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Vertex Pharmaceuticals (VRTX) Competitors

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$521.64 -7.26 (-1.37%)
As of 01:33 PM Eastern
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VRTX vs. AMZN, AXSM, CRSP, GOOG, and ISRG

Should you buy Vertex Pharmaceuticals stock or one of its competitors? Vertex Pharmaceuticals's main competitors and comparable companies include Amazon.com (AMZN), Axsome Therapeutics (AXSM), CRISPR Therapeutics (CRSP), Alphabet (GOOG), and Intuitive Surgical (ISRG). Companies are selected based on similarities in market, industry, and size.

How does Vertex Pharmaceuticals compare to Amazon.com?

Vertex Pharmaceuticals (NASDAQ:VRTX) and Amazon.com (NASDAQ:AMZN) are related large-cap companies, but which is the better stock? We will compare the two businesses based on the strength of their profitability, media sentiment, earnings, analyst recommendations, valuation, risk, dividends and institutional ownership.

Vertex Pharmaceuticals has a net margin of 35.00% compared to Amazon.com's net margin of 17.44%. Vertex Pharmaceuticals' return on equity of 23.09% beat Amazon.com's return on equity.

Company Net Margins Return on Equity Return on Assets
Vertex Pharmaceuticals35.00% 23.09% 16.72%
Amazon.com 17.44%18.00%8.97%

Amazon.com has higher revenue and earnings than Vertex Pharmaceuticals. Amazon.com is trading at a lower price-to-earnings ratio than Vertex Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Vertex Pharmaceuticals$12.59B10.51$3.95B$17.1830.34
Amazon.com$775.68B3.50$77.67B$12.4320.26

Vertex Pharmaceuticals currently has a consensus target price of $569.52, indicating a potential upside of 9.26%. Amazon.com has a consensus target price of $323.26, indicating a potential upside of 28.34%. Given Amazon.com's stronger consensus rating and higher possible upside, analysts clearly believe Amazon.com is more favorable than Vertex Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Vertex Pharmaceuticals
0 Sell rating(s)
2 Hold rating(s)
20 Buy rating(s)
1 Strong Buy rating(s)
2.96
Amazon.com
0 Sell rating(s)
2 Hold rating(s)
56 Buy rating(s)
1 Strong Buy rating(s)
2.98

In the previous week, Amazon.com had 258 more articles in the media than Vertex Pharmaceuticals. MarketBeat recorded 277 mentions for Amazon.com and 19 mentions for Vertex Pharmaceuticals. Vertex Pharmaceuticals' average media sentiment score of 1.01 beat Amazon.com's score of 0.67 indicating that Vertex Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Vertex Pharmaceuticals
13 Very Positive mention(s)
3 Positive mention(s)
1 Neutral mention(s)
1 Negative mention(s)
1 Very Negative mention(s)
Positive
Amazon.com
163 Very Positive mention(s)
37 Positive mention(s)
37 Neutral mention(s)
27 Negative mention(s)
12 Very Negative mention(s)
Positive

Vertex Pharmaceuticals has a beta of 0.32, meaning that its stock price is 68% less volatile than the broader market. Comparatively, Amazon.com has a beta of 1.44, meaning that its stock price is 44% more volatile than the broader market.

91.0% of Vertex Pharmaceuticals shares are owned by institutional investors. Comparatively, 72.2% of Amazon.com shares are owned by institutional investors. 0.2% of Vertex Pharmaceuticals shares are owned by company insiders. Comparatively, 8.9% of Amazon.com shares are owned by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock will outperform the market over the long term.

Summary

Vertex Pharmaceuticals and Amazon.com tied by winning 8 of the 16 factors compared between the two stocks.

How does Vertex Pharmaceuticals compare to Axsome Therapeutics?

Axsome Therapeutics (NASDAQ:AXSM) and Vertex Pharmaceuticals (NASDAQ:VRTX) are both large-cap healthcare companies, but which is the superior investment? We will contrast the two businesses based on the strength of their earnings, institutional ownership, profitability, media sentiment, valuation, risk, dividends and analyst recommendations.

Vertex Pharmaceuticals has a net margin of 35.00% compared to Axsome Therapeutics' net margin of -24.68%. Vertex Pharmaceuticals' return on equity of 23.09% beat Axsome Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Axsome Therapeutics-24.68% -265.55% -28.10%
Vertex Pharmaceuticals 35.00%23.09%16.72%

In the previous week, Vertex Pharmaceuticals had 8 more articles in the media than Axsome Therapeutics. MarketBeat recorded 19 mentions for Vertex Pharmaceuticals and 11 mentions for Axsome Therapeutics. Axsome Therapeutics' average media sentiment score of 1.01 beat Vertex Pharmaceuticals' score of 1.01 indicating that Axsome Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Axsome Therapeutics
9 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Vertex Pharmaceuticals
13 Very Positive mention(s)
3 Positive mention(s)
1 Neutral mention(s)
1 Negative mention(s)
1 Very Negative mention(s)
Positive

81.5% of Axsome Therapeutics shares are owned by institutional investors. Comparatively, 91.0% of Vertex Pharmaceuticals shares are owned by institutional investors. 20.6% of Axsome Therapeutics shares are owned by company insiders. Comparatively, 0.2% of Vertex Pharmaceuticals shares are owned by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock will outperform the market over the long term.

Vertex Pharmaceuticals has higher revenue and earnings than Axsome Therapeutics. Axsome Therapeutics is trading at a lower price-to-earnings ratio than Vertex Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Axsome Therapeutics$638.50M17.20-$183.17M-$3.75N/A
Vertex Pharmaceuticals$12.59B10.51$3.95B$17.1830.34

Axsome Therapeutics has a beta of 0.71, suggesting that its share price is 29% less volatile than the broader market. Comparatively, Vertex Pharmaceuticals has a beta of 0.32, suggesting that its share price is 68% less volatile than the broader market.

Axsome Therapeutics currently has a consensus price target of $267.60, suggesting a potential upside of 27.61%. Vertex Pharmaceuticals has a consensus price target of $569.52, suggesting a potential upside of 9.26%. Given Axsome Therapeutics' higher possible upside, research analysts plainly believe Axsome Therapeutics is more favorable than Vertex Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Axsome Therapeutics
1 Sell rating(s)
2 Hold rating(s)
17 Buy rating(s)
2 Strong Buy rating(s)
2.91
Vertex Pharmaceuticals
0 Sell rating(s)
2 Hold rating(s)
20 Buy rating(s)
1 Strong Buy rating(s)
2.96

Summary

Vertex Pharmaceuticals beats Axsome Therapeutics on 11 of the 17 factors compared between the two stocks.

How does Vertex Pharmaceuticals compare to CRISPR Therapeutics?

Vertex Pharmaceuticals (NASDAQ:VRTX) and CRISPR Therapeutics (NASDAQ:CRSP) are both healthcare companies, but which is the superior investment? We will compare the two businesses based on the strength of their dividends, analyst recommendations, earnings, media sentiment, institutional ownership, valuation, profitability and risk.

Vertex Pharmaceuticals has higher revenue and earnings than CRISPR Therapeutics. CRISPR Therapeutics is trading at a lower price-to-earnings ratio than Vertex Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Vertex Pharmaceuticals$12.59B10.51$3.95B$17.1830.34
CRISPR Therapeutics$3.51M1,483.76-$581.60M-$4.76N/A

Vertex Pharmaceuticals has a net margin of 35.00% compared to CRISPR Therapeutics' net margin of -3,368.72%. Vertex Pharmaceuticals' return on equity of 23.09% beat CRISPR Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Vertex Pharmaceuticals35.00% 23.09% 16.72%
CRISPR Therapeutics -3,368.72%-24.39%-18.25%

Vertex Pharmaceuticals has a beta of 0.32, meaning that its share price is 68% less volatile than the broader market. Comparatively, CRISPR Therapeutics has a beta of 1.76, meaning that its share price is 76% more volatile than the broader market.

91.0% of Vertex Pharmaceuticals shares are held by institutional investors. Comparatively, 69.2% of CRISPR Therapeutics shares are held by institutional investors. 0.2% of Vertex Pharmaceuticals shares are held by insiders. Comparatively, 5.2% of CRISPR Therapeutics shares are held by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company is poised for long-term growth.

In the previous week, Vertex Pharmaceuticals had 9 more articles in the media than CRISPR Therapeutics. MarketBeat recorded 19 mentions for Vertex Pharmaceuticals and 10 mentions for CRISPR Therapeutics. Vertex Pharmaceuticals' average media sentiment score of 1.01 beat CRISPR Therapeutics' score of 0.57 indicating that Vertex Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Vertex Pharmaceuticals
13 Very Positive mention(s)
3 Positive mention(s)
1 Neutral mention(s)
1 Negative mention(s)
1 Very Negative mention(s)
Positive
CRISPR Therapeutics
3 Very Positive mention(s)
2 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Positive

Vertex Pharmaceuticals presently has a consensus price target of $569.52, suggesting a potential upside of 9.26%. CRISPR Therapeutics has a consensus price target of $68.06, suggesting a potential upside of 26.35%. Given CRISPR Therapeutics' higher possible upside, analysts clearly believe CRISPR Therapeutics is more favorable than Vertex Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Vertex Pharmaceuticals
0 Sell rating(s)
2 Hold rating(s)
20 Buy rating(s)
1 Strong Buy rating(s)
2.96
CRISPR Therapeutics
1 Sell rating(s)
6 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.61

Summary

Vertex Pharmaceuticals beats CRISPR Therapeutics on 12 of the 16 factors compared between the two stocks.

How does Vertex Pharmaceuticals compare to Alphabet?

Vertex Pharmaceuticals (NASDAQ:VRTX) and Alphabet (NASDAQ:GOOG) are related large-cap companies, but which is the better stock? We will compare the two companies based on the strength of their dividends, institutional ownership, earnings, media sentiment, profitability, analyst recommendations, risk and valuation.

Alphabet has higher revenue and earnings than Vertex Pharmaceuticals. Alphabet is trading at a lower price-to-earnings ratio than Vertex Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Vertex Pharmaceuticals$12.59B10.51$3.95B$17.1830.34
Alphabet$402.84B9.96$132.17B$19.9116.48

Alphabet has a net margin of 54.77% compared to Vertex Pharmaceuticals' net margin of 35.00%. Alphabet's return on equity of 51.32% beat Vertex Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Vertex Pharmaceuticals35.00% 23.09% 16.72%
Alphabet 54.77%51.32%35.42%

Vertex Pharmaceuticals currently has a consensus target price of $569.52, indicating a potential upside of 9.26%. Alphabet has a consensus target price of $415.55, indicating a potential upside of 26.64%. Given Alphabet's stronger consensus rating and higher possible upside, analysts plainly believe Alphabet is more favorable than Vertex Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Vertex Pharmaceuticals
0 Sell rating(s)
2 Hold rating(s)
20 Buy rating(s)
1 Strong Buy rating(s)
2.96
Alphabet
0 Sell rating(s)
4 Hold rating(s)
30 Buy rating(s)
6 Strong Buy rating(s)
3.05

91.0% of Vertex Pharmaceuticals shares are owned by institutional investors. Comparatively, 27.3% of Alphabet shares are owned by institutional investors. 0.2% of Vertex Pharmaceuticals shares are owned by company insiders. Comparatively, 13.0% of Alphabet shares are owned by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock will outperform the market over the long term.

Vertex Pharmaceuticals has a beta of 0.32, indicating that its share price is 68% less volatile than the broader market. Comparatively, Alphabet has a beta of 1.21, indicating that its share price is 21% more volatile than the broader market.

In the previous week, Alphabet had 188 more articles in the media than Vertex Pharmaceuticals. MarketBeat recorded 207 mentions for Alphabet and 19 mentions for Vertex Pharmaceuticals. Vertex Pharmaceuticals' average media sentiment score of 1.01 beat Alphabet's score of 0.87 indicating that Vertex Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Vertex Pharmaceuticals
13 Very Positive mention(s)
3 Positive mention(s)
1 Neutral mention(s)
1 Negative mention(s)
1 Very Negative mention(s)
Positive
Alphabet
124 Very Positive mention(s)
20 Positive mention(s)
34 Neutral mention(s)
21 Negative mention(s)
8 Very Negative mention(s)
Positive

Summary

Alphabet beats Vertex Pharmaceuticals on 13 of the 17 factors compared between the two stocks.

How does Vertex Pharmaceuticals compare to Intuitive Surgical?

Intuitive Surgical (NASDAQ:ISRG) and Vertex Pharmaceuticals (NASDAQ:VRTX) are both large-cap healthcare companies, but which is the better business? We will compare the two companies based on the strength of their earnings, institutional ownership, dividends, media sentiment, profitability, analyst recommendations, risk and valuation.

In the previous week, Intuitive Surgical had 11 more articles in the media than Vertex Pharmaceuticals. MarketBeat recorded 30 mentions for Intuitive Surgical and 19 mentions for Vertex Pharmaceuticals. Intuitive Surgical's average media sentiment score of 1.09 beat Vertex Pharmaceuticals' score of 1.01 indicating that Intuitive Surgical is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Intuitive Surgical
23 Very Positive mention(s)
2 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Vertex Pharmaceuticals
13 Very Positive mention(s)
3 Positive mention(s)
1 Neutral mention(s)
1 Negative mention(s)
1 Very Negative mention(s)
Positive

Vertex Pharmaceuticals has a net margin of 35.00% compared to Intuitive Surgical's net margin of 28.45%. Vertex Pharmaceuticals' return on equity of 23.09% beat Intuitive Surgical's return on equity.

Company Net Margins Return on Equity Return on Assets
Intuitive Surgical28.45% 16.91% 14.83%
Vertex Pharmaceuticals 35.00%23.09%16.72%

Vertex Pharmaceuticals has higher revenue and earnings than Intuitive Surgical. Vertex Pharmaceuticals is trading at a lower price-to-earnings ratio than Intuitive Surgical, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Intuitive Surgical$11.03B11.24$2.86B$8.7340.21
Vertex Pharmaceuticals$12.59B10.51$3.95B$17.1830.34

83.6% of Intuitive Surgical shares are owned by institutional investors. Comparatively, 91.0% of Vertex Pharmaceuticals shares are owned by institutional investors. 0.6% of Intuitive Surgical shares are owned by insiders. Comparatively, 0.2% of Vertex Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company will outperform the market over the long term.

Intuitive Surgical currently has a consensus price target of $508.68, indicating a potential upside of 44.91%. Vertex Pharmaceuticals has a consensus price target of $569.52, indicating a potential upside of 9.26%. Given Intuitive Surgical's higher probable upside, research analysts clearly believe Intuitive Surgical is more favorable than Vertex Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Intuitive Surgical
1 Sell rating(s)
8 Hold rating(s)
22 Buy rating(s)
0 Strong Buy rating(s)
2.68
Vertex Pharmaceuticals
0 Sell rating(s)
2 Hold rating(s)
20 Buy rating(s)
1 Strong Buy rating(s)
2.96

Intuitive Surgical has a beta of 1.47, suggesting that its share price is 47% more volatile than the broader market. Comparatively, Vertex Pharmaceuticals has a beta of 0.32, suggesting that its share price is 68% less volatile than the broader market.

Summary

Vertex Pharmaceuticals beats Intuitive Surgical on 9 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding VRTX and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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VRTX vs. The Competition

MetricVertex PharmaceuticalsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$132.30B$3.87B$7.16B$12.78B
Dividend YieldN/A3.60%2.54%9.15%
P/E Ratio30.3413.22271.8825.30
Price / Sales10.511,619.38700.01108.13
Price / Cash31.07108.6077.0752.39
Price / Book7.0916.2110.866.36
Net Income$3.95B-$22.81M$3.48B$358.07M
7 Day Performance-6.37%0.56%-0.82%-0.05%
1 Month Performance5.08%5.75%2.80%-0.94%
1 Year Performance31.47%46.72%21.60%11.95%

Vertex Pharmaceuticals Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
VRTX
Vertex Pharmaceuticals
3.8434 of 5 stars
$521.64
-1.4%
$569.52
+9.2%
+33.8%$132.40B$12.59B30.366,400
AMZN
Amazon.com
4.9116 of 5 stars
$258.51
flat
$323.26
+25.0%
+9.0%$2.79T$716.92B20.801,576,000
AXSM
Axsome Therapeutics
4.3257 of 5 stars
$206.68
flat
$267.60
+29.5%
+60.7%$10.83B$638.50MN/A380
CRSP
CRISPR Therapeutics
2.7549 of 5 stars
$55.79
flat
$68.06
+22.0%
+1.3%$5.39B$3.51MN/A460
GOOG
Alphabet
4.8611 of 5 stars
$335.31
flat
$415.55
+23.9%
+43.2%$4.10T$402.84B16.84190,200

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This page (NASDAQ:VRTX) was last updated on 9/9/2026 by MarketBeat.com Staff.
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