NYSEARCA:SBIO ALPS Medical Breakthroughs ETF (SBIO) Price, Holdings, & News $50.12 -2.10 (-4.02%) Closing price 04:10 PM EasternExtended Trading$50.03 -0.09 (-0.18%) As of 07:30 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more. Add Compare Share Share Stock Analysis Stock AnalysisChartDividendHoldingsNews and TrendsOwnershipRatingsShort Interest About ALPS Medical Breakthroughs ETF (NYSEARCA:SBIO) View Price History Chart DataSkip Price History Chart 1 Day 5 Days 30 Days 90 Days 1 Year Advanced 1 Day 1 Day 5 Days 30 Days 90 Days 1 Year Advanced Show volume Show extended hours Get SBIO alerts:Sign Up Key Stats Today's Range$49.93▼$52.2250-Day Range$50.12▼$70.7952-Week Range$41.73▼$70.85Volume20,709 shsAverage Volume38,441 shsMarket Capitalization$173.92 millionAssets Under Management$180.02 millionDividend YieldN/ANet Expense Ratio0.50%Aggregate RatingModerate Buy ETF Overview The ALPS Medical Breakthroughs ETF (SBIO) is an exchange-traded fund that is based on the S-Network Medical Breakthroughs index. The fund tracks, a market-cap weighted index comprising US-listed biotech companies with one or more drugs currently in either Phase II or Phase III FDA clinical trials. SBIO was launched on Dec 31, 2014 and is managed by ALPS. Read More ALPS Medical Breakthroughs ETF ExpensesTypeSBIOHealth Care ETFsEquity ETFsNYSEARCA ETFsAll ETFsManagement Fee0.50%0.55%0.57%0.50%0.53%Other Expenses0.00%0.52%0.53%0.60%0.54%Total Expense0.50%0.76%0.75%0.75%0.73%Fee Waiver0.00%-0.85%-0.67%-0.78%-0.68%Net Expense0.50%0.58%0.63%0.57%0.60% Receive SBIO Stock News and Ratings via Email Sign-up to receive the latest news and ratings for ALPS Medical Breakthroughs ETF and its competitors with MarketBeat's FREE daily newsletter. Submit View SMS TermsSMS is currently available in Australia, Belgium, Canada, France, Germany, Ireland, Italy, New Zealand, the Netherlands, Singapore, South Africa, Spain, Switzerland, the United Kingdom, and the United States. By entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. SBIO ETF News HeadlinesSBIO: Promising Pipelines, Insufficient Return PotentialSeptember 25, 2026 | seekingalpha.comSBIO: Big Pharma Needs What This Fund OwnsSeptember 22, 2026 | seekingalpha.comFinancial legend: “This is bad, really bad...”Dr. Martin D. Weiss has publicly predicted six major American financial crashes over his 55-year career leading Weiss Ratings, the only conflict-free rating agency in the US. Now he says a $3 trillion problem could trigger a chain reaction of crashes and failures, causing a global freeze in financial markets.October 16 at 1:00 AM | Weiss Ratings (Ad)(SBIO) ALPS Medical Breakthroughs ETFAugust 29, 2026 | sa.investing.comSBIO: Dividendenhistorie, Rendite und Ex-Dividenden-TagAugust 22, 2026 | de.investing.comSBIO: Biotech Breakthrough Opportunities Screened For Cash BurnJuly 7, 2026 | seekingalpha.comSee More Headlines SBIO ETF - Frequently Asked Questions How have SBIO shares performed this year? ALPS Medical Breakthroughs ETF's stock was trading at $51.22 at the beginning of 2026. Since then, SBIO shares have decreased by 2.1% and is now trading at $50.12. Who are ALPS Medical Breakthroughs ETF's major shareholders? ALPS Medical Breakthroughs ETF's top institutional shareholders include Fig Financial Advisory Services Inc. ADV (0.86%) and Rhodes Investment Advisors Inc. ADV (0.13%). How do I buy shares of ALPS Medical Breakthroughs ETF? Shares of SBIO stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. What other stocks do shareholders of ALPS Medical Breakthroughs ETF own? Based on aggregate information from My MarketBeat watchlists, some other companies that ALPS Medical Breakthroughs ETF investors own include Alibaba Group (BABA), NVIDIA (NVDA), Walmart (WMT), Advanced Micro Devices (AMD), Johnson & Johnson (JNJ), Keysight Technologies (KEYS) and Block (XYZ). Fund Details IssuerALPS Fund NameALPS Medical Breakthroughs ETF Tax ClassificationRegulated Investment Company Stock ExchangeNYSEARCACurrent SymbolNYSEARCA:SBIO Inception Date12/30/2014 Fund ManagerRyan Mischker, Andrew Hicks WebN/A PhoneN/AFund Focus Asset ClassEquity BenchmarkS-Network Medical Breakthroughs Index CategorySector FocusHealth Care Development LevelDeveloped Markets RegionNorth America Number of Holdings106 Fund Statistics Assets Under Management$180.02 million Average Daily Volume$46.95 thousand Discount/Premium0.04% Administrator, Advisor and Custodian AdministratorALPS Fund Services, Inc. AdvisorALPS Advisors, Inc. CustodianState Street Bank and Trust Company DistributorALPS Distributors, Inc. Transfer AgentState Street Bank and Trust Company TrusteeN/A Lead Market MakerGTS Options OptionableN/A Short Interest6,672 shs Miscellaneous Outstanding Shares3,470,000Beta0.76 Creation Unit50,000 Creation Fee$500.00 7 Best Space Stocks to Own in 2026The space race is growing fast, and you don’t have to have gotten in early on SpaceX to profit. This report shows seven space stocks you can buy today that may grow as rockets, satellites, defense, space internet, and new space technology become more important.Get This Free Report Top 10 SBIO HoldingsCG Oncology (NASDAQ:CGON)Holding Weight: 3.90%Oruka Therapeutics (NASDAQ:ORKA)Holding Weight: 3.56%Travere Therapeutics (NASDAQ:TVTX)Holding Weight: 3.45%Definium Therapeutics (NASDAQ:DFTX)Holding Weight: 3.25%Dianthus Therapeutics (NASDAQ:DNTH)Holding Weight: 3.18%Veradermics (NYSE:MANE)Holding Weight: 3.15%Edgewise Therapeutics (NASDAQ:EWTX)Holding Weight: 2.83%Relay Therapeutics (NASDAQ:RLAY)Holding Weight: 2.61%Xenon Pharmaceuticals (NASDAQ:XENE)Holding Weight: 2.43%IDEAYA Biosciences (NASDAQ:IDYA)Holding Weight: 2.35%Full Holdings DetailsSBIO Sector ExposureSBIO Industry Exposure This page (NYSEARCA:SBIO) was last updated on 10/16/2026 by MarketBeat.com Staff. 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Every quarte...Profits Run | Sponsored Adding Choose a watchlist: Watchlist Adding You have already added ten stocks to your watchlist. Upgrade to MarketBeat All Access to add more stocks to your watchlist. Adding ALPS Medical Breakthroughs ETF Please log in to your account or sign up in order to add this asset to your watchlist. Share ALPS Medical Breakthroughs ETF With A Colleague Link copied to clipboard. Unlock superior investment research and tools. Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools and reports. Get MarketBeat All Access MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. 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