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Stocks to Compare Sections All Sections Selected Performance Chart Price & Volume MarketRank Analyst Ratings Sales & Book Value Profitability & Earnings Dividends Debt Ownership Miscellaneous Headlines About Compare NASDAQ:ALDR NASDAQ:CNST NASDAQ:ESPR NASDAQ:LGND On This Page Performance ChartPrice & VolumeMarketRank™Analyst RatingsSales & Book ValueProfitability & EarningsDividendsDebtOwnershipMiscellaneousHeadlinesAbout Comparison Ideas Stock Ideas Comparative Price Performance Over Time1 day7 days30 days90 days365 daysCompare Price & VolumeCompanyCurrent Price50-Day Moving Average52-Week RangeMarket CapBetaAvg. VolumeToday's VolumeALDRAlder Biopharmaceuticals$18.88$18.88$8.39▼$19.12$1.58B2.645.12 million shsN/ACNSTConstellation Pharmaceuticals$33.99$33.89$17.00▼$39.30$1.63B2.59940,325 shsN/AESPREsperion Therapeutics$2.78-2.1%$1.82$0.69▼$3.94$560.51M0.894.97 million shs5.42 million shsLGNDLigand Pharmaceuticals$165.51-0.1%$146.09$93.58▼$169.49$3.24B0.96150,812 shs315,457 shsThe 10 Best AI Stocks to Own in 2025Wondering where to start (or end) with AI stocks? These 10 simple stocks can help investors build long-term wealth as artificial intelligence continues to grow into the future.Get This Free ReportCompare Price PerformanceCompany1-Day Performance7-Day Performance30-Day Performance90-Day Performance1-Year PerformanceALDRAlder Biopharmaceuticals0.00%0.00%0.00%0.00%0.00%CNSTConstellation Pharmaceuticals0.00%0.00%0.00%0.00%0.00%ESPREsperion Therapeutics0.00%+5.97%+38.54%+142.74%+48.69%LGNDLigand Pharmaceuticals0.00%-0.60%+9.71%+44.12%+58.20%Compare Price & VolumeCompanyCurrent Price50-Day Moving Average52-Week RangeMarket CapBetaAvg. VolumeToday's VolumeALDRAlder Biopharmaceuticals$18.88$18.88$8.39▼$19.12$1.58B2.645.12 million shsN/ACNSTConstellation Pharmaceuticals$33.99$33.89$17.00▼$39.30$1.63B2.59940,325 shsN/AESPREsperion Therapeutics$2.78-2.1%$1.82$0.69▼$3.94$560.51M0.894.97 million shs5.42 million shsLGNDLigand Pharmaceuticals$165.51-0.1%$146.09$93.58▼$169.49$3.24B0.96150,812 shs315,457 shsThe 10 Best AI Stocks to Own in 2025Wondering where to start (or end) with AI stocks? These 10 simple stocks can help investors build long-term wealth as artificial intelligence continues to grow into the future.Get This Free ReportCompare Price PerformanceCompany1-Day Performance7-Day Performance30-Day Performance90-Day Performance1-Year PerformanceALDRAlder Biopharmaceuticals0.00%0.00%0.00%0.00%0.00%CNSTConstellation Pharmaceuticals0.00%0.00%0.00%0.00%0.00%ESPREsperion Therapeutics0.00%+5.97%+38.54%+142.74%+48.69%LGNDLigand Pharmaceuticals0.00%-0.60%+9.71%+44.12%+58.20%Compare Analyst ForecastsCompanyConsensus Rating ScoreConsensus RatingConsensus Price Target% Upside from Current PriceALDRAlder Biopharmaceuticals 0.00N/AN/AN/ACNSTConstellation Pharmaceuticals 0.00N/AN/AN/AESPREsperion Therapeutics 2.80Moderate Buy$7.00149.55% UpsideLGNDLigand Pharmaceuticals 3.00Buy$176.506.96% UpsideCurrent Analyst Ratings BreakdownLatest ALDR, ESPR, CNST, and LGND Analyst RatingsDateCompanyBrokerageActionRatingPrice TargetDetails9/3/2025LGNDLigand PharmaceuticalsOppenheimerSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingBoost Price TargetOutperform$167.00 ➝ $190.009/2/2025LGNDLigand PharmaceuticalsBenchmarkSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingBoost Price TargetBuy$160.00 ➝ $175.008/28/2025LGNDLigand PharmaceuticalsHC WainwrightSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingBoost Price TargetBuy$157.00 ➝ $206.008/8/2025LGNDLigand PharmaceuticalsRoyal Bank Of CanadaSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingBoost Price TargetOutperform$155.00 ➝ $185.007/30/2025LGNDLigand PharmaceuticalsOppenheimerSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingBoost Price TargetOutperform$145.00 ➝ $162.006/17/2025ESPREsperion TherapeuticsHC WainwrightSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingReiterated RatingBuy$16.00(Data available from 9/15/2022 forward. View 10+ years of historical ratings with our analyst ratings screener.)Compare Sales & Book ValueCompanyAnnual RevenuePrice/SalesCashflowPrice/CashBook ValuePrice/BookALDRAlder Biopharmaceuticals$1.62M977.10N/AN/A$1.61 per share11.73CNSTConstellation PharmaceuticalsN/AN/AN/AN/A$8.63 per shareN/AESPREsperion Therapeutics$268.13M2.11$0.02 per share118.20($1.97) per share-1.42LGNDLigand Pharmaceuticals$187.58M17.24$1.60 per share103.15$43.95 per share3.75Compare Profitability & EarningsCompanyNet IncomeEPSTrailing P/E RatioForward P/E RatioP/E GrowthNet MarginsReturn on Equity (ROE)Return on Assets (ROA)Next Earnings DateALDRAlder Biopharmaceuticals-$296.43M-$4.87N/AN/AN/AN/A-226.13%-66.86%N/ACNSTConstellation Pharmaceuticals-$126.36M-$2.81N/AN/AN/AN/A-33.12%-29.92%N/AESPREsperion Therapeutics-$51.74M-$0.49N/AN/A63.79-35.84%-0.91%-28.41%11/6/2025 (Estimated)LGNDLigand Pharmaceuticals-$4.03M-$4.00N/A44.48N/A-40.44%-9.21%-8.09%11/6/2025 (Estimated)Latest ALDR, ESPR, CNST, and LGND EarningsDateQuarterCompanyConsensus EstimateReported EPSBeat/MissGap EPSRevenue EstimateActual RevenueDetails8/7/2025Q2 2025LGNDLigand Pharmaceuticals$1.54$1.60+$0.06$0.24$43.87 million$47.63 million8/5/2025Q2 2025ESPREsperion Therapeutics-$0.17-$0.02+$0.15-$0.02$62.55 million$82.39 millionCompare DividendsCompanyAnnual PayoutDividend Yield3-Year Dividend GrowthPayout RatioYears of Consecutive GrowthALDRAlder BiopharmaceuticalsN/AN/AN/AN/AN/ACNSTConstellation PharmaceuticalsN/AN/AN/AN/AN/AESPREsperion TherapeuticsN/AN/AN/AN/AN/ALGNDLigand PharmaceuticalsN/AN/AN/AN/AN/ACompare DebtCompanyDebt-to-Equity RatioCurrent RatioQuick RatioALDRAlder Biopharmaceuticals1.748.948.94CNSTConstellation PharmaceuticalsN/A15.3915.39ESPREsperion TherapeuticsN/A1.150.76LGNDLigand PharmaceuticalsN/A5.455.21Compare OwnershipInstitutional OwnershipCompanyInstitutional OwnershipALDRAlder BiopharmaceuticalsN/ACNSTConstellation PharmaceuticalsN/AESPREsperion Therapeutics47.39%LGNDLigand Pharmaceuticals91.28%Insider OwnershipCompanyInsider OwnershipALDRAlder Biopharmaceuticals15.40%CNSTConstellation Pharmaceuticals43.70%ESPREsperion Therapeutics1.70%LGNDLigand Pharmaceuticals7.00%Compare Miscellaneous StatsCompanyEmployeesShares OutstandingFree FloatOptionableALDRAlder Biopharmaceuticals20283.84 millionN/AOptionableCNSTConstellation Pharmaceuticals15447.92 millionN/ANot OptionableESPREsperion Therapeutics200201.62 million198.20 millionOptionableLGNDLigand Pharmaceuticals8019.60 million18.23 millionOptionableALDR, ESPR, CNST, and LGND HeadlinesRecent News About These CompaniesRhumbline Advisers Sells 1,989 Shares of Ligand Pharmaceuticals Incorporated $LGNDSeptember 15 at 4:59 AM | marketbeat.comEllsworth Advisors LLC Makes New Investment in Ligand Pharmaceuticals Incorporated $LGNDSeptember 13 at 6:52 AM | marketbeat.comLigand Pharmaceuticals Incorporated (NASDAQ:LGND) Sees Large Growth in Short InterestSeptember 11, 2025 | marketbeat.comBaird Financial Group Inc. Reduces Stock Position in Ligand Pharmaceuticals Incorporated $LGNDSeptember 10, 2025 | marketbeat.comJacobs Levy Equity Management Inc. Invests $16.53 Million in Ligand Pharmaceuticals Incorporated $LGNDSeptember 9, 2025 | marketbeat.comLigand Pharmaceuticals Incorporated $LGND Shares Bought by Clark Capital Management Group Inc.September 7, 2025 | marketbeat.comLigand Pharmaceuticals (NASDAQ:LGND) Price Target Raised to $190.00 at OppenheimerSeptember 5, 2025 | marketbeat.comInsider Selling: Ligand Pharmaceuticals (NASDAQ:LGND) Director Sells 467 Shares of StockSeptember 5, 2025 | insidertrades.comLigand Pharmaceuticals (NASDAQ:LGND) Sets New 52-Week High After Analyst UpgradeSeptember 5, 2025 | marketbeat.comLigand Pharmaceuticals (NASDAQ:LGND) Sets New 52-Week High Following Analyst UpgradeSeptember 5, 2025 | americanbankingnews.comBenchmark Forecasts Strong Price Appreciation for Ligand Pharmaceuticals (NASDAQ:LGND) StockSeptember 4, 2025 | marketbeat.comWhat Analysts Are Saying About Ligand Pharmaceuticals StockSeptember 3, 2025 | benzinga.comLigand Pharmaceuticals Incorporated $LGND Stake Reduced by Ashford Capital Management Inc.September 1, 2025 | marketbeat.comLigand Pharmaceuticals Incorporated $LGND Shares Acquired by Northern Trust CorpSeptember 1, 2025 | marketbeat.comLigand Pharmaceuticals Incorporated $LGND Shares Purchased by American Century Companies Inc.September 1, 2025 | marketbeat.comLigand Pharmaceuticals (NASDAQ:LGND) Reaches New 52-Week High Following Analyst UpgradeAugust 31, 2025 | marketbeat.comNuveen LLC Buys New Stake in Ligand Pharmaceuticals Incorporated $LGNDAugust 29, 2025 | marketbeat.comLigand Pharmaceuticals Incorporated (NASDAQ:LGND) Receives Consensus Rating of "Buy" from BrokeragesAugust 26, 2025 | marketbeat.comLigand Pharmaceuticals Incorporated $LGND Shares Bought by CW Advisors LLCAugust 24, 2025 | marketbeat.comInvesco Ltd. Purchases 8,473 Shares of Ligand Pharmaceuticals Incorporated $LGNDAugust 23, 2025 | marketbeat.comA Fresh Look at Ligand Pharmaceuticals (LGND) Valuation Following $400 Million Convertible Note Offering and Capital Structure ShiftAugust 22, 2025 | finance.yahoo.comNew MarketBeat Followers Over TimeMedia Sentiment Over TimeALDR, ESPR, CNST, and LGND Company DescriptionsAlder Biopharmaceuticals NASDAQ:ALDRAlder BioPharmaceuticals, Inc. operates as a clinical-stage biopharmaceutical company. It discovers, develops, and commercializes therapeutic antibodies to transform the treatment paradigm for patients with migraine in the United States, Australia, and Ireland. The company's lead product candidate is eptinezumab, a monoclonal antibody (mAb) inhibiting calcitonin gene-related peptide, which is in the late-stage clinical development for the prevention of migraine. It also develops ALD1910, a preclinical mAb that inhibits pituitary adenylate cyclase-activating polypeptide-38 for migraine prevention; and Clazakizumab, a mAb inhibiting the pro-inflammatory cytokine interleukin-6 that has completed two Phase 2b clinical trials. The company has strategic collaboration with CSL Limited for the development of clazakizumab as a therapeutic option for solid organ transplant rejection. Alder BioPharmaceuticals, Inc. was incorporated in 2002 and is headquartered in Bothell, Washington.Constellation Pharmaceuticals NASDAQ:CNSTConstellation Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, discovers and develops therapeutics to address serious unmet medical needs in patients with cancers associated with abnormal gene expression or drug resistance. The company's lead product candidates include Pelabresib that is in Phase 3 clinical trials for the treatment of patients with myelofibrosis in combination with ruxolitinib. It is also developing CPI-0209 that is in Phase 1 dose escalation portion of a Phase 1/2 clinical trial to treat solid tumors; and CPI-482, which is in preclinical stage for cancer patients. The company was formerly known as Epigenetix, Inc. and changed its name to Constellation Pharmaceuticals, Inc. in March 2008. Constellation Pharmaceuticals, Inc. was incorporated in 2008 and is headquartered in Cambridge, Massachusetts.Esperion Therapeutics NASDAQ:ESPR$2.78 -0.06 (-2.11%) Closing price 04:00 PM EasternExtended Trading$2.80 +0.02 (+0.72%) As of 06:23 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.Esperion Therapeutics, Inc., a pharmaceutical company, develops and commercializes medicines for the treatment of patients with elevated low density lipoprotein cholesterol (LDL-C). Its marketed products include NEXLETOL (bempedoic acid) and NEXLIZET (bempedoic acid and ezetimibe) tablets that are oral, once-daily, non-statin medicines for the treatment of primary hyperlipidemia in adults with heterozygous familial hypercholesterolemia or atherosclerotic cardiovascular disease who require additional lowering of LDL-C. The company's products also include NILEMDO, an ATP Citrate Lyase (ACL) inhibitor that lowers LDL-C and cardiovascular risk by reducing cholesterol biosynthesis and up-regulating the LDL receptors; and NUSTENDI, a bempedoic acid and ezetimibe tablet to treat elevated LDL-C. The company has license and collaboration agreements with Daiichi Sankyo Co. Ltd to; Otsuka Pharmaceutical Co., Ltd; and Daiichi Sankyo Europe GmbH. Esperion Therapeutics, Inc. was incorporated in 2008 and is headquartered in Ann Arbor, Michigan.Ligand Pharmaceuticals NASDAQ:LGND$165.51 -0.24 (-0.14%) Closing price 04:00 PM EasternExtended Trading$165.31 -0.20 (-0.12%) As of 06:16 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.Ligand Pharmaceuticals Incorporated, a biopharmaceutical company, engages in the development and licensing of biopharmaceutical assets worldwide. Its commercial programs include Kyprolis and Evomela, which are used to treat multiple myeloma; Rylaze, a recombinant erwinia asparaginase for the treatment of acute lymphoblastic leukemia or lymphoblastic lymphoma in adult and pediatric patients; Filspari, a dual endothelin and angiotensin II receptor antagonist in development for rare kidney diseases and non-immunosuppressive treatment indicated for immunoglobulin A nephropathy; Teriparatide injection product for osteoporosis; Vaxneuvance for the prevention of invasive disease caused by streptococcus pneumoniae serotypes; and Pneumosil, a pneumococcal conjugate vaccine to help fight against pneumococcal pneumonia among children. The company also offers TZIELD, a CD3-directed antibody indicated to delay the onset of Stage 3 type 1 diabetes (T1D) in adults and children aged 8 years and older with Stage 2 T1D; Nexterone, a captisol-enabled formulation of amiodarone; Zulresso, a captisol-enabled formulation of brexanolone for the treatment of postpartum depression; and Veklury, an antiviral treatment for moderate or severe COVID-19. In addition, it provides Noxafil-IV, a captisol-enabled formulation of posaconazole for IV use; Duavee for the treatment of post-menopausal symptoms in women; Exemptia for autoimmune diseases; Vivitra for breast cancer; and Bryxta and Zybev for various indications. The company has alliances, licenses, and other business relationships with Amgen, Merck, Pfizer, Jazz, Takeda, Gilead Sciences, and Baxter International. Further, it sells Captisol materials. Ligand Pharmaceuticals Incorporated was incorporated in 1987 and is based in Jupiter, Florida. 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