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Vertex Pharmaceuticals (VRTX) Short Interest Ratio & Short Volume

Vertex Pharmaceuticals logo
$446.67 +9.45 (+2.16%)
As of 02:22 PM Eastern
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Vertex Pharmaceuticals Short Interest Overview

As of May 15, 2026, Vertex Pharmaceuticals (VRTX) had a short interest of 4.46 million shares sold short, representing 1.76% of the public float. This marks a 6.92% increase in short interest since the prior report. The short interest ratio (days to cover) is 3.6, meaning it would take 3.6 days of the average trading volume of 1.37 million shares to cover all short positions.

Current Short Interest
4,461,773 shares
Previous Short Interest
4,172,829 shares
Change Vs. Previous Month
6.92%
Dollar Volume Sold Short
$1.95 billion
Short Interest Ratio
3.6 Days to Cover
Last Record Date
May 15, 2026
Outstanding Shares
253,800,000 shares
Short Percent of Float
1.76%
Today's Trading Volume
459,755 shares
Average Trading Volume
1,372,117 shares
Today's Volume Vs. Average
34%
Short Selling Vertex Pharmaceuticals?
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Short Interest ChartDays to Cover ChartShort Percent of Float Chart

VRTX Short Interest Over Time

VRTX Days to Cover Over Time

VRTX Percentage of Float Shorted Over Time

Vertex Pharmaceuticals Tesla Short Interest History & Recent Changes

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Report DateTotal Shares Sold ShortDollar Volume Sold ShortChange from Previous ReportPercentage of Float ShortedDays to CoverPrice on Report Date
5/15/20264,461,773 shares $1.95 billion +6.9%1.8%3.64 $436.95
4/30/20264,172,829 shares $1.78 billion -3.8%1.6%4.31 $427.38
4/15/20264,336,502 shares $1.92 billion +7.8%1.7%3.78 $441.70
3/31/20264,021,854 shares $1.80 billion -2.6%1.6%2.69 $446.54
3/13/20264,127,429 shares $1.94 billion -6.9%1.6%2.85 $469.34
2/27/20264,433,365 shares $2.20 billion -0.7%1.7%3.51 $496.83
2/13/20264,466,182 shares $2.19 billion +1.0%1.8%2.66 $491.47
1/30/20264,422,490 shares $2.08 billion 0.0%1.7%2.79 $469.90
1/15/20264,423,965 shares $1.94 billion -11.9%1.7%3.08 $438.92
12/31/20255,022,282 shares $2.28 billion +17.2%2.0%4.09 $453.36
12/15/20254,287,121 shares $1.95 billion -3.8%1.7%3.15 $455.71
11/28/20254,455,217 shares $1.93 billion +11.2%1.8%3.2 $433.45
11/14/20254,006,159 shares $1.75 billion -3.0%1.6%2.68 $437.15
10/31/20254,131,677 shares $1.76 billion +16.2%1.6%3.22 $425.57
10/15/20253,560,000 shares $1.45 billion No Change1.4%1.9 $407.90
9/30/20253,560,000 shares $1.39 billion -12.1%1.4%2 $391.64
9/15/20254,050,000 shares $1.59 billion +11.3%1.6%2.4 $393.21
8/31/20253,640,000 shares $1.42 billion -1.6%1.4%2.2 $391.02
8/15/20253,700,000 shares $1.45 billion -15.1%1.5%2.3 $392.79
7/31/20254,360,000 shares $1.99 billion +4.1%1.7%2.6 $456.87
7/15/20254,190,000 shares $1.94 billion +4,237.5%1.6%2.8 $464.20
6/30/202596,600 shares $43.01 million -97.6%1.5%1 $445.20
6/15/20254,030,000 shares $1.84 billion -8.6%1.6%2.4 $455.45
5/31/20254,410,000 shares $1.95 billion -8.5%1.7%2.6 $443.01
5/15/20254,820,000 shares $2.09 billion +27.5%1.9%2.8 $434.38
4/30/20253,780,000 shares $1.93 billion -13.5%1.5%2.3 $509.50
4/15/20254,370,000 shares $2.19 billion -2.0%1.7%2.9 $500.49
3/31/20254,460,000 shares $2.16 billion -22.4%1.7%2.9 $484.82
3/15/20255,750,000 shares $2.90 billion +4.9%2.3%3.5 $504.77
2/28/20255,480,000 shares $2.63 billion +8.1%2.1%3.4 $479.79
2/15/20255,070,000 shares $2.33 billion +11.2%2.0%3.2 $459.00
1/31/20254,560,000 shares $2.11 billion +3.9%1.8%2.8 $461.68
1/15/20254,390,000 shares $1.86 billion +10.9%1.7%2.9 $424.26
12/31/20243,960,000 shares $1.59 billion +12.8%1.5%2.7 $402.70
12/15/20243,510,000 shares $1.63 billion -4.4%1.4%2.5 $463.73
11/30/20243,670,000 shares $1.72 billion -10.7%1.4%3.2 $468.13
11/15/20244,110,000 shares $1.91 billion -8.7%1.6%3.6 $465.70
10/31/20244,500,000 shares $2.14 billion +4.9%1.8%4.3 $475.98
10/15/20244,290,000 shares $2.08 billion +5.2%1.7%4 $484.30
9/30/20244,080,000 shares $1.90 billion -6.0%1.6%3.7 $465.08
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9/15/20244,340,000 shares $2.11 billion -0.9%1.7%3.8 $485.37
8/31/20244,380,000 shares $2.17 billion -0.9%1.7%3.8 $495.89
8/15/20244,420,000 shares $2.09 billion -13.0%1.7%3.7 $472.00
7/31/20245,080,000 shares $2.52 billion +23.3%2.0%4.2 $495.72
7/15/20244,120,000 shares $2.02 billion +0.5%1.6%3.5 $490.85
6/30/20244,100,000 shares $1.92 billion -8.3%1.6%3.5 $468.72
6/15/20244,470,000 shares $2.15 billion +2.8%1.7%4 $480.73
5/31/20244,350,000 shares $1.98 billion +15.4%1.7%4 $455.34
5/15/20243,770,000 shares $1.65 billion -2.6%1.5%3.6 $437.49
4/30/20243,870,000 shares $1.52 billion -4.0%1.5%3.7 $392.81
4/15/20244,030,000 shares $1.60 billion +1.3%1.6%3.3 $397.36
3/31/20243,980,000 shares $1.66 billion -3.6%1.6%3.1 $418.01
3/15/20244,130,000 shares $1.68 billion +2.0%1.6%3.3 $407.69
2/29/20244,050,000 shares $1.70 billion -1.9%1.6%2.8 $420.74
2/15/20244,130,000 shares $1.76 billion +24.8%1.6%2.8 $426.29
1/31/20243,310,000 shares $1.43 billion -1.2%1.3%2.1 $433.38
1/15/20243,350,000 shares $1.45 billion +2.8%1.3%2.3 $433.40
12/31/20233,260,000 shares $1.33 billion -8.2%1.3%2.3 $406.89
12/15/20233,550,000 shares $1.46 billion +32.0%1.4%2.5 $410.68
11/30/20232,690,000 shares $954.44 million +7.2%1.1%2.2 $354.81
11/15/20232,510,000 shares $876.84 million -3.5%1.0%2.2 $349.34
10/31/20232,600,000 shares $941.49 million -9.1%1.0%2.6 $362.11
10/15/20232,860,000 shares $1.06 billion +0.4%1.1%2.9 $371.00
9/30/20232,850,000 shares $991.06 million -0.4%1.1%2.9 $347.74
9/15/20232,860,000 shares $997.85 million -2.1%1.1%2.9 $348.90
8/31/20232,920,000 shares $1.02 billion +7.0%1.1%2.7 $348.34
8/15/20232,730,000 shares $954.90 million -4.6%1.1%2.2 $349.78
7/31/20232,860,000 shares $1.01 billion +13.9%1.1%2.3 $352.34
7/15/20232,510,000 shares $885.38 million -8.1%1.0%1.9 $352.74
6/30/20232,730,000 shares $960.71 million No Change1.1%2.2 $351.91
6/15/20232,730,000 shares $952.99 million -11.1%1.1%2.2 $349.08
5/31/20233,070,000 shares $993.36 million -5.0%1.2%2.6 $323.57
5/15/20233,230,000 shares $1.13 billion -0.3%1.3%3 $348.65
4/30/20233,240,000 shares $1.10 billion -4.1%1.3%2.9 $340.73
4/15/20233,380,000 shares $1.13 billion -3.4%1.3%2.9 $333.52
3/31/20233,500,000 shares $1.10 billion +19.9%1.4%2.8 $315.07
3/15/20232,920,000 shares $859.27 million +9.0%1.1%2.3 $294.27
2/28/20232,680,000 shares $777.98 million -4.3%1.1%2.1 $290.29
2/15/20232,800,000 shares $836.50 million -11.1%1.1%2 $298.75
1/31/20233,150,000 shares $1.02 billion +19.8%1.2%2.2 $323.10
1/15/20232,630,000 shares $791.47 million +5.2%1.0%1.8 $300.94
12/30/20222,500,000 shares $721.95 million -19.1%1.0%1.8 $288.78
12/15/20223,090,000 shares $952.96 million +10.0%1.2%2.1 $308.40
11/30/20222,810,000 shares $889.08 million -7.3%1.1%1.9 $316.40
11/15/20223,030,000 shares $925.00 million +6.7%1.2%2.2 $305.28
10/31/20222,840,000 shares $886.08 million -3.1%1.1%2.1 $312.00
10/15/20222,930,000 shares $859.11 million -5.8%1.2%2.2 $293.21
9/30/20223,110,000 shares $900.47 million +7.6%1.2%2.3 $289.54
9/15/20222,890,000 shares $831.37 million +2.1%1.1%2 $287.67
8/31/20222,830,000 shares $797.38 million +10.1%1.1%1.9 $281.76
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Most investors are focused on the historic $1.75 trillion SpaceX IPO expected around June 30. But there's a lesser-known angle that could matter more to your portfolio. One under-the-radar tech firm has already shipped 5 billion critical components to SpaceX - making it a linchpin of the operation. Because SpaceX has been private, this partnership has gone almost entirely unnoticed by Wall Street.tc pixel

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8/15/20222,570,000 shares $785.21 million -24.9%1.0%1.6 $305.53
7/31/20223,420,000 shares $959.00 million -4.7%1.3%2 $280.41
7/15/20223,590,000 shares $1.05 billion +14.0%1.4%2.1 $292.84
6/30/20223,150,000 shares $887.64 million -7.9%1.2%1.8 $281.79
6/15/20223,420,000 shares $867.00 million -10.9%1.3%1.9 $253.51
5/31/20223,840,000 shares $1.03 billion +7.3%1.5%2.3 $268.65
5/15/20223,580,000 shares $883.26 million +5.0%1.4%2.2 $246.72
4/30/20223,410,000 shares $931.68 million -16.8%1.4%2.1 $273.22
4/15/20224,100,000 shares $1.18 billion +2.2%1.6%2.4 $287.97
3/31/20224,010,000 shares $1.05 billion +19.4%1.6%2.3 $260.97
3/15/20223,360,000 shares $829.89 million -6.4%1.3%2 $246.99
2/28/20223,590,000 shares $825.77 million +10.1%1.4%2.1 $230.02
2/15/20223,260,000 shares $760.92 million +8.7%1.3%1.7 $233.41
1/31/20223,000,000 shares $729.15 million -1.3%1.2%1.5 $243.05
1/15/20223,040,000 shares $711.54 million +4.5%1.2%1.6 $234.06
12/31/20212,910,000 shares $639.04 million -9.4%N/A0 $219.60
12/15/20213,210,000 shares $677.73 million +12.6%1.3%1.7 $211.13
11/30/20212,850,000 shares $532.78 million -1.7%1.1%1.6 $186.94
11/15/20212,900,000 shares $541.89 million -39.1%1.2%1.9 $186.86
10/29/20214,760,000 shares $880.27 million +7.2%1.9%2.9 $184.93
10/15/20214,440,000 shares $807.06 million -12.4%1.7%2.7 $181.77
9/30/20215,070,000 shares $919.65 million +2.2%2.0%2.8 $181.39
9/15/20214,960,000 shares $936.75 million +2.7%1.9%2.5 $188.86
8/31/20214,830,000 shares $967.40 million -4.2%1.9%2 $200.29
8/13/20215,040,000 shares $979.57 million +20.3%2.0%2.1 $194.36
7/30/20214,190,000 shares $844.62 million +2.4%1.6%1.8 $201.58
7/15/20214,090,000 shares $818.37 million +0.5%1.6%1.9 $200.09
6/30/20214,070,000 shares $820.63 million -10.0%1.6%1.9 $201.63
6/15/20214,520,000 shares $854.14 million +11.6%1.8%2.3 $188.97
5/28/20214,050,000 shares $844.95 million -1.5%1.6%2.5 $208.63

VRTX Short Interest - Frequently Asked Questions

Short interest is the volume of Vertex Pharmaceuticals shares that have been sold short but have not yet been closed out or covered. As of May 15th, traders have sold 4,461,773 shares of VRTX short. 1.76% of Vertex Pharmaceuticals' shares are currently sold short. Learn More on Vertex Pharmaceuticals' current short interest.

The short interest ratio, also known as the "days to cover ratio", is calculated by dividing the number of shares of a stock sold short divided by its average trading volume. A short interest ratio ranging between 1 and 4 generally indicates strong positive sentiment about a stock and a lack of short sellers. A short interest ratio of 10 or greater indicates strong pessimism about a stock. VRTX shares currently have a short interest ratio of 3.6. Learn More on Vertex Pharmaceuticals's short interest ratio.

As of the most recent reporting period, the following institutional investors, funds, and major shareholders have reported short positions of Vertex Pharmaceuticals: Hsbc Holdings PLC, and PEAK6 LLC. These positions are disclosed in Form 13F filings with the Securities and Exchange Commission.

Companies that have a short interest as a percentage of float below 10% indicates positive investor sentiment and few short sellers. Stocks with a short interest percentage above 10% is considered high, suggesting some investors are pessimistic about the stock. Companies with a short interest percentage of 20% or more indicates widespread negative sentiment. 1.76% of Vertex Pharmaceuticals' floating shares are currently sold short.

Vertex Pharmaceuticals saw a increase in short interest in the month of May. As of May 15th, there was short interest totaling 4,461,773 shares, an increase of 6.9% from the previous total of 4,172,829 shares. Changes in short volume can be used to identify positive and negative investor sentiment. Investors that short sell a stock are betting that its price will decline in the future. An increase in short sale volume suggests bearish (negative) sentiment among investors. A decrease on short sale volume suggests bullish (positive) sentiment.

1.76% of Vertex Pharmaceuticals' shares are currently sold short. Here is how the short interest of companies compare to Vertex Pharmaceuticals: Amazon.com, Inc. (1.06%), Axsome Therapeutics, Inc. (6.80%), CRISPR Therapeutics AG (29.57%), Alphabet Inc. (0.41%), Intuitive Surgical, Inc. (1.91%), Moderna, Inc. (16.41%), Repligen Corporation (10.16%), AbbVie Inc. (1.28%), Eli Lilly and Company (0.90%), Pfizer Inc. (2.78%),

As of the most recent reporting period, the following stocks had the largest short interest positions: SPDR S&P 500 ETF Trust ($80.71 billion), Invesco QQQ ($47.96 billion), iShares Russell 2000 ETF ($22.13 billion), Western Digital Corporation ($14.35 billion), Sandisk Corporation ($12.86 billion), Salesforce Inc. ($10.89 billion), Nebius Group N.V. ($9.92 billion), SPDR S&P Biotech ETF ($9.72 billion), Lumentum Holdings Inc. ($8.89 billion), and iShares 20+ Year Treasury Bond ETF ($8.18 billion). View all of the most shorted stocks.

Short selling VRTX is an investing strategy that aims to generate trading profit from Vertex Pharmaceuticals as its price is falling. VRTX shares are trading up $3.67 today. To short a stock, an investor borrows shares, sells them and buys the shares back on the public market later to return it to the lender. Short sellers are betting that a stock will decline in price. If the stock does drop after selling, the short seller buys it back at a lower price and returns it to the lender. The difference between the sell price and the buy price is the trader's profit.

A short squeeze for Vertex Pharmaceuticals occurs when it has a large amount of short interest and its stock appreciates in price. This forces short sellers to cover their short interest positions by buying actual shares of VRTX, which in turn drives the price of the stock up even further.

Short interest is typically published by a stock exchange once per month. However, NASDAQ publishes a report for U.S. stocks, including VRTX, twice per month. The most recent reporting period available is May, 15 2026.

Understanding short interest metrics can help you assess how traders are positioning around a stock like VRTX:

  • Shares Sold Short: The total number of shares that have been sold by short sellers but have not yet been covered or closed out. A high number may indicate bearish sentiment.
  • Short Float: The percentage of a company’s publicly available shares (or "float") that are sold short. A higher short float suggests a greater portion of the stock is being bet against.
  • Days to Cover (Short Interest Ratio): This estimates how many days it would take short sellers to cover their positions, based on average daily trading volume. Higher values can signal potential for a short squeeze if buying pressure increases.

These metrics are often used by traders to gauge sentiment, volatility risk, and the potential for price movements based on short covering activity.


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This page (NASDAQ:VRTX) was last updated on 5/28/2026 by MarketBeat.com Staff.
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