SPDR S&P Biotech ETF (XBI) Holdings $106.52 +1.08 (+1.02%) Closing price 04:10 PM EasternExtended Trading$106.67 +0.15 (+0.14%) As of 08:00 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Holdings Stock AnalysisChartDividendHeadlinesHoldingsOwnershipRatingsShort InterestBuy This Stock Top 25 XBI HoldingsRankCompanyCurrent PriceWeightShares Held1CRSPCRISPR Therapeutics$74.24-3.3%2.48%2,076,0582MRNAModerna$27.50-1.5%2.07%4,455,3533ABBVAbbVie$230.96-0.1%1.99%511,6074UTHRUnited Therapeutics$444.76-0.9%1.99%273,1825EXELExelixis$38.59-0.1%1.95%2,872,9816BIIBBiogen$148.81-1.4%1.93%759,5127REGNRegeneron Pharmaceuticals$566.69+0.5%1.92%194,8768AMGNAmgen$295.16+0.2%1.90%388,9179IONSIonis Pharmaceuticals$70.58+0.9%1.90%1,692,39510VRTXVertex Pharmaceuticals$415.21-1.4%1.87%278,781 Get the Latest News and Ratings for XBI and Related StocksEnter your email address below to receive the latest news and analysts' ratings for SPDR S&P Biotech ETF and its competitors with MarketBeat's FREE daily newsletter. 11INSMInsmed$163.90+1.3%1.86%742,28712MDGLMadrigal Pharmaceuticals$431.13-1.3%1.86%251,83413EXASExact Sciences$59.34+0.0%1.82%1,977,57814BMRNBioMarin Pharmaceutical$54.00-1.3%1.81%1,987,33115RVMDRevolution Medicines$47.63-0.4%1.81%2,419,83316BBIOBridgeBio Pharma$54.79-0.9%1.79%2,045,17317INCYIncyte$84.83-0.6%1.78%1,255,83218ALNYAlnylam Pharmaceuticals$455.13+1.0%1.75%230,74019NBIXNeurocrine Biosciences$139.09+0.0%1.72%766,82320TGTXTG Therapeutics$35.20-1.5%1.72%2,853,36021GILDGilead Sciences$116.89-1.1%1.71%939,84522RNAAvidity Biosciences$50.48+4.6%1.69%2,334,34923HALOHalozyme Therapeutics$64.59-0.9%1.68%1,428,90424NTRANatera$172.60+0.3%1.68%637,92525ROIVRoivant Sciences$16.13+0.6%1.65%6,303,388 Geographic ExposureUnited States92.6%Switzerland2.4%Bermuda1.6%Ireland1.2%Netherlands1.0%Virgin Islands, British0.5%Currency ExposureUSD100.0%Sector ExposureHealth Care98.1%Consumer Discretionary1.1%Biotechnology0.6%Energy0.2%Industry ExposureBiotechnology93.2%Health Care Equipment & Supplies3.7%Health Care Providers & Services1.7%Distributors0.9%Diversified Consumer Services0.2%Renewable Energy0.2%SubIndustry ExposureBiotechnology93.4%Life Sciences Tools & Services3.3%Health Care Services1.7%Pharmaceuticals0.7%Health Care Equipment0.3%Renewable Energy Equipment0.2%Health Care Supplies0.1%Coupon Exposure4-60.1%Maturity Exposure5-100.1% Related Companies and Tools Related Companies IBB Portfolio Companies IHI Portfolio Companies IXJ Portfolio Companies IYH Portfolio Companies FHLC Portfolio Companies PPH Portfolio Companies FBT Portfolio Companies RYH Portfolio Companies FXH Portfolio Companies IHF Portfolio Companies This page (NYSEARCA:XBI) was last updated on 10/9/2025 by MarketBeat.com Staff From Our PartnersBitcoin grabs headlines, but smart money likes this tokenBitcoin grabs headlines, but smart money likes this token My research team has identified the token positio...Crypto 101 Media | SponsoredMagnificent 7 being replaced by the “Hidden 7”?BULLISH: It's time to buy this 'hidden' AI stock An award-winning stock-rating system has turned BULLISH on...Chaikin Analytics | SponsoredCapital Gains Tax Strategies for SeniorsCapital gains taxes can take a bite out of your retirement income—unless you have a smart strategy. 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