Xeris Biopharma (XERS) Competitors $7.68 +0.38 (+5.21%) Closing price 08/15/2025 04:00 PM EasternExtended Trading$7.60 -0.08 (-1.04%) As of 08/15/2025 07:56 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsFinancialsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock XERS vs. PTGX, AAPG, HCM, INDV, APLS, MOR, KYMR, RARE, IMVT, and ALVOShould you be buying Xeris Biopharma stock or one of its competitors? The main competitors of Xeris Biopharma include Protagonist Therapeutics (PTGX), Ascentage Pharma Group International (AAPG), HUTCHMED (HCM), Indivior (INDV), Apellis Pharmaceuticals (APLS), MorphoSys (MOR), Kymera Therapeutics (KYMR), Ultragenyx Pharmaceutical (RARE), Immunovant (IMVT), and Alvotech (ALVO). These companies are all part of the "pharmaceutical products" industry. Xeris Biopharma vs. Its Competitors Protagonist Therapeutics Ascentage Pharma Group International HUTCHMED Indivior Apellis Pharmaceuticals MorphoSys Kymera Therapeutics Ultragenyx Pharmaceutical Immunovant Alvotech Protagonist Therapeutics (NASDAQ:PTGX) and Xeris Biopharma (NASDAQ:XERS) are both medical companies, but which is the better stock? We will contrast the two companies based on the strength of their institutional ownership, profitability, analyst recommendations, dividends, valuation, earnings, media sentiment and risk. Is PTGX or XERS more profitable? Protagonist Therapeutics has a net margin of 24.88% compared to Xeris Biopharma's net margin of -13.01%. Protagonist Therapeutics' return on equity of 8.12% beat Xeris Biopharma's return on equity.Company Net Margins Return on Equity Return on Assets Protagonist Therapeutics24.88% 8.12% 7.41% Xeris Biopharma -13.01%N/A -8.00% Does the media prefer PTGX or XERS? In the previous week, Xeris Biopharma had 14 more articles in the media than Protagonist Therapeutics. MarketBeat recorded 26 mentions for Xeris Biopharma and 12 mentions for Protagonist Therapeutics. Protagonist Therapeutics' average media sentiment score of 1.14 beat Xeris Biopharma's score of 0.87 indicating that Protagonist Therapeutics is being referred to more favorably in the media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment Protagonist Therapeutics 5 Very Positive mention(s) 1 Positive mention(s) 0 Neutral mention(s) 1 Negative mention(s) 0 Very Negative mention(s) Positive Xeris Biopharma 9 Very Positive mention(s) 3 Positive mention(s) 6 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Positive Which has preferable valuation & earnings, PTGX or XERS? Protagonist Therapeutics has higher earnings, but lower revenue than Xeris Biopharma. Xeris Biopharma is trading at a lower price-to-earnings ratio than Protagonist Therapeutics, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioProtagonist Therapeutics$209.18M16.68$275.19M$0.7080.10Xeris Biopharma$246.03M5.04-$54.84M-$0.21-36.57 Do institutionals & insiders have more ownership in PTGX or XERS? 98.6% of Protagonist Therapeutics shares are owned by institutional investors. Comparatively, 42.8% of Xeris Biopharma shares are owned by institutional investors. 4.9% of Protagonist Therapeutics shares are owned by company insiders. Comparatively, 6.5% of Xeris Biopharma shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company will outperform the market over the long term. Do analysts rate PTGX or XERS? Protagonist Therapeutics presently has a consensus target price of $67.20, suggesting a potential upside of 19.85%. Xeris Biopharma has a consensus target price of $6.58, suggesting a potential downside of 14.28%. Given Protagonist Therapeutics' stronger consensus rating and higher possible upside, analysts plainly believe Protagonist Therapeutics is more favorable than Xeris Biopharma.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Protagonist Therapeutics 0 Sell rating(s) 1 Hold rating(s) 7 Buy rating(s) 1 Strong Buy rating(s) 3.00Xeris Biopharma 0 Sell rating(s) 1 Hold rating(s) 5 Buy rating(s) 0 Strong Buy rating(s) 2.83 Which has more risk & volatility, PTGX or XERS? Protagonist Therapeutics has a beta of 2.33, suggesting that its stock price is 133% more volatile than the S&P 500. Comparatively, Xeris Biopharma has a beta of 0.65, suggesting that its stock price is 35% less volatile than the S&P 500. SummaryProtagonist Therapeutics beats Xeris Biopharma on 14 of the 17 factors compared between the two stocks. Get Xeris Biopharma News Delivered to You Automatically Sign up to receive the latest news and ratings for XERS and its competitors with MarketBeat's FREE daily newsletter. Email Address New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding XERS and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart XERS vs. The Competition Export to ExcelMetricXeris BiopharmaMED IndustryMedical SectorNASDAQ ExchangeMarket Cap$1.24B$2.75B$5.67B$9.82BDividend YieldN/A1.77%3.79%4.07%P/E Ratio-36.5721.8930.5825.12Price / Sales5.04740.48464.45115.80Price / CashN/A177.1637.4059.05Price / Book-64.005.079.096.18Net Income-$54.84M$31.61M$3.25B$264.89M7 Day Performance12.28%25.12%7.32%4.18%1 Month Performance46.01%3.84%5.42%1.99%1 Year Performance185.50%10.43%30.66%24.22% Xeris Biopharma Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)XERSXeris Biopharma3.4233 of 5 stars$7.68+5.2%$6.58-14.3%+193.1%$1.24B$246.03M-36.57290News CoverageAnalyst ForecastInsider TradeAnalyst RevisionPTGXProtagonist Therapeutics2.063 of 5 stars$53.83flat$66.10+22.8%+38.1%$3.34B$434.43M71.77120Positive NewsAAPGAscentage Pharma Group InternationalN/A$37.60+1.1%N/AN/A$3.25B$134.35M0.00600News CoverageGap UpHCMHUTCHMED2.8642 of 5 stars$17.28+0.1%$28.00+62.0%-16.3%$3.01B$630.20M0.001,811Positive NewsINDVIndivior2.3798 of 5 stars$21.22+0.8%$17.75-16.4%+92.0%$2.90B$1.17B34.231,051APLSApellis Pharmaceuticals3.9994 of 5 stars$24.26+5.7%$36.83+51.8%-26.2%$2.90B$781.37M-13.33770Short Interest ↑MORMorphoSysN/A$18.96flatN/AN/A$2.86B$238.28M-5.45730KYMRKymera Therapeutics2.8086 of 5 stars$43.66+1.6%$59.11+35.4%-3.2%$2.80B$47.07M-14.08170Trending NewsEarnings ReportAnalyst DowngradeAnalyst RevisionRAREUltragenyx Pharmaceutical4.6668 of 5 stars$28.46+0.1%$83.08+191.9%-42.6%$2.69B$560.23M-4.841,294IMVTImmunovant2.9059 of 5 stars$16.09+2.4%$36.40+126.2%-50.7%$2.69BN/A-5.87120News CoverageEarnings ReportAnalyst ForecastAnalyst RevisionALVOAlvotech2.7885 of 5 stars$8.87+0.9%$14.00+57.8%-32.8%$2.65B$491.98M23.971,032Trending NewsEarnings ReportShort Interest ↓ Related Companies and Tools Related Companies PTGX Alternatives AAPG Alternatives HCM Alternatives INDV Alternatives APLS Alternatives MOR Alternatives KYMR Alternatives RARE Alternatives IMVT Alternatives ALVO Alternatives Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:XERS) was last updated on 8/16/2025 by MarketBeat.com Staff From Our PartnersAmazon’s big Bitcoin embarrassmentBitcoin just passed Amazon in total market cap — but most investors are missing the bigger opportunity. 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