SPDR S&P Biotech ETF (XBI) Holdings List

$168.23 -0.16 (-0.10%)

Closing price 04:10 PM Eastern

Extended Trading

$168.22 -0.01 (-0.01%)

As of 08:00 PM Eastern

What stocks does XBI hold?

The SPDR S&P Biotech ETF (XBI) top stock holdings include Twist Bioscience, Oruka Therapeutics, and Apogee Therapeutics. The top 25 XBI holdings ordered by weight make up 33.16% of the total fund. XBI is an equity fund in the sector category that invests in publicly traded companies, focused on health care strategies within the North America region. This page includes a complete XBI stock holdings list ranked by weight, along with a full breakdown of sector, geographic, industry, and currency exposure.

Top 25 XBI Holdings

Rank	Company	Current Price	Weight	Shares Held
1	TWST Twist Bioscience	$153.10 +2.0%	1.76%	1,490,081
2	ORKA Oruka Therapeutics	$96.54 -2.9%	1.61%	1,577,165
3	APGE Apogee Therapeutics	$134.96 +0.0%	1.55%	1,220,826
4	PRAX Praxis Precision Medicines	$367.85 -2.5%	1.46%	419,605
5	KYMR Kymera Therapeutics	$120.23 -4.2%	1.39%	1,290,855
6	NTRA Natera	$338.70 +0.1%	1.37%	466,434
7	DNTH Dianthus Therapeutics	$111.54 +0.7%	1.37%	1,321,394
8	PTGX Protagonist Therapeutics	$149.50 -1.3%	1.36%	954,790
9	HALO Halozyme Therapeutics	$106.92 -0.1%	1.36%	1,432,438
10	RVMD Revolution Medicines	$221.15 +2.7%	1.33%	700,345
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11	MRNA Moderna	$142.77 -4.6%	1.32%	2,195,735
12	INSM Insmed	$121.39 -2.4%	1.31%	1,099,117
13	CGON CG Oncology	$79.01 +0.8%	1.30%	1,838,730
14	SYRE Spyre Therapeutics	$93.61	1.29%	1,345,036
15	RYTM Rhythm Pharmaceuticals	$112.53 +0.6%	1.29%	1,178,151
16	REGN Regeneron Pharmaceuticals	$807.71 -0.9%	1.28%	167,859
17	ERAS Erasca	$19.49 +1.8%	1.27%	7,553,019
18	TVTX Travere Therapeutics	$67.52 +0.6%	1.25%	2,160,366
19	PCVX Vaxcyte	$61.15 +0.1%	1.23%	2,223,314
20	ROIV Roivant Sciences	$37.58 +2.3%	1.22%	3,554,594
21	RLAY Relay Therapeutics	$19.42 -0.2%	1.20%	6,394,207
22	AMGN Amgen	$436.99 -0.8%	1.18%	299,011
23	BMRN BioMarin Pharmaceutical	$65.29 -0.5%	1.16%	1,797,815
24	ARWR Arrowhead Pharmaceuticals	$88.59 -0.6%	1.15%	1,427,787
25	BBIO BridgeBio Pharma	$78.68 -0.9%	1.15%	1,498,221

XBI Geographic Exposure

XBI's largest geographic exposure is United States at 93.4%, followed by Bermuda at 1.1%.

United States
93.4%
Bermuda
1.1%
Ireland
1.1%
Switzerland
1.1%
Netherlands
1.1%
Virgin Islands, British
0.5%
Cayman Islands
0.2%
Canada
0.2%

XBI Currency Exposure

XBI is exclusively exposed to USD.

USD
100.0%

XBI Sector Exposure

XBI's largest sector exposure is Health Care at 97.5%, followed by Consumer Discretionary at 0.2%.

Health Care
97.5%
Consumer Discretionary
0.2%
Energy
0.2%

XBI Industry Exposure

XBI's largest industry exposure is Biotechnology at 93.4%, followed by Health Care Equipment & Supplies at 1.8%.

Biotechnology
93.4%
Health Care Equipment & Supplies
1.8%
Health Care Providers & Services
1.4%
Diversified Consumer Services
1.2%
Renewable Energy
0.2%

XBI Sub-Industry Exposure

XBI's largest sub-industry exposure is Biotechnology at 91.6%, followed by Health Care Services at 1.4%.

Biotechnology
91.6%
Health Care Services
1.4%
Life Sciences Tools & Services
1.1%
Pharmaceuticals
1.1%
Health Care Equipment
0.5%
Renewable Energy Equipment
0.2%
Health Care Supplies
0.1%

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MarketBeat tracks SPDR S&P Biotech ETF holdings and portfolio composition, last updated on 8/20/2026.

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SPDR S&P Biotech ETF (XBI) Holdings List