Spruce Biosciences (SPRB) News Today $129.54 -18.62 (-12.57%) Closing price 10/21/2025 04:00 PM EasternExtended Trading$132.30 +2.76 (+2.13%) As of 10/21/2025 08:00 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Headlines Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestTrendsBuy This Stock SPRB Latest News All Sources Trusted Sources MarketBeat Barchart Benzinga Bloomberg GlobeNewswire GuruFocus MarketWatch Motley Fool NASDAQ PR Newswire Reuters Seeking Alpha TalkMarkets The Street TipRanks The Wall Street Journal Wall Street Zen Yahoo Finance Source Sentiment refers to the positivity or negativity of each headline according to our language processing algorithm. Sentiment All Sentiments Very Positive Positive Neutral Negative Very Negative Most Recent October 2025 September 2025 August 2025 July 2025 June 2025 May 2025 April 2025 March 2025 February 2025 January 2025 December 2024 November 2024 October 2024 September 2024 August 2024 July 2024 June 2024 May 2024 April 2024 March 2024 February 2024 January 2024 December 2023 November 2023 October 2023 September 2023 August 2023 July 2023 June 2023 May 2023 April 2023 March 2023 February 2023 January 2023 December 2022 November 2022 Time Period Spruce Biosciences price target raised to $160 from $10 at LeerinkOctober 21 at 5:16 PM | msn.comSpruce Biosciences (NASDAQ:SPRB) Rating Increased to Strong-Buy at Zacks ResearchOctober 18, 2025 | marketbeat.comSpruce Biosciences (NASDAQ:SPRB) Earns "Sell (D-)" Rating from Weiss RatingsOctober 16, 2025 | americanbankingnews.comSpruce Biosciences' (SPRB) "Sell (D-)" Rating Reaffirmed at Weiss RatingsOctober 14, 2025 | marketbeat.comSpruce Biosciences (NASDAQ:SPRB) Shares Down 1% - What's Next?October 11, 2025 | marketbeat.comSpruce: BTD For TA-ERT For MPS IIIB Could Ignite BLA Submission With Added Bonuses (Rating Upgrade)October 7, 2025 | seekingalpha.comSpruce Biosciences Shares Hit 52-Week High After FDA Breakthrough Therapy DesignationOctober 6, 2025 | marketwatch.comSpruce Biosciences Shares Hit 52-Week High After FDA Breakthrough Therapy DesignationOctober 6, 2025 | marketwatch.comWhy Spruce Biosciences Just Skyrocketed More Than 1,600%October 6, 2025 | msn.comSpruce Biosciences Stock More Than Quadruples After Breakthrough Therapy Designation To Therapy For Rare And Fatal Genetic DiseaseOctober 6, 2025 | msn.comSmall Cap Stocks To Follow Today - October 6thOctober 6, 2025 | marketbeat.comSpruce Biosciences Stock Is Soaring Today: Here's WhyOctober 6, 2025 | benzinga.comSpruce Biosciences stock soars after receiving FDA Breakthrough Therapy statusOctober 6, 2025 | investing.comSpruce Biosciences Receives U.S. FDA Breakthrough Therapy Designation for Tralesinidase Alfa Enzyme Replacement Therapy (TA-ERT) in Sanfilippo Syndrome Type B (MPS IIIB)October 6, 2025 | businesswire.comSpruce Biosciences Resumes Trading on the Nasdaq Capital MarketSeptember 15, 2025 | finance.yahoo.comOne new option listing and two option delistings on September 5thSeptember 5, 2025 | msn.comSpruce Biosciences Reports Second Quarter 2025 Financial Results and Provides Corporate UpdatesAugust 14, 2025 | businesswire.comSpruce Biosciences to enact 1-for-75 reverse stock splitJuly 24, 2025 | msn.comSpruce Biosciences Announces Reverse Stock SplitJuly 24, 2025 | finance.yahoo.comHMNC Brain Health and Spruce Biosciences Announce First Patient Dosed in Phase 2 TAMARIND Trial For Major Depressive DisorderJuly 22, 2025 | globenewswire.comSPRB Spruce Biosciences, Inc. - Seeking AlphaJune 24, 2025 | seekingalpha.comSpruce Biosciences gets conditional approval to resume trading on Nasdaq Capital MarketJune 13, 2025 | msn.comSpruce Biosciences Announces Conditional Nasdaq Approval to Resume Trading on the Nasdaq Capital MarketJune 12, 2025 | finance.yahoo.comSpruce Biosciences’ Compliance Plan Accepted by NasdaqJune 12, 2025 | tipranks.comSpruce Biosciences’ SWOT analysis: stock pivots amid clinical setbacksMay 7, 2025 | investing.comSpruce Biosciences Inc Ordinary SharesMay 6, 2025 | morningstar.comMSpruce Biosciences Reports First Quarter 2025 Financial Results and Provides Corporate UpdatesMay 6, 2025 | finance.yahoo.comSpruce Biosciences (SPRB) Receives a Hold from RBC CapitalApril 17, 2025 | markets.businessinsider.comSpruce Biosciences, Inc. (NASDAQ:SPRB) Q1 2023 Earnings Call TranscriptApril 17, 2025 | insidermonkey.comWith BioMarin deal, Spruce Biosciences hits reset on rare-disease drugApril 15, 2025 | bizjournals.comSpruce Biosciences, Inc. (SPRB) Corporate Update Conference Call (Transcript)April 15, 2025 | seekingalpha.comSpruce Biosciences reports delayed annual filingApril 3, 2025 | investing.comHold Rating for Spruce Biosciences Amid Clinical Setbacks and Strategic UncertaintiesDecember 16, 2024 | markets.businessinsider.comJMP Securities Downgrades Spruce Biosciences (SPRB)December 12, 2024 | msn.comSpruce Biosciences Downgraded to Hold Amid Unmet Clinical Trial Endpoints and Strategic ReevaluationDecember 11, 2024 | markets.businessinsider.comOppenheimer Downgrades Spruce Biosciences (SPRB)December 11, 2024 | msn.comSpruce Biosciences Announces Topline Results from CAHmelia-204 in Adult CAH and CAHptain-205 in Adult and Pediatric CAHDecember 11, 2024 | finance.yahoo.comSpruce Biosciences CAHmelia-204 study did not achieve primary efficacy endpointDecember 11, 2024 | markets.businessinsider.comJMP Securities downgrades Spruce Biosciences (SPRB) to a HoldDecember 11, 2024 | markets.businessinsider.comSpruce Biosciences downgraded to Market Perform from Outperform at JMPDecember 11, 2024 | msn.comSpruce Biosciences to wind down investment for genetic disorder drugDecember 10, 2024 | reuters.comCautious Optimism for Tildacerfont in CAH Trials: Potential Market Opportunities and Competitive Edge Over CrinecerfontDecember 6, 2024 | markets.businessinsider.comRBC Capital Sticks to Their Hold Rating for Spruce Biosciences (SPRB)November 13, 2024 | markets.businessinsider.comSpruce Biosciences Faces Nasdaq Delisting Threat: Can a Reverse Stock Split Save Its Market Presence?November 13, 2024 | markets.businessinsider.comSpruce Biosciences Reports Q3 2024 Earnings and UpdatesNovember 11, 2024 | tipranks.comSpruce Biosciences Reports Third Quarter 2024 Financial Results and Provides Corporate UpdatesNovember 11, 2024 | finanznachrichten.deSpruce Biosciences, Inc. Is Being Investigated For Securities Fraud And The Schall Law Firm Urges Affected Shareholders To Reach OutNovember 1, 2024 | stockhouse.comSpruce Biosciences to Participate in the Guggenheim Securities Healthcare Innovation ConferenceOctober 28, 2024 | businesswire.comSpruce Biosciences (NASDAQ:SPRB) Stock Quotes, Forecast and News SummaryOctober 5, 2024 | benzinga.comAnalysts Offer Insights on Healthcare Companies: Acrivon Therapeutics, Inc. (ACRV) and Spruce Biosciences (SPRB)September 12, 2024 | markets.businessinsider.com Get Spruce Biosciences News Delivered to You Automatically Sign up to receive the latest news and ratings for SPRB and its competitors with MarketBeat's FREE daily newsletter. Subscribe Now View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. 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We track news headlines from hundreds of news outlets and tag them by company. This chart compares the number of articles about this company in the last seven days compared with the average number of articles about this company on a typical week. SPRB Articles This Week▼41▲SPRB Articles Average Week Get the Latest News and Ratings for SPRB and Related Stocks Enter your email address to receive the latest news and analysts' ratings for Spruce Biosciences and its competitors. Sign Up View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. 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