SPDR S&P Biotech ETF (XBI) Holdings List

$150.90 -5.29 (-3.39%)

Closing price 10/6/2026 04:10 PM Eastern

Extended Trading

$150.30 -0.60 (-0.40%)

As of 05:47 AM Eastern

What stocks does XBI hold?

The SPDR S&P Biotech ETF (XBI) has 171 holdings, with Twist Bioscience, Moderna, and Natera among its largest positions. The top 25 XBI holdings ordered by weight make up 38.26% of the total fund. XBI is an equity fund in the sector category that invests in publicly traded companies, focused on health care strategies within the North America region. This page includes a complete XBI stock holdings list ranked by weight, along with a full breakdown of sector, geographic, industry, and currency exposure.

Top 25 XBI Holdings

Rank	Company	Current Price	Weight	Shares Held
1	TWST Twist Bioscience	$166.97 -18.6%	2.37%	1,204,792
2	MRNA Moderna	$187.46 -7.8%	2.17%	1,115,150
3	NTRA Natera	$400.65 -5.9%	1.87%	457,851
4	IOVA Iovance Biotherapeutics	$12.96 -8.4%	1.56%	11,514,064
5	SYRE Spyre Therapeutics	$80.11 -13.6%	1.55%	1,739,557
6	BIIB Biogen	$222.89 -0.3%	1.54%	717,614
7	ABBV AbbVie	$266.65 +0.3%	1.54%	602,746
8	UTHR United Therapeutics	$541.62 +1.0%	1.54%	298,406
9	CRSP CRISPR Therapeutics	$54.00 -5.8%	1.53%	2,779,916
10	AMGN Amgen	$402.60 -0.1%	1.49%	386,520
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11	GRAL GRAIL	$137.28 -10.9%	1.48%	1,002,348
12	EXEL Exelixis	$58.33 -0.9%	1.46%	2,592,540
13	HALO Halozyme Therapeutics	$109.72 +1.3%	1.46%	1,408,146
14	RVMD Revolution Medicines	$199.87 -3.8%	1.45%	728,225
15	PCVX Vaxcyte	$66.70 -9.6%	1.44%	2,036,908
16	GILD Gilead Sciences	$144.23 -0.3%	1.44%	1,038,299
17	TGTX TG Therapeutics	$52.19 -3.2%	1.43%	2,767,148
18	VRTX Vertex Pharmaceuticals	$502.31 -0.2%	1.40%	290,215
19	PTGX Protagonist Therapeutics	$138.69 -1.4%	1.40%	1,037,220
20	KRYS Krystal Biotech	$326.81 -2.4%	1.40%	434,464
21	PTCT PTC Therapeutics	$63.70 +0.1%	1.37%	2,238,071
22	ALKS Alkermes	$41.65 -2.6%	1.37%	3,330,931
23	NBIX Neurocrine Biosciences	$145.51 +0.9%	1.35%	974,750
24	ORKA Oruka Therapeutics	$80.18 -5.0%	1.34%	1,652,716
25	INCY Incyte	$112.73 -1.2%	1.31%	1,200,052

XBI Geographic Exposure

XBI's largest geographic exposure is United States at 93.3%, followed by Switzerland at 1.5%.

United States
93.3%
Switzerland
1.5%
Ireland
1.4%
Bermuda
1.3%
Netherlands
0.5%
Virgin Islands, British
0.5%
Cayman Islands
0.2%
Canada
0.1%

XBI Currency Exposure

XBI is exclusively exposed to USD.

USD
100.0%

XBI Sector Exposure

XBI's largest sector exposure is Health Care at 97.0%, followed by Energy at 0.3%.

Health Care
97.0%
Energy
0.3%
Consumer Discretionary
0.1%

XBI Industry Exposure

XBI's largest industry exposure is Biotechnology at 91.7%, followed by Health Care Equipment & Supplies at 2.6%.

Biotechnology
91.7%
Health Care Equipment & Supplies
2.6%
Health Care Providers & Services
1.8%
Diversified Consumer Services
1.0%
Renewable Energy
0.3%

XBI Sub-Industry Exposure

XBI's largest sub-industry exposure is Biotechnology at 89.0%, followed by Health Care Services at 1.8%.

Biotechnology
89.0%
Health Care Services
1.8%
Life Sciences Tools & Services
1.6%
Health Care Equipment
0.9%
Pharmaceuticals
0.7%
Renewable Energy Equipment
0.3%
Health Care Supplies
0.1%

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MarketBeat tracks SPDR S&P Biotech ETF holdings and portfolio composition, last updated on 10/6/2026.

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SPDR S&P Biotech ETF (XBI) Holdings List