This company has been marked as potentially delisted and may not be actively trading. Zafgen (ZFGN) Competitors Add Compare Share Share Competitors Stock AnalysisCompetitorsTrendsBuy This Stock ZFGN vs. MBX, SBTX, AVTE, NLTX, CYBN, BIOA, VIRI, WHWK, OSTX, and ELYMShould you be buying Zafgen stock or one of its competitors? The main competitors of Zafgen include MBX Biosciences (MBX), Silverback Therapeutics (SBTX), Aerovate Therapeutics (AVTE), Neoleukin Therapeutics (NLTX), Cybin (CYBN), BioAge Labs (BIOA), Virios Therapeutics (VIRI), Whitehawk Therapeutics (WHWK), OS Therapies (OSTX), and Eliem Therapeutics (ELYM). Zafgen vs. Its Competitors MBX Biosciences Silverback Therapeutics Aerovate Therapeutics Neoleukin Therapeutics Cybin BioAge Labs Virios Therapeutics Whitehawk Therapeutics OS Therapies Eliem Therapeutics Zafgen (NASDAQ:ZFGN) and MBX Biosciences (NYSE:MBX) are both small-cap medical companies, but which is the superior business? We will contrast the two businesses based on the strength of their earnings, media sentiment, valuation, dividends, profitability, analyst recommendations, institutional ownership and risk. Is ZFGN or MBX more profitable? MBX Biosciences' return on equity of 0.00% beat Zafgen's return on equity.Company Net Margins Return on Equity Return on Assets ZafgenN/A -51.34% -34.55% MBX Biosciences N/A N/A N/A Which has better earnings and valuation, ZFGN or MBX? Zafgen is trading at a lower price-to-earnings ratio than MBX Biosciences, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioZafgenN/AN/A-$45.41M-$1.07-3.47MBX BiosciencesN/AN/AN/A-$4.54-3.17 Do insiders and institutionals believe in ZFGN or MBX? 70.4% of Zafgen shares are held by institutional investors. 14.2% of Zafgen shares are held by insiders. Comparatively, 52.2% of MBX Biosciences shares are held by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock is poised for long-term growth. Do analysts recommend ZFGN or MBX? MBX Biosciences has a consensus price target of $37.63, indicating a potential upside of 161.28%. Given MBX Biosciences' stronger consensus rating and higher possible upside, analysts plainly believe MBX Biosciences is more favorable than Zafgen.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Zafgen 0 Sell rating(s) 0 Hold rating(s) 0 Buy rating(s) 0 Strong Buy rating(s) 0.00MBX Biosciences 0 Sell rating(s) 0 Hold rating(s) 8 Buy rating(s) 0 Strong Buy rating(s) 3.00 Does the media refer more to ZFGN or MBX? In the previous week, MBX Biosciences had 4 more articles in the media than Zafgen. MarketBeat recorded 4 mentions for MBX Biosciences and 0 mentions for Zafgen. MBX Biosciences' average media sentiment score of 0.89 beat Zafgen's score of 0.00 indicating that MBX Biosciences is being referred to more favorably in the news media. Company Overall Sentiment Zafgen Neutral MBX Biosciences Positive SummaryMBX Biosciences beats Zafgen on 9 of the 11 factors compared between the two stocks. Get Zafgen News Delivered to You Automatically Sign up to receive the latest news and ratings for ZFGN and its competitors with MarketBeat's FREE daily newsletter. Subscribe Now View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding ZFGN and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart ZFGN vs. The Competition Export to ExcelMetricZafgenPharmaceutical Preparations IndustryMedical SectorNASDAQ ExchangeMarket Cap$139.01M$842.47M$5.75B$9.83BDividend YieldN/A4.84%6.66%4.49%P/E Ratio-3.861.1482.4426.63Price / SalesN/A26.92530.59110.56Price / CashN/A19.5625.7028.92Price / Book2.756.5710.646.56Net Income-$45.41M-$5.07M$3.28B$266.04M Zafgen Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)ZFGNZafgenN/A$3.71+2.5%N/A-54.2%$139.01MN/A-3.8638High Trading VolumeMBXMBX Biosciences2.3171 of 5 stars$15.37+10.7%$37.63+144.8%N/A$516.34MN/A-3.3936SBTXSilverback TherapeuticsN/A$13.51+0.1%N/A-10.5%$487.14MN/A-5.5883High Trading VolumeAVTEAerovate TherapeuticsN/A$7.90-4.0%N/A-88.3%$228.98MN/A-2.6420News CoveragePositive NewsHigh Trading VolumeNLTXNeoleukin TherapeuticsN/A$19.98-0.1%N/A-50.6%$187.77MN/A-6.4290CYBNCybin1.8805 of 5 stars$7.45+2.8%$85.00+1,040.9%N/A$175.75MN/A-1.7050News CoverageGap UpBIOABioAge LabsN/A$4.61+2.2%N/AN/A$161.68MN/A0.00N/AVIRIVirios Therapeutics0.1104 of 5 stars$5.06+2.3%$5.00-1.2%+2,456.7%$97.45MN/A-18.745WHWKWhitehawk TherapeuticsN/A$1.81+6.5%N/AN/A$80.12M$21.60M-30.1740News CoveragePositive NewsOSTXOS Therapies2.0912 of 5 stars$2.33+6.4%$18.00+672.5%-46.1%$74.31MN/A-2.95N/ANews CoverageAnalyst ForecastGap DownELYMEliem TherapeuticsN/A$2.48+4.2%N/A-68.1%$73.79MN/A-4.689High Trading Volume Related Companies and Tools Related Companies MBX Alternatives SBTX Alternatives AVTE Alternatives NLTX Alternatives CYBN Alternatives BIOA Alternatives VIRI Alternatives WHWK Alternatives OSTX Alternatives ELYM Alternatives Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:ZFGN) was last updated on 9/3/2025 by MarketBeat.com Staff From Our PartnersHow “Trump’s New Dollar” Could Impact Your WealthPresident Trump just signed a game-changing law… That could soon upgrade the U.S. dollar in your checking a...Brownstone Research | SponsoredForget Tesla — This Tiny AI Stock Is Musk’s Real PlayWhile Wall Street focused on Tesla’s earnings, Elon Musk was quietly building a supercomputer so powerful it c...Behind the Markets | SponsoredWhat's the Best Way to Lower RMD Taxes?Turning 73 triggers a key IRS rule: you must begin taking required minimum distributions (RMDs) from certain r...SmartAsset | SponsoredWhat Steve Bannon revealed about Trump’s gold playA Trump advisor just said 3 words that could reset the dollar. 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