Ra Capital Management, L.P. Top Holdings and 13F Report (2025) About Ra Capital Management, L.P.Investment ActivityRa Capital Management, L.P. has $5.99 billion in total holdings as of March 31, 2025.Ra Capital Management, L.P. owns shares of 85 different stocks, but just 21 companies or ETFs make up 80% of its holdings.Approximately 12.20% of the portfolio was purchased this quarter.About 13.16% of the portfolio was sold this quarter.This quarter, Ra Capital Management, L.P. has purchased 89 new stocks and bought additional shares in 14 stocks.Ra Capital Management, L.P. sold shares of 4 stocks and completely divested from 15 stocks this quarter.Largest Holdings Ascendis Pharma A/S $1,602,473,967Vaxcyte $460,262,266Rhythm Pharmaceuticals $322,291,304Janux Therapeutics $302,121,711NewAmsterdam Pharma $207,544,061 Largest New Holdings this Quarter 829401108 - SIONNA THERAPEUTICS INC $109,258,068 Holding254604101 - Disc Medicine $78,287,542 HoldingM96088105 - UroGen Pharma $35,461,357 Holding377322102 - Glaukos $18,724,996 Holding59267L107 - METSERA INC $18,387,791 Holding Largest Purchases this Quarter Vaxcyte 3,499,959 shares (about $132.16M)SIONNA THERAPEUTICS INC 10,445,322 shares (about $109.26M)Disc Medicine 1,577,106 shares (about $78.29M)Geron 30,369,830 shares (about $48.29M)89bio 5,714,285 shares (about $41.54M) Largest Sales this Quarter 10x Genomics 1,335,154 shares (about $11.66M)Bright Minds Biosciences Inc 254,402 shares (about $9.18M)Kura Oncology 446,431 shares (about $2.95M)BIOAGE LABS INC 258,095 shares (about $970.44K) Sector Allocation Over TimeMap of 500 Largest Holdings ofRa Capital Management, L.P. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorASNDAscendis Pharma A/S$1,602,473,967$26,301,687 ▲1.7%10,281,49626.8%MedicalPCVXVaxcyte$460,262,266$132,158,452 ▲40.3%12,189,1497.7%MedicalRYTMRhythm Pharmaceuticals$322,291,3040.0%6,084,4125.4%MedicalJANXJanux Therapeutics$302,121,711$22,249,107 ▲7.9%11,189,6935.0%MedicalNAMSNewAmsterdam Pharma$207,544,061$26,486,911 ▲14.6%10,138,9383.5%MedicalACLXArcellx$199,196,171$16,347,520 ▲8.9%3,036,5273.3%MedicalEWTXEdgewise Therapeutics$196,000,0020.0%8,909,0913.3%MedicalRNAAvidity Biosciences$185,988,0440.0%6,300,4083.1%MedicalWVEWave Life Sciences$147,072,2330.0%18,202,0092.5%MedicalETNB89bio$144,597,995$41,542,852 ▲40.3%19,889,6832.4%MedicalSPRYARS Pharmaceuticals$136,631,0910.0%10,860,9772.3%MedicalSIONNA THERAPEUTICS INC$109,258,068$109,258,068 ▲New Holding10,445,3221.8%SHLENZ THERAPEUTICS INC$107,437,5390.0%4,178,8231.8%SHDYNE THERAPEUTICS INC$101,612,540$34,865,774 ▲52.2%9,714,3921.7%SHTYRATyra Biosciences$98,926,7970.0%10,637,2901.7%MedicalMLYSMineralys Therapeutics$97,618,806$20,585,180 ▲26.7%6,147,2801.6%MedicalGERNGeron$96,003,192$48,288,030 ▲101.2%60,379,3661.6%MedicalRXSTRxSight$94,511,2050.0%3,743,0181.6%MedicalBICARA THERAPEUTICS INC$90,636,5890.0%6,955,9931.5%SHIRONDisc Medicine$78,287,542$78,287,542 ▲New Holding1,577,1061.3%MedicalGHRSGH Research$76,599,467$2,845,288 ▲3.9%6,944,6481.3%MedicalAPOGEE THERAPEUTICS INC$58,636,1840.0%1,569,4911.0%SHDIANTHUS THERAPEUTICS INC$52,002,537$18,146,041 ▲53.6%2,866,7330.9%SHZLABZai Lab$46,802,7460.0%1,295,0400.8%MedicalDAWNDay One Biopharmaceuticals$45,641,7260.0%5,755,5770.8%MedicalSEPTERNA INC$40,506,0180.0%6,995,8580.7%SHTOURMALINE BIO INC$38,617,0490.0%2,538,9250.6%SHELYMEliem Therapeutics$38,331,5060.0%31,419,2670.6%MedicalSRRKScholar Rock$36,536,964$35,970,610 ▲6,351.3%1,136,4530.6%MedicalURGNUroGen Pharma$35,461,357$35,461,357 ▲New Holding3,206,2710.6%MedicalARTIVA BIOTHERAPEUTICS INC$29,559,9060.0%9,853,3020.5%SHFULCFulcrum Therapeutics$29,459,8050.0%10,229,0990.5%MedicalVORVor Biopharma$28,446,0330.0%39,646,0390.5%MedicalATXSAstria Therapeutics$27,261,8370.0%5,105,2130.5%MedicalKURAKura Oncology$26,430,426$2,946,445 ▼-10.0%4,004,6100.4%MedicalGPCRStructure Therapeutics$26,266,5060.0%1,517,4180.4%MedicalCIDARA THERAPEUTICS INC$23,538,8260.0%1,092,7960.4%SHAVTEAerovate Therapeutics$23,072,1510.0%9,192,0920.4%MedicalIDYAIDEAYA Biosciences$22,067,9880.0%1,347,2520.4%MedicalITOSiTeos Therapeutics$21,784,870$9,294,084 ▲74.4%3,649,0570.4%MedicalTVTXTravere Therapeutics$20,608,0000.0%1,150,0000.3%MedicalNKTXNkarta$19,881,4370.0%10,805,1290.3%MedicalGKOSGlaukos$18,724,996$18,724,996 ▲New Holding190,2560.3%MedicalMONOPAR THERAPEUTICS INC$18,613,0470.0%511,2070.3%SHMETSERA INC$18,387,791$18,387,791 ▲New Holding675,5250.3%SHEYPTEyePoint Pharmaceuticals$17,245,4540.0%3,181,8180.3%MedicalTXG10x Genomics$16,973,276$11,655,894 ▼-40.7%1,944,2470.3%MedicalACRVAcrivon Therapeutics$16,931,2310.0%8,340,5080.3%MedicalELVNEnliven Therapeutics$16,708,0440.0%848,9860.3%MedicalABOSAcumen Pharmaceuticals$16,425,2690.0%14,932,0630.3%MedicalSLDBSolid Biosciences$16,022,6500.0%4,330,4460.3%MedicalCERIBELL INC$15,840,2200.0%824,5820.3%SHNRIXNurix Therapeutics$15,839,9960.0%1,333,3330.3%MedicalINSMInsmed$15,258,0000.0%200,0000.3%MedicalTSHATaysha Gene Therapies$15,112,7790.0%10,872,5030.3%MedicalPEPGPepGen$15,018,8110.0%10,689,5450.3%MedicalFDMT4D Molecular Therapeutics$14,739,1720.0%4,563,2110.2%MedicalTARAProtara Therapeutics$14,484,0000.0%3,400,0000.2%MedicalLRMRLarimar Therapeutics$12,997,5050.0%6,045,3510.2%MedicalELDNEledon Pharmaceuticals$12,089,8860.0%3,566,3380.2%MedicalALECAlector$11,925,1300.0%9,695,2280.2%MedicalSERASera Prognostics$11,160,7330.0%3,032,8080.2%MedicalMBX BIOSCIENCES INC$11,153,6450.0%1,511,3340.2%SHBCYCBicycle Therapeutics$9,283,6200.0%1,093,4770.2%MedicalRCUSArcus Biosciences$8,920,457$8,920,457 ▲New Holding1,136,3640.1%MedicalSURROZEN INC$7,918,656$4,623,773 ▲140.3%679,1300.1%SHIMTXImmatics$7,892,5000.0%1,750,0000.1%MedicalAVALO THERAPEUTICS INC$7,745,6700.0%967,0000.1%SHPERCEPTIVE CAPITAL SOLUTIONS$7,725,0000.0%750,0000.1%SHBright Minds Biosciences Inc$7,445,822$9,176,280 ▼-55.2%206,4270.1%SHACRSAclaris Therapeutics$7,140,0010.0%4,666,6670.1%MedicalACHCAcadia Healthcare$6,579,440$6,579,440 ▲New Holding217,0000.1%MedicalBETA BIONICS INC$6,120,000$6,120,000 ▲New Holding500,0000.1%SHXNCRXencor$6,118,0000.0%575,0000.1%MedicalHOWLWerewolf Therapeutics$5,974,0530.0%6,144,8810.1%MedicalACETAdicet Bio$5,693,4550.0%7,541,0000.1%MedicalHUMAHumacyte$5,647,567$5,647,567 ▲New Holding3,312,3560.1%MedicalZURAZura Bio$4,150,5790.0%3,217,5030.1%MedicalBIOAGE LABS INC$3,957,377$970,437 ▼-19.7%1,052,4940.1%SHBOUNDLESS BIO INC$3,292,7530.0%2,180,6310.1%SHNAMSWNewAmsterdam Pharma$2,996,6640.0%333,3330.1%MedicalSTROSutro Biopharma$2,885,175$2,885,175 ▲New Holding4,434,6370.0%MedicalLEXEO THERAPEUTICS INC$1,896,5420.0%546,5540.0%SHCTMXCytomX Therapeutics$635,800$635,800 ▲New Holding1,000,0000.0%MedicalSCLXScilex$257,5000.0%1,036,2180.0%MedicalLEGNLegend Biotech$0$244,275,632 ▼-100.0%00.0%MedicalXBISPDR S&P Biotech ETF$0$110,615,294 ▼-100.0%00.0%ETFAXSMAxsome Therapeutics$0$84,610,000 ▼-100.0%00.0%MedicalVRNAVerona Pharma$0$82,051,585 ▼-100.0%00.0%MedicalPRAXIS PRECISION MEDICINES I$0$58,640,057 ▼-100.0%00.0%SHRXRXRecursion Pharmaceuticals$0$52,221,649 ▼-100.0%00.0%MedicalEVHEvolent Health$0$40,243,466 ▼-100.0%00.0%Computer and TechnologyCMRXChimerix$0$30,624,000 ▼-100.0%00.0%MedicalCCCCC4 Therapeutics$0$17,560,800 ▼-100.0%00.0%MedicalPLRXPliant Therapeutics$0$16,870,770 ▼-100.0%00.0%MedicalTHRDTF Financial$0$9,884,780 ▼-100.0%00.0%MedicalARVNArvinas$0$8,077,241 ▼-100.0%00.0%MedicalENTAEnanta Pharmaceuticals$0$5,968,500 ▼-100.0%00.0%MedicalALLKAllakos$0$1,367,217 ▼-100.0%00.0%MedicalRGLSRegulus Therapeutics$0$532,212 ▼-100.0%00.0%MedicalShowing largest 100 holdings. 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