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Cyclerion Therapeutics (CYCN) Competitors

Cyclerion Therapeutics logo
$4.25 -0.71 (-14.31%)
As of 09/4/2026 04:00 PM Eastern

CYCN vs. DWTX, ZYBT, LONA, CING, and SPRO

Should you buy Cyclerion Therapeutics stock or one of its competitors? Cyclerion Therapeutics's main competitors and comparable companies include Dogwood Therapeutics (DWTX), Zhengye Biotechnology (ZYBT), Athira Pharma (LONA), Cingulate (CING), and Spero Therapeutics (SPRO). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "pharmaceuticals" industry.

How does Cyclerion Therapeutics compare to Dogwood Therapeutics?

Dogwood Therapeutics (NASDAQ:DWTX) and Cyclerion Therapeutics (NASDAQ:CYCN) are both small-cap healthcare companies, but which is the better stock? We will contrast the two companies based on the strength of their media sentiment, risk, dividends, valuation, institutional ownership, profitability, earnings and analyst recommendations.

9.1% of Dogwood Therapeutics shares are owned by institutional investors. Comparatively, 75.6% of Cyclerion Therapeutics shares are owned by institutional investors. 0.3% of Dogwood Therapeutics shares are owned by company insiders. Comparatively, 34.3% of Cyclerion Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock is poised for long-term growth.

In the previous week, Dogwood Therapeutics had 2 more articles in the media than Cyclerion Therapeutics. MarketBeat recorded 3 mentions for Dogwood Therapeutics and 1 mentions for Cyclerion Therapeutics. Dogwood Therapeutics' average media sentiment score of -0.39 beat Cyclerion Therapeutics' score of -2.00 indicating that Dogwood Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Dogwood Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
2 Very Negative mention(s)
Neutral
Cyclerion Therapeutics
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Negative

Dogwood Therapeutics has a net margin of 0.00% compared to Cyclerion Therapeutics' net margin of -170.11%. Dogwood Therapeutics' return on equity of -75.55% beat Cyclerion Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Dogwood TherapeuticsN/A -75.55% -40.28%
Cyclerion Therapeutics -170.11%-87.96%-74.86%

Cyclerion Therapeutics has higher revenue and earnings than Dogwood Therapeutics. Cyclerion Therapeutics is trading at a lower price-to-earnings ratio than Dogwood Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Dogwood TherapeuticsN/AN/A-$34.26M-$8.95N/A
Cyclerion Therapeutics$1.90M10.47-$3.53M-$1.66N/A

Dogwood Therapeutics has a beta of 1.81, suggesting that its stock price is 81% more volatile than the broader market. Comparatively, Cyclerion Therapeutics has a beta of 1.75, suggesting that its stock price is 75% more volatile than the broader market.

Dogwood Therapeutics presently has a consensus price target of $12.00, indicating a potential upside of 424.02%. Given Dogwood Therapeutics' stronger consensus rating and higher probable upside, equities analysts plainly believe Dogwood Therapeutics is more favorable than Cyclerion Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Dogwood Therapeutics
1 Sell rating(s)
0 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.00
Cyclerion Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00

Summary

Dogwood Therapeutics beats Cyclerion Therapeutics on 10 of the 15 factors compared between the two stocks.

How does Cyclerion Therapeutics compare to Zhengye Biotechnology?

Cyclerion Therapeutics (NASDAQ:CYCN) and Zhengye Biotechnology (NASDAQ:ZYBT) are both small-cap healthcare companies, but which is the better investment? We will contrast the two companies based on the strength of their institutional ownership, risk, media sentiment, analyst recommendations, profitability, dividends, valuation and earnings.

Cyclerion Therapeutics has a beta of 1.75, indicating that its stock price is 75% more volatile than the broader market. Comparatively, Zhengye Biotechnology has a beta of -2.56, indicating that its stock price is 356% less volatile than the broader market.

In the previous week, Cyclerion Therapeutics had 1 more articles in the media than Zhengye Biotechnology. MarketBeat recorded 1 mentions for Cyclerion Therapeutics and 0 mentions for Zhengye Biotechnology. Zhengye Biotechnology's average media sentiment score of 0.00 beat Cyclerion Therapeutics' score of -2.00 indicating that Zhengye Biotechnology is being referred to more favorably in the news media.

Company Overall Sentiment
Cyclerion Therapeutics Very Negative
Zhengye Biotechnology Neutral

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Cyclerion Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00
Zhengye Biotechnology
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00

75.6% of Cyclerion Therapeutics shares are held by institutional investors. 34.3% of Cyclerion Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock is poised for long-term growth.

Zhengye Biotechnology has a net margin of 0.00% compared to Cyclerion Therapeutics' net margin of -170.11%. Zhengye Biotechnology's return on equity of 0.00% beat Cyclerion Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Cyclerion Therapeutics-170.11% -87.96% -74.86%
Zhengye Biotechnology N/A N/A N/A

Cyclerion Therapeutics has higher earnings, but lower revenue than Zhengye Biotechnology.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Cyclerion Therapeutics$1.90M10.47-$3.53M-$1.66N/A
Zhengye Biotechnology$16.64M4.59-$9.98MN/AN/A

Summary

Cyclerion Therapeutics beats Zhengye Biotechnology on 6 of the 11 factors compared between the two stocks.

How does Cyclerion Therapeutics compare to Athira Pharma?

Athira Pharma (NASDAQ:LONA) and Cyclerion Therapeutics (NASDAQ:CYCN) are both small-cap healthcare companies, but which is the better business? We will compare the two companies based on the strength of their risk, analyst recommendations, institutional ownership, earnings, valuation, dividends, profitability and media sentiment.

In the previous week, Athira Pharma had 3 more articles in the media than Cyclerion Therapeutics. MarketBeat recorded 4 mentions for Athira Pharma and 1 mentions for Cyclerion Therapeutics. Athira Pharma's average media sentiment score of 0.34 beat Cyclerion Therapeutics' score of -2.00 indicating that Athira Pharma is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Athira Pharma
1 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Cyclerion Therapeutics
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Negative

Cyclerion Therapeutics has higher revenue and earnings than Athira Pharma. Cyclerion Therapeutics is trading at a lower price-to-earnings ratio than Athira Pharma, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Athira PharmaN/AN/A-$105.61M-$4.21N/A
Cyclerion Therapeutics$1.90M10.47-$3.53M-$1.66N/A

Athira Pharma has a net margin of 0.00% compared to Cyclerion Therapeutics' net margin of -170.11%. Cyclerion Therapeutics' return on equity of -87.96% beat Athira Pharma's return on equity.

Company Net Margins Return on Equity Return on Assets
Athira PharmaN/A -411.58% -225.73%
Cyclerion Therapeutics -170.11%-87.96%-74.86%

Athira Pharma has a beta of 2.05, indicating that its share price is 105% more volatile than the broader market. Comparatively, Cyclerion Therapeutics has a beta of 1.75, indicating that its share price is 75% more volatile than the broader market.

57.1% of Athira Pharma shares are held by institutional investors. Comparatively, 75.6% of Cyclerion Therapeutics shares are held by institutional investors. 25.7% of Athira Pharma shares are held by company insiders. Comparatively, 34.3% of Cyclerion Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock is poised for long-term growth.

Athira Pharma presently has a consensus price target of $17.33, suggesting a potential upside of 129.28%. Given Athira Pharma's stronger consensus rating and higher probable upside, equities analysts clearly believe Athira Pharma is more favorable than Cyclerion Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Athira Pharma
1 Sell rating(s)
1 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.50
Cyclerion Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00

Summary

Athira Pharma beats Cyclerion Therapeutics on 8 of the 15 factors compared between the two stocks.

How does Cyclerion Therapeutics compare to Cingulate?

Cingulate (NASDAQ:CING) and Cyclerion Therapeutics (NASDAQ:CYCN) are both small-cap healthcare companies, but which is the better investment? We will compare the two businesses based on the strength of their risk, analyst recommendations, dividends, media sentiment, institutional ownership, earnings, valuation and profitability.

41.3% of Cingulate shares are held by institutional investors. Comparatively, 75.6% of Cyclerion Therapeutics shares are held by institutional investors. 5.3% of Cingulate shares are held by company insiders. Comparatively, 34.3% of Cyclerion Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company will outperform the market over the long term.

In the previous week, Cyclerion Therapeutics had 1 more articles in the media than Cingulate. MarketBeat recorded 1 mentions for Cyclerion Therapeutics and 0 mentions for Cingulate. Cingulate's average media sentiment score of 0.59 beat Cyclerion Therapeutics' score of -2.00 indicating that Cingulate is being referred to more favorably in the media.

Company Overall Sentiment
Cingulate Positive
Cyclerion Therapeutics Very Negative

Cingulate currently has a consensus target price of $27.00, suggesting a potential upside of 429.41%. Given Cingulate's stronger consensus rating and higher probable upside, equities research analysts plainly believe Cingulate is more favorable than Cyclerion Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Cingulate
1 Sell rating(s)
0 Hold rating(s)
3 Buy rating(s)
0 Strong Buy rating(s)
2.50
Cyclerion Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00

Cyclerion Therapeutics has higher revenue and earnings than Cingulate. Cyclerion Therapeutics is trading at a lower price-to-earnings ratio than Cingulate, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
CingulateN/AN/A-$22.45M-$3.59N/A
Cyclerion Therapeutics$1.90M10.47-$3.53M-$1.66N/A

Cingulate has a beta of -0.88, indicating that its share price is 188% less volatile than the broader market. Comparatively, Cyclerion Therapeutics has a beta of 1.75, indicating that its share price is 75% more volatile than the broader market.

Cingulate has a net margin of 0.00% compared to Cyclerion Therapeutics' net margin of -170.11%. Cyclerion Therapeutics' return on equity of -87.96% beat Cingulate's return on equity.

Company Net Margins Return on Equity Return on Assets
CingulateN/A -238.40% -128.67%
Cyclerion Therapeutics -170.11%-87.96%-74.86%

Summary

Cyclerion Therapeutics beats Cingulate on 9 of the 15 factors compared between the two stocks.

How does Cyclerion Therapeutics compare to Spero Therapeutics?

Spero Therapeutics (NASDAQ:SPRO) and Cyclerion Therapeutics (NASDAQ:CYCN) are both small-cap healthcare companies, but which is the superior investment? We will contrast the two businesses based on the strength of their valuation, analyst recommendations, institutional ownership, media sentiment, earnings, dividends, profitability and risk.

25.6% of Spero Therapeutics shares are held by institutional investors. Comparatively, 75.6% of Cyclerion Therapeutics shares are held by institutional investors. 2.9% of Spero Therapeutics shares are held by company insiders. Comparatively, 34.3% of Cyclerion Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term.

Spero Therapeutics has a net margin of 24.90% compared to Cyclerion Therapeutics' net margin of -170.11%. Spero Therapeutics' return on equity of 16.17% beat Cyclerion Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Spero Therapeutics24.90% 16.17% 12.57%
Cyclerion Therapeutics -170.11%-87.96%-74.86%

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spero Therapeutics
0 Sell rating(s)
2 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
2.00
Cyclerion Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00

Spero Therapeutics has higher revenue and earnings than Cyclerion Therapeutics. Cyclerion Therapeutics is trading at a lower price-to-earnings ratio than Spero Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spero Therapeutics$42.96M1.64$8.57M$0.1111.00
Cyclerion Therapeutics$1.90M10.47-$3.53M-$1.66N/A

Spero Therapeutics has a beta of 1.49, indicating that its stock price is 49% more volatile than the broader market. Comparatively, Cyclerion Therapeutics has a beta of 1.75, indicating that its stock price is 75% more volatile than the broader market.

In the previous week, Spero Therapeutics had 1 more articles in the media than Cyclerion Therapeutics. MarketBeat recorded 2 mentions for Spero Therapeutics and 1 mentions for Cyclerion Therapeutics. Spero Therapeutics' average media sentiment score of 0.17 beat Cyclerion Therapeutics' score of -2.00 indicating that Spero Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Spero Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Cyclerion Therapeutics
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Negative

Summary

Spero Therapeutics beats Cyclerion Therapeutics on 10 of the 14 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding CYCN and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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CYCN vs. The Competition

MetricCyclerion TherapeuticsPharmaceuticals IndustryHealthcare SectorNASDAQ Exchange
Market Cap$19.90M$12.27B$7.26B$12.91B
Dividend YieldN/A2.59%2.53%8.90%
P/E Ratio-2.56792.20273.8325.45
Price / Sales10.47794.57608.0379.09
Price / CashN/A92.1877.3952.28
Price / Book3.9012.4712.856.17
Net Income-$3.53M$2.83B$3.49B$350.08M
7 Day Performance12.14%4.03%1.04%-0.14%
1 Month Performance19.72%6.29%5.52%1.02%
1 Year Performance90.58%9.93%24.39%14.51%

Cyclerion Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
CYCN
Cyclerion Therapeutics
0.5148 of 5 stars
$4.25
-14.3%
N/A+77.8%$19.90M$1.90MN/A30
DWTX
Dogwood Therapeutics
2.3913 of 5 stars
$2.49
-5.3%
$12.00
+381.9%
-54.2%$84.64MN/AN/A5
ZYBT
Zhengye Biotechnology
0.1307 of 5 stars
$1.64
-0.6%
N/A-79.5%$77.72M$16.64MN/A278
LONA
Athira Pharma
3.53 of 5 stars
$7.90
+4.0%
$17.33
+119.5%
N/A$76.00MN/AN/A40
CING
Cingulate
2.7229 of 5 stars
$5.22
+2.1%
$27.00
+417.7%
+34.6%$75.51MN/AN/A20

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This page (NASDAQ:CYCN) was last updated on 9/5/2026 by MarketBeat.com Staff.
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