Sofinnova Investments, Inc. Top Holdings and 13F Report (2025) About Sofinnova Investments, Inc.Investment ActivitySofinnova Investments, Inc. has $1.64 billion in total holdings as of June 30, 2025.Sofinnova Investments, Inc. owns shares of 58 different stocks, but just 24 companies or ETFs make up 80% of its holdings.Approximately 33.78% of the portfolio was purchased this quarter.About 34.15% of the portfolio was sold this quarter.This quarter, Sofinnova Investments, Inc. has purchased 62 new stocks and bought additional shares in 19 stocks.Sofinnova Investments, Inc. sold shares of 17 stocks and completely divested from 17 stocks this quarter.Largest Holdings Natera $261,904,303Gilead Sciences $116,447,648Eli Lilly and Company $75,628,442Jazz Pharmaceuticals $73,657,468Vera Therapeutics $65,826,334 Largest New Holdings this Quarter 00287Y109 - AbbVie $49,347,077 Holding464287556 - iShares Biotechnology ETF $47,441,250 Holding101137107 - Boston Scientific $46,315,192 Holding91307C102 - United Therapeutics $34,054,711 HoldingN5749R100 - Merus $21,279,961 Holding Largest Purchases this Quarter Gilead Sciences 631,408 shares (about $70.00M)AbbVie 265,850 shares (about $49.35M)iShares Biotechnology ETF 375,000 shares (about $47.44M)Boston Scientific 431,200 shares (about $46.32M)Eli Lilly and Company 44,218 shares (about $34.47M) Largest Sales this Quarter Soleno Therapeutics 598,552 shares (about $50.15M)iShares Russell 2000 ETF 100,000 shares (about $21.58M)IDEAYA Biosciences 474,397 shares (about $9.97M)PTC Therapeutics 203,400 shares (about $9.93M)Axsome Therapeutics 81,707 shares (about $8.53M) Sector Allocation Over TimeMap of 500 Largest Holdings ofSofinnova Investments, Inc. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorNTRANatera$261,904,3030.0%1,550,28016.0%MedicalGILDGilead Sciences$116,447,648$70,004,205 ▲150.7%1,050,3087.1%MedicalLLYEli Lilly and Company$75,628,442$34,469,258 ▲83.7%97,0184.6%MedicalJAZZJazz Pharmaceuticals$73,657,468$19,530,962 ▲36.1%694,0964.5%MedicalVERAVera Therapeutics$65,826,3340.0%2,793,9874.0%MedicalIWMiShares Russell 2000 ETF$53,947,500$21,579,000 ▼-28.6%250,0003.3%FinanceRYTMRhythm Pharmaceuticals$51,247,722$23,011,966 ▲81.5%811,0103.1%MedicalABBVAbbVie$49,347,077$49,347,077 ▲New Holding265,8503.0%MedicalIBBiShares Biotechnology ETF$47,441,250$47,441,250 ▲New Holding375,0002.9%FinanceBSXBoston Scientific$46,315,192$46,315,192 ▲New Holding431,2002.8%MedicalROIVRoivant Sciences$46,080,934$31,660,856 ▲219.6%4,088,8142.8%MedicalDXCMDexCom$45,713,249$11,148,591 ▲32.3%523,6942.8%MedicalIDYAIDEAYA Biosciences$45,146,651$9,971,825 ▼-18.1%2,147,7952.8%MedicalBBIOBridgeBio Pharma$42,881,756$11,177,834 ▲35.3%993,0932.6%MedicalISRGIntuitive Surgical$38,387,569$31,875,344 ▲489.5%70,6422.3%MedicalArrivent BioPharma Inc$36,938,2910.0%1,696,7522.3%COMSLNOSoleno Therapeutics$34,787,048$50,146,687 ▼-59.0%415,2192.1%MedicalUTHRUnited Therapeutics$34,054,711$34,054,711 ▲New Holding118,5132.1%MedicalINSMInsmed$31,593,211$973,088 ▲3.2%313,9231.9%MedicalREPLReplimune Group$30,717,654$7,679,021 ▲33.3%3,306,5291.9%MedicalAKROAkero Therapeutics$29,283,328$2,068,661 ▲7.6%548,7881.8%MedicalSUPNSupernus Pharmaceuticals$25,192,455$8,780,684 ▲53.5%799,2531.5%MedicalANABAnaptysBio$22,918,436$2,834,296 ▼-11.0%1,032,3621.4%MedicalRapport Therapeutics Inc$22,689,9040.0%1,995,5941.4%COMQUREuniQure$21,723,483$14,115,435 ▲185.5%1,558,3561.3%MedicalCOGTCogent Biosciences$21,651,326$5,983,697 ▲38.2%3,015,5051.3%MedicalMRUSMerus$21,279,961$21,279,961 ▲New Holding404,5621.3%MedicalAZNAstraZeneca$20,521,031$20,521,031 ▲New Holding293,6611.3%MedicalPTCTPTC Therapeutics$18,360,861$9,934,056 ▼-35.1%375,9391.1%MedicalINZYInozyme Pharma$17,121,2320.0%4,280,3081.0%MedicalCidara Therapeutics Inc$17,098,720$17,098,720 ▲New Holding351,0311.0%COMRNAAvidity Biosciences$16,608,348$5,818,308 ▲53.9%584,8011.0%MedicalSMMTSummit Therapeutics$14,896,000$14,896,000 ▲New Holding700,0000.9%MedicalSNDXSyndax Pharmaceuticals$14,276,381$7,031,083 ▼-33.0%1,524,4400.9%MedicalIMTXImmatics$12,054,041$3,691,885 ▲44.1%2,240,5280.7%MedicalEXASExact Sciences$11,069,062$11,069,062 ▲New Holding208,3000.7%MedicalPHVSPharvaris$10,305,363$138,530 ▼-1.3%585,5320.6%MedicalInhibrx Biosciences Inc$10,112,835$153,574 ▲1.5%708,6780.6%COMRCUSArcus Biosciences$9,898,370$1,450,874 ▲17.2%1,216,0160.6%MedicalYMABY-mAbs Therapeutics$9,896,1940.0%2,194,2780.6%MedicalAXSMAxsome Therapeutics$9,771,948$8,529,394 ▼-46.6%93,6100.6%MedicalBioAge Labs Inc$9,519,2410.0%2,304,9010.6%COMEWTXEdgewise Therapeutics$9,398,205$711,283 ▲8.2%716,8730.6%MedicalIMNMImmunome$7,239,827$94,767 ▼-1.3%778,4760.4%MedicalDyne Therapeutics Inc$5,853,515$971,335 ▼-14.2%614,8650.4%COMSVRASavara$5,602,763$6,895,436 ▼-55.2%2,457,3520.3%MedicalApogee Therapeutics Inc$3,308,497$3,308,497 ▲New Holding76,1800.2%COMNXTCNextCure$1,229,0540.0%2,671,8560.1%MedicalESTAEstablishment Labs$1,201,005$23,704 ▼-1.9%28,1200.1%MedicalJade Biosciences Inc$1,072,836$1,072,836 ▲New Holding107,3910.1%COMMetsera Inc$1,029,634$17,326 ▼-1.7%36,1910.1%COMSRRKScholar Rock$936,505$3,176,360 ▼-77.2%26,4400.1%MedicalBolt Biotherapeutics Inc$794,650$794,650 ▲New Holding137,7210.0%COMWVEWAVE Life Sciences$766,370$766,370 ▲New Holding117,9030.0%MedicalGPCRStructure Therapeutics$712,481$12,423 ▼-1.7%34,3530.0%MedicalPraxis Precision Medicines Inc$660,900$5,967,864 ▼-90.0%15,7170.0%COMIkena Oncology Inc$512,7050.0%382,6160.0%COMIRONDisc Medicine$387,244$9,162 ▼-2.3%7,3120.0%MedicalSYKStryker$0$111,141,566 ▼-100.0%00.0%MedicalQQQInvesco QQQ$0$82,061,000 ▼-100.0%00.0%FinanceMDTMedtronic$0$50,590,461 ▼-100.0%00.0%MedicalALNYAlnylam Pharmaceuticals$0$47,572,394 ▼-100.0%00.0%MedicalBPMCBlueprint Medicines$0$23,104,562 ▼-100.0%00.0%MedicalBMYBristol Myers Squibb$0$22,657,602 ▼-100.0%00.0%MedicalINCYIncyte$0$21,664,790 ▼-100.0%00.0%MedicalSRPTSarepta Therapeutics$0$20,908,581 ▼-100.0%00.0%MedicalDHRDanaher$0$12,014,230 ▼-100.0%00.0%MedicalPENPenumbra$0$11,481,516 ▼-100.0%00.0%MedicalAVTEAerovate Therapeutics$0$9,434,302 ▼-100.0%00.0%MedicalACADACADIA Pharmaceuticals$0$8,305,000 ▼-100.0%00.0%MedicalKURAKura Oncology$0$5,225,002 ▼-100.0%00.0%MedicalERASErasca$0$2,571,606 ▼-100.0%00.0%MedicalBOLTBolt Biotherapeutics$0$1,101,775 ▼-100.0%00.0%MedicalELVNEnliven Therapeutics$0$660,205 ▼-100.0%00.0%MedicalVIRVir Biotechnology$0$537,905 ▼-100.0%00.0%MedicalShowing largest 100 holdings. 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