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Pliant Therapeutics (PLRX) Competitors

Pliant Therapeutics logo
$1.13 -0.03 (-2.59%)
As of 09/3/2026 04:00 PM Eastern

PLRX vs. RNAC, ALXO, TRDA, ACIU, and YDES

Should you buy Pliant Therapeutics stock or one of its competitors? Pliant Therapeutics's main competitors and comparable companies include Cartesian Therapeutics (RNAC), ALX Oncology (ALXO), Entrada Therapeutics (TRDA), AC Immune (ACIU), and YD Bio (YDES). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Pliant Therapeutics compare to Cartesian Therapeutics?

Cartesian Therapeutics (NASDAQ:RNAC) and Pliant Therapeutics (NASDAQ:PLRX) are both small-cap healthcare companies, but which is the better business? We will compare the two companies based on the strength of their risk, valuation, institutional ownership, earnings, analyst recommendations, dividends, profitability and media sentiment.

Cartesian Therapeutics has a beta of 0.62, meaning that its share price is 38% less volatile than the broader market. Comparatively, Pliant Therapeutics has a beta of 1.27, meaning that its share price is 27% more volatile than the broader market.

Pliant Therapeutics has a net margin of 0.00% compared to Cartesian Therapeutics' net margin of -8,550.65%. Cartesian Therapeutics' return on equity of 0.00% beat Pliant Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Cartesian Therapeutics-8,550.65% N/A -29.84%
Pliant Therapeutics N/A -52.17%-40.46%

Cartesian Therapeutics has higher revenue and earnings than Pliant Therapeutics. Cartesian Therapeutics is trading at a lower price-to-earnings ratio than Pliant Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Cartesian Therapeutics$2.80M98.53-$130.30M-$5.94N/A
Pliant Therapeutics$1.58M44.28-$149.34M-$1.49N/A

In the previous week, Cartesian Therapeutics had 1 more articles in the media than Pliant Therapeutics. MarketBeat recorded 2 mentions for Cartesian Therapeutics and 1 mentions for Pliant Therapeutics. Pliant Therapeutics' average media sentiment score of 0.59 beat Cartesian Therapeutics' score of 0.00 indicating that Pliant Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Cartesian Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Pliant Therapeutics
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Cartesian Therapeutics currently has a consensus target price of $32.60, indicating a potential upside of 257.46%. Pliant Therapeutics has a consensus target price of $3.00, indicating a potential upside of 165.49%. Given Cartesian Therapeutics' stronger consensus rating and higher probable upside, analysts plainly believe Cartesian Therapeutics is more favorable than Pliant Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Cartesian Therapeutics
1 Sell rating(s)
1 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.57
Pliant Therapeutics
2 Sell rating(s)
1 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
1.75

87.0% of Cartesian Therapeutics shares are held by institutional investors. Comparatively, 97.3% of Pliant Therapeutics shares are held by institutional investors. 37.2% of Cartesian Therapeutics shares are held by company insiders. Comparatively, 8.7% of Pliant Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock will outperform the market over the long term.

Summary

Cartesian Therapeutics beats Pliant Therapeutics on 10 of the 16 factors compared between the two stocks.

How does Pliant Therapeutics compare to ALX Oncology?

ALX Oncology (NASDAQ:ALXO) and Pliant Therapeutics (NASDAQ:PLRX) are both small-cap healthcare companies, but which is the better stock? We will contrast the two businesses based on the strength of their earnings, valuation, dividends, risk, profitability, media sentiment, analyst recommendations and institutional ownership.

98.0% of ALX Oncology shares are owned by institutional investors. Comparatively, 97.3% of Pliant Therapeutics shares are owned by institutional investors. 12.4% of ALX Oncology shares are owned by company insiders. Comparatively, 8.7% of Pliant Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock will outperform the market over the long term.

ALX Oncology has a beta of 0.39, indicating that its stock price is 61% less volatile than the broader market. Comparatively, Pliant Therapeutics has a beta of 1.27, indicating that its stock price is 27% more volatile than the broader market.

In the previous week, ALX Oncology had 3 more articles in the media than Pliant Therapeutics. MarketBeat recorded 4 mentions for ALX Oncology and 1 mentions for Pliant Therapeutics. ALX Oncology's average media sentiment score of 1.26 beat Pliant Therapeutics' score of 0.59 indicating that ALX Oncology is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
ALX Oncology
3 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Pliant Therapeutics
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

ALX Oncology currently has a consensus price target of $4.60, suggesting a potential upside of 126.60%. Pliant Therapeutics has a consensus price target of $3.00, suggesting a potential upside of 165.49%. Given Pliant Therapeutics' higher probable upside, analysts plainly believe Pliant Therapeutics is more favorable than ALX Oncology.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
ALX Oncology
1 Sell rating(s)
0 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.67
Pliant Therapeutics
2 Sell rating(s)
1 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
1.75

Pliant Therapeutics' return on equity of -52.17% beat ALX Oncology's return on equity.

Company Net Margins Return on Equity Return on Assets
ALX OncologyN/A -90.30% -67.28%
Pliant Therapeutics N/A -52.17%-40.46%

ALX Oncology has higher earnings, but lower revenue than Pliant Therapeutics. ALX Oncology is trading at a lower price-to-earnings ratio than Pliant Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
ALX OncologyN/AN/A-$101.69M-$1.13N/A
Pliant Therapeutics$1.58M44.28-$149.34M-$1.49N/A

Summary

ALX Oncology beats Pliant Therapeutics on 8 of the 14 factors compared between the two stocks.

How does Pliant Therapeutics compare to Entrada Therapeutics?

Pliant Therapeutics (NASDAQ:PLRX) and Entrada Therapeutics (NASDAQ:TRDA) are both small-cap healthcare companies, but which is the superior investment? We will contrast the two businesses based on the strength of their institutional ownership, media sentiment, dividends, analyst recommendations, earnings, risk, profitability and valuation.

Pliant Therapeutics has a beta of 1.27, indicating that its share price is 27% more volatile than the broader market. Comparatively, Entrada Therapeutics has a beta of -0.25, indicating that its share price is 125% less volatile than the broader market.

Pliant Therapeutics has a net margin of 0.00% compared to Entrada Therapeutics' net margin of -3,537.73%. Pliant Therapeutics' return on equity of -52.17% beat Entrada Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Pliant TherapeuticsN/A -52.17% -40.46%
Entrada Therapeutics -3,537.73%-57.61%-46.54%

Entrada Therapeutics has higher revenue and earnings than Pliant Therapeutics. Entrada Therapeutics is trading at a lower price-to-earnings ratio than Pliant Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Pliant Therapeutics$1.58M44.28-$149.34M-$1.49N/A
Entrada Therapeutics$25.42M10.98-$143.75M-$3.96N/A

Pliant Therapeutics presently has a consensus price target of $3.00, indicating a potential upside of 165.49%. Entrada Therapeutics has a consensus price target of $17.75, indicating a potential upside of 147.56%. Given Pliant Therapeutics' higher probable upside, equities research analysts clearly believe Pliant Therapeutics is more favorable than Entrada Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Pliant Therapeutics
2 Sell rating(s)
1 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
1.75
Entrada Therapeutics
1 Sell rating(s)
1 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.50

97.3% of Pliant Therapeutics shares are owned by institutional investors. Comparatively, 86.4% of Entrada Therapeutics shares are owned by institutional investors. 8.7% of Pliant Therapeutics shares are owned by company insiders. Comparatively, 9.5% of Entrada Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock is poised for long-term growth.

In the previous week, Entrada Therapeutics had 15 more articles in the media than Pliant Therapeutics. MarketBeat recorded 16 mentions for Entrada Therapeutics and 1 mentions for Pliant Therapeutics. Entrada Therapeutics' average media sentiment score of 0.67 beat Pliant Therapeutics' score of 0.59 indicating that Entrada Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Pliant Therapeutics
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Entrada Therapeutics
9 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Pliant Therapeutics beats Entrada Therapeutics on 9 of the 16 factors compared between the two stocks.

How does Pliant Therapeutics compare to AC Immune?

AC Immune (NASDAQ:ACIU) and Pliant Therapeutics (NASDAQ:PLRX) are both small-cap healthcare companies, but which is the better stock? We will contrast the two businesses based on the strength of their risk, analyst recommendations, media sentiment, profitability, institutional ownership, earnings, valuation and dividends.

In the previous week, AC Immune had 1 more articles in the media than Pliant Therapeutics. MarketBeat recorded 2 mentions for AC Immune and 1 mentions for Pliant Therapeutics. AC Immune's average media sentiment score of 1.25 beat Pliant Therapeutics' score of 0.59 indicating that AC Immune is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
AC Immune
2 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Pliant Therapeutics
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

51.4% of AC Immune shares are owned by institutional investors. Comparatively, 97.3% of Pliant Therapeutics shares are owned by institutional investors. 4.6% of AC Immune shares are owned by company insiders. Comparatively, 8.7% of Pliant Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock is poised for long-term growth.

AC Immune has a beta of 1.6, suggesting that its stock price is 60% more volatile than the broader market. Comparatively, Pliant Therapeutics has a beta of 1.27, suggesting that its stock price is 27% more volatile than the broader market.

AC Immune presently has a consensus target price of $7.50, indicating a potential upside of 155.97%. Pliant Therapeutics has a consensus target price of $3.00, indicating a potential upside of 165.49%. Given Pliant Therapeutics' higher possible upside, analysts plainly believe Pliant Therapeutics is more favorable than AC Immune.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
AC Immune
1 Sell rating(s)
1 Hold rating(s)
3 Buy rating(s)
0 Strong Buy rating(s)
2.40
Pliant Therapeutics
2 Sell rating(s)
1 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
1.75

Pliant Therapeutics has a net margin of 0.00% compared to AC Immune's net margin of -245.32%. Pliant Therapeutics' return on equity of -52.17% beat AC Immune's return on equity.

Company Net Margins Return on Equity Return on Assets
AC Immune-245.32% -100.17% -28.36%
Pliant Therapeutics N/A -52.17%-40.46%

AC Immune has higher revenue and earnings than Pliant Therapeutics. AC Immune is trading at a lower price-to-earnings ratio than Pliant Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
AC Immune$4.31M69.18-$85.03M-$0.54N/A
Pliant Therapeutics$1.58M44.28-$149.34M-$1.49N/A

Summary

AC Immune beats Pliant Therapeutics on 10 of the 16 factors compared between the two stocks.

How does Pliant Therapeutics compare to YD Bio?

YD Bio (NASDAQ:YDES) and Pliant Therapeutics (NASDAQ:PLRX) are both small-cap healthcare companies, but which is the better investment? We will contrast the two companies based on the strength of their earnings, institutional ownership, profitability, media sentiment, analyst recommendations, risk, dividends and valuation.

In the previous week, YD Bio had 5 more articles in the media than Pliant Therapeutics. MarketBeat recorded 6 mentions for YD Bio and 1 mentions for Pliant Therapeutics. Pliant Therapeutics' average media sentiment score of 0.59 beat YD Bio's score of 0.32 indicating that Pliant Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
YD Bio
1 Very Positive mention(s)
1 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Pliant Therapeutics
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

YD Bio has higher earnings, but lower revenue than Pliant Therapeutics.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
YD BioN/AN/AN/AN/AN/A
Pliant Therapeutics$1.58M44.28-$149.34M-$1.49N/A

97.3% of Pliant Therapeutics shares are held by institutional investors. 8.7% of Pliant Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company is poised for long-term growth.

Pliant Therapeutics has a consensus target price of $3.00, suggesting a potential upside of 165.49%. Given Pliant Therapeutics' stronger consensus rating and higher probable upside, analysts plainly believe Pliant Therapeutics is more favorable than YD Bio.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
YD Bio
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00
Pliant Therapeutics
2 Sell rating(s)
1 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
1.75

YD Bio's return on equity of 0.00% beat Pliant Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
YD BioN/A N/A N/A
Pliant Therapeutics N/A -52.17%-40.46%

Summary

Pliant Therapeutics beats YD Bio on 7 of the 10 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding PLRX and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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PLRX vs. The Competition

MetricPliant TherapeuticsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$71.83M$4.03B$7.26B$12.73B
Dividend YieldN/A3.60%2.53%8.86%
P/E Ratio-0.7612.66273.2825.38
Price / Sales44.281,309.16613.4892.60
Price / CashN/A106.8777.8252.26
Price / Book0.4816.2912.896.14
Net Income-$149.34M-$22.72M$3.47B$349.01M
7 Day Performance1.80%0.34%0.61%-0.27%
1 Month Performance7.62%8.52%5.73%0.68%
1 Year Performance-30.67%52.66%25.37%14.84%

Pliant Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
PLRX
Pliant Therapeutics
2.3052 of 5 stars
$1.13
-2.6%
$3.00
+165.5%
-33.9%$71.83M$1.58MN/A90
RNAC
Cartesian Therapeutics
1.6931 of 5 stars
$9.18
-1.1%
$32.60
+255.2%
-11.0%$273.88M$2.80MN/A64
ALXO
ALX Oncology
2.6063 of 5 stars
$1.98
+2.3%
$4.60
+132.9%
+99.0%$273.10MN/AN/A40
TRDA
Entrada Therapeutics
2.4624 of 5 stars
$7.02
-0.5%
$17.75
+153.0%
+34.8%$272.93M$25.42MN/A110
ACIU
AC Immune
2.6972 of 5 stars
$2.66
+0.6%
$7.50
+182.5%
+29.6%$270.20M$4.31MN/A140

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This page (NASDAQ:PLRX) was last updated on 9/4/2026 by MarketBeat.com Staff.
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