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Spyre Therapeutics (SYRE) Institutional Ownership

Spyre Therapeutics logo
$16.02 +0.73 (+4.77%)
Closing price 09/23/2025 04:00 PM Eastern
Extended Trading
$16.38 +0.36 (+2.25%)
As of 09:15 AM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.
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Institutional Ownership Changes (13F Filings) for Spyre Therapeutics (NASDAQ:SYRE)

Current
Institutional Ownership
Percentage
80.39%
Number of
Institutional Buyers
(last 12 months)
89
Total
Institutional Inflows
(last 12 months)
$390.47M
Number of
Institutional Sellers
(last 12 months)
35
Total
Institutional Outflows
(last 12 months)
$112.63M
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SYRE Institutional Buying and Selling by Quarter

Spyre Therapeutics Major Shareholders & Ownership History

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Reporting DateMajor Shareholder NameShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
8/15/2025 Tower Research Capital LLC TRC 5,769$86K0.0%+182.2%0.010%
8/15/2025 Rafferty Asset Management LLC50,957$763K0.0%-27.5%0.084%
8/15/2025 Perceptive Advisors LLC1,529,445$22.90M2.0%-33.9%2.532%
8/15/2025 Man Group plc10,843$162K0.0%N/A0.018%
8/15/2025 BNP Paribas Financial Markets223,320$3.34M0.0%+300.0%0.370%
8/15/2025 Bank of America Corp DE396,351$5.93M0.0%-7.2%0.656%
8/15/2025 Adage Capital Partners GP L.L.C.610,200$9.14M0.0%-24.0%1.010%
8/14/2025 California State Teachers Retirement System33,201$497K0.0%+1.8%0.055%
8/14/2025 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.29,812$447K0.0%+10.3%0.049%
8/14/2025 Armistice Capital LLC172,000$2.58M0.0%-14.0%0.285%
8/14/2025 The Manufacturers Life Insurance Company 79,896$1.20M0.0%+48.2%0.132%
8/14/2025 HighVista Strategies LLC112,805$1.69M0.6%+18.5%0.187%
8/14/2025 B Group Inc.80,000$1.20M0.9%+14.3%0.132%
8/13/2025 Affinity Asset Advisors LLC606,678$9.08M1.2%+26.0%1.004%
8/13/2025 Invesco Ltd.34,680$519K0.0%+37.6%0.057%
8/13/2025 New York State Common Retirement Fund16,565$248K0.0%+61.4%0.027%
8/13/2025 Schroder Investment Management Group129,558$1.97M0.0%+19.4%0.215%
8/13/2025 Virtus Investment Advisers LLC5,310$79K0.0%-22.6%0.009%
8/13/2025 F m Investments LLC52,546$787K0.0%+1.4%0.087%
8/12/2025 Foresite Capital Management VI LLC70,000$1.05M0.6%N/A0.116%
8/12/2025 Ameritas Investment Partners Inc.5,091$76K0.0%+25.8%0.008%
8/12/2025Jefferies Financial Group Inc.1,388,854$20.79M0.2%+11.2%2.299%
8/12/2025 Rhumbline Advisers73,168$1.10M0.0%+30.6%0.121%
8/12/2025 Franklin Resources Inc.795,275$11.91M0.0%+4.6%1.317%
8/12/2025 Legal & General Group Plc34,969$523K0.0%-7.6%0.058%
8/12/2025 JPMorgan Chase & Co.47,279$708K0.0%+13.8%0.078%
8/11/2025 Universal Beteiligungs und Servicegesellschaft mbH109,284$1.64M0.0%-9.2%0.181%
8/8/2025 Intech Investment Management LLC24,945$373K0.0%+22.1%0.041%
8/8/2025 Police & Firemen s Retirement System of New Jersey11,525$173K0.0%+31.5%0.019%
8/8/2025 Geode Capital Management LLC1,227,232$18.37M0.0%+15.8%2.036%
8/7/2025 ProShare Advisors LLC12,479$187K0.0%+9.7%0.021%
8/7/2025 Profund Advisors LLC11,043$165K0.0%-24.7%0.018%
8/4/2025 Emerald Mutual Fund Advisers Trust329,430$4.93M0.3%-15.4%0.547%
8/4/2025 Emerald Advisers LLC565,863$8.47M0.3%+3.3%0.939%
7/31/2025 AlphaQuest LLC4,174$62K0.0%+30.8%0.007%
7/28/2025 TD Asset Management Inc113,968$1.71M0.0%+409.5%0.189%
7/25/2025 CWM LLC1,712$26K0.0%+357.8%0.003%
6/27/2025 Goldman Sachs Group Inc.197,068$3.18M0.0%-73.6%0.327%
5/29/2025Rhumbline Advisers56,023$904K0.0%-2.8%0.093%
5/23/2025Siren L.L.C.368,598$5.95M0.3%-1.4%0.612%
5/16/2025Woodline Partners LP464,808$7.50M0.0%+31.8%0.771%
5/16/2025Goldman Sachs Group Inc.197,068$3.18M0.0%-73.6%0.327%
5/16/2025MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.27,018$442K0.0%+18.8%0.045%
5/16/2025Adage Capital Partners GP L.L.C.803,200$12.96M0.0%-22.0%1.333%
5/16/2025ADAR1 Capital Management LLC15,033$243K0.0%N/A0.025%
5/15/2025Paradigm Biocapital Advisors LP2,127,205$34.32M1.6%+39.3%3.529%
5/15/2025Driehaus Capital Management LLC2,717,312$43.84M0.4%-3.1%4.508%
5/15/2025Siren L.L.C.368,598$5.95M0.3%-1.4%0.612%
5/14/2025Affinity Asset Advisors LLC481,678$7.77M0.7%-41.6%0.799%
5/14/2025Rafferty Asset Management LLC70,323$1.14M0.0%-8.4%0.117%
5/14/2025Corebridge Financial Inc.19,595$316K0.0%+13.8%0.033%
5/14/2025MetLife Investment Management LLC23,733$383K0.0%+11.0%0.039%
5/14/2025AlphaQuest LLC3,191$51K0.0%+45.2%0.005%
5/14/2025Candriam S.C.A.246,030$3.97M0.0%-0.6%0.408%
5/14/2025Wellington Management Group LLP1,593,678$25.71M0.0%-0.7%2.644%
5/12/2025Nuveen LLC140,129$2.26M0.0%N/A0.232%
5/12/2025Invesco Ltd.25,207$407K0.0%+28.2%0.042%
5/9/2025Deutsche Bank AG28,483$460K0.0%-9.3%0.047%
5/9/2025Charles Schwab Investment Management Inc.382,636$6.17M0.0%+0.8%0.635%
5/9/2025Vanguard Group Inc.2,898,267$46.76M0.0%+1.8%4.808%
5/8/2025Jefferies Financial Group Inc.1,248,854$20.15M0.2%+2.6%2.072%
5/8/2025Natixis Advisors LLC16,401$265K0.0%-5.2%0.027%
5/8/2025XTX Topco Ltd28,499$460K0.0%N/A0.047%
5/7/2025TD Asset Management Inc22,368$361K0.0%-65.6%0.037%
5/6/2025Universal Beteiligungs und Servicegesellschaft mbH120,321$1.94M0.0%-1.5%0.200%
5/2/2025Victory Capital Management Inc.251,846$4.06M0.0%-6.1%0.418%
5/1/2025Emerald Advisers LLC547,827$8.84M0.4%+0.2%0.909%
5/1/2025Emerald Mutual Fund Advisers Trust389,422$6.28M0.4%+0.8%0.646%
4/29/2025Bank of New York Mellon Corp114,240$1.84M0.0%+10.2%0.190%
4/8/2025Rhumbline Advisers56,023$904K0.0%-2.8%0.093%
4/7/2025GAMMA Investing LLC4,356$70K0.0%N/A0.007%
3/24/2025Wellington Management Group LLP1,604,508$37.35M0.0%+6.5%2.663%
3/18/2025California State Teachers Retirement System32,598$759K0.0%+32.1%0.054%
2/28/2025Universal Beteiligungs und Servicegesellschaft mbH122,153$2.84M0.0%N/A0.238%
2/19/2025GF Fund Management CO. LTD.1,232$29K0.0%N/A0.002%
2/17/2025UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC48,981$1.14M0.0%+85.2%0.095%
2/17/2025Voloridge Investment Management LLC115,470$2.69M0.0%-26.2%0.225%
2/17/2025Woodline Partners LP352,680$8.21M0.1%+33.5%0.686%
2/17/2025Squarepoint Ops LLC15,231$355K0.0%+79.7%0.030%
2/17/2025RTW Investments LP3,621,996$84.32M1.3%+11.2%7.043%
2/17/2025Rafferty Asset Management LLC76,740$1.79M0.0%+8.7%0.149%
2/17/2025Polar Capital Holdings Plc750,000$17.46M0.1%+50.0%1.458%
2/17/2025ProShare Advisors LLC12,531$292K0.0%N/A0.024%
2/17/2025Prosight Management LP80,000$1.86M0.5%N/A0.156%
2/17/2025Paradigm Biocapital Advisors LP1,527,205$35.55M1.2%+20.5%2.969%
2/17/2025Millennium Management LLC167,804$3.91M0.0%N/A0.326%
2/17/2025MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.22,741$527K0.0%+4.2%0.044%
2/17/2025Janus Henderson Group PLC1,456,740$33.93M0.0%+30.0%2.832%
2/17/2025Jefferies Financial Group Inc.1,216,954$28.33M0.2%+167.6%2.366%
2/17/2025Deutsche Bank AG31,418$731K0.0%+46.1%0.061%
2/17/2025Deerfield Management Company L.P. Series C450,000$10.48M0.2%N/A0.875%
2/17/2025Driehaus Capital Management LLC2,803,655$65.27M0.5%+308.1%5.451%
2/17/2025Deep Track Capital LP219,015$5.10M0.2%-78.1%0.426%
2/17/2025Braidwell LP2,578,404$60.03M1.8%+17.7%5.013%
2/17/2025Brevan Howard Capital Management LP16,899$393K0.0%N/A0.033%
2/17/2025Blackstone Inc.449,201$10.46M0.0%+53.3%0.873%
2/17/2025Bank of America Corp DE7,142$166K0.0%-97.2%0.014%
2/17/2025BNP Paribas Financial Markets18,784$437K0.0%N/A0.037%
2/14/2025Boxer Capital Management LLC466,680$10.86M0.9%N/A0.907%
2/14/2025Soros Fund Management LLC250,000$5.82M0.1%+72.4%0.486%
(Data available from 1/1/2016 forward)

SYRE Institutional Ownership - Frequently Asked Questions

Who are the largest shareholders of SYRE shares?

During the previous two years, 112 institutional investors and hedge funds held shares of Spyre Therapeutics. The most heavily invested institutionals were FMR LLC ($204.89M), RTW Investments LP ($84.32M), Braidwell LP ($60.03M), Vanguard Group Inc. ($46.76M), State Street Corp ($45.34M), Driehaus Capital Management LLC ($43.84M), and Avoro Capital Advisors LLC ($43.24M).Learn more on Spyre Therapeutics' institutional investors.

What percentage of Spyre Therapeutics' stock is owned by institutional investors?

80.39% of Spyre Therapeutics' stock is owned by institutional investors. Learn more on SYRE's institutional investor holdings.

Which institutional investors have been buying Spyre Therapeutics' stock?

Of the 102 institutional investors that purchased Spyre Therapeutics' stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: Driehaus Capital Management LLC ($2.80M), Avoro Capital Advisors LLC ($1.84M), FMR LLC ($1.29M), Assenagon Asset Management S.A. ($1.14M), Affinity Asset Advisors LLC ($964.33K), Jefferies Financial Group Inc. ($934.05K), and Wellington Management Group LLP ($905.87K).

How much institutional buying is happening at Spyre Therapeutics?

Institutional investors have bought a total of 16,361,706 shares in the last 24 months. This purchase volume represents approximately $390.47M in transactions.

Which of Spyre Therapeutics' major shareholders have been selling company stock?

Of the 35 institutional investors that sold Spyre Therapeutics' stock in the last 24 months, the following investors and hedge funds have sold the highest volume of shares: Assenagon Asset Management S.A. ($1.12M), Goldman Sachs Group Inc. ($1.10M), Perceptive Advisors LLC ($783.83K), Deep Track Capital LP ($780.99K), Adage Capital Partners GP L.L.C. ($444.80K), Affinity Asset Advisors LLC ($342.65K), and Braidwell LP ($324.70K).

How much institutional selling is happening at Spyre Therapeutics?

Institutional investors have sold a total of 5,722,746 shares in the last 24 months. This volume of shares sold represents approximately $112.63M in transactions.


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This page (NASDAQ:SYRE) was last updated on 9/24/2025 by MarketBeat.com Staff
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