NYSEARCA:SBIO ALPS Medical Breakthroughs ETF (SBIO) Price, Holdings, & News $57.56 -0.99 (-1.69%) Closing price 09/25/2026 04:10 PM EasternExtended Trading$57.79 +0.23 (+0.40%) As of 09/25/2026 07:59 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more. Add Compare Share Share Stock Analysis Stock AnalysisChartDividendHoldingsNews and TrendsOwnershipRatingsShort Interest About ALPS Medical Breakthroughs ETF (NYSEARCA:SBIO) View Price History Chart DataSkip Price History Chart 1 Day 5 Days 30 Days 90 Days 1 Year Advanced 1 Day 1 Day 5 Days 30 Days 90 Days 1 Year Advanced Show volume Show extended hours Get SBIO alerts:Sign Up Key Stats Today's Range$57.56▼$58.9850-Day Range$57.56▼$70.7952-Week Range$37.04▼$70.85Volume36,976 shsAverage Volume38,268 shsMarket Capitalization$208.37 millionAssets Under Management$208.97 millionDividend YieldN/ANet Expense Ratio0.50%Aggregate RatingModerate Buy ETF Overview The ALPS Medical Breakthroughs ETF (SBIO) is an exchange-traded fund that is based on the S-Network Medical Breakthroughs index. The fund tracks, a market-cap weighted index comprising US-listed biotech companies with one or more drugs currently in either Phase II or Phase III FDA clinical trials. SBIO was launched on Dec 31, 2014 and is managed by ALPS. Read More ALPS Medical Breakthroughs ETF ExpensesTypeSBIOHealth Care ETFsEquity ETFsNYSEARCA ETFsAll ETFsManagement Fee0.50%0.55%0.57%0.50%0.53%Other Expenses0.00%0.52%0.53%0.60%0.54%Total Expense0.50%0.76%0.75%0.75%0.73%Fee Waiver0.00%-0.85%-0.67%-0.78%-0.68%Net Expense0.50%0.58%0.63%0.57%0.60% Receive SBIO Stock News and Ratings via Email Sign-up to receive the latest news and ratings for ALPS Medical Breakthroughs ETF and its competitors with MarketBeat's FREE daily newsletter. Submit View SMS TermsSMS is currently available in Australia, Belgium, Canada, France, Germany, Ireland, Italy, New Zealand, the Netherlands, Singapore, South Africa, Spain, Switzerland, the United Kingdom, and the United States. 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SBIO ETF News HeadlinesSBIO: Promising Pipelines, Insufficient Return PotentialSeptember 25 at 3:00 AM | seekingalpha.comALPS Medical Breakthroughs ETF (NYSEARCA:SBIO) Sees Significant Drop in Short InterestSeptember 25 at 1:21 AM | americanbankingnews.comMajor Buy Alert Issued for September 30thKeith Kaplan has invested $17 million into his own AI research tools, building a platform now used by 180,000 people worldwide. His system has flagged a handful of stocks worth watching ahead of September 30th. See which stocks his AI research platform is flagging right now.September 26 at 1:00 AM | TradeSmith (Ad)SBIO: Big Pharma Needs What This Fund OwnsSeptember 22, 2026 | seekingalpha.com(SBIO) ALPS Medical Breakthroughs ETFAugust 29, 2026 | sa.investing.comSBIO: Dividendenhistorie, Rendite und Ex-Dividenden-TagAugust 22, 2026 | de.investing.comSee More Headlines SBIO ETF - Frequently Asked Questions How have SBIO shares performed this year? ALPS Medical Breakthroughs ETF's stock was trading at $51.22 on January 1st, 2026. Since then, SBIO stock has increased by 12.4% and is now trading at $57.56. Who are ALPS Medical Breakthroughs ETF's major shareholders? Top institutional shareholders of ALPS Medical Breakthroughs ETF include Sterling Investment Advisors Ltd. (0.75%), Fulcrum Equity Management (0.14%) and Harbor Investment Advisory LLC (0.02%). How do I buy shares of ALPS Medical Breakthroughs ETF? Shares of SBIO stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. What other stocks do shareholders of ALPS Medical Breakthroughs ETF own? Based on aggregate information from My MarketBeat watchlists, some other companies that ALPS Medical Breakthroughs ETF investors own include Waste Connections (WCN), American Water Works (AWK), iShares Micro-Cap ETF (IWC), The RMR Group (RMR), AUO (AUOTY), DiamondRock Hospitality (DRH) and Triple Flag Precious Metals (TFPM). Fund Details IssuerALPS Fund NameALPS Medical Breakthroughs ETF Tax ClassificationRegulated Investment Company Stock ExchangeNYSEARCACurrent SymbolNYSEARCA:SBIO Inception Date12/30/2014 Fund ManagerRyan Mischker, Andrew Hicks WebN/A PhoneN/AFund Focus Asset ClassEquity BenchmarkS-Network Medical Breakthroughs Index CategorySector FocusHealth Care Development LevelDeveloped Markets RegionNorth America Number of Holdings106 Fund Statistics Assets Under Management$208.97 million Average Daily Volume$39.45 thousand Discount/Premium-0.09% Administrator, Advisor and Custodian AdministratorALPS Fund Services, Inc. AdvisorALPS Advisors, Inc. CustodianState Street Bank and Trust Company DistributorALPS Distributors, Inc. Transfer AgentState Street Bank and Trust Company TrusteeN/A Lead Market MakerGTS Options OptionableOptionable Options Volume2 Put Options0 Call Options2 Short Interest13,369 shs Miscellaneous Outstanding Shares3,620,000Beta0.74 Creation Unit50,000 Creation Fee$500.00 The Infrastructure's Backbone: 10 Stocks Powering the AI BuildoutThe AI boom extends far beyond the biggest tech names. Discover 10 companies supplying the memory, storage, networking, semiconductor manufacturing, and power infrastructure that make AI possible. Learn where the next wave of AI investment opportunities may emerge—and the key risks investors should watch as the global AI buildout accelerates.Get This Free Report Top 10 SBIO HoldingsCG Oncology (NASDAQ:CGON)Holding Weight: 3.86%Oruka Therapeutics (NASDAQ:ORKA)Holding Weight: 3.67%Travere Therapeutics (NASDAQ:TVTX)Holding Weight: 3.45%Dianthus Therapeutics (NASDAQ:DNTH)Holding Weight: 3.16%Definium Therapeutics (NASDAQ:DFTX)Holding Weight: 3.04%Edgewise Therapeutics (NASDAQ:EWTX)Holding Weight: 2.87%ACADIA Pharmaceuticals (NASDAQ:ACAD)Holding Weight: 2.74%Veradermics (NYSE:MANE)Holding Weight: 2.60%Relay Therapeutics (NASDAQ:RLAY)Holding Weight: 2.41%Amylyx Pharmaceuticals (NASDAQ:AMLX)Holding Weight: 2.37%Full Holdings DetailsSBIO Sector ExposureSBIO Industry Exposure This page (NYSEARCA:SBIO) was last updated on 9/26/2026 by MarketBeat.com Staff. From Our PartnersA letter from Shannon StansberryPorter Stansberry nearly canceled the entire project. 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