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Cyclerion Therapeutics (CYCN) Competitors

Cyclerion Therapeutics logo
$3.49 +0.13 (+3.87%)
Closing price 09/8/2026
Extended Trading
$3.49 0.00 (0.00%)
As of 09/8/2026 07:42 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.

CYCN vs. ZYBT, SPRO, LONA, TLPH, and HRTX

Should you buy Cyclerion Therapeutics stock or one of its competitors? Cyclerion Therapeutics's main competitors and comparable companies include Zhengye Biotechnology (ZYBT), Spero Therapeutics (SPRO), Athira Pharma (LONA), Talphera (TLPH), and Heron Therapeutics (HRTX). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "pharmaceuticals" industry.

How does Cyclerion Therapeutics compare to Zhengye Biotechnology?

Cyclerion Therapeutics (NASDAQ:CYCN) and Zhengye Biotechnology (NASDAQ:ZYBT) are both small-cap healthcare companies, but which is the superior business? We will compare the two businesses based on the strength of their profitability, institutional ownership, earnings, media sentiment, analyst recommendations, risk, dividends and valuation.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Cyclerion Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00
Zhengye Biotechnology
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00

Cyclerion Therapeutics has higher earnings, but lower revenue than Zhengye Biotechnology.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Cyclerion Therapeutics$2.07M7.89-$3.53M-$1.66N/A
Zhengye Biotechnology$116.36M0.53-$9.98MN/AN/A

Zhengye Biotechnology has a net margin of 0.00% compared to Cyclerion Therapeutics' net margin of -170.11%. Zhengye Biotechnology's return on equity of 0.00% beat Cyclerion Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Cyclerion Therapeutics-170.11% -87.96% -74.86%
Zhengye Biotechnology N/A N/A N/A

Cyclerion Therapeutics has a beta of 1.75, suggesting that its share price is 75% more volatile than the broader market. Comparatively, Zhengye Biotechnology has a beta of -2.56, suggesting that its share price is 356% less volatile than the broader market.

75.6% of Cyclerion Therapeutics shares are owned by institutional investors. 34.3% of Cyclerion Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company is poised for long-term growth.

In the previous week, Cyclerion Therapeutics and Cyclerion Therapeutics both had 1 articles in the media. Zhengye Biotechnology's average media sentiment score of 1.82 beat Cyclerion Therapeutics' score of 0.00 indicating that Zhengye Biotechnology is being referred to more favorably in the news media.

Company Overall Sentiment
Cyclerion Therapeutics Neutral
Zhengye Biotechnology Very Positive

Summary

Cyclerion Therapeutics and Zhengye Biotechnology tied by winning 5 of the 10 factors compared between the two stocks.

How does Cyclerion Therapeutics compare to Spero Therapeutics?

Spero Therapeutics (NASDAQ:SPRO) and Cyclerion Therapeutics (NASDAQ:CYCN) are both small-cap healthcare companies, but which is the superior business? We will compare the two companies based on the strength of their valuation, dividends, risk, media sentiment, institutional ownership, earnings, profitability and analyst recommendations.

Spero Therapeutics has higher revenue and earnings than Cyclerion Therapeutics. Cyclerion Therapeutics is trading at a lower price-to-earnings ratio than Spero Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spero Therapeutics$66.80M1.07$8.57M$0.1111.18
Cyclerion Therapeutics$2.07M7.89-$3.53M-$1.66N/A

25.6% of Spero Therapeutics shares are held by institutional investors. Comparatively, 75.6% of Cyclerion Therapeutics shares are held by institutional investors. 2.9% of Spero Therapeutics shares are held by insiders. Comparatively, 34.3% of Cyclerion Therapeutics shares are held by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock is poised for long-term growth.

Spero Therapeutics currently has a consensus target price of $6.00, suggesting a potential upside of 387.80%. Given Spero Therapeutics' stronger consensus rating and higher probable upside, analysts plainly believe Spero Therapeutics is more favorable than Cyclerion Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spero Therapeutics
0 Sell rating(s)
3 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.25
Cyclerion Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00

In the previous week, Spero Therapeutics and Spero Therapeutics both had 1 articles in the media. Spero Therapeutics' average media sentiment score of 1.82 beat Cyclerion Therapeutics' score of 0.00 indicating that Spero Therapeutics is being referred to more favorably in the media.

Company Overall Sentiment
Spero Therapeutics Very Positive
Cyclerion Therapeutics Neutral

Spero Therapeutics has a beta of 1.49, suggesting that its stock price is 49% more volatile than the broader market. Comparatively, Cyclerion Therapeutics has a beta of 1.75, suggesting that its stock price is 75% more volatile than the broader market.

Spero Therapeutics has a net margin of 24.90% compared to Cyclerion Therapeutics' net margin of -170.11%. Spero Therapeutics' return on equity of 16.17% beat Cyclerion Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Spero Therapeutics24.90% 16.17% 12.57%
Cyclerion Therapeutics -170.11%-87.96%-74.86%

Summary

Spero Therapeutics beats Cyclerion Therapeutics on 11 of the 15 factors compared between the two stocks.

How does Cyclerion Therapeutics compare to Athira Pharma?

Athira Pharma (NASDAQ:LONA) and Cyclerion Therapeutics (NASDAQ:CYCN) are both small-cap healthcare companies, but which is the superior stock? We will contrast the two businesses based on the strength of their valuation, analyst recommendations, media sentiment, dividends, earnings, profitability, risk and institutional ownership.

Cyclerion Therapeutics has higher revenue and earnings than Athira Pharma. Cyclerion Therapeutics is trading at a lower price-to-earnings ratio than Athira Pharma, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Athira PharmaN/AN/A-$105.61M-$4.21N/A
Cyclerion Therapeutics$2.07M7.89-$3.53M-$1.66N/A

Athira Pharma has a net margin of 0.00% compared to Cyclerion Therapeutics' net margin of -170.11%. Cyclerion Therapeutics' return on equity of -87.96% beat Athira Pharma's return on equity.

Company Net Margins Return on Equity Return on Assets
Athira PharmaN/A -411.58% -225.73%
Cyclerion Therapeutics -170.11%-87.96%-74.86%

Athira Pharma has a beta of 2.05, suggesting that its stock price is 105% more volatile than the broader market. Comparatively, Cyclerion Therapeutics has a beta of 1.75, suggesting that its stock price is 75% more volatile than the broader market.

57.1% of Athira Pharma shares are held by institutional investors. Comparatively, 75.6% of Cyclerion Therapeutics shares are held by institutional investors. 25.7% of Athira Pharma shares are held by company insiders. Comparatively, 34.3% of Cyclerion Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company will outperform the market over the long term.

Athira Pharma presently has a consensus price target of $17.33, suggesting a potential upside of 433.33%. Given Athira Pharma's stronger consensus rating and higher probable upside, equities analysts clearly believe Athira Pharma is more favorable than Cyclerion Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Athira Pharma
1 Sell rating(s)
1 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.50
Cyclerion Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00

In the previous week, Athira Pharma had 1 more articles in the media than Cyclerion Therapeutics. MarketBeat recorded 2 mentions for Athira Pharma and 1 mentions for Cyclerion Therapeutics. Athira Pharma's average media sentiment score of 1.41 beat Cyclerion Therapeutics' score of 0.00 indicating that Athira Pharma is being referred to more favorably in the media.

Company Overall Sentiment
Athira Pharma Positive
Cyclerion Therapeutics Neutral

Summary

Athira Pharma beats Cyclerion Therapeutics on 8 of the 15 factors compared between the two stocks.

How does Cyclerion Therapeutics compare to Talphera?

Talphera (NASDAQ:TLPH) and Cyclerion Therapeutics (NASDAQ:CYCN) are both small-cap healthcare companies, but which is the better investment? We will compare the two businesses based on the strength of their risk, analyst recommendations, profitability, dividends, institutional ownership, earnings, media sentiment and valuation.

Cyclerion Therapeutics has higher revenue and earnings than Talphera. Talphera is trading at a lower price-to-earnings ratio than Cyclerion Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Talphera$1K61,249.08-$14.29M-$0.27N/A
Cyclerion Therapeutics$2.07M7.89-$3.53M-$1.66N/A

Talphera currently has a consensus price target of $3.00, indicating a potential upside of 154.24%. Given Talphera's stronger consensus rating and higher possible upside, equities research analysts clearly believe Talphera is more favorable than Cyclerion Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Talphera
1 Sell rating(s)
1 Hold rating(s)
2 Buy rating(s)
0 Strong Buy rating(s)
2.25
Cyclerion Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00

37.7% of Talphera shares are owned by institutional investors. Comparatively, 75.6% of Cyclerion Therapeutics shares are owned by institutional investors. 3.5% of Talphera shares are owned by insiders. Comparatively, 34.3% of Cyclerion Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company is poised for long-term growth.

Talphera has a net margin of 0.00% compared to Cyclerion Therapeutics' net margin of -170.11%. Talphera's return on equity of -87.28% beat Cyclerion Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
TalpheraN/A -87.28% -51.36%
Cyclerion Therapeutics -170.11%-87.96%-74.86%

In the previous week, Talphera had 1 more articles in the media than Cyclerion Therapeutics. MarketBeat recorded 2 mentions for Talphera and 1 mentions for Cyclerion Therapeutics. Talphera's average media sentiment score of 0.91 beat Cyclerion Therapeutics' score of 0.00 indicating that Talphera is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Talphera
0 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Cyclerion Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Talphera has a beta of 0.69, suggesting that its share price is 31% less volatile than the broader market. Comparatively, Cyclerion Therapeutics has a beta of 1.75, suggesting that its share price is 75% more volatile than the broader market.

Summary

Talphera beats Cyclerion Therapeutics on 10 of the 16 factors compared between the two stocks.

How does Cyclerion Therapeutics compare to Heron Therapeutics?

Heron Therapeutics (NASDAQ:HRTX) and Cyclerion Therapeutics (NASDAQ:CYCN) are both small-cap healthcare companies, but which is the superior investment? We will contrast the two businesses based on the strength of their institutional ownership, valuation, earnings, risk, dividends, analyst recommendations, profitability and media sentiment.

In the previous week, Heron Therapeutics had 1 more articles in the media than Cyclerion Therapeutics. MarketBeat recorded 2 mentions for Heron Therapeutics and 1 mentions for Cyclerion Therapeutics. Heron Therapeutics' average media sentiment score of 0.65 beat Cyclerion Therapeutics' score of 0.00 indicating that Heron Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Heron Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Cyclerion Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

80.0% of Heron Therapeutics shares are owned by institutional investors. Comparatively, 75.6% of Cyclerion Therapeutics shares are owned by institutional investors. 6.1% of Heron Therapeutics shares are owned by insiders. Comparatively, 34.3% of Cyclerion Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.

Heron Therapeutics presently has a consensus target price of $2.00, suggesting a potential upside of 578.66%. Given Heron Therapeutics' stronger consensus rating and higher possible upside, research analysts plainly believe Heron Therapeutics is more favorable than Cyclerion Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Heron Therapeutics
1 Sell rating(s)
3 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.00
Cyclerion Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00

Cyclerion Therapeutics has lower revenue, but higher earnings than Heron Therapeutics. Cyclerion Therapeutics is trading at a lower price-to-earnings ratio than Heron Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Heron Therapeutics$154.90M0.36-$20.19M-$0.19N/A
Cyclerion Therapeutics$2.07M7.89-$3.53M-$1.66N/A

Heron Therapeutics has a net margin of -22.52% compared to Cyclerion Therapeutics' net margin of -170.11%. Cyclerion Therapeutics' return on equity of -87.96% beat Heron Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Heron Therapeutics-22.52% -293.02% -10.00%
Cyclerion Therapeutics -170.11%-87.96%-74.86%

Heron Therapeutics has a beta of 1.61, suggesting that its share price is 61% more volatile than the broader market. Comparatively, Cyclerion Therapeutics has a beta of 1.75, suggesting that its share price is 75% more volatile than the broader market.

Summary

Heron Therapeutics beats Cyclerion Therapeutics on 11 of the 16 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding CYCN and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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CYCN vs. The Competition

MetricCyclerion TherapeuticsPharmaceuticals IndustryHealthcare SectorNASDAQ Exchange
Market Cap$16.33M$12.52B$7.26B$13.16B
Dividend YieldN/A2.62%2.52%12.57%
P/E Ratio-2.10792.35274.7125.77
Price / Sales7.891,000.51681.32110.43
Price / CashN/A88.6477.8052.76
Price / Book1.5110.6210.466.30
Net Income-$3.53M$2.81B$3.49B$359.77M
7 Day PerformanceN/A-1.02%-1.25%-0.16%
1 Month Performance-87.54%-2.93%-4.51%-4.06%
1 Year Performance-81.74%2.57%16.42%6.10%

Cyclerion Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
CYCN
Cyclerion Therapeutics
0.6603 of 5 stars
$3.49
+3.9%
N/A-84.7%$16.33M$2.07MN/A30
ZYBT
Zhengye Biotechnology
0.9713 of 5 stars
$1.37
-0.4%
N/A-73.6%$65.12M$116.36MN/A278
SPRO
Spero Therapeutics
4.0771 of 5 stars
$1.12
-1.3%
$6.00
+438.1%
-36.5%$64.94M$66.80M10.14150
LONA
Athira Pharma
3.9192 of 5 stars
$6.81
-5.9%
$17.33
+154.5%
N/A$64.93MN/AN/A40
TLPH
Talphera
2.2468 of 5 stars
$1.19
flat
$3.00
+152.1%
+26.7%$61.77M$1KN/A19

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This page (NASDAQ:CYCN) was last updated on 9/25/2026 by MarketBeat.com Staff.
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