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Skye Bioscience (SKYE) Competitors

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$1.76 +0.20 (+12.42%)
Closing price 09/18/2026 04:00 PM Eastern
Extended Trading
$1.79 +0.03 (+1.42%)
As of 09/18/2026 07:30 PM Eastern
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SKYE vs. MDXH, KYNB, CNTX, ALGS, and GOSS

Should you buy Skye Bioscience stock or one of its competitors? Skye Bioscience's main competitors and comparable companies include MDxHealth (MDXH), Kyntra Bio (KYNB), Context Therapeutics (CNTX), Aligos Therapeutics (ALGS), and Gossamer Bio (GOSS). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Skye Bioscience compare to MDxHealth?

MDxHealth (NASDAQ:MDXH) and Skye Bioscience (NASDAQ:SKYE) are both small-cap healthcare companies, but which is the better investment? We will compare the two businesses based on the strength of their risk, dividends, profitability, earnings, analyst recommendations, institutional ownership, valuation and media sentiment.

Skye Bioscience has a net margin of 0.00% compared to MDxHealth's net margin of -33.46%. MDxHealth's return on equity of 0.00% beat Skye Bioscience's return on equity.

Company Net Margins Return on Equity Return on Assets
MDxHealth-33.46% N/A -24.25%
Skye Bioscience N/A -329.08%-201.79%

MDxHealth presently has a consensus target price of $2.17, suggesting a potential upside of 243.92%. Skye Bioscience has a consensus target price of $64.00, suggesting a potential upside of 3,526.06%. Given Skye Bioscience's higher probable upside, analysts clearly believe Skye Bioscience is more favorable than MDxHealth.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
MDxHealth
1 Sell rating(s)
1 Hold rating(s)
3 Buy rating(s)
0 Strong Buy rating(s)
2.40
Skye Bioscience
1 Sell rating(s)
2 Hold rating(s)
2 Buy rating(s)
0 Strong Buy rating(s)
2.20

MDxHealth has higher revenue and earnings than Skye Bioscience. MDxHealth is trading at a lower price-to-earnings ratio than Skye Bioscience, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
MDxHealth$107.88M0.29-$33.52M-$0.72N/A
Skye BioscienceN/AN/A-$55.92M-$10.16N/A

21.1% of Skye Bioscience shares are owned by institutional investors. 1.7% of MDxHealth shares are owned by insiders. Comparatively, 6.2% of Skye Bioscience shares are owned by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term.

MDxHealth has a beta of 1.57, meaning that its stock price is 57% more volatile than the broader market. Comparatively, Skye Bioscience has a beta of 2.9, meaning that its stock price is 190% more volatile than the broader market.

In the previous week, Skye Bioscience had 3 more articles in the media than MDxHealth. MarketBeat recorded 4 mentions for Skye Bioscience and 1 mentions for MDxHealth. MDxHealth's average media sentiment score of 0.00 beat Skye Bioscience's score of -0.55 indicating that MDxHealth is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
MDxHealth
0 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Skye Bioscience
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Negative

Summary

MDxHealth beats Skye Bioscience on 8 of the 15 factors compared between the two stocks.

How does Skye Bioscience compare to Kyntra Bio?

Kyntra Bio (NASDAQ:KYNB) and Skye Bioscience (NASDAQ:SKYE) are both small-cap healthcare companies, but which is the superior investment? We will contrast the two businesses based on the strength of their institutional ownership, earnings, dividends, profitability, risk, valuation, media sentiment and analyst recommendations.

Kyntra Bio has a beta of 1.06, suggesting that its stock price is 6% more volatile than the broader market. Comparatively, Skye Bioscience has a beta of 2.9, suggesting that its stock price is 190% more volatile than the broader market.

In the previous week, Skye Bioscience had 1 more articles in the media than Kyntra Bio. MarketBeat recorded 4 mentions for Skye Bioscience and 3 mentions for Kyntra Bio. Kyntra Bio's average media sentiment score of 0.67 beat Skye Bioscience's score of -0.55 indicating that Kyntra Bio is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Kyntra Bio
0 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Skye Bioscience
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Negative

Kyntra Bio currently has a consensus target price of $37.25, indicating a potential upside of 426.87%. Skye Bioscience has a consensus target price of $64.00, indicating a potential upside of 3,526.06%. Given Skye Bioscience's higher probable upside, analysts plainly believe Skye Bioscience is more favorable than Kyntra Bio.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Kyntra Bio
1 Sell rating(s)
1 Hold rating(s)
3 Buy rating(s)
1 Strong Buy rating(s)
2.67
Skye Bioscience
1 Sell rating(s)
2 Hold rating(s)
2 Buy rating(s)
0 Strong Buy rating(s)
2.20

Kyntra Bio has a net margin of 2,199.13% compared to Skye Bioscience's net margin of 0.00%. Kyntra Bio's return on equity of 0.00% beat Skye Bioscience's return on equity.

Company Net Margins Return on Equity Return on Assets
Kyntra Bio2,199.13% N/A -47.27%
Skye Bioscience N/A -329.08%-201.79%

Kyntra Bio has higher revenue and earnings than Skye Bioscience. Skye Bioscience is trading at a lower price-to-earnings ratio than Kyntra Bio, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Kyntra Bio$6.44M4.45$183.45M$45.300.16
Skye BioscienceN/AN/A-$55.92M-$10.16N/A

72.7% of Kyntra Bio shares are owned by institutional investors. Comparatively, 21.1% of Skye Bioscience shares are owned by institutional investors. 4.2% of Kyntra Bio shares are owned by company insiders. Comparatively, 6.2% of Skye Bioscience shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock will outperform the market over the long term.

Summary

Kyntra Bio beats Skye Bioscience on 12 of the 16 factors compared between the two stocks.

How does Skye Bioscience compare to Context Therapeutics?

Skye Bioscience (NASDAQ:SKYE) and Context Therapeutics (NASDAQ:CNTX) are both small-cap healthcare companies, but which is the superior investment? We will compare the two companies based on the strength of their risk, institutional ownership, dividends, analyst recommendations, valuation, media sentiment, profitability and earnings.

Skye Bioscience currently has a consensus price target of $64.00, suggesting a potential upside of 3,526.06%. Context Therapeutics has a consensus price target of $6.17, suggesting a potential upside of 1,575.27%. Given Skye Bioscience's higher possible upside, equities research analysts plainly believe Skye Bioscience is more favorable than Context Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Skye Bioscience
1 Sell rating(s)
2 Hold rating(s)
2 Buy rating(s)
0 Strong Buy rating(s)
2.20
Context Therapeutics
1 Sell rating(s)
1 Hold rating(s)
8 Buy rating(s)
0 Strong Buy rating(s)
2.70

Context Therapeutics is trading at a lower price-to-earnings ratio than Skye Bioscience, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Skye BioscienceN/AN/A-$55.92M-$10.16N/A
Context TherapeuticsN/AN/A-$36.12M-$0.48N/A

In the previous week, Skye Bioscience had 3 more articles in the media than Context Therapeutics. MarketBeat recorded 4 mentions for Skye Bioscience and 1 mentions for Context Therapeutics. Context Therapeutics' average media sentiment score of 0.00 beat Skye Bioscience's score of -0.55 indicating that Context Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Skye Bioscience
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Negative
Context Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Skye Bioscience has a beta of 2.9, suggesting that its share price is 190% more volatile than the broader market. Comparatively, Context Therapeutics has a beta of 1.69, suggesting that its share price is 69% more volatile than the broader market.

21.1% of Skye Bioscience shares are held by institutional investors. Comparatively, 14.0% of Context Therapeutics shares are held by institutional investors. 6.2% of Skye Bioscience shares are held by insiders. Comparatively, 4.8% of Context Therapeutics shares are held by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock will outperform the market over the long term.

Context Therapeutics' return on equity of -82.06% beat Skye Bioscience's return on equity.

Company Net Margins Return on Equity Return on Assets
Skye BioscienceN/A -329.08% -201.79%
Context Therapeutics N/A -82.06%-72.74%

Summary

Context Therapeutics beats Skye Bioscience on 7 of the 13 factors compared between the two stocks.

How does Skye Bioscience compare to Aligos Therapeutics?

Skye Bioscience (NASDAQ:SKYE) and Aligos Therapeutics (NASDAQ:ALGS) are both small-cap healthcare companies, but which is the better investment? We will contrast the two businesses based on the strength of their institutional ownership, media sentiment, risk, valuation, analyst recommendations, dividends, earnings and profitability.

Aligos Therapeutics has higher revenue and earnings than Skye Bioscience. Aligos Therapeutics is trading at a lower price-to-earnings ratio than Skye Bioscience, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Skye BioscienceN/AN/A-$55.92M-$10.16N/A
Aligos Therapeutics$2.19M14.93-$24.19M-$7.30N/A

21.1% of Skye Bioscience shares are held by institutional investors. Comparatively, 60.4% of Aligos Therapeutics shares are held by institutional investors. 6.2% of Skye Bioscience shares are held by company insiders. Comparatively, 7.8% of Aligos Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company is poised for long-term growth.

Skye Bioscience currently has a consensus price target of $64.00, indicating a potential upside of 3,526.06%. Aligos Therapeutics has a consensus price target of $38.50, indicating a potential upside of 634.73%. Given Skye Bioscience's higher probable upside, equities research analysts clearly believe Skye Bioscience is more favorable than Aligos Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Skye Bioscience
1 Sell rating(s)
2 Hold rating(s)
2 Buy rating(s)
0 Strong Buy rating(s)
2.20
Aligos Therapeutics
1 Sell rating(s)
0 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.86

In the previous week, Skye Bioscience had 2 more articles in the media than Aligos Therapeutics. MarketBeat recorded 4 mentions for Skye Bioscience and 2 mentions for Aligos Therapeutics. Aligos Therapeutics' average media sentiment score of 0.00 beat Skye Bioscience's score of -0.55 indicating that Aligos Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Skye Bioscience
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Negative
Aligos Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Skye Bioscience has a net margin of 0.00% compared to Aligos Therapeutics' net margin of -241.01%. Aligos Therapeutics' return on equity of -160.72% beat Skye Bioscience's return on equity.

Company Net Margins Return on Equity Return on Assets
Skye BioscienceN/A -329.08% -201.79%
Aligos Therapeutics -241.01%-160.72%-92.30%

Skye Bioscience has a beta of 2.9, indicating that its share price is 190% more volatile than the broader market. Comparatively, Aligos Therapeutics has a beta of 2.34, indicating that its share price is 134% more volatile than the broader market.

Summary

Aligos Therapeutics beats Skye Bioscience on 11 of the 16 factors compared between the two stocks.

How does Skye Bioscience compare to Gossamer Bio?

Skye Bioscience (NASDAQ:SKYE) and Gossamer Bio (NASDAQ:GOSS) are both small-cap healthcare companies, but which is the better business? We will contrast the two businesses based on the strength of their analyst recommendations, media sentiment, earnings, dividends, valuation, institutional ownership, profitability and risk.

Skye Bioscience has a net margin of 0.00% compared to Gossamer Bio's net margin of -235.00%. Gossamer Bio's return on equity of 0.00% beat Skye Bioscience's return on equity.

Company Net Margins Return on Equity Return on Assets
Skye BioscienceN/A -329.08% -201.79%
Gossamer Bio -235.00%N/A -112.04%

21.1% of Skye Bioscience shares are held by institutional investors. Comparatively, 81.2% of Gossamer Bio shares are held by institutional investors. 6.2% of Skye Bioscience shares are held by insiders. Comparatively, 3.7% of Gossamer Bio shares are held by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth.

Skye Bioscience has a beta of 2.9, suggesting that its share price is 190% more volatile than the broader market. Comparatively, Gossamer Bio has a beta of 2, suggesting that its share price is 100% more volatile than the broader market.

In the previous week, Skye Bioscience and Skye Bioscience both had 4 articles in the media. Gossamer Bio's average media sentiment score of 0.11 beat Skye Bioscience's score of -0.55 indicating that Gossamer Bio is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Skye Bioscience
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Negative
Gossamer Bio
0 Very Positive mention(s)
1 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Skye Bioscience currently has a consensus price target of $64.00, suggesting a potential upside of 3,526.06%. Gossamer Bio has a consensus price target of $256.00, suggesting a potential upside of 2,285.83%. Given Skye Bioscience's higher probable upside, equities research analysts plainly believe Skye Bioscience is more favorable than Gossamer Bio.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Skye Bioscience
1 Sell rating(s)
2 Hold rating(s)
2 Buy rating(s)
0 Strong Buy rating(s)
2.20
Gossamer Bio
2 Sell rating(s)
3 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.22

Skye Bioscience has higher earnings, but lower revenue than Gossamer Bio. Gossamer Bio is trading at a lower price-to-earnings ratio than Skye Bioscience, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Skye BioscienceN/AN/A-$55.92M-$10.16N/A
Gossamer Bio$53.29M0.59-$170.37M-$56.00N/A

Summary

Skye Bioscience and Gossamer Bio tied by winning 7 of the 14 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding SKYE and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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SKYE vs. The Competition

MetricSkye BioscienceBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$7.81M$3.88B$7.24B$12.95B
Dividend YieldN/A3.64%2.57%12.80%
P/E Ratio-0.1714.23275.4925.40
Price / SalesN/A1,434.96642.7086.83
Price / CashN/A108.9076.2551.42
Price / Book0.3515.4510.466.33
Net Income-$55.92M-$22.86M$3.49B$358.33M
7 Day Performance-13.48%-1.21%0.59%1.12%
1 Month Performance-21.32%-3.29%-1.74%-2.39%
1 Year Performance-94.48%37.74%18.13%5.35%

Skye Bioscience Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
SKYE
Skye Bioscience
3.2127 of 5 stars
$1.77
+12.4%
$64.00
+3,526.1%
-94.5%$7.81MN/AN/A12
MDXH
MDxHealth
2.1118 of 5 stars
$0.67
-4.8%
$2.17
+221.8%
-84.8%$35.01M$107.88MN/A300
KYNB
Kyntra Bio
3.8759 of 5 stars
$7.77
-3.2%
$36.00
+363.3%
N/A$32.51M$6.44M0.17570
CNTX
Context Therapeutics
2.3865 of 5 stars
$0.36
+3.8%
$6.17
+1,592.3%
-62.0%$32.25MN/AN/A7
ALGS
Aligos Therapeutics
2.1854 of 5 stars
$4.99
-1.0%
$38.50
+671.5%
-45.8%$31.47M$2.19MN/A90

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This page (NASDAQ:SKYE) was last updated on 9/20/2026 by MarketBeat.com Staff.
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