NASDAQ:IONS Ionis Pharmaceuticals (IONS) Stock Price, News & Analysis $43.50 -0.04 (-0.09%) Closing price 10/5/2026 04:00 PM EasternExtended Trading$43.83 +0.33 (+0.76%) As of 06:40 AM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more. Add Compare Share Share Stock Analysis Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsFinancialsInsider TradesNews and TrendsOptions ChainOwnershipSEC FilingsShort Interest About Ionis Pharmaceuticals Stock (NASDAQ:IONS) View Price History Chart DataSkip Price History Chart 1 Day 5 Days 30 Days 90 Days 1 Year Advanced 1 Day 1 Day 5 Days 30 Days 90 Days 1 Year Advanced Show volume Show extended hours Get Ionis Pharmaceuticals alerts:Sign Up Key Stats Today's Range$42.63▼$43.9650-Day Range$43.50▼$63.5752-Week Range$42.63▼$86.74Volume2.87 million shsAverage Volume4.46 million shsMarket Capitalization$7.23 billionP/E RatioN/ADividend YieldN/APrice Target$89.20Consensus RatingModerate Buy Company Overview Ionis Pharmaceuticals, Inc. is a biotechnology company focused on discovering and developing RNA-targeted medicines. The company’s antisense technology is designed to selectively bind to RNA and modify the production of disease-associated proteins. Its research programs address neurological, cardiovascular, metabolic and other serious diseases. Ionis has developed medicines both independently and through collaborations with larger pharmaceutical companies. Its products and partnered therapies have included treatments for spinal muscular atrophy, hereditary transthyretin-mediated amyloidosis, familial chylomicronemia syndrome and transthyretin amyloidosis with cardiomyopathy or polyneuropathy. The company also maintains a pipeline of investigational antisense medicines targeting conditions with significant unmet medical needs. Founded in 1989 as Isis Pharmaceuticals, the company adopted the name Ionis Pharmaceuticals in 2015. Based in Carlsbad, California, Ionis serves international markets through its own commercial activities and strategic partnerships. Brett P. Monia serves as chief executive officer.AI Generated. May Contain Errors. Read More Ionis Pharmaceuticals Stock Analysis - MarketRank™See Top-Rated MarketRank™ Stocks64th Percentile Overall ScoreIONS MarketRank™: Ionis Pharmaceuticals scored higher than 64% of companies evaluated by MarketBeat, and ranked 284th out of 888 stocks in the healthcare sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation. Analyst's Opinion4.4 / 5Analyst RatingModerate Buy Consensus RatingIonis Pharmaceuticals has received a consensus rating of Moderate Buy. The company's average rating score is 2.73, and is based on no strong buy ratings, 17 buy ratings, 4 hold ratings, and 1 sell rating.Upside PotentialIonis Pharmaceuticals has a consensus price target of $89.20, representing about 105.1% upside from its current price of $43.50.Amount of Analyst CoverageIonis Pharmaceuticals has been the subject of 18 research reports in the past 90 days, demonstrating strong analyst interest in this stock.Read more about Ionis Pharmaceuticals' stock forecast and price target. Earnings and Valuation0.6 / 5Proj. Earnings GrowthGrowing Earnings GrowthEarnings for Ionis Pharmaceuticals are expected to grow in the coming year, from ($3.59) to ($2.43) per share.Price to Earnings Ratio vs. the MarketThe P/E ratio of Ionis Pharmaceuticals is -12.57, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Earnings Ratio vs. SectorThe P/E ratio of Ionis Pharmaceuticals is -12.57, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Book Value per Share RatioIonis Pharmaceuticals has a P/B Ratio of 14.40. P/B Ratios above 3 indicate that a company could be overvalued with respect to its assets and liabilities.Read more about Ionis Pharmaceuticals' valuation and earnings. Short Interest2.0 / 5Short Interest LevelBearish Percentage of Shares Shorted12.80% of the float of Ionis Pharmaceuticals has been sold short.Short Interest Ratio / Days to CoverIonis Pharmaceuticals has a short interest ratio ("days to cover") of 5.2.Change versus previous monthShort interest in Ionis Pharmaceuticals has recently decreased by 0.16%, indicating that investor sentiment is improving. Dividend0.0 / 5Dividend StrengthN/A Dividend YieldIonis Pharmaceuticals does not currently pay a dividend.Dividend GrowthIonis Pharmaceuticals does not have a long track record of dividend growth. News and Social Media1.4 / 5News Sentiment0.20 News SentimentIonis Pharmaceuticals has a news sentiment score of 0.20. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a lower news sentiment than the 0.43 average news sentiment score of Healthcare companies.News Coverage This WeekMarketBeat has tracked 5 news articles for Ionis Pharmaceuticals this week, compared to 9 articles on an average week.Search InterestOnly 15 people have searched for IONS on MarketBeat in the last 30 days. This is a decrease of -12% compared to the previous 30 days.MarketBeat FollowsOnly 7 people have added Ionis Pharmaceuticals to their MarketBeat watchlist in the last 30 days. This is a decrease of -13% compared to the previous 30 days. Company Ownership2.2 / 5Insider TradingSelling Shares Insider Buying vs. Insider SellingIn the past three months, Ionis Pharmaceuticals insiders have sold 149.25% more of their company's stock than they have bought. Specifically, they have bought $1,058,700.00 in company stock and sold $2,638,797.00 in company stock.Percentage Held by Insiders1.81% of the stock of Ionis Pharmaceuticals is held by insiders.Percentage Held by Institutions93.86% of the stock of Ionis Pharmaceuticals is held by institutions. High institutional ownership can be a signal of strong market trust in this company.Read more about Ionis Pharmaceuticals' insider trading history. Receive IONS Stock News and Ratings via Email Sign-up to receive the latest news and ratings for Ionis Pharmaceuticals and its competitors with MarketBeat's FREE daily newsletter. Submit View SMS TermsSMS is currently available in Australia, Belgium, Canada, France, Germany, Ireland, Italy, New Zealand, the Netherlands, Singapore, South Africa, Spain, Switzerland, the United Kingdom, and the United States. 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IONS Stock News HeadlinesIonis Pharmaceuticals (NASDAQ:IONS) Sets New 1-Year Low - Time to Sell?October 5 at 11:01 AM | americanbankingnews.comConsensus price target for Ionis Pharmaceuticals rises 20.88% to MX$1,849.62October 2, 2026 | msn.comThe investigation Porter spent tens of thousands to documentPorter Stansberry flew the Porter and Co. team 3,300 miles to Dublin to investigate a 17-year investing experiment called Project Prophet - and documented everything on film. Rooted in the laws of physics, this quantitative approach challenges conventional wealth-building wisdom. With 17 years of verified data behind it, Porter calls it unlike anything he has seen in nearly 30 years in the business.October 6 at 1:00 AM | Porter & Company (Ad)Critical Review: Alector (NASDAQ:ALEC) vs. Ionis Pharmaceuticals (NASDAQ:IONS)October 1, 2026 | americanbankingnews.comIonis Pharmaceuticals, Inc. (NASDAQ:IONS) Stock Rated "Moderate Buy" by Sell-Side AnalystsSeptember 30, 2026 | americanbankingnews.comReviewing Synlogic (NASDAQ:SYBX) & Ionis Pharmaceuticals (NASDAQ:IONS)September 28, 2026 | americanbankingnews.comHC Wainwright Reaffirms "Buy" Rating for Ionis Pharmaceuticals (NASDAQ:IONS)September 26, 2026 | americanbankingnews.comAnalysts Offer Insights on Healthcare Companies: NanoViricides (NNVC) and Ionis Pharmaceuticals (IONS)September 25, 2026 | theglobeandmail.comSee More Headlines IONS Stock Analysis - Frequently Asked Questions How have IONS shares performed this year? Ionis Pharmaceuticals' stock was trading at $79.11 at the start of the year. Since then, IONS shares have decreased by 45.0% and is now trading at $43.50. How were Ionis Pharmaceuticals' earnings last quarter? Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) posted its earnings results on Wednesday, April, 29th. The company reported ($0.56) earnings per share for the quarter, topping the consensus estimate of ($0.85) by $0.29. Ionis Pharmaceuticals's revenue was up 86.4% on a year-over-year basis. Read the conference call transcript. Who are Ionis Pharmaceuticals' major shareholders? Top institutional investors of Ionis Pharmaceuticals include Versant Capital Management Inc. Insiders that own company stock include Brett P Monia, Spencer R Berthelsen, Elizabeth L Hougen, Eugene Schneider, C Frank Bennett, Brian Birchler, Patrick R O'neil, Richard S Geary, B Lynne Parshall, Joseph H Wender, Onaiza Cadoret-Manier, Michael R Hayden, Kyle Jenne, Holly B Kordasiewicz, Eric Swayze, Joseph Baroldi, Shannon L Devers, Joseph Klein III and Allene M Diaz. View institutional ownership trends. How do I buy shares of Ionis Pharmaceuticals? Shares of IONS stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. What other stocks do shareholders of Ionis Pharmaceuticals own? Based on aggregate information from My MarketBeat watchlists, some other companies that Ionis Pharmaceuticals investors own include NVIDIA (NVDA), Meta Platforms (META), Broadcom (AVGO), Advanced Micro Devices (AMD), Arista Networks (ANET), Adobe (ADBE) and CrowdStrike (CRWD). Company Calendar Last Earnings4/29/2026Today10/05/2026Next Earnings (Estimated)11/04/2026Fiscal Year End12/31/2026Get Stock Alerts Health Indicator TradeSmith's Health IndicatorA long-term volatility-based measure designed for securities held 12 months or longer.Green: Strong and healthy uptrend with normal pullbacks.Yellow: Significant pullback but still within expected volatility.Red: Dropped beyond expected volatility; considered unhealthy. Red Zone (2m+) 1-Year History Oct 25 Jan 26 Apr 26 Jul 26 Oct 26 IONS's financial health is in the Red zone, according to TradeSmith. IONS has been in this zone for over 2 months. Industry, Sector and Symbol Stock ExchangeNASDAQ SectorHealthcare Industry Biotechnology Sub-IndustryBiotechnology Current SymbolNASDAQ:IONS CIK874015 Webwww.ionis.com Phone(760) 931-9200Fax760-603-2700Employees1,402Year Founded1989Price Target and Rating Average Price Target for Ionis Pharmaceuticals$89.20 High Price Target$129.00 Low Price Target$54.00 Potential Upside/Downside+105.1%Consensus RatingModerate Buy Rating Score (0-4)2.73 Research Coverage22 Analysts Profitability EPS (Trailing Twelve Months)($3.46) Trailing P/E RatioN/A Forward P/E RatioN/A P/E GrowthN/ANet Income-$381.39 million Net Margins-64.76% Pretax Margin-64.30% Return on Equity-111.08% Return on Assets-17.41% Debt Debt-to-Equity Ratio3.07 Current Ratio7.89 Quick Ratio7.73 Sales & Book Value Annual Sales$944 million Price / Sales7.66 Cash FlowN/A Price / Cash FlowN/A Book Value$3.02 per share Price / Book14.40Miscellaneous Outstanding Shares166,180,000Free Float163,176,000Market Cap$7.23 billion OptionableOptionable Beta0.38 Social Links Options Trading Made Easy - Download NowLearn the basics of options trading and how to use them to boost returns and manage risk with this free report from MarketBeat. Click the link below to get your free copy.Get This Free Report This page (NASDAQ:IONS) was last updated on 10/6/2026 by MarketBeat.com Staff. From Our PartnersThey're not telling you how bad this could getValuations have reached levels seen only a handful of times in the past century, while debt concerns and tarif...Parkview Capital Group | SponsoredA weekly dividend fund holding Nvidia and PalantirCrowdStrike, Palantir, Nvidia none of them pay a real dividend. But one fund holding the biggest AI names dist...Investors Alley | SponsoredThis smart glasses tech is bringing the screen to your eyesGlobal AI smart-glasses shipments surged 263% in the first half of 2026, and Citi projects the market could re...The Tomorrow Investor | SponsoredMILLIONAIRE MASTERCLASS INVITE: AltucherJames Altucher says Elon Musk is preparing an unprecedented project set to surface on December 8th. 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