holdings ofOpaleye Management Inc.

Latest 13F Holdings and Changes Since Previous Quarterly Filing

More Institutional Buying and Selling Information

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Best-in-Class Portfolio Monitoring

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