SPDR S&P Biotech ETF (XBI) Holdings List

$154.26 +2.26 (+1.49%)

As of 04:10 PM Eastern

What stocks does XBI hold?

The SPDR S&P Biotech ETF (XBI) top stock holdings include Apogee Therapeutics, Kymera Therapeutics, and Moderna. The top 25 XBI holdings ordered by weight make up 30.59% of the total fund. XBI is an equity fund in the sector category that invests in publicly traded companies, focused on health care strategies within the North America region. This page includes a complete XBI stock holdings list ranked by weight, along with a full breakdown of sector, geographic, industry, and currency exposure.

Top 25 XBI Holdings

Rank	Company	Current Price	Weight	Shares Held
1	APGE Apogee Therapeutics	$134.00 -0.1%	1.49%	1,207,226
2	KYMR Kymera Therapeutics	$115.77 +1.6%	1.41%	1,276,506
3	MRNA Moderna	$61.82 -2.1%	1.37%	2,171,255
4	VKTX Viking Therapeutics	$37.08 +2.0%	1.29%	3,598,582
5	ERAS Erasca	$19.17 +0.8%	1.28%	7,469,141
6	CGON CG Oncology	$71.85 +3.4%	1.26%	1,818,284
7	ORKA Oruka Therapeutics	$92.70 +11.6%	1.25%	1,559,594
8	PRAX Praxis Precision Medicines	$314.41 +2.0%	1.25%	414,961
9	TWST Twist Bioscience	$93.85 +2.9%	1.23%	1,473,447
10	SYRE Spyre Therapeutics	$100.23 +6.5%	1.20%	1,329,947
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11	MIRM Mirum Pharmaceuticals	$118.86 +1.3%	1.20%	1,062,334
12	RVMD Revolution Medicines	$186.16 +3.9%	1.20%	692,539
13	SRRK Scholar Rock	$52.86 +2.2%	1.19%	2,264,900
14	PCVX Vaxcyte	$56.20 +0.3%	1.18%	2,198,578
15	DNTH Dianthus Therapeutics	$105.60 +10.7%	1.18%	1,306,761
16	BBIO BridgeBio Pharma	$81.38 +1.3%	1.18%	1,481,541
17	RLAY Relay Therapeutics	$19.91 +2.8%	1.17%	6,323,301
18	ROIV Roivant Sciences	$34.51 +1.7%	1.17%	3,514,992
19	CYTK Cytokinetics	$80.18 -0.2%	1.17%	1,488,850
20	RYTM Rhythm Pharmaceuticals	$106.60 +0.5%	1.17%	1,165,096
21	INSM Insmed	$108.32 +0.8%	1.16%	1,086,924
22	NTRA Natera	$271.39 +0.6%	1.15%	461,297
23	RARE Ultragenyx Pharmaceutical	$29.28 -3.1%	1.15%	3,677,684
24	PTGX Protagonist Therapeutics	$140.91 +6.7%	1.15%	944,143
25	COGT Cogent Biosciences	$39.08 +3.0%	1.14%	3,182,349

XBI Geographic Exposure

XBI's largest geographic exposure is United States at 94.5%, followed by Ireland at 1.3%.

United States
94.5%
Ireland
1.3%
Bermuda
1.2%
Switzerland
1.0%
Netherlands
0.9%
Virgin Islands, British
0.5%
Canada
0.2%

XBI Currency Exposure

XBI is exclusively exposed to USD.

USD
100.0%

XBI Sector Exposure

XBI's largest sector exposure is Health Care at 98.6%, followed by Consumer Discretionary at 0.2%.

Health Care
98.6%
Consumer Discretionary
0.2%
Energy
0.2%

XBI Industry Exposure

XBI's largest industry exposure is Biotechnology at 94.4%, followed by Health Care Equipment & Supplies at 2.0%.

Biotechnology
94.4%
Health Care Equipment & Supplies
2.0%
Health Care Providers & Services
1.2%
Diversified Consumer Services
1.2%
Renewable Energy
0.2%

XBI Sub-Industry Exposure

XBI's largest sub-industry exposure is Biotechnology at 93.1%, followed by Life Sciences Tools & Services at 1.6%.

Biotechnology
93.1%
Life Sciences Tools & Services
1.6%
Health Care Services
1.2%
Pharmaceuticals
1.0%
Health Care Equipment
0.3%
Renewable Energy Equipment
0.2%
Health Care Supplies
0.1%

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This page (NYSEARCA:XBI) was last updated on 7/17/2026 by MarketBeat.com Staff.

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SPDR S&P Biotech ETF (XBI) Holdings List