Sphera Funds Management Ltd. Top Holdings and 13F Report (2026) About Sphera Funds Management Ltd.Investment ActivitySphera Funds Management Ltd. has $766.54 million in total holdings as of June 30, 2026.Sphera Funds Management Ltd. owns shares of 101 different stocks, but just 50 companies or ETFs make up 80% of its holdings.Approximately 28.12% of the portfolio was purchased this quarter.About 24.10% of the portfolio was sold this quarter.This quarter, Sphera Funds Management Ltd. has purchased 95 new stocks and bought additional shares in 34 stocks.Sphera Funds Management Ltd. sold shares of 28 stocks and completely divested from 18 stocks this quarter.Largest Holdings Teva Pharmaceutical Industries $50,822,778Biogen $42,483,014Mineralys Therapeutics $39,659,818Tower Semiconductor $28,218,190Cytokinetics $27,259,693 Largest New Holdings this Quarter 457669307 - Insmed $12,666,456 Holding76243J105 - Rhythm Pharmaceuticals $8,926,812 Holding512807306 - LAM RESEARCH CORP $8,003,605 Holding038222105 - Applied Materials $7,981,920 Holding45166A102 - IDEAYA Biosciences $7,320,126 Holding Largest Purchases this Quarter Biogen 104,100 shares (about $22.49M)Insmed 118,800 shares (about $12.67M)Teva Pharmaceutical Industries 363,107 shares (about $12.30M)BioMarin Pharmaceutical 188,650 shares (about $10.79M)Rhythm Pharmaceuticals 80,400 shares (about $8.93M) Largest Sales this Quarter CURIS INC 1,895,941 shares (about $19.80M)Nova 28,197 shares (about $15.31M)Tower Semiconductor 37,470 shares (about $9.77M)SPDR S&P Biotech ETF 50,000 shares (about $7.91M)Ultragenyx Pharmaceutical 220,839 shares (about $7.37M) Sector Allocation Over TimeMap of 500 Largest Holdings ofSphera Funds Management Ltd. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorTEVATeva Pharmaceutical Industries$50,822,778$12,302,065 â–²31.9%1,500,0826.6%HealthcareBIIBBiogen$42,483,014$22,491,846 â–²112.5%196,6265.5%HealthcareMLYSMineralys Therapeutics$39,659,818$3,507,400 â–²9.7%1,469,9715.2%HealthcareTSEMTower Semiconductor$28,218,190$9,766,181 â–¼-25.7%108,2653.7%TechnologyCYTKCytokinetics$27,259,693$1,777,915 â–²7.0%319,9873.6%HealthcareXBISPDR S&P Biotech ETF$23,737,500$7,912,500 â–¼-25.0%150,0003.1%ETFSNDXSyndax Pharmaceuticals$22,179,287$6,340,340 â–²40.0%1,014,6062.9%HealthcareRAREUltragenyx Pharmaceutical$19,649,815$7,373,814 â–¼-27.3%588,4942.6%HealthcareBMRNBioMarin Pharmaceutical$18,799,631$10,794,553 â–²134.8%328,5502.5%HealthcareBBIOBridgeBio Pharma$18,273,370$7,448 â–²0.0%245,3462.4%HealthcareCOGTCogent Biosciences$17,776,458$1,664,100 â–²10.3%459,3402.3%HealthcareNVMINova$13,665,257$15,309,279 â–¼-52.8%25,1691.8%TechnologyINSMInsmed$12,666,456$12,666,456 â–²New Holding118,8001.7%HealthcareMAZE THERAPEUTICS INC$12,460,110$5,676,195 â–²83.7%417,5641.6%COMAZNCFAstraZeneca$11,856,9390.0%62,5301.5%HealthcareSNYSanofi$11,497,5100.0%269,5151.5%HealthcareCYBIN INC$10,713,177$4,188,512 â–²64.2%1,620,7531.4%COM NEWLLYEli Lilly and Company$9,643,417$1,199,430 â–¼-11.1%8,0401.3%HealthcareMDGLMadrigal Pharmaceuticals$9,353,132$4,499,104 â–²92.7%17,4191.2%HealthcareTRVITrevi Therapeutics$9,306,891$1,398,750 â–¼-13.1%499,0291.2%HealthcareORICOric Pharmaceuticals$9,237,806$3,415,295 â–²58.7%852,9831.2%HealthcareACADACADIA Pharmaceuticals$9,020,310$2,538,400 â–²39.2%356,5341.2%HealthcareCLDXCelldex Therapeutics$8,962,698$100,727 â–¼-1.1%240,8681.2%HealthcareRYTMRhythm Pharmaceuticals$8,926,812$8,926,812 â–²New Holding80,4001.2%HealthcareLAM RESEARCH CORP$8,003,605$8,003,605 â–²New Holding18,4701.0%COM NEWAMATApplied Materials$7,981,920$7,981,920 â–²New Holding11,0401.0%TechnologyTNGXTango Therapeutics$7,947,855$2,791,924 â–¼-26.0%254,2501.0%HealthcareNVSNovartis$7,832,904$2,036,555 â–²35.1%50,0001.0%HealthcareSOLAREDGE TECHNOLOGIES INC$7,747,1900.0%4,000,0001.0%NOTE 2.250% 7/0VOR BIOPHARMA INC$7,666,237$1,739,745 â–²29.4%416,4171.0%COM NEWABBVAbbVie$7,613,6200.0%30,2561.0%HealthcareMRKMerck & Co., Inc.$7,530,100$1,285,000 â–²20.6%58,6001.0%HealthcareJNJJohnson & Johnson$7,322,2090.0%28,8311.0%HealthcareIDYAIDEAYA Biosciences$7,320,126$7,320,126 â–²New Holding196,4081.0%HealthcareIMTXImmatics$7,294,177$242,634 â–²3.4%720,0571.0%HealthcareNVCTNuvectis Pharma$7,042,359$7,042,359 â–²New Holding382,9450.9%HealthcarePFEPfizer$6,886,880$2,408,000 â–²53.8%286,0000.9%HealthcareHRMYHarmony Biosciences$6,432,300$6,432,300 â–²New Holding176,6630.8%HealthcareXENEXenon Pharmaceuticals$6,337,800$1,327,920 â–¼-17.3%105,0000.8%HealthcareELYMEliem Therapeutics$6,308,061$841,080 â–²15.4%483,7470.8%HealthcareZENAS BIOPHARMA INC$5,858,567$418,770 â–²7.7%230,8340.8%COMNVONovo Nordisk A/S$5,785,2550.0%120,6770.8%HealthcareELVNEnliven Therapeutics$5,722,824$2,055,375 â–¼-26.4%112,7650.7%HealthcarePRLDPrelude Therapeutics$5,435,705$2,459,758 â–²82.7%1,019,8320.7%HealthcareGSKGSK$5,346,840$1,048,400 â–¼-16.4%102,0000.7%HealthcareFORTE BIOSCIENCES INC$5,305,976$1,375,066 â–²35.0%249,6930.7%COM NEWBIOAGE LABS INC$5,237,076$3,116,520 â–²147.0%213,6710.7%COMSRRKScholar Rock$5,184,5750.0%94,2650.7%HealthcareSATELLOS BIOSCIENCE INC$5,073,887$1,270,303 â–²33.4%652,5900.7%COMPALISADE BIO INC$4,717,352$1,094,397 â–²30.2%2,257,1060.6%COMELDNEledon Pharmaceuticals$4,693,277$2,288,919 â–¼-32.8%1,191,1870.6%HealthcareVSTVistra$4,671,654$4,671,654 â–²New Holding29,4500.6%UtilitiesTALEN ENERGY CORP$4,662,995$4,662,995 â–²New Holding12,1350.6%COMSVRASavara$4,657,970$104,720 â–²2.3%756,1640.6%HealthcareIRONDisc Medicine$4,647,169$731,400 â–²18.7%63,5380.6%HealthcareCLOUGlobal X Cloud Computing ETF$4,454,766$4,454,766 â–²New Holding195,9000.6%ETFDYNE THERAPEUTICS INC$4,432,983$866,190 â–²24.3%199,5940.6%COMRLAYRelay Therapeutics$4,375,072$3,266,766 â–¼-42.7%233,8360.6%HealthcareAVALO THERAPEUTICS INC$4,292,793$4,292,793 â–²New Holding232,2940.6%COM NEWPROMIS NEUROSCIENCES INC$4,284,7840.0%325,5910.6%COM SHSBCRXBioCryst Pharmaceuticals$4,220,510$4,444,130 â–¼-51.3%422,0510.6%HealthcareRVMDRevolution Medicines$4,195,072$6,125,929 â–¼-59.4%22,4000.5%HealthcarePRAXIS PRECISION MEDICINES I$4,184,875$4,184,875 â–²New Holding12,5000.5%COM NEWCABACabaletta Bio$4,133,227$4,133,227 â–²New Holding1,329,0120.5%HealthcareGENERATE BIOMEDICINES INC$4,133,150$1,012,200 â–²32.4%245,0000.5%COM SHSTLTiShares 20+ Year Treasury Bond ETF$4,061,7400.0%47,0000.5%ETFMDWDMediWound$4,015,9220.0%273,1920.5%HealthcareALPHA COGNITION INC$3,940,792$157,396 â–¼-3.8%545,8160.5%COM NEWWVEWAVE Life Sciences$3,708,360$522,900 â–²16.4%638,2720.5%HealthcareCRVSCorvus Pharmaceuticals$3,659,717$44,820 â–¼-1.2%244,9610.5%HealthcareOVIDOvid Therapeutics$3,639,570$725,837 â–¼-16.6%1,353,0000.5%HealthcareTENAX THERAPEUTICS INC$3,605,490$1,626,472 â–²82.2%247,8000.5%COM NEWBRIDGEBIO ONCOLOGY THERAPEUT$3,512,706$3,512,706 â–²New Holding460,9850.5%COM NEWCTMXCytomX Therapeutics$3,296,250$2,471,250 â–²299.5%879,0000.4%HealthcarePRQRProQR Therapeutics$3,268,872$3,268,872 â–²New Holding1,757,4580.4%HealthcareALNYAlnylam Pharmaceuticals$3,251,124$3,251,124 â–²New Holding10,8000.4%HealthcareKURAKura Oncology$3,236,578$5,299 â–¼-0.2%295,0390.4%HealthcareKODKodiak Sciences$3,186,772$1,285,680 â–¼-28.7%81,7960.4%HealthcareORAOrmat Technologies$3,050,834$4,381,592 â–¼-59.0%28,0150.4%UtilitiesCONTINEUM THERAPEUTICS INC$3,007,155$163,900 â–²5.8%183,4750.4%CL ALRMRLarimar Therapeutics$2,824,312$2,824,312 â–²New Holding926,0040.4%HealthcareIMMXImmix Biopharma$2,783,700$2,783,700 â–²New Holding270,0000.4%HealthcareAMGNAmgen$2,715,9000.0%7,5000.4%HealthcareABIVAX SA$2,665,200$2,665,200 â–²New Holding20,0000.3%SPONSORED ADSBHVNBiohaven$2,446,823$6,391,899 â–¼-72.3%164,4370.3%HealthcareCEGConstellation Energy$2,446,445$2,446,445 â–²New Holding9,8500.3%UtilitiesVSTMVerastem$2,416,654$1,103,804 â–²84.1%632,6320.3%HealthcareTSHATaysha Gene Therapies$1,702,500$1,702,500 â–²New Holding250,0000.2%HealthcareGPCRStructure Therapeutics$1,534,962$1,191,474 â–¼-43.7%28,6000.2%HealthcareUPSTREAM BIO INC$1,520,324$957,036 â–¼-38.6%219,7000.2%COMVYGRVoyager Therapeutics$1,496,439$147,725 â–¼-9.0%427,5540.2%HealthcareORGOOrganogenesis$1,336,5000.0%550,0000.2%HealthcareINHIBIKASE THERAPEUTICS INC$1,318,097$1,318,097 â–²New Holding649,3090.2%COM NEWCURIS INC$1,033,717$19,797,431 â–¼-95.0%98,9960.1%COMSTTKShattuck Labs$600,039$1,348,615 â–¼-69.2%86,4610.1%HealthcareFIRST TRACKS BIOTHERAPEUTICS$560,865$560,865 â–²New Holding27,8760.1%ORD SHSSKYE BIOSCIENCE INC$470,7010.0%678,9280.1%COM NEWTRAWS PHARMA INC$336,043$336,043 â–²New Holding398,4860.0%COM NEWEVOMMUNE INC$300,779$738,950 â–¼-71.1%22,6320.0%COM SHSHOWLWerewolf Therapeutics$225,5890.0%626,8100.0%HealthcareShowing largest 100 holdings. 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