Amicus Therapeutics (FOLD) Competitors $7.61 +0.01 (+0.13%) Closing price 08/22/2025 04:00 PM EasternExtended Trading$7.62 +0.01 (+0.13%) As of 08/22/2025 07:41 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsFDA EventsFinancialsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock FOLD vs. EXAS, MDGL, HALO, RGEN, IONS, ALKS, LGND, BCRX, CLDX, and NVAXShould you be buying Amicus Therapeutics stock or one of its competitors? The main competitors of Amicus Therapeutics include Exact Sciences (EXAS), Madrigal Pharmaceuticals (MDGL), Halozyme Therapeutics (HALO), Repligen (RGEN), Ionis Pharmaceuticals (IONS), Alkermes (ALKS), Ligand Pharmaceuticals (LGND), BioCryst Pharmaceuticals (BCRX), Celldex Therapeutics (CLDX), and Novavax (NVAX). These companies are all part of the "biotechnology" industry. Amicus Therapeutics vs. Its Competitors Exact Sciences Madrigal Pharmaceuticals Halozyme Therapeutics Repligen Ionis Pharmaceuticals Alkermes Ligand Pharmaceuticals BioCryst Pharmaceuticals Celldex Therapeutics Novavax Exact Sciences (NASDAQ:EXAS) and Amicus Therapeutics (NASDAQ:FOLD) are both mid-cap medical companies, but which is the better stock? We will contrast the two companies based on the strength of their earnings, profitability, institutional ownership, analyst recommendations, valuation, dividends, media sentiment and risk. Is EXAS or FOLD more profitable? Amicus Therapeutics has a net margin of -6.67% compared to Exact Sciences' net margin of -34.19%. Exact Sciences' return on equity of -1.75% beat Amicus Therapeutics' return on equity.Company Net Margins Return on Equity Return on Assets Exact Sciences-34.19% -1.75% -0.76% Amicus Therapeutics -6.67%-5.07%-1.23% Which has stronger valuation and earnings, EXAS or FOLD? Amicus Therapeutics has lower revenue, but higher earnings than Exact Sciences. Amicus Therapeutics is trading at a lower price-to-earnings ratio than Exact Sciences, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioExact Sciences$2.76B3.26-$1.03B-$5.43-8.74Amicus Therapeutics$528.29M4.44-$56.11M-$0.12-63.42 Which has more risk and volatility, EXAS or FOLD? Exact Sciences has a beta of 0.93, indicating that its stock price is 7% less volatile than the S&P 500. Comparatively, Amicus Therapeutics has a beta of 0.53, indicating that its stock price is 47% less volatile than the S&P 500. Do analysts prefer EXAS or FOLD? Exact Sciences currently has a consensus target price of $67.43, indicating a potential upside of 42.04%. Amicus Therapeutics has a consensus target price of $16.22, indicating a potential upside of 113.17%. Given Amicus Therapeutics' higher probable upside, analysts clearly believe Amicus Therapeutics is more favorable than Exact Sciences.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Exact Sciences 0 Sell rating(s) 3 Hold rating(s) 20 Buy rating(s) 1 Strong Buy rating(s) 2.92Amicus Therapeutics 0 Sell rating(s) 2 Hold rating(s) 8 Buy rating(s) 0 Strong Buy rating(s) 2.80 Does the media refer more to EXAS or FOLD? In the previous week, Exact Sciences had 3 more articles in the media than Amicus Therapeutics. MarketBeat recorded 13 mentions for Exact Sciences and 10 mentions for Amicus Therapeutics. Amicus Therapeutics' average media sentiment score of 1.40 beat Exact Sciences' score of 1.08 indicating that Amicus Therapeutics is being referred to more favorably in the news media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment Exact Sciences 8 Very Positive mention(s) 0 Positive mention(s) 4 Neutral mention(s) 0 Negative mention(s) 1 Very Negative mention(s) Positive Amicus Therapeutics 8 Very Positive mention(s) 0 Positive mention(s) 2 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Positive Do insiders & institutionals believe in EXAS or FOLD? 88.8% of Exact Sciences shares are owned by institutional investors. 1.2% of Exact Sciences shares are owned by insiders. Comparatively, 2.2% of Amicus Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth. SummaryExact Sciences beats Amicus Therapeutics on 10 of the 17 factors compared between the two stocks. Get Amicus Therapeutics News Delivered to You Automatically Sign up to receive the latest news and ratings for FOLD and its competitors with MarketBeat's FREE daily newsletter. Email Address New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding FOLD and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart FOLD vs. The Competition Export to ExcelMetricAmicus TherapeuticsMED IndustryMedical SectorNASDAQ ExchangeMarket Cap$2.34B$3.11B$5.76B$9.58BDividend YieldN/A2.23%4.41%4.10%P/E Ratio-63.4120.8831.1026.04Price / Sales4.44343.33433.45102.77Price / CashN/A43.1937.7358.48Price / Book11.538.129.536.61Net Income-$56.11M-$54.72M$3.26B$265.56M7 Day Performance2.84%2.63%2.10%1.97%1 Month Performance20.60%2.78%2.81%-0.36%1 Year Performance-35.29%11.01%30.56%19.03% Amicus Therapeutics Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)FOLDAmicus Therapeutics4.3654 of 5 stars$7.61+0.1%$16.22+113.2%-35.0%$2.34B$528.29M-63.41480News CoveragePositive NewsEXASExact Sciences4.9304 of 5 stars$45.09-1.1%$67.43+49.5%-19.6%$8.63B$2.76B-8.307,000MDGLMadrigal Pharmaceuticals3.5437 of 5 stars$391.43+5.8%$439.71+12.3%+66.8%$8.21B$180.13M-30.4690News CoverageAnalyst ForecastInsider TradeAnalyst RevisionHALOHalozyme Therapeutics4.7045 of 5 stars$68.96+2.5%$67.11-2.7%+16.5%$7.87B$1.18B15.78390News CoveragePositive NewsRGENRepligen4.8568 of 5 stars$124.08-0.2%$169.45+36.6%-15.7%$7.00B$634.44M-496.301,778News CoveragePositive NewsIONSIonis Pharmaceuticals4.653 of 5 stars$43.43-0.8%$59.38+36.7%-10.2%$6.98B$705M-23.601,069Trending NewsAnalyst ForecastInsider TradeALKSAlkermes4.743 of 5 stars$28.11-3.2%$41.08+46.2%+6.3%$4.80B$1.56B13.511,800Trending NewsAnalyst RevisionLGNDLigand Pharmaceuticals4.1324 of 5 stars$153.26+1.4%$157.00+2.4%+53.5%$2.96B$167.13M-38.3280Positive NewsShort Interest ↓BCRXBioCryst Pharmaceuticals4.1557 of 5 stars$8.38+0.1%$16.70+99.3%+7.9%$1.76B$450.71M-46.55530CLDXCelldex Therapeutics1.6401 of 5 stars$24.48-4.0%$51.75+111.4%-36.3%$1.69B$7.02M-8.13150News CoverageAnalyst ForecastNVAXNovavax4.6288 of 5 stars$9.71+1.4%$15.86+63.3%-34.4%$1.56B$682.16M4.261,990Analyst Forecast Related Companies and Tools Related Companies EXAS Alternatives MDGL Alternatives HALO Alternatives RGEN Alternatives IONS Alternatives ALKS Alternatives LGND Alternatives BCRX Alternatives CLDX Alternatives NVAX Alternatives Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:FOLD) was last updated on 8/23/2025 by MarketBeat.com Staff From Our PartnersMarket Panic: Trump Just Dropped a Bomb on Your Stockstock Market Panic: Trump Just Dropped a Bomb on Your Stocks The market is in freefall—and Trump's new tarif...American Alternative | SponsoredBONUS GUIDE - Ben Stein Prepares For the Next Financial CrisisWith inflation high, debt soaring, and global tensions rising, a financial storm may be brewing. 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