SPDR S&P Biotech ETF (XBI) Holdings List

$157.37 +2.87 (+1.86%)

As of 04:10 PM Eastern

What stocks does XBI hold?

The SPDR S&P Biotech ETF (XBI) top stock holdings include Apogee Therapeutics, Erasca, and Oruka Therapeutics. The top 25 XBI holdings ordered by weight make up 31.81% of the total fund. XBI is an equity fund in the sector category that invests in publicly traded companies, focused on health care strategies within the North America region. This page includes a complete XBI stock holdings list ranked by weight, along with a full breakdown of sector, geographic, industry, and currency exposure.

Top 25 XBI Holdings

Rank	Company	Current Price	Weight	Shares Held
1	APGE Apogee Therapeutics	$134.84 +0.3%	1.59%	1,222,634
2	ERAS Erasca	$18.41 +0.8%	1.42%	7,564,206
3	ORKA Oruka Therapeutics	$98.82 +0.4%	1.41%	1,579,501
4	KYMR Kymera Therapeutics	$107.52 +1.0%	1.38%	1,292,767
5	DNTH Dianthus Therapeutics	$108.87 -1.0%	1.35%	1,323,354
6	TWST Twist Bioscience	$115.67 +6.0%	1.34%	1,492,289
7	PRAX Praxis Precision Medicines	$360.76 -2.5%	1.31%	420,225
8	SYRE Spyre Therapeutics	$104.91 +1.4%	1.31%	1,347,028
9	RVMD Revolution Medicines	$205.15 +3.7%	1.28%	701,381
10	CGON CG Oncology	$75.10 +0.3%	1.27%	1,841,454
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11	COGT Cogent Biosciences	$42.39 +1.4%	1.26%	3,222,935
12	PTGX Protagonist Therapeutics	$145.87 -0.2%	1.26%	956,206
13	VKTX Viking Therapeutics	$34.26 +2.9%	1.25%	3,644,535
14	MRNA Moderna	$59.17 +9.9%	1.22%	2,199,023
15	ROIV Roivant Sciences	$36.34 +3.5%	1.21%	3,559,862
16	BBIO BridgeBio Pharma	$84.48 +2.0%	1.21%	1,500,441
17	ARWR Arrowhead Pharmaceuticals	$87.65 +2.1%	1.20%	1,429,903
18	PCVX Vaxcyte	$58.07 -1.4%	1.20%	2,226,610
19	NTRA Natera	$322.10 +21.4%	1.20%	467,126
20	CYTK Cytokinetics	$76.78 -5.6%	1.20%	1,507,908
21	MIRM Mirum Pharmaceuticals	$100.65 +6.9%	1.19%	1,075,881
22	TVTX Travere Therapeutics	$61.32 -1.8%	1.19%	2,163,631
23	RLAY Relay Therapeutics	$19.77 +0.1%	1.19%	6,403,683
24	ALKS Alkermes	$49.17 +1.7%	1.19%	2,306,902
25	RYTM Rhythm Pharmaceuticals	$115.63 +3.1%	1.18%	1,179,931

XBI Geographic Exposure

XBI's largest geographic exposure is United States at 93.3%, followed by Ireland at 1.2%.

United States
93.3%
Ireland
1.2%
Bermuda
1.2%
Netherlands
1.0%
Switzerland
1.0%
Virgin Islands, British
0.5%
Cayman Islands
0.2%
Canada
0.2%

XBI Currency Exposure

XBI is exclusively exposed to USD.

USD
100.0%

XBI Sector Exposure

XBI's largest sector exposure is Health Care at 97.5%, followed by Consumer Discretionary at 0.2%.

Health Care
97.5%
Consumer Discretionary
0.2%
Energy
0.2%

XBI Industry Exposure

XBI's largest industry exposure is Biotechnology at 93.3%, followed by Health Care Equipment & Supplies at 1.9%.

Biotechnology
93.3%
Health Care Equipment & Supplies
1.9%
Diversified Consumer Services
1.3%
Health Care Providers & Services
1.2%
Renewable Energy
0.2%

XBI Sub-Industry Exposure

XBI's largest sub-industry exposure is Biotechnology at 92.0%, followed by Life Sciences Tools & Services at 1.3%.

Biotechnology
92.0%
Life Sciences Tools & Services
1.3%
Health Care Services
1.2%
Pharmaceuticals
1.1%
Health Care Equipment
0.5%
Renewable Energy Equipment
0.2%
Health Care Supplies
0.1%

XBI Coupon Exposure

XBI's largest coupon exposure is 2-4 at 0.1%.

2-4
0.1%

XBI Maturity Exposure

XBI's largest maturity exposure is 20-30 at 0.1%, followed by 3-5 at 0.0%.

20-30
0.1%

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This page (NYSEARCA:XBI) was last updated on 8/7/2026 by MarketBeat.com Staff.

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SPDR S&P Biotech ETF (XBI) Holdings List