Free Trial

Vertex Pharmaceuticals (VRTX) Competitors

Vertex Pharmaceuticals logo
$447.54 -0.43 (-0.10%)
Closing price 05/29/2026 04:00 PM Eastern
Extended Trading
$446.83 -0.71 (-0.16%)
As of 05/29/2026 07:52 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.

VRTX vs. AMZN, AXSM, CRSP, EDIT, and GOOG

Should you buy Vertex Pharmaceuticals stock or one of its competitors? MarketBeat compares Vertex Pharmaceuticals with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Vertex Pharmaceuticals include Amazon.com (AMZN), Axsome Therapeutics (AXSM), CRISPR Therapeutics (CRSP), Editas Medicine (EDIT), and Alphabet (GOOG).

How does Vertex Pharmaceuticals compare to Amazon.com?

Vertex Pharmaceuticals (NASDAQ:VRTX) and Amazon.com (NASDAQ:AMZN) are related large-cap companies, but which is the better stock? We will contrast the two companies based on the strength of their dividends, valuation, risk, institutional ownership, analyst recommendations, media sentiment, earnings and profitability.

In the previous week, Amazon.com had 265 more articles in the media than Vertex Pharmaceuticals. MarketBeat recorded 295 mentions for Amazon.com and 30 mentions for Vertex Pharmaceuticals. Vertex Pharmaceuticals' average media sentiment score of 1.21 beat Amazon.com's score of 0.89 indicating that Vertex Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Vertex Pharmaceuticals
21 Very Positive mention(s)
3 Positive mention(s)
3 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive
Amazon.com
185 Very Positive mention(s)
38 Positive mention(s)
34 Neutral mention(s)
21 Negative mention(s)
9 Very Negative mention(s)
Positive

Vertex Pharmaceuticals has a net margin of 35.51% compared to Amazon.com's net margin of 12.22%. Vertex Pharmaceuticals' return on equity of 23.86% beat Amazon.com's return on equity.

Company Net Margins Return on Equity Return on Assets
Vertex Pharmaceuticals35.51% 23.86% 17.13%
Amazon.com 12.22%19.92%9.86%

Vertex Pharmaceuticals currently has a consensus target price of $555.91, indicating a potential upside of 24.22%. Amazon.com has a consensus target price of $312.83, indicating a potential upside of 15.59%. Given Vertex Pharmaceuticals' higher possible upside, equities research analysts plainly believe Vertex Pharmaceuticals is more favorable than Amazon.com.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Vertex Pharmaceuticals
0 Sell rating(s)
3 Hold rating(s)
22 Buy rating(s)
0 Strong Buy rating(s)
2.88
Amazon.com
0 Sell rating(s)
3 Hold rating(s)
57 Buy rating(s)
0 Strong Buy rating(s)
2.95

91.0% of Vertex Pharmaceuticals shares are held by institutional investors. Comparatively, 72.2% of Amazon.com shares are held by institutional investors. 0.2% of Vertex Pharmaceuticals shares are held by company insiders. Comparatively, 8.9% of Amazon.com shares are held by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company will outperform the market over the long term.

Amazon.com has higher revenue and earnings than Vertex Pharmaceuticals. Vertex Pharmaceuticals is trading at a lower price-to-earnings ratio than Amazon.com, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Vertex Pharmaceuticals$12.00B9.46$3.95B$16.8626.54
Amazon.com$716.92B4.06$77.67B$8.3632.37

Vertex Pharmaceuticals has a beta of 0.3, indicating that its stock price is 70% less volatile than the broader market. Comparatively, Amazon.com has a beta of 1.45, indicating that its stock price is 45% more volatile than the broader market.

Summary

Vertex Pharmaceuticals and Amazon.com tied by winning 8 of the 16 factors compared between the two stocks.

How does Vertex Pharmaceuticals compare to Axsome Therapeutics?

Vertex Pharmaceuticals (NASDAQ:VRTX) and Axsome Therapeutics (NASDAQ:AXSM) are both large-cap medical companies, but which is the better business? We will contrast the two businesses based on the strength of their risk, media sentiment, institutional ownership, valuation, dividends, analyst recommendations, earnings and profitability.

Vertex Pharmaceuticals has higher revenue and earnings than Axsome Therapeutics. Axsome Therapeutics is trading at a lower price-to-earnings ratio than Vertex Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Vertex Pharmaceuticals$12.00B9.46$3.95B$16.8626.54
Axsome Therapeutics$638.50M18.90-$183.17M-$3.73N/A

Vertex Pharmaceuticals has a beta of 0.3, indicating that its stock price is 70% less volatile than the broader market. Comparatively, Axsome Therapeutics has a beta of 0.61, indicating that its stock price is 39% less volatile than the broader market.

In the previous week, Vertex Pharmaceuticals had 21 more articles in the media than Axsome Therapeutics. MarketBeat recorded 30 mentions for Vertex Pharmaceuticals and 9 mentions for Axsome Therapeutics. Vertex Pharmaceuticals' average media sentiment score of 1.21 beat Axsome Therapeutics' score of 0.67 indicating that Vertex Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Vertex Pharmaceuticals
21 Very Positive mention(s)
3 Positive mention(s)
3 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive
Axsome Therapeutics
3 Very Positive mention(s)
1 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Positive

Vertex Pharmaceuticals presently has a consensus price target of $555.91, indicating a potential upside of 24.22%. Axsome Therapeutics has a consensus price target of $251.26, indicating a potential upside of 7.16%. Given Vertex Pharmaceuticals' higher possible upside, equities research analysts clearly believe Vertex Pharmaceuticals is more favorable than Axsome Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Vertex Pharmaceuticals
0 Sell rating(s)
3 Hold rating(s)
22 Buy rating(s)
0 Strong Buy rating(s)
2.88
Axsome Therapeutics
1 Sell rating(s)
1 Hold rating(s)
18 Buy rating(s)
1 Strong Buy rating(s)
2.90

Vertex Pharmaceuticals has a net margin of 35.51% compared to Axsome Therapeutics' net margin of -26.59%. Vertex Pharmaceuticals' return on equity of 23.86% beat Axsome Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Vertex Pharmaceuticals35.51% 23.86% 17.13%
Axsome Therapeutics -26.59%-267.16%-28.53%

91.0% of Vertex Pharmaceuticals shares are held by institutional investors. Comparatively, 81.5% of Axsome Therapeutics shares are held by institutional investors. 0.2% of Vertex Pharmaceuticals shares are held by insiders. Comparatively, 20.6% of Axsome Therapeutics shares are held by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock will outperform the market over the long term.

Summary

Vertex Pharmaceuticals beats Axsome Therapeutics on 11 of the 16 factors compared between the two stocks.

How does Vertex Pharmaceuticals compare to CRISPR Therapeutics?

CRISPR Therapeutics (NASDAQ:CRSP) and Vertex Pharmaceuticals (NASDAQ:VRTX) are both medical companies, but which is the better business? We will contrast the two companies based on the strength of their media sentiment, institutional ownership, risk, earnings, profitability, dividends, valuation and analyst recommendations.

CRISPR Therapeutics has a beta of 1.74, indicating that its stock price is 74% more volatile than the broader market. Comparatively, Vertex Pharmaceuticals has a beta of 0.3, indicating that its stock price is 70% less volatile than the broader market.

CRISPR Therapeutics presently has a consensus target price of $65.47, indicating a potential upside of 16.71%. Vertex Pharmaceuticals has a consensus target price of $555.91, indicating a potential upside of 24.22%. Given Vertex Pharmaceuticals' stronger consensus rating and higher probable upside, analysts plainly believe Vertex Pharmaceuticals is more favorable than CRISPR Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
CRISPR Therapeutics
2 Sell rating(s)
6 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.53
Vertex Pharmaceuticals
0 Sell rating(s)
3 Hold rating(s)
22 Buy rating(s)
0 Strong Buy rating(s)
2.88

Vertex Pharmaceuticals has higher revenue and earnings than CRISPR Therapeutics. CRISPR Therapeutics is trading at a lower price-to-earnings ratio than Vertex Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
CRISPR Therapeutics$3.51M1,541.44-$581.60M-$6.22N/A
Vertex Pharmaceuticals$12.00B9.46$3.95B$16.8626.54

In the previous week, Vertex Pharmaceuticals had 24 more articles in the media than CRISPR Therapeutics. MarketBeat recorded 30 mentions for Vertex Pharmaceuticals and 6 mentions for CRISPR Therapeutics. CRISPR Therapeutics' average media sentiment score of 1.33 beat Vertex Pharmaceuticals' score of 1.21 indicating that CRISPR Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
CRISPR Therapeutics
3 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Vertex Pharmaceuticals
21 Very Positive mention(s)
3 Positive mention(s)
3 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive

Vertex Pharmaceuticals has a net margin of 35.51% compared to CRISPR Therapeutics' net margin of -13,856.54%. Vertex Pharmaceuticals' return on equity of 23.86% beat CRISPR Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
CRISPR Therapeutics-13,856.54% -25.66% -20.39%
Vertex Pharmaceuticals 35.51%23.86%17.13%

69.2% of CRISPR Therapeutics shares are owned by institutional investors. Comparatively, 91.0% of Vertex Pharmaceuticals shares are owned by institutional investors. 4.1% of CRISPR Therapeutics shares are owned by company insiders. Comparatively, 0.2% of Vertex Pharmaceuticals shares are owned by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company is poised for long-term growth.

Summary

Vertex Pharmaceuticals beats CRISPR Therapeutics on 11 of the 16 factors compared between the two stocks.

How does Vertex Pharmaceuticals compare to Editas Medicine?

Editas Medicine (NASDAQ:EDIT) and Vertex Pharmaceuticals (NASDAQ:VRTX) are both medical companies, but which is the better business? We will compare the two companies based on the strength of their risk, valuation, analyst recommendations, institutional ownership, profitability, media sentiment, dividends and earnings.

Editas Medicine has a beta of 2.16, meaning that its stock price is 116% more volatile than the broader market. Comparatively, Vertex Pharmaceuticals has a beta of 0.3, meaning that its stock price is 70% less volatile than the broader market.

Editas Medicine currently has a consensus target price of $5.40, indicating a potential upside of 56.07%. Vertex Pharmaceuticals has a consensus target price of $555.91, indicating a potential upside of 24.22%. Given Editas Medicine's higher probable upside, equities research analysts clearly believe Editas Medicine is more favorable than Vertex Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Editas Medicine
1 Sell rating(s)
1 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.57
Vertex Pharmaceuticals
0 Sell rating(s)
3 Hold rating(s)
22 Buy rating(s)
0 Strong Buy rating(s)
2.88

In the previous week, Editas Medicine had 5 more articles in the media than Vertex Pharmaceuticals. MarketBeat recorded 35 mentions for Editas Medicine and 30 mentions for Vertex Pharmaceuticals. Vertex Pharmaceuticals' average media sentiment score of 1.21 beat Editas Medicine's score of 0.75 indicating that Vertex Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Editas Medicine
7 Very Positive mention(s)
3 Positive mention(s)
5 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Positive
Vertex Pharmaceuticals
21 Very Positive mention(s)
3 Positive mention(s)
3 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive

Vertex Pharmaceuticals has higher revenue and earnings than Editas Medicine. Editas Medicine is trading at a lower price-to-earnings ratio than Vertex Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Editas Medicine$40.52M8.36-$160.06M-$1.23N/A
Vertex Pharmaceuticals$12.00B9.46$3.95B$16.8626.54

71.9% of Editas Medicine shares are owned by institutional investors. Comparatively, 91.0% of Vertex Pharmaceuticals shares are owned by institutional investors. 3.1% of Editas Medicine shares are owned by insiders. Comparatively, 0.2% of Vertex Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company is poised for long-term growth.

Vertex Pharmaceuticals has a net margin of 35.51% compared to Editas Medicine's net margin of -281.59%. Vertex Pharmaceuticals' return on equity of 23.86% beat Editas Medicine's return on equity.

Company Net Margins Return on Equity Return on Assets
Editas Medicine-281.59% -677.39% -58.25%
Vertex Pharmaceuticals 35.51%23.86%17.13%

Summary

Vertex Pharmaceuticals beats Editas Medicine on 11 of the 15 factors compared between the two stocks.

How does Vertex Pharmaceuticals compare to Alphabet?

Alphabet (NASDAQ:GOOG) and Vertex Pharmaceuticals (NASDAQ:VRTX) are related large-cap companies, but which is the superior investment? We will compare the two companies based on the strength of their valuation, institutional ownership, dividends, analyst recommendations, media sentiment, profitability, risk and earnings.

Alphabet has higher revenue and earnings than Vertex Pharmaceuticals. Vertex Pharmaceuticals is trading at a lower price-to-earnings ratio than Alphabet, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Alphabet$402.84B11.32$132.17B$13.1128.71
Vertex Pharmaceuticals$12.00B9.46$3.95B$16.8626.54

Alphabet presently has a consensus target price of $372.65, indicating a potential downside of 1.01%. Vertex Pharmaceuticals has a consensus target price of $555.91, indicating a potential upside of 24.22%. Given Vertex Pharmaceuticals' higher possible upside, analysts clearly believe Vertex Pharmaceuticals is more favorable than Alphabet.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Alphabet
0 Sell rating(s)
4 Hold rating(s)
28 Buy rating(s)
6 Strong Buy rating(s)
3.05
Vertex Pharmaceuticals
0 Sell rating(s)
3 Hold rating(s)
22 Buy rating(s)
0 Strong Buy rating(s)
2.88

27.3% of Alphabet shares are held by institutional investors. Comparatively, 91.0% of Vertex Pharmaceuticals shares are held by institutional investors. 13.0% of Alphabet shares are held by company insiders. Comparatively, 0.2% of Vertex Pharmaceuticals shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock is poised for long-term growth.

In the previous week, Alphabet had 150 more articles in the media than Vertex Pharmaceuticals. MarketBeat recorded 180 mentions for Alphabet and 30 mentions for Vertex Pharmaceuticals. Vertex Pharmaceuticals' average media sentiment score of 1.21 beat Alphabet's score of 0.81 indicating that Vertex Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Alphabet
110 Very Positive mention(s)
20 Positive mention(s)
21 Neutral mention(s)
24 Negative mention(s)
4 Very Negative mention(s)
Positive
Vertex Pharmaceuticals
21 Very Positive mention(s)
3 Positive mention(s)
3 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive

Alphabet has a beta of 1.23, suggesting that its stock price is 23% more volatile than the broader market. Comparatively, Vertex Pharmaceuticals has a beta of 0.3, suggesting that its stock price is 70% less volatile than the broader market.

Alphabet has a net margin of 37.92% compared to Vertex Pharmaceuticals' net margin of 35.51%. Alphabet's return on equity of 38.99% beat Vertex Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Alphabet37.92% 38.99% 27.41%
Vertex Pharmaceuticals 35.51%23.86%17.13%

Summary

Alphabet beats Vertex Pharmaceuticals on 13 of the 17 factors compared between the two stocks.

Get Vertex Pharmaceuticals News Delivered to You Automatically

Sign up to receive the latest news and ratings for VRTX and its competitors with MarketBeat's FREE daily newsletter.

Subscribe Now
SMS is currently available in Australia, Belgium, Canada, France, Germany, Ireland, Italy, New Zealand, the Netherlands, Singapore, South Africa, Spain, Switzerland, the United Kingdom, and the United States. By entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy.

New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding VRTX and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
Skip Chart

Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
Skip Chart

VRTX vs. The Competition

MetricVertex PharmaceuticalsMED IndustryMedical SectorNASDAQ Exchange
Market Cap$113.59B$3.41B$5.96B$12.56B
Dividend YieldN/A2.29%2.69%5.31%
P/E Ratio26.5419.0421.4126.27
Price / Sales9.46342.04626.55142.41
Price / Cash25.46121.8843.2256.84
Price / Book6.087.1210.557.30
Net Income$3.95B$24.20M$3.56B$337.27M
7 Day Performance3.00%4.11%2.85%3.58%
1 Month Performance4.72%6.66%4.59%5.71%
1 Year Performance1.02%66.00%37.62%39.70%

Vertex Pharmaceuticals Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
VRTX
Vertex Pharmaceuticals
4.5414 of 5 stars
$447.54
-0.1%
$555.91
+24.2%
+1.0%$113.59B$12.00B26.546,400
AMZN
Amazon.com
4.5807 of 5 stars
$266.32
flat
$312.66
+17.4%
+32.7%$2.86T$716.92B31.861,576,000
AXSM
Axsome Therapeutics
2.4089 of 5 stars
$235.97
flat
$251.26
+6.5%
+123.5%$12.14B$638.50MN/A380
CRSP
CRISPR Therapeutics
2.4549 of 5 stars
$50.36
flat
$65.47
+30.0%
+55.6%$4.86B$3.51MN/A460
EDIT
Editas Medicine
3.4014 of 5 stars
$2.76
flat
$5.40
+95.7%
+99.4%$270.23M$40.52MN/A230

Related Companies and Tools


This page (NASDAQ:VRTX) was last updated on 5/31/2026 by MarketBeat.com Staff.
From Our Partners