| 06/26/2026 8:54 AM | Bozic Carmen (1790029) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 06/23/2026 3:08 PM | Bozic Carmen (1790029) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/18/2026 10:33 AM | Bozic Carmen (1790029) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 06/15/2026 2:07 PM | Bozic Carmen (1790029) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 06/09/2026 3:24 PM | Bozic Carmen (1790029) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/05/2026 1:33 PM | Bozic Carmen (1790029) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 06/03/2026 3:06 PM | Liu Joy (1847529) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/02/2026 3:04 PM | Bozic Carmen (1790029) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/01/2026 1:13 PM | Liu Joy (1847529) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 05/29/2026 12:31 PM | Bozic Carmen (1790029) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 05/19/2026 3:04 PM | Bozic Carmen (1790029) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
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| 05/19/2026 3:05 PM | Bunnage Mark E. (2100735) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 05/15/2026 9:41 AM | Bozic Carmen (1790029) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 05/15/2026 9:02 AM | Bunnage Mark E. (2100735) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 05/14/2026 12:55 PM | Capital World Investors (1422849) Filed by Vertex Pharmaceuticals (875320) Subject | Form SCHEDULE 13G/A | |
| 05/14/2026 9:19 AM | Capital Research Global Investors (1422848) Filed by Vertex Pharmaceuticals (875320) Subject | Form SCHEDULE 13G/A | |
| 05/13/2026 3:03 PM | Vertex Pharmaceuticals (875320) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 05/13/2026 3:07 PM | Vertex Pharmaceuticals (875320) Filer | Form S-8 Registration statement under Securities Act of 1933 to be offered to employees pursuant to certain plans | |
| 05/12/2026 12:11 PM | Bozic Carmen (1790029) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 05/06/2026 1:13 PM | Biller Jonathan (1744749) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 05/05/2026 4:37 PM | Thornberry Nancy (1797826) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 05/05/2026 4:44 PM | Upadhyay Suketu (1533149) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 05/05/2026 4:24 PM | SACHS BRUCE I (1197036) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 05/05/2026 4:29 PM | Schneider Jennifer (1783060) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 05/05/2026 4:11 PM | Liu Joy (1847529) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 05/05/2026 4:18 PM | MCKENZIE DIANA (1754648) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 05/05/2026 3:58 PM | Garber Alan M (1312907) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 05/05/2026 4:06 PM | Lagarde Michel (1518973) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 05/05/2026 3:51 PM | Bhatia Sangeeta N. (1643921) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 05/04/2026 3:05 PM | Vertex Pharmaceuticals (875320) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 05/04/2026 9:18 AM | Bhatia Sangeeta N. (1643921) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 05/01/2026 1:28 PM | Liu Joy (1847529) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 04/30/2026 1:29 PM | VANGUARD CAPITAL MANAGEMENT LLC (2100119) Filed by Vertex Pharmaceuticals (875320) Subject | Form SCHEDULE 13G | |
| 04/29/2026 3:05 PM | Vertex Pharmaceuticals (875320) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 04/17/2026 3:14 PM | Garber Alan M (1312907) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 04/17/2026 3:17 PM | SACHS BRUCE I (1197036) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 04/17/2026 3:20 PM | Upadhyay Suketu (1533149) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 04/03/2026 3:53 PM | Liu Joy (1847529) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 04/01/2026 12:02 PM | Liu Joy (1847529) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 03/31/2026 3:10 PM | Bozic Carmen (1790029) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 03/27/2026 12:54 PM | VANGUARD GROUP INC (102909) Filed by Vertex Pharmaceuticals (875320) Subject | Form SCHEDULE 13G/A | |
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| 03/27/2026 9:32 AM | Bozic Carmen (1790029) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 03/13/2026 10:38 AM | Bozic Carmen (1790029) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 03/11/2026 8:44 AM | McKechnie Duncan (2062139) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 03/06/2026 3:05 PM | McKechnie Duncan (2062139) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 03/04/2026 3:21 PM | Liu Joy (1847529) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 03/04/2026 9:09 AM | McKechnie Duncan (2062139) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/27/2026 3:41 PM | Kewalramani Reshma (1735944) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/27/2026 8:50 AM | Bozic Carmen (1790029) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/26/2026 5:01 PM | Biller Jonathan (1744749) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/26/2026 5:05 PM | Bozic Carmen (1790029) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/26/2026 5:06 PM | Bunnage Mark E. (2100735) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/26/2026 5:09 PM | Kewalramani Reshma (1735944) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/26/2026 5:11 PM | LEIDEN JEFFREY M (1242825) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/26/2026 5:48 PM | McKechnie Duncan (2062139) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/26/2026 5:50 PM | Sachdev Amit (1406338) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/26/2026 5:55 PM | Tatsis Ourania (1789815) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/26/2026 5:56 PM | Vertex Pharmaceuticals (875320) Issuer WAGNER CHARLES F JR (1223348) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/26/2026 4:56 PM | Ambrose Kristen (1856587) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/25/2026 10:28 AM | McKechnie Duncan (2062139) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/25/2026 10:12 AM | Tatsis Ourania (1789815) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/25/2026 10:02 AM | Bunnage Mark E. (2100735) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/25/2026 9:35 AM | Atkinson Edward Morrow III (1914164) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/25/2026 8:41 AM | Biller Jonathan (1744749) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/25/2026 9:06 AM | Sachdev Amit (1406338) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/23/2026 3:21 PM | Sachdev Amit (1406338) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/19/2026 3:18 PM | LEIDEN JEFFREY M (1242825) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/19/2026 3:18 PM | Sachdev Amit (1406338) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/19/2026 3:21 PM | McKechnie Duncan (2062139) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/19/2026 3:24 PM | Sachdev Amit (1406338) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/19/2026 3:08 PM | Biller Jonathan (1744749) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/19/2026 3:10 PM | Bozic Carmen (1790029) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/19/2026 3:12 PM | Bunnage Mark E. (2100735) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/18/2026 3:37 PM | McKechnie Duncan (2062139) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/18/2026 3:39 PM | Sachdev Amit (1406338) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/18/2026 3:43 PM | Tatsis Ourania (1789815) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/18/2026 11:28 AM | Tatsis Ourania (1789815) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/18/2026 9:46 AM | Biller Jonathan (1744749) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/18/2026 8:55 AM | Atkinson Edward Morrow III (1914164) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/18/2026 9:17 AM | Bunnage Mark E. (2100735) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/17/2026 1:34 PM | Tatsis Ourania (1789815) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/17/2026 12:52 PM | Biller Jonathan (1744749) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/17/2026 12:20 PM | Atkinson Edward Morrow III (1914164) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/13/2026 1:43 PM | Tatsis Ourania (1789815) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/13/2026 1:54 PM | Bhatia Sangeeta N. (1643921) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/13/2026 1:59 PM | Biller Jonathan (1744749) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/12/2026 3:47 PM | Ambrose Kristen (1856587) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/12/2026 3:50 PM | Atkinson Edward Morrow III (1914164) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/12/2026 9:25 AM | Capital Research Global Investors (1422848) Filed by Vertex Pharmaceuticals (875320) Subject | Form SCHEDULE 13G/A | |
| 02/11/2026 9:58 AM | Atkinson Edward Morrow III (1914164) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/11/2026 10:30 AM | Biller Jonathan (1744749) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
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| 02/11/2026 9:18 AM | Bunnage Mark E. (2100735) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/11/2026 8:47 AM | Tatsis Ourania (1789815) Reporting Vertex Pharmaceuticals (875320) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 01/26/2026 3:28 PM | LEIDEN JEFFREY M (1242825) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 01/26/2026 3:30 PM | McKechnie Duncan (2062139) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 01/26/2026 3:35 PM | Sachdev Amit (1406338) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 01/26/2026 3:37 PM | Tatsis Ourania (1789815) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 01/26/2026 3:38 PM | Vertex Pharmaceuticals (875320) Issuer WAGNER CHARLES F JR (1223348) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 01/26/2026 3:10 PM | ALTSHULER DAVID (1550395) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 01/26/2026 3:12 PM | Ambrose Kristen (1856587) Reporting Vertex Pharmaceuticals (875320) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |