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Comparative Price Performance Over Time

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
CLDI Calidi Biotherapeutics	$5.29 +5.0%	$5.45	$2.43 ▼ $46.68	$16.01M	1.15	648,749 shs	116,336 shs
IKT Inhibikase Therapeutics	$1.75 +15.9%	$1.81	$1.12 ▼ $4.20	$130.10M	0.9	196,334 shs	167,813 shs
NITE Nightstar Therapeutics	$32.09 +0.1%	$25.41	$9.59 ▼ $29.55	$1.08B	2.84	185,808 shs	259 shs
PRME Prime Medicine	$3.46 -1.4%	$3.15	$1.11 ▼ $5.17	$465.36M	2.39	2.50 million shs	4.89 million shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
CLDI Calidi Biotherapeutics	+0.60%	-29.19%	-44.74%	-3.89%	-75.86%
IKT Inhibikase Therapeutics	+5.59%	-5.63%	-18.38%	-32.29%	+17.97%
NITE Nightstar Therapeutics	0.00%	+2.66%	+1.93%	+8.47%	+39.47%
PRME Prime Medicine	-7.39%	-22.00%	-19.31%	+176.38%	-16.33%

Compare MarketRank™

Company	Overall Score	Analyst's Opinion	Short Interest Score	Dividend Strength	ESG Score	News and Social Media Sentiment	Company Ownership	Earnings & Valuation
CLDI Calidi Biotherapeutics	0.1745 of 5 stars	0.0	2.0	0.0	0.0	1.3	0.0	0.6
IKT Inhibikase Therapeutics	1.9857 of 5 stars	3.3	3.0	0.0	0.0	1.1	0.0	1.3
NITE Nightstar Therapeutics	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
PRME Prime Medicine	3.6244 of 5 stars	4.4	1.0	0.0	0.0	2.3	5.0	0.6

Compare Analyst Forecasts

Company	Consensus Rating Score	Consensus Rating	Consensus Price Target	% Upside from Current Price
CLDI Calidi Biotherapeutics	0.00	N/A	N/A	N/A
IKT Inhibikase Therapeutics	2.50	Moderate Buy	$6.50	271.43% Upside
NITE Nightstar Therapeutics	0.00	N/A	N/A	N/A
PRME Prime Medicine	2.75	Moderate Buy	$8.92	157.71% Upside

Current Analyst Ratings Breakdown

Latest NITE, PRME, CLDI, and IKT Analyst Ratings

Date	Company	Brokerage	Action	Rating	Price Target
8/8/2025	PRME Prime Medicine	Chardan Capital Subscribe to MarketBeat All Access for the recommendation accuracy rating	Lower Price Target	Buy ➝ Buy	$12.00 ➝ $10.00
7/16/2025	PRME Prime Medicine	Wedbush Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Outperform	$8.00
5/27/2025	PRME Prime Medicine	Citigroup Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Buy ➝ Neutral	$10.00 ➝ $1.50
5/20/2025	PRME Prime Medicine	JMP Securities Subscribe to MarketBeat All Access for the recommendation accuracy rating	Lower Price Target	Market Outperform ➝ Market Outperform	$10.00 ➝ $6.00
5/20/2025	PRME Prime Medicine	HC Wainwright Subscribe to MarketBeat All Access for the recommendation accuracy rating	Downgrade	Buy ➝ Neutral
5/20/2025	PRME Prime Medicine	JPMorgan Chase & Co. Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Overweight ➝ Neutral
5/19/2025	PRME Prime Medicine	Chardan Capital Subscribe to MarketBeat All Access for the recommendation accuracy rating	Lower Price Target	Buy ➝ Buy	$16.00 ➝ $12.00

(Data available from 8/12/2022 forward. View 10+ years of historical ratings with our analyst ratings screener.)

Compare Sales & Book Value

Company	Annual Revenue	Price/Sales	Cashflow	Price/Cash	Book Value	Price/Book
CLDI Calidi Biotherapeutics	N/A	N/A	N/A	N/A	($2.32) per share	N/A
IKT Inhibikase Therapeutics	N/A	N/A	N/A	N/A	$1.78 per share	N/A
NITE Nightstar Therapeutics	N/A	N/A	N/A	N/A	$5.89 per share	N/A
PRME Prime Medicine	$4.96M	93.80	N/A	N/A	$1.37 per share	2.53

Compare Profitability & Earnings

Company	Net Income	EPS	Trailing P/E Ratio	Forward P/E Ratio	P/E Growth	Net Margins	Return on Equity (ROE)	Return on Assets (ROA)	Next Earnings Date
CLDI Calidi Biotherapeutics	-$29.22M	N/A	0.00	N/A	N/A	N/A	N/A	-344.45%	N/A
IKT Inhibikase Therapeutics	-$19.03M	-$2.67	N/A	N/A	N/A	N/A	-350.63%	-201.82%	N/A
NITE Nightstar Therapeutics	-$36.86M	-$1.26	N/A	N/A	N/A	N/A	-30.89%	-27.65%	N/A
PRME Prime Medicine	-$198.13M	-$1.56	N/A	N/A	N/A	N/A	-107.87%	-74.97%	N/A

Compare Dividends

Company	Annual Payout	Dividend Yield	3-Year Dividend Growth	Payout Ratio	Years of Consecutive Growth
CLDI Calidi Biotherapeutics	N/A	N/A	N/A	N/A	N/A
IKT Inhibikase Therapeutics	N/A	N/A	N/A	N/A	N/A
NITE Nightstar Therapeutics	N/A	N/A	N/A	N/A	N/A
PRME Prime Medicine	$1.45	41.79%	N/A	N/A	N/A

Compare Debt

Company	Debt-to-Equity Ratio	Current Ratio	Quick Ratio
CLDI Calidi Biotherapeutics	N/A	0.19	0.19
IKT Inhibikase Therapeutics	N/A	0.85	0.85
NITE Nightstar Therapeutics	N/A	8.54	8.54
PRME Prime Medicine	N/A	6.50	6.50

Compare Ownership

Institutional Ownership

Company	Institutional Ownership
CLDI Calidi Biotherapeutics	12.53%
IKT Inhibikase Therapeutics	3.81%
NITE Nightstar Therapeutics	32.83%
PRME Prime Medicine	70.37%

Insider Ownership

Company	Insider Ownership
CLDI Calidi Biotherapeutics	6.70%
IKT Inhibikase Therapeutics	7.30%
NITE Nightstar Therapeutics	N/A
PRME Prime Medicine	22.74%

Compare Miscellaneous Stats

Company	Employees	Shares Outstanding	Free Float	Optionable
CLDI Calidi Biotherapeutics	38	3.03 million	20.04 million	N/A
IKT Inhibikase Therapeutics	6	74.34 million	66.18 million	Not Optionable
NITE Nightstar Therapeutics	47	33.54 million	N/A	Not Optionable
PRME Prime Medicine	234	134.50 million	100.38 million	Optionable

NITE, PRME, CLDI, and IKT Headlines

Recent News About These Companies

Chardan Capital Lowers Prime Medicine (NYSE:PRME) Price Target to $10.00

August 10 at 4:59 PM | marketbeat.com

Prime Medicine (NYSE:PRME) Price Target Cut to $10.00 by Analysts at Chardan Capital

August 10 at 2:49 AM | americanbankingnews.com

Prime Medicine, Inc.: Strong Buy Rating Backed by Promising Pipeline and Robust Financial Position

August 8, 2025 | tipranks.com

PRME Revenue Misses by 73%

August 8, 2025 | aol.comA

Prime Medicine, Inc. (PRME) Reports Q2 Loss, Lags Revenue Estimates

August 7, 2025 | zacks.com

Prime Medicine Reports Second Quarter 2025 Financial Results and Provides Business Updates

August 7, 2025 | globenewswire.com

Prime Medicine (NYSE:PRME) Trading Down 6.7% - Here's What Happened

August 6, 2025 | marketbeat.com

Prime Medicine (NYSE:PRME) Shares Gap Up Following Insider Buying Activity

August 6, 2025 | americanbankingnews.com

Prime Medicine Holds Special Stockholder Meeting

August 5, 2025 | tipranks.com

Prime Medicine (NYSE:PRME) Shares Gap Up on Insider Buying Activity

August 5, 2025 | marketbeat.com

Friday’s Insider Trades: Key Buys and Sells in US Stocks Revealed

August 4, 2025 | investing.com

Arch Venture Partners Xii, Llc Purchases 3,030,300 Shares of Prime Medicine, Inc. (NYSE:PRME) Stock

August 2, 2025 | marketbeat.com

Prime Medicine, Inc. (NYSE:PRME) Major Shareholder Arch Venture Partners Xii, Llc Purchases 3,030,300 Shares

August 2, 2025 | insidertrades.com

Prime Medicine Halts Sales Agreement Prospectus

August 1, 2025 | theglobeandmail.com

Prime Medicine Announces Closing of Public Offering and Full Exercise of the Underwriters’ Option to Purchase Additional Shares

August 1, 2025 | finance.yahoo.com

Prime Medicine Announces Closing of Public Offering and Full Exercise of the Underwriters' Option to Purchase Additional Shares

August 1, 2025 | globenewswire.com

Prime Medicine (NYSE:PRME) Shares Gap Down - Here's Why

August 1, 2025 | marketbeat.com

Prime Medicine stock falls after pricing public offering

August 1, 2025 | za.investing.com

JonesTrading Maintains a Buy on Prime Medicine (PRME)

August 1, 2025 | msn.com

Prime Medicine (NYSE:PRME) Trading Up 6.9% - Here's Why

July 31, 2025 | marketbeat.com

Prime Medicine Announces Pricing of Public Offering

July 30, 2025 | globenewswire.com

New MarketBeat Followers Over Time

Media Sentiment Over Time

Top Headlines

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NITE, PRME, CLDI, and IKT Company Descriptions

Calidi Biotherapeutics NYSE:CLDI

$5.29 +0.25 (+4.96%)

Closing price 04:00 PM Eastern

Extended Trading

$5.23 -0.06 (-1.13%)

As of 05:15 PM Eastern

Calidi Biotherapeutics, Inc., a clinical stage immuno-oncology company, engages in developing allogeneic stem cell-based platforms to potentiate and deliver oncolytic viruses to cancer patients in the United States. Its product pipeline comprising CLD-101, which is in phase 1b clinical trial for the treatment of high grade glioma; CLD-101, which is in phase 1 clinical trial for the treatment of recurrent high grade glioma; CLD-201, which is in preclinical trial for the treatment of advanced solid tumors, such as triple-negative breast cancer, metastatic/unresectable melanoma, head and neck squamous cell carcinoma, advanced soft tissue sarcoma, and advanced basal cell carcinoma; and CLD-400, which is in preclinical trial for the treatment of lung cancer and metastatic solid tumors. The company offers NeuroNova platform and SuperNova platform. The company is headquartered in San Diego, California.

Inhibikase Therapeutics NYSE:IKT

$1.75 +0.24 (+15.89%)

Closing price 04:00 PM Eastern

Extended Trading

$1.75 +0.00 (+0.06%)

As of 05:00 PM Eastern

Inhibikase Therapeutics, Inc., a clinical-stage pharmaceutical company, develops therapeutics for Parkinson's disease and related disorders. Its lead product candidate is IkT-148009, a non-receptor Abelson tyrosine kinase inhibitor, which is in Phase 2a clinical trials to the treatment of Parkinson's disease and gastrointestinal tract. The company is also developing IkT-001Pro, a prodrug of the anticancer agent imatinib mesylate to treat stable phase chronic myelogenous leukemia. Inhibikase Therapeutics, Inc. has research and development collaborations with Johns Hopkins University, Arizona State University, and Michigan State University; and a collaborative research and development agreement with Sphaera Pharma Pte. Ltd. The company was founded in 2008 and is headquartered in Atlanta, Georgia.

Nightstar Therapeutics NASDAQ:NITE

Nightstar Therapeutics plc, a clinical-stage gene therapy company, focuses on developing and commercializing novel one-time treatments for patients suffering from rare inherited retinal diseases in the United Kingdom. The company's lead product candidate is NSR-REP1, a candidate that is in phase 3 clinical development for the treatment of patients with choroideremia. It is also developing NSR-RPGR, a candidate that is in Phase 1/2 clinical trials for the treatment of patients with X-linked retinitis pigmentosa, an inherited X-linked recessive retinal disease; and NSR-BEST1, a candidate that is in preclinical development stage for the treatment of best vitelliform macular dystrophy. In addition, the company is developing NSR-ABCA4, a candidate that is in preclinical development stage for the treatment of Stargardt disease. The company was founded in 2013 and is headquartered in London, the United Kingdom.

Prime Medicine NYSE:PRME

$3.46 -0.05 (-1.42%)

Closing price 04:00 PM Eastern

Extended Trading

$3.49 +0.03 (+0.98%)

As of 05:36 PM Eastern

Prime Medicine, Inc., a biotechnology company, delivers genetic therapies to address the spectrum of diseases by deploying gene editing technology. The company offers Prime Editors with a Prime Editor protein, comprising a fusion between a Cas protein and a reverse transcriptase enzyme; and a pegRNA, which targets the Prime Editor to a specific genomic location and provides a template for making the desired edit to the target DNA sequence. It has a research collaboration with Cimeio Therapeutics to develop Prime Edited Shielded-Cell & Immunotherapy Pairs for genetic diseases, acute myeloid leukemia, and myelodysplastic syndrome. The company was incorporated in 2019 and is based in Cambridge, Massachusetts.

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Comparative Price Performance Over Time