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Stoke Therapeutics (STOK) Competitors

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$29.03 -0.31 (-1.06%)
Closing price 09/11/2026 04:00 PM Eastern
Extended Trading
$29.00 -0.04 (-0.12%)
As of 09/11/2026 07:59 PM Eastern
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STOK vs. ALKS, SYRE, RYTM, SRRK, and CGON

Should you buy Stoke Therapeutics stock or one of its competitors? Stoke Therapeutics's main competitors and comparable companies include Alkermes (ALKS), Spyre Therapeutics (SYRE), Rhythm Pharmaceuticals (RYTM), Scholar Rock (SRRK), and CG Oncology (CGON). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Stoke Therapeutics compare to Alkermes?

Stoke Therapeutics (NASDAQ:STOK) and Alkermes (NASDAQ:ALKS) are both healthcare companies, but which is the better investment? We will compare the two businesses based on the strength of their earnings, risk, dividends, media sentiment, valuation, institutional ownership, profitability and analyst recommendations.

95.2% of Alkermes shares are owned by institutional investors. 9.6% of Stoke Therapeutics shares are owned by insiders. Comparatively, 4.6% of Alkermes shares are owned by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company will outperform the market over the long term.

Stoke Therapeutics currently has a consensus target price of $44.25, suggesting a potential upside of 52.43%. Alkermes has a consensus target price of $54.56, suggesting a potential upside of 18.69%. Given Stoke Therapeutics' stronger consensus rating and higher probable upside, equities analysts clearly believe Stoke Therapeutics is more favorable than Alkermes.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Stoke Therapeutics
1 Sell rating(s)
0 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.82
Alkermes
1 Sell rating(s)
4 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.72

Alkermes has a net margin of 3.96% compared to Stoke Therapeutics' net margin of -753.60%. Alkermes' return on equity of 4.15% beat Stoke Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Stoke Therapeutics-753.60% -59.36% -51.46%
Alkermes 3.96%4.15%2.19%

Alkermes has higher revenue and earnings than Stoke Therapeutics. Stoke Therapeutics is trading at a lower price-to-earnings ratio than Alkermes, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Stoke Therapeutics$184.42M10.16-$6.89M-$3.34N/A
Alkermes$1.67B4.62$241.66M$0.38120.97

In the previous week, Alkermes had 3 more articles in the media than Stoke Therapeutics. MarketBeat recorded 6 mentions for Alkermes and 3 mentions for Stoke Therapeutics. Stoke Therapeutics' average media sentiment score of 1.77 beat Alkermes' score of 0.99 indicating that Stoke Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Stoke Therapeutics
2 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Positive
Alkermes
2 Very Positive mention(s)
2 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Stoke Therapeutics has a beta of 1.23, suggesting that its share price is 23% more volatile than the broader market. Comparatively, Alkermes has a beta of 0.31, suggesting that its share price is 69% less volatile than the broader market.

Summary

Alkermes beats Stoke Therapeutics on 11 of the 17 factors compared between the two stocks.

How does Stoke Therapeutics compare to Spyre Therapeutics?

Spyre Therapeutics (NASDAQ:SYRE) and Stoke Therapeutics (NASDAQ:STOK) are both healthcare companies, but which is the better stock? We will contrast the two companies based on the strength of their earnings, institutional ownership, valuation, risk, dividends, profitability, media sentiment and analyst recommendations.

In the previous week, Spyre Therapeutics had 14 more articles in the media than Stoke Therapeutics. MarketBeat recorded 17 mentions for Spyre Therapeutics and 3 mentions for Stoke Therapeutics. Stoke Therapeutics' average media sentiment score of 1.77 beat Spyre Therapeutics' score of 0.70 indicating that Stoke Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Spyre Therapeutics
5 Very Positive mention(s)
3 Positive mention(s)
6 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Stoke Therapeutics
2 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Positive

Spyre Therapeutics has a beta of 2.99, indicating that its share price is 199% more volatile than the broader market. Comparatively, Stoke Therapeutics has a beta of 1.23, indicating that its share price is 23% more volatile than the broader market.

80.4% of Spyre Therapeutics shares are owned by institutional investors. 15.7% of Spyre Therapeutics shares are owned by company insiders. Comparatively, 9.6% of Stoke Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.

Stoke Therapeutics has higher revenue and earnings than Spyre Therapeutics. Spyre Therapeutics is trading at a lower price-to-earnings ratio than Stoke Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spyre TherapeuticsN/AN/A-$155.20M-$1.95N/A
Stoke Therapeutics$184.42M10.16-$6.89M-$3.34N/A

Spyre Therapeutics presently has a consensus price target of $109.69, suggesting a potential upside of 21.07%. Stoke Therapeutics has a consensus price target of $44.25, suggesting a potential upside of 52.43%. Given Stoke Therapeutics' higher possible upside, analysts plainly believe Stoke Therapeutics is more favorable than Spyre Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spyre Therapeutics
1 Sell rating(s)
1 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.87
Stoke Therapeutics
1 Sell rating(s)
0 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.82

Spyre Therapeutics has a net margin of 0.00% compared to Stoke Therapeutics' net margin of -753.60%. Spyre Therapeutics' return on equity of -30.74% beat Stoke Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Spyre TherapeuticsN/A -30.74% -22.23%
Stoke Therapeutics -753.60%-59.36%-51.46%

Summary

Spyre Therapeutics beats Stoke Therapeutics on 11 of the 16 factors compared between the two stocks.

How does Stoke Therapeutics compare to Rhythm Pharmaceuticals?

Rhythm Pharmaceuticals (NASDAQ:RYTM) and Stoke Therapeutics (NASDAQ:STOK) are both healthcare companies, but which is the better business? We will compare the two companies based on the strength of their dividends, analyst recommendations, valuation, profitability, earnings, media sentiment, institutional ownership and risk.

In the previous week, Rhythm Pharmaceuticals had 3 more articles in the media than Stoke Therapeutics. MarketBeat recorded 6 mentions for Rhythm Pharmaceuticals and 3 mentions for Stoke Therapeutics. Stoke Therapeutics' average media sentiment score of 1.77 beat Rhythm Pharmaceuticals' score of 1.16 indicating that Stoke Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Rhythm Pharmaceuticals
1 Very Positive mention(s)
0 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Stoke Therapeutics
2 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Positive

Rhythm Pharmaceuticals presently has a consensus price target of $141.12, indicating a potential upside of 34.77%. Stoke Therapeutics has a consensus price target of $44.25, indicating a potential upside of 52.43%. Given Stoke Therapeutics' stronger consensus rating and higher possible upside, analysts plainly believe Stoke Therapeutics is more favorable than Rhythm Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Rhythm Pharmaceuticals
1 Sell rating(s)
3 Hold rating(s)
15 Buy rating(s)
0 Strong Buy rating(s)
2.74
Stoke Therapeutics
1 Sell rating(s)
0 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.82

Stoke Therapeutics has lower revenue, but higher earnings than Rhythm Pharmaceuticals. Rhythm Pharmaceuticals is trading at a lower price-to-earnings ratio than Stoke Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Rhythm Pharmaceuticals$189.76M37.82-$196.54M-$3.11N/A
Stoke Therapeutics$184.42M10.16-$6.89M-$3.34N/A

Rhythm Pharmaceuticals has a beta of 1.97, meaning that its share price is 97% more volatile than the broader market. Comparatively, Stoke Therapeutics has a beta of 1.23, meaning that its share price is 23% more volatile than the broader market.

Rhythm Pharmaceuticals has a net margin of -85.59% compared to Stoke Therapeutics' net margin of -753.60%. Stoke Therapeutics' return on equity of -59.36% beat Rhythm Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Rhythm Pharmaceuticals-85.59% -159.87% -44.00%
Stoke Therapeutics -753.60%-59.36%-51.46%

Summary

Rhythm Pharmaceuticals beats Stoke Therapeutics on 8 of the 14 factors compared between the two stocks.

How does Stoke Therapeutics compare to Scholar Rock?

Scholar Rock (NASDAQ:SRRK) and Stoke Therapeutics (NASDAQ:STOK) are both healthcare companies, but which is the better investment? We will compare the two companies based on the strength of their institutional ownership, analyst recommendations, valuation, profitability, media sentiment, risk, dividends and earnings.

Stoke Therapeutics has higher revenue and earnings than Scholar Rock. Scholar Rock is trading at a lower price-to-earnings ratio than Stoke Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Scholar RockN/AN/A-$377.94M-$3.45N/A
Stoke Therapeutics$184.42M10.16-$6.89M-$3.34N/A

Scholar Rock has a beta of 0.67, meaning that its share price is 33% less volatile than the broader market. Comparatively, Stoke Therapeutics has a beta of 1.23, meaning that its share price is 23% more volatile than the broader market.

In the previous week, Scholar Rock had 8 more articles in the media than Stoke Therapeutics. MarketBeat recorded 11 mentions for Scholar Rock and 3 mentions for Stoke Therapeutics. Stoke Therapeutics' average media sentiment score of 1.77 beat Scholar Rock's score of 0.61 indicating that Stoke Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Scholar Rock
2 Very Positive mention(s)
2 Positive mention(s)
5 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Stoke Therapeutics
2 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Positive

91.1% of Scholar Rock shares are held by institutional investors. 10.3% of Scholar Rock shares are held by insiders. Comparatively, 9.6% of Stoke Therapeutics shares are held by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.

Scholar Rock presently has a consensus target price of $58.77, suggesting a potential upside of 6.06%. Stoke Therapeutics has a consensus target price of $44.25, suggesting a potential upside of 52.43%. Given Stoke Therapeutics' higher probable upside, analysts clearly believe Stoke Therapeutics is more favorable than Scholar Rock.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Scholar Rock
1 Sell rating(s)
1 Hold rating(s)
10 Buy rating(s)
4 Strong Buy rating(s)
3.06
Stoke Therapeutics
1 Sell rating(s)
0 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.82

Scholar Rock has a net margin of 0.00% compared to Stoke Therapeutics' net margin of -753.60%. Stoke Therapeutics' return on equity of -59.36% beat Scholar Rock's return on equity.

Company Net Margins Return on Equity Return on Assets
Scholar RockN/A -160.19% -87.18%
Stoke Therapeutics -753.60%-59.36%-51.46%

Summary

Stoke Therapeutics beats Scholar Rock on 9 of the 15 factors compared between the two stocks.

How does Stoke Therapeutics compare to CG Oncology?

Stoke Therapeutics (NASDAQ:STOK) and CG Oncology (NASDAQ:CGON) are both healthcare companies, but which is the better business? We will compare the two companies based on the strength of their dividends, analyst recommendations, risk, media sentiment, profitability, institutional ownership, valuation and earnings.

26.6% of CG Oncology shares are owned by institutional investors. 9.6% of Stoke Therapeutics shares are owned by company insiders. Comparatively, 4.8% of CG Oncology shares are owned by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.

Stoke Therapeutics has a net margin of -753.60% compared to CG Oncology's net margin of -3,602.68%. CG Oncology's return on equity of -25.20% beat Stoke Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Stoke Therapeutics-753.60% -59.36% -51.46%
CG Oncology -3,602.68%-25.20%-23.98%

Stoke Therapeutics has higher revenue and earnings than CG Oncology. CG Oncology is trading at a lower price-to-earnings ratio than Stoke Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Stoke Therapeutics$184.42M10.16-$6.89M-$3.34N/A
CG Oncology$6.23M1,029.72-$160.99M-$2.69N/A

Stoke Therapeutics has a beta of 1.23, suggesting that its share price is 23% more volatile than the broader market. Comparatively, CG Oncology has a beta of 0.24, suggesting that its share price is 76% less volatile than the broader market.

In the previous week, CG Oncology had 3 more articles in the media than Stoke Therapeutics. MarketBeat recorded 6 mentions for CG Oncology and 3 mentions for Stoke Therapeutics. Stoke Therapeutics' average media sentiment score of 1.77 beat CG Oncology's score of 1.35 indicating that Stoke Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Stoke Therapeutics
2 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Positive
CG Oncology
3 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Stoke Therapeutics currently has a consensus target price of $44.25, suggesting a potential upside of 52.43%. CG Oncology has a consensus target price of $87.78, suggesting a potential upside of 21.32%. Given Stoke Therapeutics' stronger consensus rating and higher possible upside, equities analysts clearly believe Stoke Therapeutics is more favorable than CG Oncology.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Stoke Therapeutics
1 Sell rating(s)
0 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.82
CG Oncology
1 Sell rating(s)
1 Hold rating(s)
9 Buy rating(s)
0 Strong Buy rating(s)
2.73

Summary

Stoke Therapeutics beats CG Oncology on 10 of the 16 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding STOK and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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STOK vs. The Competition

MetricStoke TherapeuticsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$1.89B$3.84B$7.13B$12.72B
Dividend YieldN/A3.63%2.56%11.15%
P/E Ratio-8.6914.25275.2425.29
Price / Sales10.161,473.16656.0298.94
Price / CashN/A106.6877.0451.44
Price / Book4.7115.1210.336.20
Net Income-$6.89M-$22.86M$3.50B$358.50M
7 Day Performance-2.62%-4.34%-3.32%-2.35%
1 Month Performance-11.95%-0.02%-0.41%-2.77%
1 Year Performance23.74%40.64%19.21%7.63%

Stoke Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
STOK
Stoke Therapeutics
3.4499 of 5 stars
$29.03
-1.1%
$44.25
+52.4%
+21.6%$1.89B$184.42MN/A170
ALKS
Alkermes
2.8632 of 5 stars
$46.99
-0.9%
$54.56
+16.1%
+65.9%$7.95B$1.48B123.662,050
SYRE
Spyre Therapeutics
2.4172 of 5 stars
$89.33
-1.1%
$109.69
+22.8%
+459.3%$7.95B$890KN/A73
RYTM
Rhythm Pharmaceuticals
2.855 of 5 stars
$106.13
-1.0%
$141.12
+33.0%
+6.9%$7.34B$189.76MN/A140
SRRK
Scholar Rock
1.801 of 5 stars
$56.80
-1.7%
$58.77
+3.5%
+74.0%$7.04BN/AN/A140

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This page (NASDAQ:STOK) was last updated on 9/12/2026 by MarketBeat.com Staff.
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