Free Trial
→ Here’s How to Claim Your Stake in Elon’s Private Company, xAI (From Brownstone Research) (Ad) Buy SYRE Stock  Free SYRE Stock Alerts

Spyre Therapeutics (SYRE) Institutional Ownership

Spyre Therapeutics logo
$15.00 -0.23 (-1.52%)
As of 11:24 AM Eastern
This is a fair market value price provided by Polygon.io. Learn more.
Compare

Institutional Ownership Changes (13F Filings) for Spyre Therapeutics (NASDAQ:SYRE)

Current
Institutional Ownership
Percentage
80.39%
Number of
Institutional Buyers
(last 12 months)
90
Total
Institutional Inflows
(last 12 months)
$516.36M
Number of
Institutional Sellers
(last 12 months)
17
Total
Institutional Outflows
(last 12 months)
$65.75M
Get SYRE Insider Trade Alerts

Want to know when executives and insiders are buying or selling Spyre Therapeutics stock? Sign up for InsiderTrades.com's daily newsletter to get the latest insider transactions delivered to your inbox daily.

Skip Chart & View Institutional Buying and Selling Data

SYRE Institutional Buying and Selling by Quarter

Spyre Therapeutics Major Shareholders & Ownership History

Export to Excel
Reporting DateMajor Shareholder NameShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
4/29/2025 Bank of New York Mellon Corp114,240$1.84M0.0%+10.2%0.190%
4/8/2025 Rhumbline Advisers56,023$904K0.0%-2.8%0.093%
4/7/2025 GAMMA Investing LLC4,356$70K0.0%N/A0.007%
3/24/2025Wellington Management Group LLP1,604,508$37.35M0.0%+6.5%2.663%
3/18/2025California State Teachers Retirement System32,598$759K0.0%+32.1%0.054%
2/28/2025Universal Beteiligungs und Servicegesellschaft mbH122,153$2.84M0.0%N/A0.238%
2/19/2025 GF Fund Management CO. LTD.1,232$29K0.0%N/A0.002%
2/17/2025UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC48,981$1.14M0.0%+85.2%0.095%
2/17/2025Voloridge Investment Management LLC115,470$2.69M0.0%-26.2%0.225%
2/17/2025Woodline Partners LP352,680$8.21M0.1%+33.5%0.686%
2/17/2025Squarepoint Ops LLC15,231$355K0.0%+79.7%0.030%
2/17/2025RTW Investments LP3,621,996$84.32M1.3%+11.2%7.043%
2/17/2025Rafferty Asset Management LLC76,740$1.79M0.0%+8.7%0.149%
2/17/2025Polar Capital Holdings Plc750,000$17.46M0.1%+50.0%1.458%
2/17/2025ProShare Advisors LLC12,531$292K0.0%N/A0.024%
2/17/2025Prosight Management LP80,000$1.86M0.5%N/A0.156%
2/17/2025Paradigm Biocapital Advisors LP1,527,205$35.55M1.2%+20.5%2.969%
2/17/2025Millennium Management LLC167,804$3.91M0.0%N/A0.326%
2/17/2025MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.22,741$527K0.0%+4.2%0.044%
2/17/2025Janus Henderson Group PLC1,456,740$33.93M0.0%+30.0%2.832%
2/17/2025Jefferies Financial Group Inc.1,216,954$28.33M0.2%+167.6%2.366%
2/17/2025Deutsche Bank AG31,418$731K0.0%+46.1%0.061%
2/17/2025Deerfield Management Company L.P. Series C450,000$10.48M0.2%N/A0.875%
2/17/2025Driehaus Capital Management LLC2,803,655$65.27M0.5%+308.1%5.451%
2/17/2025Deep Track Capital LP219,015$5.10M0.2%-78.1%0.426%
2/17/2025Braidwell LP2,578,404$60.03M1.8%+17.7%5.013%
2/17/2025Brevan Howard Capital Management LP16,899$393K0.0%N/A0.033%
2/17/2025Blackstone Inc.449,201$10.46M0.0%+53.3%0.873%
2/17/2025Bank of America Corp DE7,142$166K0.0%-97.2%0.014%
2/17/2025BNP Paribas Financial Markets18,784$437K0.0%N/A0.037%
2/14/2025Boxer Capital Management LLC466,680$10.86M0.9%N/A0.907%
2/14/2025Soros Fund Management LLC250,000$5.82M0.1%+72.4%0.486%
2/14/2025Emerald Mutual Fund Advisers Trust386,384$9.00M0.5%+52.4%0.751%
2/14/2025Northern Trust Corp348,983$8.12M0.0%+11.0%0.679%
2/14/2025The Manufacturers Life Insurance Company 52,762$1.23M0.0%+21.4%0.103%
2/14/2025Aquatic Capital Management LLC11,767$274K0.0%N/A0.023%
2/14/2025Boothbay Fund Management LLC85,618$1.99M0.1%-6.7%0.166%
2/14/2025Voya Investment Management LLC10,495$244K0.0%-7.5%0.020%
2/14/2025Adage Capital Partners GP L.L.C.1,030,000$23.98M0.0%-2.4%2.003%
2/14/2025Price T Rowe Associates Inc. MD506,450$11.79M0.0%+18.0%0.985%
Elon Reveals Why There Soon Won’t Be Any Money For Social Security (Ad)

Elon Musk's Near-Death Experience Sparks Dire Warning for Americans After cheating death twice—once in a terrifying supercar crash with billionaire Peter Thiel, then from a deadly strain of malaria—Elon Musk emerged with a stark warning for Americans about looming financial dangers. Discover the little-known Trump IRS loophole that thousands are now using to safeguard their retirement from inflation and market turmoil—before it's too late.

See why thousands of forward-thinking retirement savers are now requesting this FREE 2025 Wealth Pro
2/14/2025B Group Inc.50,000$1.16M0.7%N/A0.097%
2/14/2025Tower Research Capital LLC TRC 8,574$200K0.0%+1,548.8%0.017%
2/14/2025Teachers Retirement System of The State of Kentucky25,799$601K0.0%+22.0%0.050%
2/14/2025MetLife Investment Management LLC21,382$498K0.0%+6.2%0.042%
2/14/2025Capital World Investors378,573$8.81M0.0%N/A0.736%
2/14/2025First Trust Advisors LP23,550$548K0.0%N/A0.046%
2/13/2025Affinity Asset Advisors LLC824,328$19.19M2.6%+65.4%1.603%
2/13/2025Barclays PLC123,071$2.87M0.0%+16.7%0.239%
2/13/2025F M Investments LLC48,806$1.14M0.0%N/A0.095%
2/13/2025Legal & General Group Plc37,490$873K0.0%+14.8%0.073%
2/13/2025Invesco Ltd.19,663$458K0.0%-85.7%0.038%
2/13/2025FMR LLC8,801,266$204.89M0.0%+15.4%17.113%
2/13/2025Wells Fargo & Company MN24,718$575K0.0%+38.8%0.048%
2/12/2025ExodusPoint Capital Management LP16,691$389K0.0%+71.5%0.032%
2/12/2025Cinctive Capital Management LP19,567$456K0.0%-68.1%0.038%
2/12/2025Huntington National Bank1,470$34K0.0%N/A0.003%
2/12/2025Geode Capital Management LLC966,129$22.50M0.0%+8.4%1.879%
2/12/2025Wellington Management Group LLP1,604,508$37.35M0.0%+6.5%3.120%
2/12/2025Schroder Investment Management Group113,620$2.56M0.0%N/A0.221%
2/12/2025Pictet Asset Management Holding SA1,092,124$25.43M0.0%+32.3%2.124%
2/12/2025JPMorgan Chase & Co.35,248$821K0.0%+19.6%0.069%
2/11/2025EFG Asset Management North America Corp.82,818$1.93M0.3%+58.6%0.161%
2/11/2025Corebridge Financial Inc.17,213$401K0.0%-7.0%0.033%
2/11/2025Emerald Advisers LLC546,791$12.73M0.5%+86.9%1.063%
2/11/2025Vanguard Group Inc.2,846,473$66.27M0.0%+13.1%5.535%
2/11/2025KLP Kapitalforvaltning AS7,800$182K0.0%N/A0.015%
2/11/2025 Teacher Retirement System of Texas10,383$242K0.0%N/A0.020%
2/10/2025Natixis Advisors LLC17,300$403K0.0%N/A0.034%
2/10/2025Swiss National Bank68,600$1.60M0.0%+38.3%0.133%
2/7/2025AlphaQuest LLC2,198$51K0.0%-61.1%0.004%
2/7/2025Candriam S.C.A.247,591$5.76M0.0%+135.8%0.481%
2/6/2025Arizona State Retirement System10,115$235K0.0%+38.4%0.020%
2/6/2025Victory Capital Management Inc.268,076$6.24M0.0%N/A0.521%
2/6/2025Charles Schwab Investment Management Inc.379,650$8.84M0.0%+13.9%0.738%
2/6/2025NBW Capital LLC19,430$452K0.1%-27.8%0.038%
2/4/2025 Bank of New York Mellon Corp103,688$2.41M0.0%-1.1%0.202%
1/30/2025 Rhumbline Advisers57,657$1.34M0.0%+6.9%0.112%
1/27/2025 Mirae Asset Global Investments Co. Ltd.1,955$46K0.0%N/A0.004%
1/24/2025China Universal Asset Management Co. Ltd.12,440$290K0.0%N/A0.024%
1/14/2025 Assenagon Asset Management S.A.22,652$527K0.0%-98.0%0.044%
12/26/2024JPMorgan Chase & Co.29,473$867K0.0%+29.4%0.057%
11/27/2024Franklin Resources Inc.760,666$23.32M0.0%+2.5%1.479%
11/18/2024Teachers Retirement System of The State of Kentucky21,154$622K0.0%N/A0.041%
11/16/2024Geode Capital Management LLC891,048$26.21M0.0%+16.4%1.733%
11/15/2024Barclays PLC105,467$3.10M0.0%+64.7%0.205%
11/15/2024Jane Street Group LLC20,641$607K0.0%+78.7%0.040%
11/15/2024Wellington Management Group LLP1,507,200$44.33M0.0%+89.4%2.931%
11/15/2024State Street Corp1,541,555$45.34M0.0%+9.4%2.997%
11/15/2024Ikarian Capital LLC302,247$8.89M1.2%N/A0.588%
11/15/2024Janus Henderson Group PLC1,120,531$32.92M0.0%+66.3%2.179%
Elon Reveals Why There Soon Won’t Be Any Money For Social Security (Ad)

Elon Musk's Near-Death Experience Sparks Dire Warning for Americans After cheating death twice—once in a terrifying supercar crash with billionaire Peter Thiel, then from a deadly strain of malaria—Elon Musk emerged with a stark warning for Americans about looming financial dangers. Discover the little-known Trump IRS loophole that thousands are now using to safeguard their retirement from inflation and market turmoil—before it's too late.

See why thousands of forward-thinking retirement savers are now requesting this FREE 2025 Wealth Pro
11/15/2024HighVista Strategies LLC105,351$3.10M1.1%-7.2%0.205%
11/15/2024Cinctive Capital Management LP61,256$1.80M0.1%N/A0.119%
11/14/2024Braidwell LP2,189,836$64.40M1.8%-12.9%4.258%
11/14/2024Walleye Capital LLC243,372$7.16M0.0%+61.4%0.473%
11/14/2024UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC26,441$778K0.0%-12.2%0.051%
11/14/2024MetLife Investment Management LLC20,132$592K0.0%+129.1%0.039%
11/13/2024FMR LLC7,623,881$224.22M0.0%+1.5%14.824%
11/13/2024The Manufacturers Life Insurance Company43,460$1.28M0.0%+15.0%0.085%
11/12/2024Charles Schwab Investment Management Inc.333,275$9.80M0.0%+239.4%0.655%
11/9/2024Intech Investment Management LLC8,371$246K0.0%N/A0.016%
(Data available from 1/1/2016 forward)

SYRE Institutional Ownership - Frequently Asked Questions

Who are the largest shareholders of SYRE shares?

During the previous two years, 100 institutional investors and hedge funds held shares of Spyre Therapeutics. The most heavily invested institutionals were FMR LLC ($204.89M), RTW Investments LP ($84.32M), Perceptive Advisors LLC ($71.26M), Vanguard Group Inc. ($66.27M), Driehaus Capital Management LLC ($65.27M), Braidwell LP ($60.03M), and State Street Corp ($45.34M).Learn more on SYRE's institutional investors.

What percentage of Spyre Therapeutics stock is owned by institutional investors?

80.39% of Spyre Therapeutics stock is owned by institutional investors. Learn more on SYRE's institutional investor holdings.

Which institutional investors have been buying Spyre Therapeutics stock?

Of the 90 institutional investors that purchased Spyre Therapeutics stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: Driehaus Capital Management LLC ($2.80M), Avoro Capital Advisors LLC ($1.84M), FMR LLC ($1.29M), Assenagon Asset Management S.A. ($1.14M), Wellington Management Group LLP ($905.87K), Affinity Asset Advisors LLC ($839.33K), and Janus Henderson Group PLC ($782.87K).

How much institutional buying is happening at Spyre Therapeutics?

Institutional investors have bought a total of 21,054,326 shares in the last 24 months. This purchase volume represents approximately $516.36M in transactions.

Which Spyre Therapeutics major shareholders have been selling company stock?

Of the 17 institutional investors that sold Spyre Therapeutics stock in the last 24 months, the following investors and hedge funds have sold the highest volume of shares: Assenagon Asset Management S.A. ($1.12M), Deep Track Capital LP ($780.99K), Braidwell LP ($324.70K), Bank of America Corp DE ($250.66K), Invesco Ltd. ($118.20K), Cinctive Capital Management LP ($41.69K), and Voloridge Investment Management LLC ($41.01K).

How much institutional selling is happening at Spyre Therapeutics?

Institutional investors have sold a total of 2,736,252 shares in the last 24 months. This volume of shares sold represents approximately $65.75M in transactions.


Related Companies

This page (NASDAQ:SYRE) was last updated on 5/1/2025 by MarketBeat.com Staff
From Our Partners
How to invest in Elon Musk’s Optimus before its launch
Elon Musk is set to completely take over the AI industry with Optimus… A breakthrough AI-powered robot that El...
InvestorPlace | Sponsored
Is he more powerful than Trump?
Is there anybody more powerful than Donald Trump right now? In a single tariff announcement, he wiped out n...
Porter & Company | Sponsored
Elon Set to Shock the World by May 1st ?
Tech legend Jeff Brown recently traveled to the industrial zone of South Memphis to investigate what he believ...
Brownstone Research | Sponsored
Trump and Buffett Are Quietly Leading America’s Gold Revival
The “Buffett Indicator” Predicts Gold Set To Dominate for Next Decade Each time the Buffett Indicator has...
Golden Portfolio | Sponsored
This isn’t a trade war. It’s worse…
Investigative Journalist Bombhsell: The Curse on the U.S Dollar Depleted retirement accounts? Meme coin inv...
Stansberry Research | Sponsored
Elon Musk’s next move from the Oval Office?
No one is closer to President Trump than Tesla CEO Elon Musk. He's been dubbed Trump's "first buddy." Tr...
Weiss Ratings | Sponsored
Trump Treasure April 19
Thanks to President Trump… A $900 investment across5 specific cryptos… Could gain 12,000% so quickly tha...
Paradigm Press | Sponsored
China’s next move could destroy U.S. tech
The U.S. fired the first shot with 145% tariffs. Apple relies heavily on Chinese production. Tesla needs Ch...
Investors Alley | Sponsored