NYSEARCA:SBIO ALPS Medical Breakthroughs ETF (SBIO) Price, Holdings, & News $51.02 +0.71 (+1.41%) As of 04:10 PM Eastern Add Compare Share Share Stock Analysis Stock AnalysisChartHoldingsOwnershipRatingsShort InterestBuy This Stock About ALPS Medical Breakthroughs ETF (NYSEARCA:SBIO) View Price History Chart DataSkip Price History Chart 1 Day 5 Days 30 Days 90 Days 1 Year Advanced 1 Day 1 Day 5 Days 30 Days 90 Days 1 Year Advanced Show volume Show extended hours Get SBIO alerts:Sign Up Key Stats Today's Range$50.02▼$51.0250-Day Range$48.06▼$57.6052-Week Range$29.33▼$57.77Volume14,156 shsAverage Volume35,866 shsMarket Capitalization$147.96 millionAssets Under Management$148.47 millionDividend YieldN/ANet Expense Ratio0.50%Aggregate RatingModerate Buy ETF Overview The ALPS Medical Breakthroughs ETF (SBIO) is an exchange-traded fund that is based on the S-Network Medical Breakthroughs index. The fund tracks, a market-cap weighted index comprising US-listed biotech companies with one or more drugs currently in either Phase II or Phase III FDA clinical trials. SBIO was launched on Dec 31, 2014 and is managed by ALPS. Read More ALPS Medical Breakthroughs ETF ExpensesTypeSBIOHealth Care ETFsEquity ETFsNYSEARCA ETFsAll ETFsManagement Fee0.50%0.56%0.57%0.51%0.53%Other Expenses0.00%0.47%0.55%0.58%0.55%Total Expense0.50%0.74%0.76%0.74%0.73%Fee Waiver0.00%-0.71%-0.64%-0.70%-0.62%Net Expense0.50%0.59%0.63%0.58%0.60% Receive SBIO Stock News and Ratings via Email Sign-up to receive the latest news and ratings for ALPS Medical Breakthroughs ETF and its competitors with MarketBeat's FREE daily newsletter. Submit View SMS TermsSMS is currently available in Australia, Belgium, Canada, France, Germany, Ireland, Italy, New Zealand, the Netherlands, Singapore, South Africa, Spain, Switzerland, the United Kingdom, and the United States. 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SBIO ETF News HeadlinesSBIO: Leaning Into Drug Discovery And Medical BreakthroughsApril 28, 2026 | seekingalpha.comCreator TV® Announces 2026 Sports Programming under Studio Label, Creator TV SportsApril 2, 2026 | prnewswire.comSpaceX eyes a 1.75 trillion valuation - here's what to knowElon Musk's team has quietly filed confidential paperwork with the SEC for what Bloomberg estimates could be a $1.75 trillion IPO - larger than Saudi Aramco and any tech offering in history. CNBC calls it 'the big market event of 2026.' According to former tech executive and angel investor Jeff Brown, there's a way to claim a stake before the public filing drops, starting with as little as $500.June 3 at 1:00 AM | Brownstone Research (Ad)Creator TV® and Convergence Announce Partnership to Bring Creator-Led Programming to TelevisionMarch 25, 2026 | prnewswire.comALPS Medical Breakthroughs ETF declares annual distribution of $0.0000December 19, 2025 | msn.comSBIO: A Shock Biotech Winner In 2025November 28, 2025 | seekingalpha.comSee More Headlines SBIO ETF - Frequently Asked Questions How have SBIO shares performed this year? ALPS Medical Breakthroughs ETF's stock was trading at $51.22 at the beginning of 2026. Since then, SBIO stock has decreased by 0.4% and is now trading at $51.02. Who are ALPS Medical Breakthroughs ETF's major shareholders? Top institutional shareholders of ALPS Medical Breakthroughs ETF include Bank of America Corp DE (3.40%), Moran Wealth Management LLC (1.17%), Sterling Investment Advisors Ltd. (0.76%) and Silver Oak Securities Incorporated (0.66%). How do I buy shares of ALPS Medical Breakthroughs ETF? Shares of SBIO stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. What other stocks do shareholders of ALPS Medical Breakthroughs ETF own? Based on aggregate information from My MarketBeat watchlists, some other companies that ALPS Medical Breakthroughs ETF investors own include Waste Connections (WCN), American Water Works (AWK), iShares Micro-Cap ETF (IWC), The RMR Group (RMR), AUO (AUOTY), DiamondRock Hospitality (DRH) and Triple Flag Precious Metals (TFPM). Fund Details IssuerALPS Fund NameALPS Medical Breakthroughs ETF Tax ClassificationRegulated Investment Company Stock ExchangeNYSEARCACurrent SymbolNYSEARCA:SBIO Inception Date12/30/2014 Fund ManagerRyan Mischker, Andrew Hicks WebN/A PhoneN/AFund Focus Asset ClassEquity BenchmarkS-Network Medical Breakthroughs Index CategorySector FocusHealth Care Development LevelDeveloped Markets RegionNorth America Number of Holdings89 Fund Statistics Assets Under Management$148.47 million Average Daily Volume$24.64 thousand Discount/Premium-0.02% Administrator, Advisor and Custodian AdministratorALPS Fund Services, Inc. AdvisorALPS Advisors, Inc. CustodianState Street Bank and Trust Company DistributorALPS Distributors, Inc. Transfer AgentState Street Bank and Trust Company TrusteeN/A Lead Market MakerGTS Options OptionableOptionable Options Volume1 Put Options1 Call Options2 Short Interest45,800 shs Miscellaneous Outstanding Shares2,900,000Beta0.77 Creation Unit50,000 Creation Fee$500.00 The 10 Best High-Yield Dividend Stocks for 2026Discover the 10 Best High-Yield Dividend Stocks for 2026 and secure reliable income in uncertain markets. Download the report now to identify top dividend payers and avoid common yield traps.Get This Free Report Top 10 SBIO HoldingsKymera Therapeutics (NASDAQ:KYMR)Holding Weight: 4.19%Celcuity (NASDAQ:CELC)Holding Weight: 4.16%Alkermes (NASDAQ:ALKS)Holding Weight: 3.99%Mirum Pharmaceuticals (NASDAQ:MIRM)Holding Weight: 3.87%Spyre Therapeutics (NASDAQ:SYRE)Holding Weight: 3.79%CG Oncology (NASDAQ:CGON)Holding Weight: 3.53%Apogee Therapeutics (NASDAQ:APGE)Holding Weight: 2.96%Xenon Pharmaceuticals (NASDAQ:XENE)Holding Weight: 2.93%Travere Therapeutics (NASDAQ:TVTX)Holding Weight: 2.67%NewAmsterdam Pharma (NASDAQ:NAMS)Holding Weight: 2.65%Full Holdings DetailsSBIO Sector ExposureSBIO Industry Exposure This page (NYSEARCA:SBIO) was last updated on 6/3/2026 by MarketBeat.com Staff. From Our PartnersThe 1934 playbookIn 1934, a legal government maneuver transferred billions in wealth overnight. 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