SPDR S&P Biotech ETF (XBI) Holdings $86.27 -1.85 (-2.10%) Closing price 07/18/2025 04:10 PM EasternExtended Trading$86.44 +0.17 (+0.20%) As of 07/18/2025 07:59 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Holdings Stock AnalysisChartDividendHeadlinesHoldingsOwnershipRatingsShort InterestBuy This Stock Top 50 XBI HoldingsRankCompanyCurrent PriceWeightShares Held1INSMInsmed$102.56-1.5%3.53%1,625,8202ALNYAlnylam Pharmaceuticals$320.53-1.3%3.25%496,5283NTRANatera$138.90-3.1%3.03%833,0034BPMCBlueprint Medicines$129.463.00%1,106,1525NBIXNeurocrine Biosciences$132.02-1.6%2.95%1,103,6766EXASExact Sciences$50.46-3.4%2.91%2,597,1607INCYIncyte$67.86-1.6%2.57%1,777,2708GILDGilead Sciences$108.22-0.5%2.42%1,056,0219UTHRUnited Therapeutics$292.01-1.8%2.41%392,06210AMGNAmgen$294.76-1.2%2.36%385,267 Get the Latest News and Ratings for XBI and Related StocksEnter your email address below to receive the latest news and analysts' ratings for SPDR S&P Biotech ETF and its competitors with MarketBeat's FREE daily newsletter. 11BIIBBiogen$124.99-2.9%2.31%858,68912VRTXVertex Pharmaceuticals$459.81-0.7%2.27%242,98213ABBVAbbVie$189.26-1.1%2.23%567,58514EXELExelixis$44.47-0.9%2.19%2,563,60315MDGLMadrigal Pharmaceuticals$334.13-4.2%2.01%333,14116BBIOBridgeBio Pharma$46.51-0.5%1.99%2,251,09117MRNAModerna$31.26-2.9%1.88%3,438,43018REGNRegeneron Pharmaceuticals$542.52-1.4%1.88%174,62819BMRNBioMarin Pharmaceutical$57.29-1.9%1.70%1,458,33720IONSIonis Pharmaceuticals$41.76-1.0%1.55%1,962,88721TGTXTG Therapeutics$37.91-3.3%1.54%2,025,50222RVMDRevolution Medicines$38.30-1.9%1.53%1,820,20923CRSPCRISPR Therapeutics$65.13+18.2%1.52%1,626,37224HALOHalozyme Therapeutics$56.45-2.4%1.38%1,237,51225ROIVRoivant Sciences$11.44-1.8%1.34%5,521,29526SWTXSpringWorks Therapeutics$46.991.23%1,235,48327CYTKCytokinetics$37.23-4.3%1.13%1,642,62828VKTXViking Therapeutics$32.01-0.2%1.13%2,046,99229SMMTSummit Therapeutics$26.20-5.2%1.11%2,558,66830ACADACADIA Pharmaceuticals$22.56+0.0%1.07%2,230,69931ALKSAlkermes$29.22-0.5%1.03%1,675,65832PCVXVaxcyte$36.21-3.1%1.02%1,468,00433RNAAvidity Biosciences$33.76-0.8%1.00%1,612,94334AKROAkero Therapeutics$52.08-4.1%0.95%825,07035ADMAADMA Biologics$16.73-4.9%0.93%2,487,34936NUVLNuvalent$83.40-2.7%0.90%570,13737SRRKScholar Rock$40.72-5.0%0.90%1,243,67938ACLXArcellx$67.59-4.7%0.87%651,69039SLNOSoleno Therapeutics$87.20-0.5%0.87%516,36140RYTMRhythm Pharmaceuticals$89.20-1.6%0.84%642,928Market Panic: Trump Just Dropped a Bomb on Your Stocks (Ad)tock Market Panic: Trump Just Dropped a Bomb on Your Stocks The market is in freefall—and Trump's new tariffs just lit the fuse. 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Get the FREE Guide Before Markets Open Tomorrow41TWSTTwist Bioscience$35.17-1.9%0.81%1,105,65142RAREUltragenyx Pharmaceutical$26.31-4.0%0.78%989,05143AGIOAgios Pharmaceuticals$40.00-0.9%0.76%1,042,82444APLSApellis Pharmaceuticals$19.47-2.8%0.75%2,006,19545KRYSKrystal Biotech$147.49-1.8%0.75%269,25746CRNXCrinetics Pharmaceuticals$31.11-5.8%0.73%1,137,54247RXRXRecursion Pharmaceuticals$5.84+5.8%0.71%6,664,94448ARWRArrowhead Pharmaceuticals$16.76-11.1%0.70%2,147,24749VCYTVeracyte$23.51-2.9%0.69%1,236,11950PTCTPTC Therapeutics$47.63-1.9%0.68%635,699 Geographic ExposureUnited States96.5%Bermuda1.7%Switzerland1.6%Ireland1.2%Virgin Islands, British0.5%Netherlands0.3%Canada0.1%Currency ExposureUSD100.0%Sector ExposureHealth Care100.7%Consumer Discretionary0.8%Biotechnology0.4%Energy0.1%Industry ExposureBiotechnology95.3%Health Care Equipment & Supplies3.7%Health Care Providers & Services2.0%Distributors0.7%Renewable Energy0.1%Diversified Consumer Services0.1%SubIndustry ExposureBiotechnology95.2%Life Sciences Tools & Services3.4%Health Care Services2.0%Pharmaceuticals0.7%Health Care Equipment0.2%Renewable Energy Equipment0.1%Health Care Supplies0.1% Related Companies and Tools Related Companies IHI Portfolio Companies IBB Portfolio Companies IXJ Portfolio Companies IYH Portfolio Companies FHLC Portfolio Companies FBT Portfolio Companies RYH Portfolio Companies FXH Portfolio Companies RSPH Portfolio Companies IHF Portfolio Companies This page (NYSEARCA:XBI) was last updated on 7/19/2025 by MarketBeat.com Staff From Our PartnersINVESTOR ALERT: Tiny “$3 AI Wonder Stock” on the Verge of Blasting OffRight now, we’re witnessing a monumental shift in the world.Traders Agency | SponsoredMarket Panic: Trump Just Dropped a Bomb on Your Stockstock Market Panic: Trump Just Dropped a Bomb on Your Stocks The market is in freefall—and Trump's new tarif...American Alternative | SponsoredThis Signal Only Flashes Once Every 4 Years – And It Just TriggeredThis same signal has appeared twice before in the past 8 years — both times, it kicked off major moves in cryp...Crypto Swap Profits | SponsoredPresidential Bombshell: $150T Resource to Be Released as soon as this Summer?Something extraordinary is happening in Washington. 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