SPDR S&P Biotech ETF (XBI) Holdings $85.28 +1.01 (+1.20%) Closing price 04:10 PM EasternExtended Trading$85.27 -0.01 (-0.01%) As of 07:12 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Holdings Stock AnalysisChartDividendHeadlinesHoldingsOwnershipRatingsShort InterestBuy This Stock Top 100 XBI HoldingsRankCompanyCurrent PriceWeightShares Held1ALNYAlnylam Pharmaceuticals$303.70-0.1%3.26%519,9642EXASExact Sciences$55.69+1.9%3.13%2,719,6323BPMCBlueprint Medicines$127.87-0.1%3.03%1,158,3164NBIXNeurocrine Biosciences$125.26-0.4%2.95%1,155,7325NTRANatera$165.28+0.7%2.87%872,3156UTHRUnited Therapeutics$277.06-15.6%2.74%410,5307INSMInsmed$89.90+27.2%2.50%1,702,5008INCYIncyte$70.37+0.7%2.49%1,861,0789GILDGilead Sciences$111.10-1.7%2.47%1,105,80910BIIBBiogen$135.43+1.0%2.42%899,189 Get the Latest News and Ratings for XBI and Related StocksEnter your email address below to receive the latest news and analysts' ratings for SPDR S&P Biotech ETF and its competitors with MarketBeat's FREE daily newsletter. 11AMGNAmgen$294.04+1.4%2.38%403,41112EXELExelixis$43.22+0.7%2.36%2,684,45513VRTXVertex Pharmaceuticals$449.00+0.6%2.32%254,43014ABBVAbbVie$189.72+0.3%2.28%594,36915MRNAModerna$28.04-0.4%2.00%3,600,53816MDGLMadrigal Pharmaceuticals$287.09+2.4%1.95%348,80117REGNRegeneron Pharmaceuticals$522.82+1.0%1.84%182,83618BMRNBioMarin Pharmaceutical$57.38+0.9%1.78%1,527,13319BBIOBridgeBio Pharma$40.26+3.2%1.71%2,357,25520RVMDRevolution Medicines$42.10+3.8%1.59%1,905,79921TGTXTG Therapeutics$40.19+0.9%1.55%2,120,97422HALOHalozyme Therapeutics$54.350.0%1.48%1,295,83223IONSIonis Pharmaceuticals$37.10+0.9%1.44%2,055,44324ROIVRoivant Sciences$11.31+2.1%1.32%5,781,57525CRSPCRISPR Therapeutics$44.66+6.1%1.29%1,703,05226SWTXSpringWorks Therapeutics$46.77+0.0%1.24%1,293,69527RNAAvidity Biosciences$33.65+3.0%1.15%1,688,97528VKTXViking Therapeutics$29.47+6.9%1.15%2,143,32929ALKSAlkermes$31.33+0.6%1.12%1,754,49930CYTKCytokinetics$33.30+0.5%1.10%1,720,06431PCVXVaxcyte$37.41+0.6%1.10%1,537,23232ADMAADMA Biologics$20.92+0.2%1.09%2,604,63733ACADACADIA Pharmaceuticals$22.64+1.5%1.03%2,335,89134SMMTSummit Therapeutics$22.63+5.0%0.97%2,679,30435NUVLNuvalent$78.96+3.8%0.94%597,02936AKROAkero Therapeutics$54.49-0.4%0.90%863,95037RYTMRhythm Pharmaceuticals$67.07+0.5%0.88%673,27638SRPTSarepta Therapeutics$40.71+2.5%0.88%1,136,66739ACLXArcellx$67.68+1.2%0.87%682,36240SLNOSoleno Therapeutics$78.76+1.3%0.84%540,661Trump’s treachery (Ad)This might just be the greatest time in America to be an energy company. Since taking office in 2025, President Donald Trump has followed through aggressively on his promises to revive the U.S. energy sector — putting fossil fuels front and center. He declared a national energy emergency on day one, signed sweeping executive orders to fast-track oil and gas development, and gutted environmental regulations that once slowed projects down. Incentives for green energy have been slashed or redirected, with renewable tax credits eliminated, tariffs placed on imported solar components, and billions in clean-energy funding pulled back.This could be the most asymmetric bet in the market today. 41APLSApellis Pharmaceuticals$19.81+2.2%0.82%2,100,80342SRRKScholar Rock$34.21+0.4%0.79%1,302,32343CRNXCrinetics Pharmaceuticals$33.36+3.3%0.78%1,191,08144RAREUltragenyx Pharmaceutical$37.59+1.5%0.77%1,035,70745ARWRArrowhead Pharmaceuticals$17.25+4.1%0.76%2,248,44346TWSTTwist Bioscience$34.89+4.6%0.74%1,157,81547AGIOAgios Pharmaceuticals$34.36+2.1%0.73%1,091,96448KRYSKrystal Biotech$137.97+1.4%0.72%281,89349VCYTVeracyte$28.28+1.6%0.71%1,294,16950PTCTPTC Therapeutics$52.04+0.7%0.67%665,61551BCRXBioCryst Pharmaceuticals$11.17+0.5%0.65%2,954,44352VERAVera Therapeutics$23.18+4.4%0.64%989,84353CPRXCatalyst Pharmaceuticals$26.43+2.3%0.62%1,221,07954IDYAIDEAYA Biosciences$22.91+5.5%0.62%1,415,66855RXRXRecursion Pharmaceuticals$5.94+10.5%0.62%6,979,00956KYMRKymera Therapeutics$48.58+3.0%0.61%687,83857MIRMMirum Pharmaceuticals$48.19+2.4%0.57%604,80058GRALGrail$41.13+2.7%0.55%710,15359TVTXTravere Therapeutics$15.46+3.7%0.54%1,691,30060PTGXProtagonist Therapeutics$56.76+1.9%0.53%516,16361ARQTArcutis Biotherapeutics$14.13-0.5%0.52%1,870,24462CLDXCelldex Therapeutics$21.63+4.4%0.52%1,263,49563IMVTImmunovant$16.83+3.3%0.51%1,619,22464NVAXNovavax$7.51+1.3%0.47%3,238,86765BEAMBeam Therapeutics$18.91+4.1%0.46%1,397,99966VCELVericel$44.68+2.0%0.46%556,23467BHVNBiohaven$17.44+2.2%0.45%1,395,79668CGONCG Oncology$27.58+2.1%0.45%833,02169DYNDyne Therapeutics$14.85+3.2%0.45%1,718,55870SNDXSyndax Pharmaceuticals$11.41+2.9%0.45%2,000,60371DNLIDenali Therapeutics$15.04+2.7%0.43%1,506,04772CDNACareDx$20.19+2.4%0.41%1,158,37073IRONDisc Medicine$52.94+3.0%0.39%396,95074DVAXDynavax Technologies$10.34+0.5%0.39%1,916,97275FOLDAmicus Therapeutics$6.15+1.9%0.37%2,959,45176APGEApogee Therapeutics$41.43+3.2%0.37%501,47077ARDXArdelyx$3.87+2.8%0.36%4,588,31278VRDNViridian Therapeutics$15.41+3.7%0.35%1,234,70179JANXJanux Therapeutics$26.98+4.0%0.34%656,29180ETNB89bio$10.570.33%1,600,68881NRIXNurix Therapeutics$12.97+3.4%0.32%1,283,90182NTLAIntellia Therapeutics$8.91+7.6%0.31%2,100,32083GERNGeron$1.64+0.9%0.30%10,281,65184QUREuniQure$17.03+0.7%0.29%963,16285PRAXPraxis Precision Medicines$44.99+1.1%0.28%341,05486MNKDMannKind$3.94-10.0%0.27%3,078,45287SPRYARS Pharmaceuticals$14.57+0.3%0.26%878,48688SYRESpyre Therapeutics$18.43+7.4%0.26%820,16289RCUSArcus Biosciences$10.12+2.7%0.25%1,310,08490AVXLAnavex Life Sciences$8.18+3.2%0.23%1,486,319Elon’s BIGGEST warning yet? (Ad)Tesla's About to Prove Everyone Wrong... Again Back in 2018, when Jeff Brown told everyone to buy Tesla… The "experts" said Elon was finished and Tesla was headed for bankruptcy. Now they're saying the same thing, but Jeff has uncovered Tesla's next breakthrough. Click here to see why Tesla's about to prove everyone wrong... again.91COGTCogent Biosciences$7.38+6.9%0.22%1,955,57492IMNMImmunome$9.61+3.7%0.22%1,195,17593IBRXImmunityBio$3.50+1.7%0.21%3,784,99994VIRVir Biotechnology$5.65+4.0%0.21%1,995,82495CAPRCapricor Therapeutics$13.90+3.8%0.20%967,80596DAWNDay One Biopharmaceuticals$7.34+3.6%0.20%1,389,70097KURAKura Oncology$6.91+2.7%0.20%1,529,01398KROSKeros Therapeutics$13.85-1.7%0.19%645,30699ALTAltimmune$6.47+8.7%0.18%1,675,564100IOVAIovance Biotherapeutics$2.44+10.2%0.18%4,916,064 Geographic ExposureUnited States94.9%Switzerland1.4%Bermuda1.3%Ireland1.2%Virgin Islands, British0.5%Netherlands0.3%Canada0.1%Currency ExposureUSD100.0%Sector ExposureHealth Care98.3%Consumer Discretionary1.0%Biotechnology0.5%Industry ExposureBiotechnology91.2%Health Care Equipment & Supplies4.8%Health Care Providers & Services2.8%Distributors0.8%Diversified Consumer Services0.2%SubIndustry ExposureBiotechnology91.2%Life Sciences Tools & Services4.3%Health Care Services2.8%Pharmaceuticals0.8%Health Care Equipment0.4%Health Care Supplies0.1%Coupon Exposure4-60.1%Maturity Exposure5-100.1% Related Companies and Tools Related Companies IHI Portfolio Companies IBB Portfolio Companies IXJ Portfolio Companies IYH Portfolio Companies FHLC Portfolio Companies FBT Portfolio Companies RYH Portfolio Companies FXH Portfolio Companies RSPH Portfolio Companies IHF Portfolio Companies This page (NYSEARCA:XBI) was last updated on 6/10/2025 by MarketBeat.com Staff From Our PartnersTrump’s Exec Order #14154 could be a “Millionaire-Maker”Former Presidential Advisor, Jim Rickards, says Trump could “rewire our economy and hand millions of Americans...Paradigm Press | SponsoredBanks aren’t ready for this altcoin—are you?While everyone's distracted by Bitcoin's moves, a stealth revolution is underway. 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