Sphera Funds Management Ltd. Top Holdings and 13F Report (2024)

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About Sphera Funds Management Ltd.

Investment Activity

Sphera Funds Management Ltd. has $711.74 million in total holdings as of March 31, 2024.
Sphera Funds Management Ltd. owns shares of 97 different stocks, but just 44 companies or ETFs make up 80% of its holdings.
Approximately 27.85% of the portfolio was purchased this quarter.
About 28.92% of the portfolio was sold this quarter.
This quarter, Sphera Funds Management Ltd. has purchased 91 new stocks and bought additional shares in 23 stocks.
Sphera Funds Management Ltd. sold shares of 33 stocks and completely divested from 19 stocks this quarter.

Largest Holdings

Teva Pharmaceutical Industries: $70,866,063
SPDR S&P Biotech ETF: $36,058,200
Sanofi: $24,276,429
NICE: $22,382,306
Cytokinetics: $19,747,954

Largest New Holdings this Quarter

JASPER THERAPEUTICS INC: $14,833,905 Holding
PRAXIS PRECISION MEDICINES I: $10,809,022 Holding
Cybin: $10,577,907 Holding
OUTLOOK THERAPEUTICS INC: $6,822,857 Holding
Applied Materials: $6,599,360 Holding

Largest Purchases this Quarter

Teva Pharmaceutical Industries: 1,269,300 shares (about $17.91M)
JASPER THERAPEUTICS INC: 505,242 shares (about $14.83M)
PERSPECTIVE THERAPEUTICS INC: 12,417,950 shares (about $14.78M)
BridgeBio Pharma: 353,810 shares (about $10.94M)
PRAXIS PRECISION MEDICINES I: 177,139 shares (about $10.81M)

Largest Sales this Quarter

Nova: 96,894 shares (about $17.19M)
Astria Therapeutics: 1,038,303 shares (about $14.61M)
Selecta Biosciences: 727,066 shares (about $14.18M)
Fusion Pharmaceuticals: 636,598 shares (about $13.57M)
Tower Semiconductor: 348,700 shares (about $11.66M)

Sector Allocation Over Time

Selling

Neutral

Buying

Latest 13F Holdings and Changes Since Previous Quarterly Filing

Issuer Name	Holdings Value	Approximate Purchase/Sale	Change in Shares	Shares Held	% of Portfolio	Sector
TEVA Teva Pharmaceutical Industries	$70,866,063	$17,909,823 ▲	33.8%	5,022,400	10.0%	Medical
XBI SPDR S&P Biotech ETF	$36,058,200	$11,386,800 ▼	-24.0%	380,000	5.1%	ETF
SNY Sanofi	$24,276,429		0.0%	499,515	3.4%	Medical
NICE NICE	$22,382,306	$4,733,641 ▲	26.8%	85,881	3.1%	Computer and Technology
CYTK Cytokinetics	$19,747,954	$1,545,996 ▲	8.5%	281,671	2.8%	Medical
BBIO BridgeBio Pharma	$19,663,760	$10,939,805 ▲	125.4%	635,956	2.8%	Medical
SNDX Syndax Pharmaceuticals	$19,348,543	$952,000 ▲	5.2%	812,964	2.7%	Medical
BIIB Biogen	$15,233,397	$5,239,809 ▲	52.4%	70,646	2.1%	Medical
JASPER THERAPEUTICS INC	$14,833,905	$14,833,905 ▲	New Holding	505,242	2.1%	COM NEW
PERSPECTIVE THERAPEUTICS INC	$14,807,909	$14,777,361 ▲	48,373.5%	12,443,621	2.1%	COM
RARE Ultragenyx Pharmaceutical	$13,705,569	$4,318,825 ▲	46.0%	293,544	1.9%	Medical
MRK Merck & Co., Inc.	$13,670,020	$2,639,000 ▼	-16.2%	103,600	1.9%	Medical
KURA Kura Oncology	$13,028,919	$1,972,193 ▼	-13.1%	610,826	1.8%	Medical
AZN AstraZeneca	$12,876,565	$677,500 ▲	5.6%	190,060	1.8%	Medical
S SentinelOne	$12,839,568	$7,864,794 ▲	158.1%	550,818	1.8%	Computer and Technology
JNJ Johnson & Johnson	$12,628,466		0.0%	79,831	1.8%	Medical
META Meta Platforms	$12,352,670	$4,304,181 ▼	-25.8%	25,439	1.7%	Computer and Technology
CLDX Celldex Therapeutics	$11,625,522	$6,477,985 ▼	-35.8%	276,996	1.6%	Medical
MSFT Microsoft	$11,589,995	$1,556,664 ▲	15.5%	27,548	1.6%	Computer and Technology
LLY Eli Lilly and Company	$11,039,252		0.0%	14,190	1.6%	Medical
PRAXIS PRECISION MEDICINES I	$10,809,022	$10,809,022 ▲	New Holding	177,139	1.5%	COM NEW
NVO Novo Nordisk A/S	$10,667,472	$1,284,000 ▼	-10.7%	83,080	1.5%	Medical
CYBN Cybin	$10,577,907	$10,577,907 ▲	New Holding	25,581,395	1.5%	Medical
INZY Inozyme Pharma	$10,516,468	$1,455,400 ▼	-12.2%	1,372,907	1.5%	Medical
FROG JFrog	$9,922,128	$5,062,129 ▲	104.2%	224,381	1.4%	Computer and Technology
AMZN Amazon.com	$9,818,444	$224,393 ▼	-2.2%	54,432	1.4%	Retail/Wholesale
FUSN Fusion Pharmaceuticals	$9,573,554	$13,572,269 ▼	-58.6%	449,041	1.3%	Medical
PHVS Pharvaris	$9,079,387	$3,417,437 ▲	60.4%	392,877	1.3%	Medical
MLYS Mineralys Therapeutics	$8,505,147	$1,094,613 ▼	-11.4%	658,803	1.2%	Medical
DAWN Day One Biopharmaceuticals	$8,138,198	$336,562 ▼	-4.0%	492,627	1.1%	Medical
GLBE Global-E Online	$7,589,298	$2,217,713 ▼	-22.6%	208,784	1.1%	Retail/Wholesale
WIX Wix.com	$7,269,530	$632,408 ▼	-8.0%	52,877	1.0%	Computer and Technology
SRPT Sarepta Therapeutics	$7,199,788	$2,163,794 ▲	43.0%	55,614	1.0%	Medical
IMTX Immatics	$7,000,827	$472,950 ▲	7.2%	666,111	1.0%	Medical
ABBV AbbVie	$6,919,800	$1,456,800 ▼	-17.4%	38,000	1.0%	Medical
OUTLOOK THERAPEUTICS INC	$6,822,857	$6,822,857 ▲	New Holding	571,429	1.0%	COM
MRUS Merus	$6,724,465	$3,647,430 ▼	-35.2%	149,333	0.9%	Medical
AMAT Applied Materials	$6,599,360	$6,599,360 ▲	New Holding	32,000	0.9%	Computer and Technology
CAMT Camtek	$6,275,127	$6,275,127 ▲	New Holding	74,909	0.9%	Computer and Technology
NVMI Nova	$6,227,102	$17,187,057 ▼	-73.4%	35,106	0.9%	Computer and Technology
TSEM Tower Semiconductor	$6,007,620	$11,664,015 ▼	-66.0%	179,600	0.8%	Computer and Technology
ETNB 89bio	$6,004,866	$1,247,901 ▲	26.2%	515,882	0.8%	Medical
VIGL Vigil Neuroscience	$5,900,712	$4,075,953 ▲	223.4%	1,730,414	0.8%	Medical
ENPH Enphase Energy	$5,708,199	$2,385,363 ▼	-29.5%	47,183	0.8%	Oils/Energy
VTYX Ventyx Biosciences	$5,460,120	$4,470,120 ▲	451.5%	992,749	0.8%	Medical
TBLA Taboola.com	$5,288,351	$2,370,418 ▼	-31.0%	1,191,070	0.7%	Computer and Technology
FDMT 4D Molecular Therapeutics	$5,166,449	$5,166,449 ▲	New Holding	162,161	0.7%	Medical
INCY Incyte	$5,102,005		0.0%	89,556	0.7%	Medical
RCKT Rocket Pharmaceuticals	$4,949,471	$190,223 ▼	-3.7%	183,722	0.7%	Medical
NVS Novartis	$4,836,500	$967,300 ▼	-16.7%	50,000	0.7%	Medical
SEDG SolarEdge Technologies	$4,753,886	$555,419 ▼	-10.5%	66,975	0.7%	Oils/Energy
IRON Disc Medicine	$4,600,142	$4,600,142 ▲	New Holding	73,886	0.6%	Medical
CPRX Catalyst Pharmaceuticals	$4,590,720	$4,590,720 ▲	New Holding	288,000	0.6%	Medical
GSK GSK	$4,287,000		0.0%	100,000	0.6%	Medical
VTGN Vistagen Therapeutics	$4,269,144		0.0%	808,550	0.6%	Medical
APLT Applied Therapeutics	$4,209,397	$4,209,397 ▲	New Holding	619,029	0.6%	Medical
ACAD ACADIA Pharmaceuticals	$4,160,250	$4,160,250 ▲	New Holding	225,000	0.6%	Medical
HOWL Werewolf Therapeutics	$4,061,729		0.0%	626,810	0.6%	Medical
AKRO Akero Therapeutics	$4,052,841	$4,052,841 ▲	New Holding	160,445	0.6%	Medical
SHLT SHL Telemedicine	$3,857,982		0.0%	632,456	0.5%	Medical
PLRX Pliant Therapeutics	$3,852,455	$968,500 ▲	33.6%	258,554	0.5%	Medical
PMN ProMIS Neurosciences	$3,503,030	$10 ▲	0.0%	1,834,047	0.5%	Medical
SWTX SpringWorks Therapeutics	$3,458,640	$4,922,049 ▼	-58.7%	70,269	0.5%	Medical
ALEC Alector	$3,371,200	$3,371,200 ▲	New Holding	560,000	0.5%	Medical
AAPL Apple	$3,000,900	$3,000,900 ▲	New Holding	17,500	0.4%	Computer and Technology
ALNY Alnylam Pharmaceuticals	$2,989,000	$5,414,574 ▼	-64.4%	20,000	0.4%	Medical
ENLT Enlight Renewable Energy	$2,864,218		0.0%	169,280	0.4%	Oils/Energy
RZLT Rezolute	$2,541,611		0.0%	996,710	0.4%	Medical
QCOM QUALCOMM	$2,539,500	$2,539,500 ▲	New Holding	15,000	0.4%	Computer and Technology
PFE Pfizer	$2,497,500		0.0%	90,000	0.4%	Medical
ELEV Elevation Oncology	$2,205,900	$2,411,100 ▼	-52.2%	430,000	0.3%	Medical
ESTC Elastic	$2,004,800	$2,004,800 ▲	New Holding	20,000	0.3%	Business Services
AMD Advanced Micro Devices	$1,985,390	$7,108,960 ▼	-78.2%	11,000	0.3%	Computer and Technology
CGEN Compugen	$1,984,637		0.0%	769,239	0.3%	Medical
NTR Nutrien	$1,940,496	$1,940,496 ▲	New Holding	35,730	0.3%	Basic Materials
KZR Kezar Life Sciences	$1,849,791		0.0%	2,051,676	0.3%	Medical
APRE Aprea Therapeutics	$1,806,300	$1,806,300 ▲	New Holding	270,000	0.3%	Medical
ALPN Alpine Immune Sciences	$1,777,497	$7,531,599 ▼	-80.9%	44,841	0.2%	Medical
FIVN Five9	$1,708,025	$776,375 ▲	83.3%	27,500	0.2%	Computer and Technology
CARGO THERAPEUTICS INC	$1,674,000		0.0%	75,000	0.2%	COM
ATXS Astria Therapeutics	$1,588,251	$14,614,113 ▼	-90.2%	112,842	0.2%	Medical
AMLX Amylyx Pharmaceuticals	$1,440,590	$635,024 ▲	78.8%	507,250	0.2%	Medical
PRME Prime Medicine	$1,436,694	$918,834 ▲	177.4%	205,242	0.2%	Medical
UPWK Upwork	$1,434,420	$1,664,712 ▼	-53.7%	117,000	0.2%	Computer and Technology
CRBP Corbus Pharmaceuticals	$1,373,400	$1,373,400 ▲	New Holding	35,000	0.2%	Medical
AVGO Broadcom	$1,326,735	$1,059,002 ▼	-44.4%	1,001	0.2%	Computer and Technology
GERN Geron	$1,268,375	$1,268,375 ▲	New Holding	384,356	0.2%	Medical
LVTX LAVA Therapeutics	$1,224,048	$1,224,048 ▲	New Holding	367,582	0.2%	Medical
GOSS Gossamer Bio	$1,212,018	$366,928 ▼	-23.2%	1,027,134	0.2%	Medical
VRNS Varonis Systems	$943,400	$943,400 ▲	New Holding	20,000	0.1%	Computer and Technology
INSM Insmed	$762,353	$762,353 ▲	New Holding	28,100	0.1%	Medical
ICL ICL Group	$701,956	$1,557,646 ▼	-68.9%	130,475	0.1%	Basic Materials
SELB Selecta Biosciences	$488,889	$14,177,918 ▼	-96.7%	25,071	0.1%	Medical
ALTO NEUROSCIENCE INC	$468,175	$468,175 ▲	New Holding	30,500	0.1%	COM SHS
IMTXW Immatics	$270,000		0.0%	100,000	0.0%	Medical
ARBE Arbe Robotics	$90,215		0.0%	43,165	0.0%	Business Services
ANNX Annexon	$81,738	$81,738 ▲	New Holding	11,400	0.0%	Medical
INBX Inhibrx	$0	$8,608,938 ▼	-100.0%	0	0.0%	Medical
PRAX Praxis Precision Medicines	$0	$7,329,808 ▼	-100.0%	0	0.0%	Medical
MDGL Madrigal Pharmaceuticals	$0	$6,424,728 ▼	-100.0%	0	0.0%	Medical