Sphera Funds Management Ltd. Top Holdings and 13F Report (2026) About Sphera Funds Management Ltd.Investment ActivitySphera Funds Management Ltd. has $629.68 million in total holdings as of March 31, 2026.Sphera Funds Management Ltd. owns shares of 95 different stocks, but just 47 companies or ETFs make up 80% of its holdings.Approximately 31.80% of the portfolio was purchased this quarter.About 21.00% of the portfolio was sold this quarter.This quarter, Sphera Funds Management Ltd. has purchased 98 new stocks and bought additional shares in 32 stocks.Sphera Funds Management Ltd. sold shares of 29 stocks and completely divested from 23 stocks this quarter.Largest Holdings Mineralys Therapeutics $36,299,814Teva Pharmaceutical Industries $34,245,687Tower Semiconductor $25,573,578SPDR S&P Biotech ETF $25,546,001Nova $23,175,786 Largest New Holdings this Quarter G0593M107 - AstraZeneca $12,332,167 HoldingM2197Q107 - Cellebrite DI $8,702,359 Holding697435105 - Palo Alto Networks $8,464,896 Holding686688102 - Ormat Technologies $7,638,540 Holding98420N105 - Xenon Pharmaceuticals $7,385,050 Holding Largest Purchases this Quarter Mineralys Therapeutics 890,968 shares (about $24.14M)SPDR S&P Biotech ETF 130,000 shares (about $16.60M)Cytokinetics 207,400 shares (about $13.67M)AstraZeneca 62,530 shares (about $12.33M)BridgeBio Pharma 137,500 shares (about $10.21M) Largest Sales this Quarter SolarEdge Technologies 143,700 shares (about $7.34M)Oric Pharmaceuticals 466,750 shares (about $5.91M)NiCE 50,089 shares (about $5.52M)DYNE THERAPEUTICS INC 232,300 shares (about $4.21M)Tango Therapeutics 201,000 shares (about $4.20M) Sector Allocation Over TimeMap of 500 Largest Holdings ofSphera Funds Management Ltd. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorMLYSMineralys Therapeutics$36,299,814$24,136,323 â–²198.4%1,339,9715.8%MedicalTEVATeva Pharmaceutical Industries$34,245,687$405,114 â–²1.2%1,136,9755.4%MedicalTSEMTower Semiconductor$25,573,578$4,074,997 â–²19.0%145,7354.1%Computer and TechnologyXBISPDR S&P Biotech ETF$25,546,001$16,604,901 â–²185.7%200,0004.1%ETFNVMINova$23,175,786$2,397,226 â–²11.5%53,3663.7%Computer and TechnologyCYTKCytokinetics$19,714,802$13,669,734 â–²226.1%299,1173.1%MedicalBBIOBridgeBio Pharma$18,211,968$10,210,750 â–²127.6%245,2462.9%MedicalBIIBBiogen$16,962,792$405,526 â–¼-2.3%92,5262.7%MedicalRAREUltragenyx Pharmaceutical$16,955,526$3,324,974 â–²24.4%809,3332.7%MedicalSNDXSyndax Pharmaceuticals$16,925,792$887,680 â–¼-5.0%724,5632.7%MedicalCOGTCogent Biosciences$16,024,927$1,456,462 â–²10.0%416,3402.5%MedicalSNYSanofi$12,985,233$1,445,400 â–²12.5%269,5152.1%MedicalAZNCFAstraZeneca$12,332,167$12,332,167 â–²New Holding62,5302.0%MedicalFOLDAmicus Therapeutics$8,724,831$795,300 â–¼-8.4%603,3771.4%MedicalCLBTCellebrite DI$8,702,359$8,702,359 â–²New Holding631,5211.4%Computer and TechnologyAPLSApellis Pharmaceuticals$8,645,990$1,450,171 â–¼-14.4%214,9141.4%MedicalPANWPalo Alto Networks$8,464,896$8,464,896 â–²New Holding52,8001.3%Computer and TechnologyLLYEli Lilly and Company$8,314,7210.0%9,0401.3%MedicalBCRXBioCryst Pharmaceuticals$8,248,737$272,034 â–²3.4%866,4641.3%MedicalCAMTCamtek$8,038,362$2,050,070 â–²34.2%53,0201.3%Computer and TechnologyBMRNBioMarin Pharmaceutical$7,902,951$401,079 â–¼-4.8%139,9001.3%MedicalCLDXCelldex Therapeutics$7,726,199$120,885 â–²1.6%243,5751.2%MedicalORAOrmat Technologies$7,638,540$7,638,540 â–²New Holding68,2501.2%EnergyXENEXenon Pharmaceuticals$7,385,050$7,385,050 â–²New Holding127,0001.2%MedicalSLNOSoleno Therapeutics$7,241,088$2,677,295 â–²58.7%216,2811.1%MedicalTNGXTango Therapeutics$7,187,338$4,204,920 â–¼-36.9%343,5631.1%MedicalJNJJohnson & Johnson$7,047,450$1,711,080 â–¼-19.5%28,8311.1%MedicalSOLAREDGE TECHNOLOGIES INC$6,909,6200.0%4,000,0001.1%NOTE 2.250% 7/0IMTXImmatics$6,849,673$1,623,600 â–¼-19.2%696,1051.1%MedicalTRVITrevi Therapeutics$6,848,166$292,345 â–¼-4.1%574,0291.1%MedicalORICOric Pharmaceuticals$6,811,747$5,913,723 â–¼-46.5%537,6281.1%MedicalMAZE THERAPEUTICS INC$6,786,189$4,641,675 â–²216.4%227,3431.1%COMGSKGSK$6,733,1800.0%122,0001.1%MedicalAMZNAmazon.com$6,652,144$6,652,144 â–²New Holding31,9401.1%Retail/WholesaleABBVAbbVie$6,580,377$1,087,450 â–²19.8%30,2561.0%MedicalAAOIApplied Optoelectronics$6,208,906$6,208,906 â–²New Holding73,4001.0%Computer and TechnologyELVNEnliven Therapeutics$6,007,988$2,881,200 â–¼-32.4%153,2651.0%MedicalMRKMerck & Co., Inc.$5,846,0940.0%48,6000.9%MedicalVOR BIOPHARMA INC$5,742,999$1,578,840 â–¼-21.6%321,9170.9%COM NEWACADACADIA Pharmaceuticals$5,703,057$979,440 â–²20.7%256,2020.9%MedicalNVSNovartis$5,651,7500.0%37,0000.9%MedicalELDNEledon Pharmaceuticals$5,458,163$1,108,800 â–¼-16.9%1,772,1310.9%MedicalENPHEnphase Energy$5,384,862$1,666,702 â–¼-23.6%142,4190.9%EnergyRVMDRevolution Medicines$5,359,448$253,823 â–²5.0%55,1100.9%MedicalPFEPfizer$5,222,880$2,808,000 â–²116.3%186,0000.8%MedicalBHVNBiohaven$5,025,240$5,025,240 â–²New Holding594,0000.8%MedicalFORTE BIOSCIENCES INC$4,791,086$22,922 â–¼-0.5%184,9840.8%COM NEWCYBIN INC$4,738,032$775,267 â–²19.6%987,0900.8%COM NEWMDGLMadrigal Pharmaceuticals$4,732,169$3,004,718 â–²173.9%9,0400.8%MedicalSRRKScholar Rock$4,634,067$3,146,240 â–¼-40.4%94,2650.7%MedicalNVONovo Nordisk A/S$4,434,880$183,750 â–²4.3%120,6770.7%MedicalMDWDMediWound$4,401,123$690,233 â–²18.6%273,1920.7%MedicalKODKodiak Sciences$4,376,024$2,314,037 â–¼-34.6%114,7960.7%MedicalZENAS BIOPHARMA INC$4,190,230$4,190,230 â–²New Holding214,3340.7%COMPROMIS NEUROSCIENCES INC$4,135,012$3,985,063 â–²2,657.6%325,5910.7%COM SHSTLTiShares 20+ Year Treasury Bond ETF$4,074,4300.0%47,0000.6%ETFRLAYRelay Therapeutics$4,063,938$4,063,938 â–²New Holding408,4360.6%MedicalSVRASavara$4,035,835$2,396,940 â–¼-37.3%739,1640.6%MedicalWVEWAVE Life Sciences$3,974,972$1,015,769 â–²34.3%548,2720.6%MedicalCRVSCorvus Pharmaceuticals$3,627,669$2,337,113 â–¼-39.2%247,9610.6%MedicalOVIDOvid Therapeutics$3,602,678$3,602,678 â–²New Holding1,622,8280.6%MedicalIRONDisc Medicine$3,423,220$3,423,220 â–²New Holding53,5380.5%MedicalUPSTREAM BIO INC$3,222,000$3,222,000 â–²New Holding358,0000.5%COMALPHA COGNITION INC$3,116,2120.0%567,6160.5%COM NEWPALISADE BIO INC$3,033,574$2,711,399 â–²841.6%1,733,4710.5%COMDYNE THERAPEUTICS INC$2,911,569$4,211,599 â–¼-59.1%160,5940.5%COMELYMEliem Therapeutics$2,871,842$3,514,050 â–¼-55.0%419,2470.5%MedicalZIMZIM Integrated Shipping Services$2,791,783$791,949 â–¼-22.1%105,9500.4%TransportationSATELLOS BIOSCIENCE INC$2,754,235$2,754,235 â–²New Holding489,2070.4%COMSEDGSolarEdge Technologies$2,697,278$7,335,886 â–¼-73.1%52,8360.4%EnergyAMGNAmgen$2,638,8750.0%7,5000.4%MedicalGPCRStructure Therapeutics$2,448,560$472,360 â–²23.9%50,8000.4%MedicalKURAKura Oncology$2,402,5940.0%295,5220.4%MedicalGENERATE BIOMEDICINES INC$2,312,500$2,312,500 â–²New Holding185,0000.4%COM SHSISHARES BITCOIN TRUST ETF$2,286,182$1,131,469 â–²98.0%59,5050.4%SHS BEN INTCONTINEUM THERAPEUTICS INC$2,265,5840.0%173,4750.4%CL ATENAX THERAPEUTICS INC$2,174,880$864,995 â–¼-28.5%136,0150.3%COM NEWPRLDPrelude Therapeutics$1,909,519$1,489,707 â–²354.9%558,3390.3%MedicalASNDAscendis Pharma A/S$1,829,840$686,190 â–¼-27.3%8,0000.3%MedicalVSTMVerastem$1,821,4930.0%343,6780.3%MedicalVYGRVoyager Therapeutics$1,813,277$501,800 â–²38.3%469,7610.3%MedicalSTTKShattuck Labs$1,805,454$550,241 â–²43.8%280,7860.3%MedicalEVOMMUNE INC$1,798,600$2,021,120 â–¼-52.9%78,2340.3%COM SHSBIOAGE LABS INC$1,513,200$2,737,483 â–¼-64.4%86,5180.2%COMOLMAOlema Pharmaceuticals$1,491,000$1,491,000 â–²New Holding100,0000.2%MedicalORGOOrganogenesis$1,303,500$1,303,500 â–²New Holding550,0000.2%MedicalCURIS INC$1,091,829$1,091,829 â–²New Holding1,994,9370.2%COMBMYBristol Myers Squibb$1,061,3750.0%17,5000.2%MedicalCTMXCytomX Therapeutics$1,034,000$1,034,000 â–²New Holding220,0000.2%MedicalNICENiCE$618,669$5,522,814 â–¼-89.9%5,6110.1%Computer and TechnologyHOWLWerewolf Therapeutics$521,8820.0%626,8100.1%MedicalSKYE BIOSCIENCE INC$417,269$122,920 â–²41.8%678,9280.1%COM NEWPRECISION BIOSCIENCES INC$220,000$1,958,638 â–¼-89.9%40,0000.0%COM NEWAPREAprea Therapeutics$205,9830.0%270,0000.0%MedicalFHTXFoghorn Therapeutics$58,431$58,431 â–²New Holding12,2240.0%MedicalASTRAZENECA PLC$0$12,416,066 â–¼-100.0%00.0%SPONSORED ADRPRAXIS PRECISION MEDICINES I$0$11,789,600 â–¼-100.0%00.0%COM NEWANNXAnnexon$0$6,607,384 â–¼-100.0%00.0%MedicalATXSAstria Therapeutics$0$4,656,440 â–¼-100.0%00.0%MedicalAMDAdvanced Micro Devices$0$3,863,446 â–¼-100.0%00.0%Computer and TechnologyShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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