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Spyre Therapeutics (SYRE) Institutional Ownership

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$14.78 -0.62 (-4.03%)
Closing price 04:00 PM Eastern
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$14.78 0.00 (-0.03%)
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Institutional Ownership Changes (13F Filings) for Spyre Therapeutics (NASDAQ:SYRE)

Current
Institutional Ownership
Percentage
80.39%
Number of
Institutional Buyers
(last 12 months)
96
Total
Institutional Inflows
(last 12 months)
$532.54M
Number of
Institutional Sellers
(last 12 months)
29
Total
Institutional Outflows
(last 12 months)
$86.65M
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SYRE Institutional Buying and Selling by Quarter

Spyre Therapeutics Major Shareholders & Ownership History

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Reporting DateMajor Shareholder NameShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
5/16/2025 Woodline Partners LP464,808$7.50M0.0%+31.8%0.771%
5/16/2025 Goldman Sachs Group Inc.197,068$3.18M0.0%-73.6%0.327%
5/16/2025 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.27,018$442K0.0%+18.8%0.045%
5/16/2025 Adage Capital Partners GP L.L.C.803,200$12.96M0.0%-22.0%1.333%
5/16/2025 ADAR1 Capital Management LLC15,033$243K0.0%N/A0.025%
5/15/2025 Paradigm Biocapital Advisors LP2,127,205$34.32M1.6%+39.3%3.529%
5/15/2025 Driehaus Capital Management LLC2,717,312$43.84M0.4%-3.1%4.508%
5/15/2025 Siren L.L.C.368,598$5.95M0.3%-1.4%0.612%
5/14/2025 Affinity Asset Advisors LLC481,678$7.77M0.7%-41.6%0.799%
5/14/2025 Rafferty Asset Management LLC70,323$1.14M0.0%-8.4%0.117%
5/14/2025 Corebridge Financial Inc.19,595$316K0.0%+13.8%0.033%
5/14/2025 MetLife Investment Management LLC23,733$383K0.0%+11.0%0.039%
5/14/2025 AlphaQuest LLC3,191$51K0.0%+45.2%0.005%
5/14/2025 Candriam S.C.A.246,030$3.97M0.0%-0.6%0.408%
5/14/2025 Wellington Management Group LLP1,593,678$25.71M0.0%-0.7%2.644%
5/12/2025 Nuveen LLC140,129$2.26M0.0%N/A0.232%
5/12/2025 Invesco Ltd.25,207$407K0.0%+28.2%0.042%
5/9/2025 Deutsche Bank AG28,483$460K0.0%-9.3%0.047%
5/9/2025 Charles Schwab Investment Management Inc.382,636$6.17M0.0%+0.8%0.635%
5/9/2025 Vanguard Group Inc.2,898,267$46.76M0.0%+1.8%4.808%
5/8/2025Jefferies Financial Group Inc.1,248,854$20.15M0.2%+2.6%2.072%
5/8/2025 Natixis Advisors LLC16,401$265K0.0%-5.2%0.027%
5/8/2025 XTX Topco Ltd28,499$460K0.0%N/A0.047%
5/7/2025 TD Asset Management Inc22,368$361K0.0%-65.6%0.037%
5/6/2025 Universal Beteiligungs und Servicegesellschaft mbH120,321$1.94M0.0%-1.5%0.200%
5/2/2025 Victory Capital Management Inc.251,846$4.06M0.0%-6.1%0.418%
5/1/2025 Emerald Advisers LLC547,827$8.84M0.4%+0.2%0.909%
5/1/2025 Emerald Mutual Fund Advisers Trust389,422$6.28M0.4%+0.8%0.646%
4/29/2025 Bank of New York Mellon Corp114,240$1.84M0.0%+10.2%0.190%
4/8/2025 Rhumbline Advisers56,023$904K0.0%-2.8%0.093%
4/7/2025 GAMMA Investing LLC4,356$70K0.0%N/A0.007%
3/24/2025 Wellington Management Group LLP1,604,508$37.35M0.0%+6.5%2.663%
3/18/2025 California State Teachers Retirement System32,598$759K0.0%+32.1%0.054%
2/28/2025 Universal Beteiligungs und Servicegesellschaft mbH122,153$2.84M0.0%N/A0.238%
2/19/2025 GF Fund Management CO. LTD.1,232$29K0.0%N/A0.002%
2/17/2025 UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC48,981$1.14M0.0%+85.2%0.095%
2/17/2025 Voloridge Investment Management LLC115,470$2.69M0.0%-26.2%0.225%
2/17/2025 Woodline Partners LP352,680$8.21M0.1%+33.5%0.686%
2/17/2025 Squarepoint Ops LLC15,231$355K0.0%+79.7%0.030%
2/17/2025 RTW Investments LP3,621,996$84.32M1.3%+11.2%7.043%
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2/17/2025 Rafferty Asset Management LLC76,740$1.79M0.0%+8.7%0.149%
2/17/2025 Polar Capital Holdings Plc750,000$17.46M0.1%+50.0%1.458%
2/17/2025 ProShare Advisors LLC12,531$292K0.0%N/A0.024%
2/17/2025 Prosight Management LP80,000$1.86M0.5%N/A0.156%
2/17/2025 Paradigm Biocapital Advisors LP1,527,205$35.55M1.2%+20.5%2.969%
2/17/2025 Millennium Management LLC167,804$3.91M0.0%N/A0.326%
2/17/2025 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.22,741$527K0.0%+4.2%0.044%
2/17/2025 Janus Henderson Group PLC1,456,740$33.93M0.0%+30.0%2.832%
2/17/2025Jefferies Financial Group Inc.1,216,954$28.33M0.2%+167.6%2.366%
2/17/2025 Deutsche Bank AG31,418$731K0.0%+46.1%0.061%
2/17/2025 Deerfield Management Company L.P. Series C450,000$10.48M0.2%N/A0.875%
2/17/2025 Driehaus Capital Management LLC2,803,655$65.27M0.5%+308.1%5.451%
2/17/2025 Deep Track Capital LP219,015$5.10M0.2%-78.1%0.426%
2/17/2025 Braidwell LP2,578,404$60.03M1.8%+17.7%5.013%
2/17/2025 Brevan Howard Capital Management LP16,899$393K0.0%N/A0.033%
2/17/2025 Blackstone Inc.449,201$10.46M0.0%+53.3%0.873%
2/17/2025 Bank of America Corp DE7,142$166K0.0%-97.2%0.014%
2/17/2025 BNP Paribas Financial Markets18,784$437K0.0%N/A0.037%
2/14/2025 Boxer Capital Management LLC466,680$10.86M0.9%N/A0.907%
2/14/2025 Soros Fund Management LLC250,000$5.82M0.1%+72.4%0.486%
2/14/2025 Emerald Mutual Fund Advisers Trust386,384$9.00M0.5%+52.4%0.751%
2/14/2025 Northern Trust Corp348,983$8.12M0.0%+11.0%0.679%
2/14/2025 The Manufacturers Life Insurance Company52,762$1.23M0.0%+21.4%0.103%
2/14/2025 Aquatic Capital Management LLC11,767$274K0.0%N/A0.023%
2/14/2025 Boothbay Fund Management LLC85,618$1.99M0.1%-6.7%0.166%
2/14/2025 Voya Investment Management LLC10,495$244K0.0%-7.5%0.020%
2/14/2025 Adage Capital Partners GP L.L.C.1,030,000$23.98M0.0%-2.4%2.003%
2/14/2025 Price T Rowe Associates Inc. MD506,450$11.79M0.0%+18.0%0.985%
2/14/2025 B Group Inc.50,000$1.16M0.7%N/A0.097%
2/14/2025 Tower Research Capital LLC TRC8,574$200K0.0%+1,548.8%0.017%
2/14/2025 Teachers Retirement System of The State of Kentucky25,799$601K0.0%+22.0%0.050%
2/14/2025 MetLife Investment Management LLC21,382$498K0.0%+6.2%0.042%
2/14/2025 Capital World Investors378,573$8.81M0.0%N/A0.736%
2/14/2025 First Trust Advisors LP23,550$548K0.0%N/A0.046%
2/13/2025 Affinity Asset Advisors LLC824,328$19.19M2.6%+65.4%1.603%
2/13/2025 Barclays PLC123,071$2.87M0.0%+16.7%0.239%
2/13/2025 F M Investments LLC48,806$1.14M0.0%N/A0.095%
2/13/2025 Legal & General Group Plc37,490$873K0.0%+14.8%0.073%
2/13/2025 Invesco Ltd.19,663$458K0.0%-85.7%0.038%
2/13/2025 FMR LLC8,801,266$204.89M0.0%+15.4%17.113%
2/13/2025 Wells Fargo & Company MN24,718$575K0.0%+38.8%0.048%
2/12/2025 ExodusPoint Capital Management LP16,691$389K0.0%+71.5%0.032%
2/12/2025 Cinctive Capital Management LP19,567$456K0.0%-68.1%0.038%
2/12/2025 Huntington National Bank1,470$34K0.0%N/A0.003%
2/12/2025 Geode Capital Management LLC966,129$22.50M0.0%+8.4%1.879%
2/12/2025 Wellington Management Group LLP1,604,508$37.35M0.0%+6.5%3.120%
2/12/2025 Schroder Investment Management Group113,620$2.56M0.0%N/A0.221%
2/12/2025 Pictet Asset Management Holding SA1,092,124$25.43M0.0%+32.3%2.124%
2/12/2025 JPMorgan Chase & Co.35,248$821K0.0%+19.6%0.069%
2/11/2025 EFG Asset Management North America Corp.82,818$1.93M0.3%+58.6%0.161%
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2/11/2025 Corebridge Financial Inc.17,213$401K0.0%-7.0%0.033%
2/11/2025 Emerald Advisers LLC546,791$12.73M0.5%+86.9%1.063%
2/11/2025 Vanguard Group Inc.2,846,473$66.27M0.0%+13.1%5.535%
2/11/2025 KLP Kapitalforvaltning AS7,800$182K0.0%N/A0.015%
2/11/2025 Teacher Retirement System of Texas10,383$242K0.0%N/A0.020%
2/10/2025 Natixis Advisors LLC17,300$403K0.0%N/A0.034%
2/10/2025 Swiss National Bank68,600$1.60M0.0%+38.3%0.133%
2/7/2025 AlphaQuest LLC2,198$51K0.0%-61.1%0.004%
2/7/2025 Candriam S.C.A.247,591$5.76M0.0%+135.8%0.481%
2/6/2025 Arizona State Retirement System10,115$235K0.0%+38.4%0.020%
(Data available from 1/1/2016 forward)

SYRE Institutional Ownership - Frequently Asked Questions

Who are the largest shareholders of SYRE shares?

During the previous two years, 105 institutional investors and hedge funds held shares of Spyre Therapeutics. The most heavily invested institutionals were FMR LLC ($204.89M), RTW Investments LP ($84.32M), Perceptive Advisors LLC ($71.26M), Braidwell LP ($60.03M), Vanguard Group Inc. ($46.76M), State Street Corp ($45.34M), and Driehaus Capital Management LLC ($43.84M).Learn more on SYRE's institutional investors.

What percentage of Spyre Therapeutics stock is owned by institutional investors?

80.39% of Spyre Therapeutics stock is owned by institutional investors. Learn more on SYRE's institutional investor holdings.

Which institutional investors have been buying Spyre Therapeutics stock?

Of the 96 institutional investors that purchased Spyre Therapeutics stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: Driehaus Capital Management LLC ($2.80M), Avoro Capital Advisors LLC ($1.84M), FMR LLC ($1.29M), Assenagon Asset Management S.A. ($1.14M), Wellington Management Group LLP ($905.87K), Paradigm Biocapital Advisors LP ($859.62K), and Affinity Asset Advisors LLC ($839.33K).

How much institutional buying is happening at Spyre Therapeutics?

Institutional investors have bought a total of 22,056,416 shares in the last 24 months. This purchase volume represents approximately $532.54M in transactions.

Which Spyre Therapeutics major shareholders have been selling company stock?

Of the 29 institutional investors that sold Spyre Therapeutics stock in the last 24 months, the following investors and hedge funds have sold the highest volume of shares: Assenagon Asset Management S.A. ($1.12M), Deep Track Capital LP ($780.99K), Goldman Sachs Group Inc. ($550.48K), Affinity Asset Advisors LLC ($342.65K), Braidwell LP ($324.70K), Adage Capital Partners GP L.L.C. ($251.80K), and Bank of America Corp DE ($250.66K).

How much institutional selling is happening at Spyre Therapeutics?

Institutional investors have sold a total of 4,031,235 shares in the last 24 months. This volume of shares sold represents approximately $86.65M in transactions.


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This page (NASDAQ:SYRE) was last updated on 5/21/2025 by MarketBeat.com Staff
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