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Vertex Pharmaceuticals (VRTX) Competitors

Vertex Pharmaceuticals logo
$485.39 -11.11 (-2.24%)
Closing price 07/10/2026 04:00 PM Eastern
Extended Trading
$487.88 +2.49 (+0.51%)
As of 07/10/2026 07:54 PM Eastern
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VRTX vs. AMZN, AXSM, CRSP, GOOG, and ISRG

Should you buy Vertex Pharmaceuticals stock or one of its competitors? MarketBeat compares Vertex Pharmaceuticals with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Vertex Pharmaceuticals include Amazon.com (AMZN), Axsome Therapeutics (AXSM), CRISPR Therapeutics (CRSP), Alphabet (GOOG), and Intuitive Surgical (ISRG).

How does Vertex Pharmaceuticals compare to Amazon.com?

Vertex Pharmaceuticals (NASDAQ:VRTX) and Amazon.com (NASDAQ:AMZN) are related large-cap companies, but which is the better business? We will compare the two companies based on the strength of their valuation, risk, earnings, dividends, institutional ownership, media sentiment, profitability and analyst recommendations.

Vertex Pharmaceuticals has a net margin of 35.51% compared to Amazon.com's net margin of 12.22%. Vertex Pharmaceuticals' return on equity of 23.86% beat Amazon.com's return on equity.

Company Net Margins Return on Equity Return on Assets
Vertex Pharmaceuticals35.51% 23.86% 17.13%
Amazon.com 12.22%19.92%9.86%

Amazon.com has higher revenue and earnings than Vertex Pharmaceuticals. Vertex Pharmaceuticals is trading at a lower price-to-earnings ratio than Amazon.com, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Vertex Pharmaceuticals$12.00B10.26$3.95B$16.8628.79
Amazon.com$716.92B3.68$77.67B$8.3629.35

Vertex Pharmaceuticals has a beta of 0.29, suggesting that its share price is 71% less volatile than the broader market. Comparatively, Amazon.com has a beta of 1.46, suggesting that its share price is 46% more volatile than the broader market.

Vertex Pharmaceuticals currently has a consensus price target of $557.09, suggesting a potential upside of 14.77%. Amazon.com has a consensus price target of $312.79, suggesting a potential upside of 27.49%. Given Amazon.com's stronger consensus rating and higher possible upside, analysts plainly believe Amazon.com is more favorable than Vertex Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Vertex Pharmaceuticals
0 Sell rating(s)
4 Hold rating(s)
21 Buy rating(s)
0 Strong Buy rating(s)
2.84
Amazon.com
0 Sell rating(s)
3 Hold rating(s)
57 Buy rating(s)
0 Strong Buy rating(s)
2.95

In the previous week, Amazon.com had 183 more articles in the media than Vertex Pharmaceuticals. MarketBeat recorded 245 mentions for Amazon.com and 62 mentions for Vertex Pharmaceuticals. Amazon.com's average media sentiment score of 0.86 beat Vertex Pharmaceuticals' score of 0.76 indicating that Amazon.com is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Vertex Pharmaceuticals
31 Very Positive mention(s)
9 Positive mention(s)
19 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Amazon.com
143 Very Positive mention(s)
32 Positive mention(s)
37 Neutral mention(s)
20 Negative mention(s)
12 Very Negative mention(s)
Positive

91.0% of Vertex Pharmaceuticals shares are owned by institutional investors. Comparatively, 72.2% of Amazon.com shares are owned by institutional investors. 0.2% of Vertex Pharmaceuticals shares are owned by company insiders. Comparatively, 8.9% of Amazon.com shares are owned by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a stock will outperform the market over the long term.

Summary

Amazon.com beats Vertex Pharmaceuticals on 10 of the 16 factors compared between the two stocks.

How does Vertex Pharmaceuticals compare to Axsome Therapeutics?

Vertex Pharmaceuticals (NASDAQ:VRTX) and Axsome Therapeutics (NASDAQ:AXSM) are both large-cap medical companies, but which is the better business? We will compare the two businesses based on the strength of their valuation, earnings, profitability, dividends, risk, institutional ownership, media sentiment and analyst recommendations.

Vertex Pharmaceuticals has a beta of 0.29, indicating that its share price is 71% less volatile than the broader market. Comparatively, Axsome Therapeutics has a beta of 0.6, indicating that its share price is 40% less volatile than the broader market.

In the previous week, Vertex Pharmaceuticals had 48 more articles in the media than Axsome Therapeutics. MarketBeat recorded 62 mentions for Vertex Pharmaceuticals and 14 mentions for Axsome Therapeutics. Axsome Therapeutics' average media sentiment score of 0.84 beat Vertex Pharmaceuticals' score of 0.76 indicating that Axsome Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Vertex Pharmaceuticals
31 Very Positive mention(s)
9 Positive mention(s)
19 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Axsome Therapeutics
6 Very Positive mention(s)
2 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

91.0% of Vertex Pharmaceuticals shares are owned by institutional investors. Comparatively, 81.5% of Axsome Therapeutics shares are owned by institutional investors. 0.2% of Vertex Pharmaceuticals shares are owned by company insiders. Comparatively, 20.6% of Axsome Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock will outperform the market over the long term.

Vertex Pharmaceuticals has a net margin of 35.51% compared to Axsome Therapeutics' net margin of -26.59%. Vertex Pharmaceuticals' return on equity of 23.86% beat Axsome Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Vertex Pharmaceuticals35.51% 23.86% 17.13%
Axsome Therapeutics -26.59%-267.16%-28.53%

Vertex Pharmaceuticals has higher revenue and earnings than Axsome Therapeutics. Axsome Therapeutics is trading at a lower price-to-earnings ratio than Vertex Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Vertex Pharmaceuticals$12.00B10.26$3.95B$16.8628.79
Axsome Therapeutics$638.50M18.84-$183.17M-$3.73N/A

Vertex Pharmaceuticals presently has a consensus price target of $557.09, indicating a potential upside of 14.77%. Axsome Therapeutics has a consensus price target of $259.05, indicating a potential upside of 10.80%. Given Vertex Pharmaceuticals' higher probable upside, analysts clearly believe Vertex Pharmaceuticals is more favorable than Axsome Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Vertex Pharmaceuticals
0 Sell rating(s)
4 Hold rating(s)
21 Buy rating(s)
0 Strong Buy rating(s)
2.84
Axsome Therapeutics
1 Sell rating(s)
0 Hold rating(s)
19 Buy rating(s)
1 Strong Buy rating(s)
2.95

Summary

Vertex Pharmaceuticals beats Axsome Therapeutics on 11 of the 17 factors compared between the two stocks.

How does Vertex Pharmaceuticals compare to CRISPR Therapeutics?

CRISPR Therapeutics (NASDAQ:CRSP) and Vertex Pharmaceuticals (NASDAQ:VRTX) are both medical companies, but which is the better investment? We will compare the two businesses based on the strength of their dividends, media sentiment, valuation, profitability, earnings, risk, institutional ownership and analyst recommendations.

CRISPR Therapeutics currently has a consensus target price of $67.78, indicating a potential upside of 27.04%. Vertex Pharmaceuticals has a consensus target price of $557.09, indicating a potential upside of 14.77%. Given CRISPR Therapeutics' higher possible upside, equities analysts clearly believe CRISPR Therapeutics is more favorable than Vertex Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
CRISPR Therapeutics
1 Sell rating(s)
7 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.58
Vertex Pharmaceuticals
0 Sell rating(s)
4 Hold rating(s)
21 Buy rating(s)
0 Strong Buy rating(s)
2.84

CRISPR Therapeutics has a beta of 1.71, indicating that its share price is 71% more volatile than the broader market. Comparatively, Vertex Pharmaceuticals has a beta of 0.29, indicating that its share price is 71% less volatile than the broader market.

Vertex Pharmaceuticals has a net margin of 35.51% compared to CRISPR Therapeutics' net margin of -13,856.54%. Vertex Pharmaceuticals' return on equity of 23.86% beat CRISPR Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
CRISPR Therapeutics-13,856.54% -25.66% -20.39%
Vertex Pharmaceuticals 35.51%23.86%17.13%

Vertex Pharmaceuticals has higher revenue and earnings than CRISPR Therapeutics. CRISPR Therapeutics is trading at a lower price-to-earnings ratio than Vertex Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
CRISPR Therapeutics$3.51M1,465.99-$581.60M-$6.22N/A
Vertex Pharmaceuticals$12.00B10.26$3.95B$16.8628.79

69.2% of CRISPR Therapeutics shares are owned by institutional investors. Comparatively, 91.0% of Vertex Pharmaceuticals shares are owned by institutional investors. 4.3% of CRISPR Therapeutics shares are owned by insiders. Comparatively, 0.2% of Vertex Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.

In the previous week, Vertex Pharmaceuticals had 49 more articles in the media than CRISPR Therapeutics. MarketBeat recorded 62 mentions for Vertex Pharmaceuticals and 13 mentions for CRISPR Therapeutics. Vertex Pharmaceuticals' average media sentiment score of 0.76 beat CRISPR Therapeutics' score of 0.64 indicating that Vertex Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
CRISPR Therapeutics
3 Very Positive mention(s)
3 Positive mention(s)
3 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive
Vertex Pharmaceuticals
31 Very Positive mention(s)
9 Positive mention(s)
19 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Vertex Pharmaceuticals beats CRISPR Therapeutics on 12 of the 17 factors compared between the two stocks.

How does Vertex Pharmaceuticals compare to Alphabet?

Vertex Pharmaceuticals (NASDAQ:VRTX) and Alphabet (NASDAQ:GOOG) are related large-cap companies, but which is the superior stock? We will compare the two companies based on the strength of their profitability, media sentiment, valuation, earnings, analyst recommendations, dividends, institutional ownership and risk.

Alphabet has higher revenue and earnings than Vertex Pharmaceuticals. Alphabet is trading at a lower price-to-earnings ratio than Vertex Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Vertex Pharmaceuticals$12.00B10.26$3.95B$16.8628.79
Alphabet$402.84B10.68$132.17B$13.1127.08

Alphabet has a net margin of 37.92% compared to Vertex Pharmaceuticals' net margin of 35.51%. Alphabet's return on equity of 38.99% beat Vertex Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Vertex Pharmaceuticals35.51% 23.86% 17.13%
Alphabet 37.92%38.99%27.41%

91.0% of Vertex Pharmaceuticals shares are owned by institutional investors. Comparatively, 27.3% of Alphabet shares are owned by institutional investors. 0.2% of Vertex Pharmaceuticals shares are owned by insiders. Comparatively, 13.0% of Alphabet shares are owned by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company will outperform the market over the long term.

Vertex Pharmaceuticals currently has a consensus target price of $557.09, indicating a potential upside of 14.77%. Alphabet has a consensus target price of $378.53, indicating a potential upside of 6.62%. Given Vertex Pharmaceuticals' higher possible upside, analysts clearly believe Vertex Pharmaceuticals is more favorable than Alphabet.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Vertex Pharmaceuticals
0 Sell rating(s)
4 Hold rating(s)
21 Buy rating(s)
0 Strong Buy rating(s)
2.84
Alphabet
0 Sell rating(s)
4 Hold rating(s)
27 Buy rating(s)
5 Strong Buy rating(s)
3.03

In the previous week, Alphabet had 69 more articles in the media than Vertex Pharmaceuticals. MarketBeat recorded 131 mentions for Alphabet and 62 mentions for Vertex Pharmaceuticals. Alphabet's average media sentiment score of 0.94 beat Vertex Pharmaceuticals' score of 0.76 indicating that Alphabet is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Vertex Pharmaceuticals
31 Very Positive mention(s)
9 Positive mention(s)
19 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Alphabet
86 Very Positive mention(s)
6 Positive mention(s)
26 Neutral mention(s)
8 Negative mention(s)
3 Very Negative mention(s)
Positive

Vertex Pharmaceuticals has a beta of 0.29, suggesting that its share price is 71% less volatile than the broader market. Comparatively, Alphabet has a beta of 1.23, suggesting that its share price is 23% more volatile than the broader market.

Summary

Alphabet beats Vertex Pharmaceuticals on 13 of the 17 factors compared between the two stocks.

How does Vertex Pharmaceuticals compare to Intuitive Surgical?

Intuitive Surgical (NASDAQ:ISRG) and Vertex Pharmaceuticals (NASDAQ:VRTX) are both large-cap medical companies, but which is the better business? We will compare the two companies based on the strength of their media sentiment, valuation, dividends, institutional ownership, analyst recommendations, risk, earnings and profitability.

Vertex Pharmaceuticals has higher revenue and earnings than Intuitive Surgical. Vertex Pharmaceuticals is trading at a lower price-to-earnings ratio than Intuitive Surgical, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Intuitive Surgical$10.06B14.31$2.86B$8.2549.31
Vertex Pharmaceuticals$12.00B10.26$3.95B$16.8628.79

Vertex Pharmaceuticals has a net margin of 35.51% compared to Intuitive Surgical's net margin of 28.15%. Vertex Pharmaceuticals' return on equity of 23.86% beat Intuitive Surgical's return on equity.

Company Net Margins Return on Equity Return on Assets
Intuitive Surgical28.15% 15.98% 14.07%
Vertex Pharmaceuticals 35.51%23.86%17.13%

Intuitive Surgical currently has a consensus price target of $569.20, suggesting a potential upside of 39.93%. Vertex Pharmaceuticals has a consensus price target of $557.09, suggesting a potential upside of 14.77%. Given Intuitive Surgical's higher probable upside, research analysts plainly believe Intuitive Surgical is more favorable than Vertex Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Intuitive Surgical
1 Sell rating(s)
7 Hold rating(s)
19 Buy rating(s)
1 Strong Buy rating(s)
2.71
Vertex Pharmaceuticals
0 Sell rating(s)
4 Hold rating(s)
21 Buy rating(s)
0 Strong Buy rating(s)
2.84

83.6% of Intuitive Surgical shares are held by institutional investors. Comparatively, 91.0% of Vertex Pharmaceuticals shares are held by institutional investors. 0.6% of Intuitive Surgical shares are held by company insiders. Comparatively, 0.2% of Vertex Pharmaceuticals shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term.

Intuitive Surgical has a beta of 1.46, indicating that its share price is 46% more volatile than the broader market. Comparatively, Vertex Pharmaceuticals has a beta of 0.29, indicating that its share price is 71% less volatile than the broader market.

In the previous week, Vertex Pharmaceuticals had 32 more articles in the media than Intuitive Surgical. MarketBeat recorded 62 mentions for Vertex Pharmaceuticals and 30 mentions for Intuitive Surgical. Intuitive Surgical's average media sentiment score of 1.02 beat Vertex Pharmaceuticals' score of 0.76 indicating that Intuitive Surgical is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Intuitive Surgical
18 Very Positive mention(s)
3 Positive mention(s)
7 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Vertex Pharmaceuticals
31 Very Positive mention(s)
9 Positive mention(s)
19 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Vertex Pharmaceuticals beats Intuitive Surgical on 10 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding VRTX and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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VRTX vs. The Competition

MetricVertex PharmaceuticalsMED IndustryMedical SectorNASDAQ Exchange
Market Cap$126.01B$3.79B$7.12B$12.61B
Dividend YieldN/A2.17%2.68%7.83%
P/E Ratio28.7921.2727.2224.56
Price / Sales10.26323.90590.16121.71
Price / Cash28.25147.6449.3460.04
Price / Book6.608.4110.906.39
Net Income$3.95B$23.85M$3.57B$331.44M
7 Day Performance-8.08%-0.76%-0.25%0.37%
1 Month Performance9.07%11.35%5.77%2.17%
1 Year Performance3.53%51.68%28.14%20.90%

Vertex Pharmaceuticals Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
VRTX
Vertex Pharmaceuticals
4.0434 of 5 stars
$485.39
-2.2%
$557.09
+14.8%
+1.2%$126.01B$12.00B28.796,400
AMZN
Amazon.com
4.8489 of 5 stars
$244.16
+0.6%
$312.79
+28.1%
+10.4%$2.63T$742.78B29.211,576,000
AXSM
Axsome Therapeutics
3.6691 of 5 stars
$242.60
-0.7%
$258.95
+6.7%
+111.1%$12.48B$638.50MN/A380
CRSP
CRISPR Therapeutics
3.7183 of 5 stars
$61.89
+3.0%
$67.78
+9.5%
-9.6%$5.97B$3.51MN/A460
GOOG
Alphabet
4.077 of 5 stars
$364.90
+2.4%
$376.19
+3.1%
+98.7%$4.42T$402.84B27.83190,200

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This page (NASDAQ:VRTX) was last updated on 7/11/2026 by MarketBeat.com Staff.
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