Vertex Pharmaceuticals (VRTX) Competitors $454.64 -2.40 (-0.52%) Closing price 07/3/2025 03:51 PM EasternExtended Trading$454.64 0.00 (0.00%) As of 07/3/2025 04:53 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFinancialsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock VRTX vs. AMZN, AXSM, CRSP, GOOG, ISRG, MRNA, RGEN, ABBV, LLY, and PFEShould you be buying Vertex Pharmaceuticals stock or one of its competitors? The main competitors of Vertex Pharmaceuticals include Amazon.com (AMZN), Axsome Therapeutics (AXSM), CRISPR Therapeutics (CRSP), Alphabet (GOOG), Intuitive Surgical (ISRG), Moderna (MRNA), Repligen (RGEN), AbbVie (ABBV), Eli Lilly and Company (LLY), and Pfizer (PFE). Vertex Pharmaceuticals vs. Its Competitors Amazon.com Axsome Therapeutics CRISPR Therapeutics Alphabet Intuitive Surgical Moderna Repligen AbbVie Eli Lilly and Company Pfizer Amazon.com (NASDAQ:AMZN) and Vertex Pharmaceuticals (NASDAQ:VRTX) are related large-cap companies, but which is the superior stock? We will contrast the two companies based on the strength of their profitability, valuation, risk, dividends, institutional ownership, media sentiment, analyst recommendations and earnings. Do analysts prefer AMZN or VRTX? Amazon.com presently has a consensus target price of $245.60, indicating a potential upside of 10.07%. Vertex Pharmaceuticals has a consensus target price of $511.62, indicating a potential upside of 12.53%. Given Vertex Pharmaceuticals' higher possible upside, analysts clearly believe Vertex Pharmaceuticals is more favorable than Amazon.com.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Amazon.com 0 Sell rating(s) 2 Hold rating(s) 45 Buy rating(s) 1 Strong Buy rating(s) 2.98Vertex Pharmaceuticals 0 Sell rating(s) 14 Hold rating(s) 13 Buy rating(s) 1 Strong Buy rating(s) 2.54 Do insiders and institutionals believe in AMZN or VRTX? 72.2% of Amazon.com shares are held by institutional investors. Comparatively, 91.0% of Vertex Pharmaceuticals shares are held by institutional investors. 9.7% of Amazon.com shares are held by company insiders. Comparatively, 0.2% of Vertex Pharmaceuticals shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company is poised for long-term growth. Does the media prefer AMZN or VRTX? In the previous week, Amazon.com had 224 more articles in the media than Vertex Pharmaceuticals. MarketBeat recorded 270 mentions for Amazon.com and 46 mentions for Vertex Pharmaceuticals. Vertex Pharmaceuticals' average media sentiment score of 1.11 beat Amazon.com's score of 0.86 indicating that Vertex Pharmaceuticals is being referred to more favorably in the news media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment Amazon.com 161 Very Positive mention(s) 36 Positive mention(s) 48 Neutral mention(s) 16 Negative mention(s) 3 Very Negative mention(s) Positive Vertex Pharmaceuticals 34 Very Positive mention(s) 1 Positive mention(s) 8 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Positive Which has more risk & volatility, AMZN or VRTX? Amazon.com has a beta of 1.33, indicating that its stock price is 33% more volatile than the S&P 500. Comparatively, Vertex Pharmaceuticals has a beta of 0.41, indicating that its stock price is 59% less volatile than the S&P 500. Which has preferable valuation and earnings, AMZN or VRTX? Amazon.com has higher revenue and earnings than Vertex Pharmaceuticals. Vertex Pharmaceuticals is trading at a lower price-to-earnings ratio than Amazon.com, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioAmazon.com$637.96B3.71$59.25B$6.1436.34Vertex Pharmaceuticals$11.02B10.59-$535.60M-$3.92-115.98 Is AMZN or VRTX more profitable? Amazon.com has a net margin of 10.14% compared to Vertex Pharmaceuticals' net margin of -8.91%. Amazon.com's return on equity of 24.14% beat Vertex Pharmaceuticals' return on equity.Company Net Margins Return on Equity Return on Assets Amazon.com10.14% 24.14% 10.90% Vertex Pharmaceuticals -8.91%-3.36%-2.42% SummaryAmazon.com beats Vertex Pharmaceuticals on 12 of the 16 factors compared between the two stocks. Get Vertex Pharmaceuticals News Delivered to You Automatically Sign up to receive the latest news and ratings for VRTX and its competitors with MarketBeat's FREE daily newsletter. Email Address New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding VRTX and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart VRTX vs. The Competition Export to ExcelMetricVertex PharmaceuticalsMED IndustryMedical SectorNASDAQ ExchangeMarket Cap$116.75B$2.89B$5.49B$9.01BDividend YieldN/A2.43%5.38%4.09%P/E Ratio-115.9821.5627.4220.26Price / Sales10.59245.52407.97121.21Price / CashN/A41.9536.6357.47Price / Book7.137.518.085.67Net Income-$535.60M-$55.05M$3.16B$248.47M7 Day Performance3.02%4.59%2.81%3.29%1 Month Performance1.97%4.86%3.68%5.19%1 Year Performance-3.33%5.82%35.29%21.35% Vertex Pharmaceuticals Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)VRTXVertex Pharmaceuticals4.7279 of 5 stars$454.64-0.5%$511.62+12.5%-3.3%$116.75B$11.02B-115.986,100Positive NewsAMZNAmazon.com4.6198 of 5 stars$219.65-1.6%$245.81+11.9%+12.9%$2.33T$637.96B35.771,556,000Trending NewsAnalyst ForecastInsider TradeAXSMAxsome Therapeutics4.7166 of 5 stars$104.34+0.9%$172.33+65.2%+31.3%$5.14B$385.69M-18.08380Trending NewsAnalyst ForecastAnalyst RevisionCRSPCRISPR Therapeutics3.0472 of 5 stars$48.54+2.2%$71.75+47.8%-3.2%$4.19B$35M-10.74473GOOGAlphabet4.865 of 5 stars$177.27-0.6%$206.38+16.4%-3.8%$2.15T$359.71B19.76190,200Trending NewsInsider TradeISRGIntuitive Surgical4.344 of 5 stars$543.38+1.8%$588.95+8.4%+25.1%$194.76B$8.35B79.6715,638Positive NewsMRNAModerna4.391 of 5 stars$27.63+1.7%$46.61+68.7%-73.7%$10.69B$3.24B-3.165,800Options VolumeRGENRepligen4.8194 of 5 stars$124.24+0.6%$172.83+39.1%+5.5%$6.98B$634.44M-276.091,778Positive NewsABBVAbbVie4.9048 of 5 stars$185.52+1.8%$211.29+13.9%+15.7%$327.70B$56.33B78.9555,000Trending NewsAnalyst RevisionLLYEli Lilly and Company4.988 of 5 stars$776.15+0.1%$1,011.61+30.3%-13.2%$735.59B$45.04B63.1547,000Positive NewsPFEPfizer4.976 of 5 stars$24.23+0.2%$29.17+20.4%-8.0%$137.76B$63.63B17.5681,000Trending News Related Companies and Tools Related Companies Amazon.com Alternatives Axsome Therapeutics Alternatives CRISPR Therapeutics Alternatives Alphabet Alternatives Intuitive Surgical Alternatives Moderna Alternatives Repligen Alternatives AbbVie Alternatives Eli Lilly and Company Alternatives Pfizer Alternatives Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:VRTX) was last updated on 7/4/2025 by MarketBeat.com Staff From Our PartnersWhite House to reset Social Security?Elon Musk's parting DOGE gift looks set to shock America... 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