Top-Rated StocksTop-RatedNASDAQ:AMLX Amylyx Pharmaceuticals (AMLX) Stock Price, News & Analysis $32.41 -1.53 (-4.51%) Closing price 09/18/2026 04:00 PM EasternExtended Trading$33.18 +0.78 (+2.39%) As of 09/18/2026 07:53 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more. Add Compare Share Share Stock Analysis Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsFinancialsInsider TradesNews and TrendsOptions ChainOwnershipSEC FilingsShort Interest About Amylyx Pharmaceuticals Stock (NASDAQ:AMLX) View Price History Chart DataSkip Price History Chart 1 Day 5 Days 30 Days 90 Days 1 Year Advanced 1 Day 1 Day 5 Days 30 Days 90 Days 1 Year Advanced Show volume Show extended hours Get Amylyx Pharmaceuticals alerts:Sign Up Key Stats Today's Range$32.25▼$34.2150-Day Range$17.02▼$39.6652-Week Range$10.83▼$41.14Volume2.05 million shsAverage Volume1.91 million shsMarket Capitalization$3.61 billionP/E RatioN/ADividend YieldN/APrice Target$38.86Consensus RatingBuy Company Overview Amylyx Pharmaceuticals, Inc. is a clinical-stage pharmaceutical company focused on developing novel therapies for communities with high unmet medical needs. The company is advancing a pipeline of investigational therapies across endocrine conditions and neurodegenerative diseases, including avexitide for post-bariatric hypoglycemia, AMX0035 for Wolfram syndrome, AMX0114 for amyotrophic lateral sclerosis, and AMX0318 for post-bariatric hypoglycemia and other rare diseases. Founded in 2013 by Joshua Cohen and Justin Klee, Amylyx is headquartered in Cambridge, Massachusetts. Cohen and Klee have served as the company’s co-chief executive officers and have led its efforts to advance therapies for diseases with high unmet needs. Read More Amylyx Pharmaceuticals Stock Analysis - MarketRank™See Top-Rated MarketRank™ Stocks78th Percentile Overall ScoreAMLX MarketRank™: Amylyx Pharmaceuticals scored higher than 78% of companies evaluated by MarketBeat, and ranked 191st out of 905 stocks in the healthcare sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation. Analyst's Opinion4.1 / 5Analyst RatingBuy Consensus RatingAmylyx Pharmaceuticals has received a consensus rating of Buy. The company's average rating score is 3.00, and is based on 2 strong buy ratings, 7 buy ratings, no hold ratings, and 1 sell rating.Upside PotentialAmylyx Pharmaceuticals has a consensus price target of $38.86, representing about 19.9% upside from its current price of $32.41.Amount of Analyst CoverageAmylyx Pharmaceuticals has been the subject of 7 research reports in the past 90 days, demonstrating strong analyst interest in this stock.Read more about Amylyx Pharmaceuticals' stock forecast and price target. Earnings and Valuation0.6 / 5Proj. Earnings GrowthGrowing Earnings GrowthEarnings for Amylyx Pharmaceuticals are expected to grow in the coming year, from ($1.48) to ($1.40) per share.Price to Earnings Ratio vs. the MarketThe P/E ratio of Amylyx Pharmaceuticals is -22.66, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Earnings Ratio vs. SectorThe P/E ratio of Amylyx Pharmaceuticals is -22.66, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Book Value per Share RatioAmylyx Pharmaceuticals has a P/B Ratio of 11.66. P/B Ratios above 3 indicate that a company could be overvalued with respect to its assets and liabilities.Read more about Amylyx Pharmaceuticals' valuation and earnings. Short Interest4.0 / 5Short Interest LevelHealthy Percentage of Shares Shorted12.83% of the float of Amylyx Pharmaceuticals has been sold short.Short Interest Ratio / Days to CoverAmylyx Pharmaceuticals has a short interest ratio ("days to cover") of 2.37, which is generally considered an acceptable ratio of short interest to trading volume.Change versus previous monthShort interest in Amylyx Pharmaceuticals has recently decreased by 5.12%, indicating that investor sentiment is improving significantly. Dividend0.0 / 5Dividend StrengthN/A Dividend YieldAmylyx Pharmaceuticals does not currently pay a dividend.Dividend GrowthAmylyx Pharmaceuticals does not have a long track record of dividend growth. News and Social Media3.3 / 5News Sentiment0.29 News SentimentAmylyx Pharmaceuticals has a news sentiment score of 0.29. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a lower news sentiment than the 0.58 average news sentiment score of Healthcare companies.News Coverage This WeekMarketBeat has tracked 10 news articles for Amylyx Pharmaceuticals this week, compared to 5 articles on an average week.Search Interest9 people have searched for AMLX on MarketBeat in the last 30 days. This is an increase of 13% compared to the previous 30 days.MarketBeat Follows8 people have added Amylyx Pharmaceuticals to their MarketBeat watchlist in the last 30 days. This is an increase of 167% compared to the previous 30 days. Company Ownership1.8 / 5Insider TradingSelling Shares Insider Buying vs. Insider SellingIn the past three months, Amylyx Pharmaceuticals insiders have sold more of their company's stock than they have bought. Specifically, they have bought $0.00 in company stock and sold $1,259,057.00 in company stock.Percentage Held by Insiders10.90% of the stock of Amylyx Pharmaceuticals is held by insiders. A high percentage of insider ownership can be a sign of company health.Percentage Held by Institutions95.84% of the stock of Amylyx Pharmaceuticals is held by institutions. High institutional ownership can be a signal of strong market trust in this company.Read more about Amylyx Pharmaceuticals' insider trading history. Receive AMLX Stock News and Ratings via Email Sign-up to receive the latest news and ratings for Amylyx Pharmaceuticals and its competitors with MarketBeat's FREE daily newsletter. Submit View SMS TermsSMS is currently available in Australia, Belgium, Canada, France, Germany, Ireland, Italy, New Zealand, the Netherlands, Singapore, South Africa, Spain, Switzerland, the United Kingdom, and the United States. By entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. 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Because my research has led me to believe we’re risking World War 3 with Iran for a completely different reason. | Banyan Hill Publishing (Ad)Amylyx Pharmaceuticals (NASDAQ:AMLX) Insider Camille Bedrosian Sells 10,028 Shares of StockSeptember 15, 2026 | americanbankingnews.comAmylyx Pharmaceuticals (NASDAQ:AMLX) Insider Gina Mazzariello Sells 9,536 Shares of StockSeptember 15, 2026 | insidertrades.comAmylyx (AMLX) Faces a Binary Phase 3 Test. Can Avexitide Rebuild the Company?August 21, 2026 | insidermonkey.comAmylyx Pharmaceuticals Readies for Pivotal LUCIDITY DataAugust 20, 2026 | theglobeandmail.comAmylyx Pharmaceuticals prices upsized $500M public offering of common stockAugust 20, 2026 | msn.comSee More Headlines AMLX Stock Analysis - Frequently Asked Questions How have AMLX shares performed this year? Amylyx Pharmaceuticals' stock was trading at $12.08 at the beginning of 2026. Since then, AMLX stock has increased by 168.3% and is now trading at $32.41. How were Amylyx Pharmaceuticals' earnings last quarter? Amylyx Pharmaceuticals, Inc. (NASDAQ:AMLX) issued its quarterly earnings results on Thursday, August, 6th. The company reported ($0.39) EPS for the quarter, missing the consensus estimate of ($0.36) by $0.03. Read the conference call transcript. When did Amylyx Pharmaceuticals IPO? Amylyx Pharmaceuticals (AMLX) raised $190 million in an IPO on Thursday, January 6th 2022. The company issued 10,000,000 shares at a price of $18.00-$20.00 per share. Who are Amylyx Pharmaceuticals' major shareholders? Top institutional shareholders of Amylyx Pharmaceuticals include BlackRock Inc. (7.94%), Jupiter Topco LLC (4.70%), First Light Asset Management LLC (2.71%) and Alyeska Investment Group L.P. (0.95%). Insiders that own company stock include Joshua B Cohen, Justin B Klee, George M Milne Jr, Camille L Bedrosian, James M Frates, Patrick D Yeramian, Gina Mazzariello, Karen Firestone, Bernhardt G Zeiher and Daphne Quimi. View institutional ownership trends. How do I buy shares of Amylyx Pharmaceuticals? Shares of AMLX stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. What other stocks do shareholders of Amylyx Pharmaceuticals own? Based on aggregate information from My MarketBeat watchlists, some other companies that Amylyx Pharmaceuticals investors own include Waste Connections (WCN), American Water Works (AWK), AUO (AUOTY), DiamondRock Hospitality (DRH), The RMR Group (RMR), iShares Micro-Cap ETF (IWC) and Triple Flag Precious Metals (TFPM). Company Calendar Last Earnings8/06/2026Today9/19/2026Next Earnings (Estimated)11/05/2026Fiscal Year End12/31/2026Get Stock Alerts Health Indicator TradeSmith's Health IndicatorA long-term volatility-based measure designed for securities held 12 months or longer.Green: Strong and healthy uptrend with normal pullbacks.Yellow: Significant pullback but still within expected volatility.Red: Dropped beyond expected volatility; considered unhealthy. Green Zone (16m+) 1-Year History Sep 25 Dec 25 Mar 26 Jun 26 Sep 26 AMLX's financial health is in the Green zone, according to TradeSmith. AMLX has been in this zone for over 16 months. Industry, Sector and Symbol Stock ExchangeNASDAQ SectorHealthcare Industry Biotechnology Sub-IndustryBiotechnology Current SymbolNASDAQ:AMLX CIK1658551 Webamylyx.com Phone617-682-0917FaxN/AEmployees136Year Founded2013Price Target and Rating Average Price Target for Amylyx Pharmaceuticals$38.86 High Price Target$57.00 Low Price Target$19.00 Potential Upside/Downside+19.9%Consensus RatingBuy Rating Score (0-4)3.00 Research Coverage10 Analysts Profitability EPS (Trailing Twelve Months)($1.43) Trailing P/E RatioN/A Forward P/E RatioN/A P/E GrowthN/ANet Income-$144.74 million Net MarginsN/A Pretax MarginN/A Return on Equity-52.92% Return on Assets-48.53% Debt Debt-to-Equity RatioN/A Current Ratio12.12 Quick Ratio12.12 Sales & Book Value Annual Sales$87.37 million Price / Sales41.33 Cash FlowN/A Price / Cash FlowN/A Book Value$2.78 per share Price / Book11.66Miscellaneous Outstanding Shares111,420,000Free Float99,278,000Market Cap$3.61 billion OptionableOptionable Beta-0.13 Social Links 10 Stocks Powering The Next AI Boom The AI boom is creating opportunities across semiconductors, cloud computing, enterprise software, infrastructure, cybersecurity, and automation. 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