NASDAQ:SPRB Spruce Biosciences (SPRB) Stock Price, News & Analysis $53.05 -0.81 (-1.50%) Closing price 09/18/2026 04:00 PM EasternExtended Trading$53.04 -0.01 (-0.02%) As of 09/18/2026 07:30 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more. Add Compare Share Share Stock Analysis Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsFinancialsInsider TradesNews and TrendsOptions ChainOwnershipSEC FilingsShort Interest About Spruce Biosciences Stock (NASDAQ:SPRB) View Price History Chart DataSkip Price History Chart 1 Day 5 Days 30 Days 90 Days 1 Year Advanced 1 Day 1 Day 5 Days 30 Days 90 Days 1 Year Advanced Show volume Show extended hours Get Spruce Biosciences alerts:Sign Up Key Stats Today's Range$51.80▼$53.8650-Day Range$41.45▼$63.4052-Week Range$7.26▼$240.00Volume99,660 shsAverage Volume104,915 shsMarket Capitalization$152.47 millionP/E RatioN/ADividend YieldN/APrice Target$158.33Consensus RatingModerate Buy Company Overview Spruce Biosciences, Inc. is a clinical-stage biopharmaceutical company focused on developing treatments for endocrine disorders. The company’s research has centered on therapies intended to address conditions involving hormone dysregulation and adrenal function. Its lead investigational product is tildacerfont, an oral, selective corticotropin-releasing factor type 1 (CRF1) receptor antagonist. The therapy is designed to reduce excessive adrenocorticotropic hormone (ACTH) signaling and adrenal androgen production, with development focused primarily on congenital adrenal hyperplasia (CAH), a rare inherited disorder affecting cortisol production. Tildacerfont has been evaluated in clinical studies involving patients with both classic and nonclassic forms of CAH. Spruce Biosciences has operated as a U.S.-based company serving the global biopharmaceutical market through clinical development activities and collaborations with research and medical communities. The company does not have a broadly marketed commercial product, and its activities have primarily involved research, clinical trials, regulatory planning and business development related to its endocrine-focused pipeline.AI Generated. May Contain Errors. Read More Spruce Biosciences Stock Analysis - MarketRank™See Top-Rated MarketRank™ Stocks58th Percentile Overall ScoreSPRB MarketRank™: Spruce Biosciences scored higher than 58% of companies evaluated by MarketBeat, and ranked 294th out of 897 stocks in the healthcare sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation. Analyst's Opinion4.4 / 5Analyst RatingModerate Buy Consensus RatingSpruce Biosciences has received a consensus rating of Moderate Buy. The company's average rating score is 2.77, and is based on no strong buy ratings, 11 buy ratings, 1 hold rating, and 1 sell rating.Upside PotentialSpruce Biosciences has a consensus price target of $158.33, representing about 198.5% upside from its current price of $53.05.Amount of Analyst CoverageSpruce Biosciences has been the subject of 8 research reports in the past 90 days, demonstrating strong analyst interest in this stock.Read more about Spruce Biosciences' stock forecast and price target. Earnings and Valuation0.6 / 5Proj. Earnings GrowthGrowing Earnings GrowthEarnings for Spruce Biosciences are expected to grow in the coming year, from ($25.53) to ($1.83) per share.Price to Earnings Ratio vs. the MarketThe P/E ratio of Spruce Biosciences is -1.33, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Earnings Ratio vs. SectorThe P/E ratio of Spruce Biosciences is -1.33, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Book Value per Share RatioSpruce Biosciences has a P/B Ratio of 1.34. P/B Ratios below 3 indicates that a company is reasonably valued with respect to its assets and liabilities.Read more about Spruce Biosciences' valuation and earnings. Short Interest1.0 / 5Short Interest LevelBearish Percentage of Shares Shorted16.01% of the float of Spruce Biosciences has been sold short.Short Interest Ratio / Days to CoverSpruce Biosciences has a short interest ratio ("days to cover") of 5.97.Change versus previous monthShort interest in Spruce Biosciences has recently increased by 9.23%, indicating that investor sentiment is decreasing significantly. Dividend0.0 / 5Dividend StrengthN/A Dividend YieldSpruce Biosciences does not currently pay a dividend.Dividend GrowthSpruce Biosciences does not have a long track record of dividend growth. News and Social Media2.9 / 5News Sentiment0.59 News SentimentSpruce Biosciences has a news sentiment score of 0.59. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This news sentiment score is similar to the average news sentiment of Healthcare companies.News Coverage This WeekMarketBeat has tracked 5 news articles for Spruce Biosciences this week, compared to 3 articles on an average week.Search Interest4 people have searched for SPRB on MarketBeat in the last 30 days. This is an increase of 300% compared to the previous 30 days. Company Ownership0.9 / 5Insider TradingN/A Insider Buying vs. Insider SellingIn the past three months, Spruce Biosciences insiders have not sold or bought any company stock.Percentage Held by Insiders4.30% of the stock of Spruce Biosciences is held by insiders.Percentage Held by Institutions91.71% of the stock of Spruce Biosciences is held by institutions. High institutional ownership can be a signal of strong market trust in this company.Read more about Spruce Biosciences' insider trading history. 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Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. SPRB Stock News HeadlinesSpruce Biosciences (NASDAQ:SPRB) Coverage Initiated at Lake Street CapitalSeptember 19 at 1:54 AM | americanbankingnews.comLake Street initiates coverage of Spruce Biosciences at buySeptember 18 at 12:46 PM | msn.comElon Musk’s Hushed FCC Filing. Sept 25th.Elon Musk quietly filed a document with the federal government tied to artificial intelligence, one of the largest markets in the world. James Altucher, who previously flagged Nvidia in 2008 and Bitcoin in 2013, says the filing could rival Tesla, SpaceX and xAI combined. Few investors know this filing exists, but that is expected to change quickly.September 20 at 1:00 AM | Paradigm Press (Ad)Spruce Biosciences to Participate in the H.C. Wainwright 28th Annual Global Investment ConferenceSeptember 8, 2026 | businesswire.comOppenheimer Sticks to Its Buy Rating for Spruce Biosciences (SPRB)August 28, 2026 | theglobeandmail.comSpruce Biosciences stock gains after analyst backs regulatory progressAugust 27, 2026 | finance.yahoo.comSpruce Biosciences Announces Launch of MPS3BStudy.comAugust 26, 2026 | finance.yahoo.comSpruce Biosciences Announces Positive Pre-BLA Meetings with FDA and Confirms BLA Submission for TA-ERT on Track for Q4 2026August 24, 2026 | finance.yahoo.comSee More Headlines SPRB Stock Analysis - Frequently Asked Questions How have SPRB shares performed this year? Spruce Biosciences' stock was trading at $87.11 at the start of the year. Since then, SPRB shares have decreased by 39.1% and is now trading at $53.05. How were Spruce Biosciences' earnings last quarter? Spruce Biosciences, Inc. (NASDAQ:SPRB) issued its quarterly earnings results on Wednesday, August, 12th. The company reported ($6.68) EPS for the quarter, missing analysts' consensus estimates of ($5.79) by $0.89. When did Spruce Biosciences' stock split? Shares of Spruce Biosciences reverse split on Monday, August 4th 2025.The 1-75 reverse split was announced on Thursday, July 24th 2025. The number of shares owned by shareholders was adjusted after the market closes on Friday, August 1st 2025. An investor that had 100 shares of stock prior to the reverse split would have 1 shares after the split. When did Spruce Biosciences IPO? Spruce Biosciences (SPRB) raised $90 million in an IPO on Friday, October 9th 2020. The company issued 6,000,000 shares at $14.00-$16.00 per share. Cowen, SVB Leerink, Credit Suisse and RBC Capital Markets served as the underwriters for the IPO. Who are Spruce Biosciences' major shareholders? Spruce Biosciences' top institutional investors include AWM Investment Company Inc. (5.12%), Bank of New York Mellon Corp (0.25%), Pale Fire Capital SE (0.13%) and SkyView Investment Advisors LLC (0.10%). Insiders that own company stock include Holdings A/S Novo and Parkman Healthcare Partners Ll. View institutional ownership trends. How do I buy shares of Spruce Biosciences? Shares of SPRB stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. What other stocks do shareholders of Spruce Biosciences own? Based on aggregate information from My MarketBeat watchlists, some other companies that Spruce Biosciences investors own include NVIDIA (NVDA), Broadcom (AVGO), Arista Networks (ANET), Jabil (JBL), Adobe (ADBE), Meta Platforms (META) and Disc Medicine (IRON). Company Calendar Last Earnings8/12/2026Today9/20/2026Next Earnings (Estimated)11/09/2026Fiscal Year End12/31/2026Get Stock Alerts Health Indicator TradeSmith's Health IndicatorA long-term volatility-based measure designed for securities held 12 months or longer.Green: Strong and healthy uptrend with normal pullbacks.Yellow: Significant pullback but still within expected volatility.Red: Dropped beyond expected volatility; considered unhealthy. Green Zone (5d) 1-Year History Sep 25 Dec 25 Mar 26 Jun 26 Sep 26 As of 5 days ago, SPRB's financial health entered the Green zone, according to TradeSmith. Industry, Sector and Symbol Stock ExchangeNASDAQ SectorHealthcare Industry Biotechnology Sub-IndustryBiotechnology Current SymbolNASDAQ:SPRB CIK1683553 Webwww.sprucebiosciences.com Phone415-655-4168FaxN/AEmployees8Year Founded2016Price Target and Rating Average Price Target for Spruce Biosciences$158.33 High Price Target$283.00 Low Price Target$104.00 Potential Upside/Downside+198.5%Consensus RatingModerate Buy Rating Score (0-4)2.77 Research Coverage13 Analysts Profitability EPS (Trailing Twelve Months)($39.78) Trailing P/E RatioN/A Forward P/E RatioN/A P/E GrowthN/ANet Income-$38.97 million Net MarginsN/A Pretax MarginN/A Return on Equity-123.53% Return on Assets-90.35% Debt Debt-to-Equity Ratio0.05 Current Ratio9.23 Quick Ratio9.23 Sales & Book Value Annual SalesN/A Price / SalesN/A Cash FlowN/A Price / Cash FlowN/A Book Value$39.72 per share Price / Book1.34Miscellaneous Outstanding Shares2,874,000Free Float2,750,000Market Cap$152.47 million OptionableOptionable Beta3.31 Social Links 7 Energy Stocks to Buy and Hold ForeverWith the proliferation of data centers and electric vehicles, the electric grid will only get more strained. Download this report to learn how energy stocks can play a role in your portfolio as the global demand for energy continues to grow.Get This Free Report This page (NASDAQ:SPRB) was last updated on 9/20/2026 by MarketBeat.com Staff. From Our Partners$40,000,000,000,000The national debt just hit 40 trillion dollars, and the U.S. now spends more on interest payments than on its ...American Alternative | SponsoredNo Wallstreet. No Advisor. No Problem.Savings accounts pay just 0.58 percent interest. 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