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Vertex Pharmaceuticals (VRTX) Competitors

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$547.29 -4.77 (-0.86%)
As of 10:21 AM Eastern
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VRTX vs. AMZN, AXSM, CRSP, GOOG, and ISRG

Should you buy Vertex Pharmaceuticals stock or one of its competitors? Vertex Pharmaceuticals's main competitors and comparable companies include Amazon.com (AMZN), Axsome Therapeutics (AXSM), CRISPR Therapeutics (CRSP), Alphabet (GOOG), and Intuitive Surgical (ISRG). Companies are selected based on similarities in market, industry, and size.

How does Vertex Pharmaceuticals compare to Amazon.com?

Amazon.com (NASDAQ:AMZN) and Vertex Pharmaceuticals (NASDAQ:VRTX) are related large-cap companies, but which is the superior investment? We will contrast the two businesses based on the strength of their risk, institutional ownership, profitability, dividends, valuation, analyst recommendations, earnings and media sentiment.

Amazon.com has a beta of 1.45, meaning that its share price is 45% more volatile than the broader market. Comparatively, Vertex Pharmaceuticals has a beta of 0.3, meaning that its share price is 70% less volatile than the broader market.

Amazon.com currently has a consensus target price of $322.39, indicating a potential upside of 23.49%. Vertex Pharmaceuticals has a consensus target price of $563.50, indicating a potential upside of 2.96%. Given Amazon.com's stronger consensus rating and higher probable upside, analysts clearly believe Amazon.com is more favorable than Vertex Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Amazon.com
0 Sell rating(s)
2 Hold rating(s)
56 Buy rating(s)
1 Strong Buy rating(s)
2.98
Vertex Pharmaceuticals
0 Sell rating(s)
3 Hold rating(s)
20 Buy rating(s)
1 Strong Buy rating(s)
2.92

72.2% of Amazon.com shares are owned by institutional investors. Comparatively, 91.0% of Vertex Pharmaceuticals shares are owned by institutional investors. 8.9% of Amazon.com shares are owned by insiders. Comparatively, 0.2% of Vertex Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company is poised for long-term growth.

In the previous week, Amazon.com had 226 more articles in the media than Vertex Pharmaceuticals. MarketBeat recorded 277 mentions for Amazon.com and 51 mentions for Vertex Pharmaceuticals. Vertex Pharmaceuticals' average media sentiment score of 1.48 beat Amazon.com's score of 0.94 indicating that Vertex Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Amazon.com
179 Very Positive mention(s)
45 Positive mention(s)
26 Neutral mention(s)
21 Negative mention(s)
4 Very Negative mention(s)
Positive
Vertex Pharmaceuticals
44 Very Positive mention(s)
2 Positive mention(s)
2 Neutral mention(s)
3 Negative mention(s)
0 Very Negative mention(s)
Positive

Vertex Pharmaceuticals has a net margin of 35.00% compared to Amazon.com's net margin of 17.44%. Vertex Pharmaceuticals' return on equity of 23.09% beat Amazon.com's return on equity.

Company Net Margins Return on Equity Return on Assets
Amazon.com17.44% 18.00% 8.97%
Vertex Pharmaceuticals 35.00%23.09%16.72%

Amazon.com has higher revenue and earnings than Vertex Pharmaceuticals. Amazon.com is trading at a lower price-to-earnings ratio than Vertex Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Amazon.com$716.92B3.93$77.67B$12.4321.00
Vertex Pharmaceuticals$12.00B11.57$3.95B$17.1831.86

Summary

Amazon.com and Vertex Pharmaceuticals tied by winning 8 of the 16 factors compared between the two stocks.

How does Vertex Pharmaceuticals compare to Axsome Therapeutics?

Axsome Therapeutics (NASDAQ:AXSM) and Vertex Pharmaceuticals (NASDAQ:VRTX) are both large-cap healthcare companies, but which is the better investment? We will compare the two businesses based on the strength of their risk, dividends, profitability, earnings, analyst recommendations, institutional ownership, valuation and media sentiment.

Axsome Therapeutics presently has a consensus target price of $267.60, suggesting a potential upside of 25.10%. Vertex Pharmaceuticals has a consensus target price of $563.50, suggesting a potential upside of 2.96%. Given Axsome Therapeutics' higher probable upside, research analysts clearly believe Axsome Therapeutics is more favorable than Vertex Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Axsome Therapeutics
1 Sell rating(s)
3 Hold rating(s)
16 Buy rating(s)
2 Strong Buy rating(s)
2.86
Vertex Pharmaceuticals
0 Sell rating(s)
3 Hold rating(s)
20 Buy rating(s)
1 Strong Buy rating(s)
2.92

Vertex Pharmaceuticals has a net margin of 35.00% compared to Axsome Therapeutics' net margin of -24.68%. Vertex Pharmaceuticals' return on equity of 23.09% beat Axsome Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Axsome Therapeutics-24.68% -265.55% -28.10%
Vertex Pharmaceuticals 35.00%23.09%16.72%

Vertex Pharmaceuticals has higher revenue and earnings than Axsome Therapeutics. Axsome Therapeutics is trading at a lower price-to-earnings ratio than Vertex Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Axsome Therapeutics$638.50M17.55-$183.17M-$3.75N/A
Vertex Pharmaceuticals$12.00B11.57$3.95B$17.1831.86

81.5% of Axsome Therapeutics shares are owned by institutional investors. Comparatively, 91.0% of Vertex Pharmaceuticals shares are owned by institutional investors. 20.6% of Axsome Therapeutics shares are owned by insiders. Comparatively, 0.2% of Vertex Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term.

Axsome Therapeutics has a beta of 0.65, meaning that its stock price is 35% less volatile than the broader market. Comparatively, Vertex Pharmaceuticals has a beta of 0.3, meaning that its stock price is 70% less volatile than the broader market.

In the previous week, Vertex Pharmaceuticals had 41 more articles in the media than Axsome Therapeutics. MarketBeat recorded 51 mentions for Vertex Pharmaceuticals and 10 mentions for Axsome Therapeutics. Vertex Pharmaceuticals' average media sentiment score of 1.48 beat Axsome Therapeutics' score of 1.17 indicating that Vertex Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Axsome Therapeutics
8 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Vertex Pharmaceuticals
44 Very Positive mention(s)
2 Positive mention(s)
2 Neutral mention(s)
3 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Vertex Pharmaceuticals beats Axsome Therapeutics on 12 of the 17 factors compared between the two stocks.

How does Vertex Pharmaceuticals compare to CRISPR Therapeutics?

CRISPR Therapeutics (NASDAQ:CRSP) and Vertex Pharmaceuticals (NASDAQ:VRTX) are both healthcare companies, but which is the better stock? We will contrast the two companies based on the strength of their analyst recommendations, profitability, media sentiment, institutional ownership, risk, dividends, valuation and earnings.

69.2% of CRISPR Therapeutics shares are owned by institutional investors. Comparatively, 91.0% of Vertex Pharmaceuticals shares are owned by institutional investors. 5.2% of CRISPR Therapeutics shares are owned by insiders. Comparatively, 0.2% of Vertex Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term.

In the previous week, Vertex Pharmaceuticals had 48 more articles in the media than CRISPR Therapeutics. MarketBeat recorded 51 mentions for Vertex Pharmaceuticals and 3 mentions for CRISPR Therapeutics. Vertex Pharmaceuticals' average media sentiment score of 1.48 beat CRISPR Therapeutics' score of 0.66 indicating that Vertex Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
CRISPR Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Vertex Pharmaceuticals
44 Very Positive mention(s)
2 Positive mention(s)
2 Neutral mention(s)
3 Negative mention(s)
0 Very Negative mention(s)
Positive

Vertex Pharmaceuticals has higher revenue and earnings than CRISPR Therapeutics. CRISPR Therapeutics is trading at a lower price-to-earnings ratio than Vertex Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
CRISPR Therapeutics$3.51M1,627.01-$581.60M-$4.76N/A
Vertex Pharmaceuticals$12.00B11.57$3.95B$17.1831.86

CRISPR Therapeutics has a beta of 1.74, indicating that its stock price is 74% more volatile than the broader market. Comparatively, Vertex Pharmaceuticals has a beta of 0.3, indicating that its stock price is 70% less volatile than the broader market.

Vertex Pharmaceuticals has a net margin of 35.00% compared to CRISPR Therapeutics' net margin of -3,368.72%. Vertex Pharmaceuticals' return on equity of 23.09% beat CRISPR Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
CRISPR Therapeutics-3,368.72% -24.39% -18.25%
Vertex Pharmaceuticals 35.00%23.09%16.72%

CRISPR Therapeutics currently has a consensus target price of $68.06, suggesting a potential upside of 15.23%. Vertex Pharmaceuticals has a consensus target price of $563.50, suggesting a potential upside of 2.96%. Given CRISPR Therapeutics' higher probable upside, analysts plainly believe CRISPR Therapeutics is more favorable than Vertex Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
CRISPR Therapeutics
1 Sell rating(s)
7 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.58
Vertex Pharmaceuticals
0 Sell rating(s)
3 Hold rating(s)
20 Buy rating(s)
1 Strong Buy rating(s)
2.92

Summary

Vertex Pharmaceuticals beats CRISPR Therapeutics on 12 of the 16 factors compared between the two stocks.

How does Vertex Pharmaceuticals compare to Alphabet?

Alphabet (NASDAQ:GOOG) and Vertex Pharmaceuticals (NASDAQ:VRTX) are related large-cap companies, but which is the superior business? We will contrast the two businesses based on the strength of their valuation, profitability, dividends, media sentiment, risk, institutional ownership, earnings and analyst recommendations.

Alphabet currently has a consensus target price of $415.55, suggesting a potential upside of 22.79%. Vertex Pharmaceuticals has a consensus target price of $563.50, suggesting a potential upside of 2.96%. Given Alphabet's stronger consensus rating and higher possible upside, analysts clearly believe Alphabet is more favorable than Vertex Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Alphabet
0 Sell rating(s)
4 Hold rating(s)
30 Buy rating(s)
6 Strong Buy rating(s)
3.05
Vertex Pharmaceuticals
0 Sell rating(s)
3 Hold rating(s)
20 Buy rating(s)
1 Strong Buy rating(s)
2.92

27.3% of Alphabet shares are owned by institutional investors. Comparatively, 91.0% of Vertex Pharmaceuticals shares are owned by institutional investors. 13.0% of Alphabet shares are owned by company insiders. Comparatively, 0.2% of Vertex Pharmaceuticals shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock is poised for long-term growth.

In the previous week, Alphabet had 157 more articles in the media than Vertex Pharmaceuticals. MarketBeat recorded 208 mentions for Alphabet and 51 mentions for Vertex Pharmaceuticals. Vertex Pharmaceuticals' average media sentiment score of 1.48 beat Alphabet's score of 0.76 indicating that Vertex Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Alphabet
112 Very Positive mention(s)
35 Positive mention(s)
40 Neutral mention(s)
17 Negative mention(s)
3 Very Negative mention(s)
Positive
Vertex Pharmaceuticals
44 Very Positive mention(s)
2 Positive mention(s)
2 Neutral mention(s)
3 Negative mention(s)
0 Very Negative mention(s)
Positive

Alphabet has a net margin of 54.77% compared to Vertex Pharmaceuticals' net margin of 35.00%. Alphabet's return on equity of 51.32% beat Vertex Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Alphabet54.77% 51.32% 35.42%
Vertex Pharmaceuticals 35.00%23.09%16.72%

Alphabet has a beta of 1.23, meaning that its share price is 23% more volatile than the broader market. Comparatively, Vertex Pharmaceuticals has a beta of 0.3, meaning that its share price is 70% less volatile than the broader market.

Alphabet has higher revenue and earnings than Vertex Pharmaceuticals. Alphabet is trading at a lower price-to-earnings ratio than Vertex Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Alphabet$402.84B10.27$132.17B$19.9117.00
Vertex Pharmaceuticals$12.00B11.57$3.95B$17.1831.86

Summary

Alphabet beats Vertex Pharmaceuticals on 13 of the 17 factors compared between the two stocks.

How does Vertex Pharmaceuticals compare to Intuitive Surgical?

Vertex Pharmaceuticals (NASDAQ:VRTX) and Intuitive Surgical (NASDAQ:ISRG) are both large-cap healthcare companies, but which is the superior stock? We will compare the two companies based on the strength of their earnings, risk, profitability, media sentiment, valuation, analyst recommendations, dividends and institutional ownership.

Vertex Pharmaceuticals has higher revenue and earnings than Intuitive Surgical. Vertex Pharmaceuticals is trading at a lower price-to-earnings ratio than Intuitive Surgical, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Vertex Pharmaceuticals$12.00B11.57$3.95B$17.1831.86
Intuitive Surgical$10.06B13.74$2.86B$8.7344.83

Vertex Pharmaceuticals has a beta of 0.3, meaning that its stock price is 70% less volatile than the broader market. Comparatively, Intuitive Surgical has a beta of 1.46, meaning that its stock price is 46% more volatile than the broader market.

91.0% of Vertex Pharmaceuticals shares are owned by institutional investors. Comparatively, 83.6% of Intuitive Surgical shares are owned by institutional investors. 0.2% of Vertex Pharmaceuticals shares are owned by company insiders. Comparatively, 0.6% of Intuitive Surgical shares are owned by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock is poised for long-term growth.

Vertex Pharmaceuticals has a net margin of 35.00% compared to Intuitive Surgical's net margin of 28.45%. Vertex Pharmaceuticals' return on equity of 23.09% beat Intuitive Surgical's return on equity.

Company Net Margins Return on Equity Return on Assets
Vertex Pharmaceuticals35.00% 23.09% 16.72%
Intuitive Surgical 28.45%16.91%14.83%

Vertex Pharmaceuticals presently has a consensus target price of $563.50, indicating a potential upside of 2.96%. Intuitive Surgical has a consensus target price of $508.68, indicating a potential upside of 29.96%. Given Intuitive Surgical's higher probable upside, analysts plainly believe Intuitive Surgical is more favorable than Vertex Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Vertex Pharmaceuticals
0 Sell rating(s)
3 Hold rating(s)
20 Buy rating(s)
1 Strong Buy rating(s)
2.92
Intuitive Surgical
1 Sell rating(s)
8 Hold rating(s)
22 Buy rating(s)
0 Strong Buy rating(s)
2.68

In the previous week, Vertex Pharmaceuticals had 30 more articles in the media than Intuitive Surgical. MarketBeat recorded 51 mentions for Vertex Pharmaceuticals and 21 mentions for Intuitive Surgical. Vertex Pharmaceuticals' average media sentiment score of 1.48 beat Intuitive Surgical's score of 0.72 indicating that Vertex Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Vertex Pharmaceuticals
44 Very Positive mention(s)
2 Positive mention(s)
2 Neutral mention(s)
3 Negative mention(s)
0 Very Negative mention(s)
Positive
Intuitive Surgical
11 Very Positive mention(s)
3 Positive mention(s)
1 Neutral mention(s)
4 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Vertex Pharmaceuticals beats Intuitive Surgical on 11 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding VRTX and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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VRTX vs. The Competition

MetricVertex PharmaceuticalsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$138.72B$4.00B$7.29B$12.79B
Dividend YieldN/A3.66%2.55%10.29%
P/E Ratio31.8211.83269.2524.15
Price / Sales11.571,339.42615.1198.81
Price / Cash30.05102.5678.2352.73
Price / Book6.8617.1613.246.23
Net Income$3.95B-$12.52M$3.47B$347.82M
7 Day Performance5.97%3.41%1.85%-0.33%
1 Month Performance13.90%6.76%4.99%2.46%
1 Year Performance38.78%61.42%28.36%20.51%

Vertex Pharmaceuticals Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
VRTX
Vertex Pharmaceuticals
4.2372 of 5 stars
$547.29
-0.9%
$563.50
+3.0%
+41.3%$138.72B$12.00B31.826,400
AMZN
Amazon.com
4.9315 of 5 stars
$261.31
-0.5%
$322.56
+23.4%
+16.6%$2.82T$716.92B21.021,576,000
AXSM
Axsome Therapeutics
3.4577 of 5 stars
$216.27
+1.2%
$267.60
+23.7%
+96.1%$11.33B$638.50MN/A380
CRSP
CRISPR Therapeutics
2.5459 of 5 stars
$54.28
+1.4%
$68.06
+25.4%
+10.4%$5.18B$11MN/A460
GOOG
Alphabet
4.8663 of 5 stars
$341.45
-0.6%
$415.55
+21.7%
+68.7%$4.18T$445.87B17.15190,200

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This page (NASDAQ:VRTX) was last updated on 8/20/2026 by MarketBeat.com Staff.
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