SPDR S&P Biotech ETF (XBI) Holdings List

$156.61 +1.58 (+1.02%)

Closing price 09/28/2026 04:10 PM Eastern

Extended Trading

$156.76 +0.15 (+0.09%)

As of 09/28/2026 08:00 PM Eastern

What stocks does XBI hold?

The SPDR S&P Biotech ETF (XBI) has 180 holdings, with Moderna, Twist Bioscience, and Natera among its largest positions. The top 25 XBI holdings ordered by weight make up 37.23% of the total fund. XBI is an equity fund in the sector category that invests in publicly traded companies, focused on health care strategies within the North America region. This page includes a complete XBI stock holdings list ranked by weight, along with a full breakdown of sector, geographic, industry, and currency exposure.

Top 25 XBI Holdings

Rank	Company	Current Price	Weight	Shares Held
1	MRNA Moderna	$197.28 -0.8%	1.95%	1,131,452
2	TWST Twist Bioscience	$179.60 -1.8%	1.84%	1,222,381
3	NTRA Natera	$411.77 -0.2%	1.72%	464,520
4	BIIB Biogen	$228.69 +0.5%	1.57%	728,105
5	ABBV AbbVie	$266.39 +0.8%	1.54%	611,560
6	HALO Halozyme Therapeutics	$112.89 -0.9%	1.52%	1,428,699
7	GILD Gilead Sciences	$152.21 +0.8%	1.51%	1,053,470
8	AMGN Amgen	$418.13 +0.8%	1.51%	392,175
9	CRSP CRISPR Therapeutics	$54.09 -0.3%	1.49%	2,820,515
10	TGTX TG Therapeutics	$56.19 -2.2%	1.49%	2,807,552
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11	SYRE Spyre Therapeutics	$85.79 +0.1%	1.47%	1,764,946
12	REGN Regeneron Pharmaceuticals	$752.25 -4.5%	1.44%	189,964
13	VRTX Vertex Pharmaceuticals	$527.67 +0.3%	1.44%	294,466
14	INCY Incyte	$124.82 +0.8%	1.44%	1,217,563
15	ORKA Oruka Therapeutics	$84.19 -0.3%	1.43%	1,676,857
16	KRYS Krystal Biotech	$337.08 -2.5%	1.43%	440,821
17	EXEL Exelixis	$58.37 +0.4%	1.41%	2,630,409
18	VKTX Viking Therapeutics	$33.03 -7.1%	1.41%	3,576,940
19	BMRN BioMarin Pharmaceutical	$59.46 -1.3%	1.40%	2,382,082
20	UTHR United Therapeutics	$485.54 +2.1%	1.40%	302,774
21	ALNY Alnylam Pharmaceuticals	$255.36 -0.2%	1.39%	594,664
22	PTGX Protagonist Therapeutics	$142.44 +0.4%	1.38%	1,052,352
23	MDGL Madrigal Pharmaceuticals	$517.04 +0.1%	1.36%	280,688
24	ALKS Alkermes	$40.15 -1.7%	1.35%	3,379,564
25	PTCT PTC Therapeutics	$65.95 +5.2%	1.34%	2,270,753

XBI Geographic Exposure

XBI's largest geographic exposure is United States at 93.1%, followed by Switzerland at 1.5%.

United States
93.1%
Switzerland
1.5%
Ireland
1.4%
Bermuda
1.3%
Netherlands
0.8%
Virgin Islands, British
0.5%
Cayman Islands
0.2%
Canada
0.1%

XBI Currency Exposure

XBI is exclusively exposed to USD.

USD
100.0%

XBI Sector Exposure

XBI's largest sector exposure is Health Care at 96.6%, followed by Energy at 0.3%.

Health Care
96.6%
Energy
0.3%
Consumer Discretionary
0.1%

XBI Industry Exposure

XBI's largest industry exposure is Biotechnology at 91.4%, followed by Health Care Equipment & Supplies at 2.5%.

Biotechnology
91.4%
Health Care Equipment & Supplies
2.5%
Health Care Providers & Services
1.8%
Diversified Consumer Services
1.1%
Renewable Energy
0.3%

XBI Sub-Industry Exposure

XBI's largest sub-industry exposure is Biotechnology at 90.0%, followed by Health Care Services at 1.8%.

Biotechnology
90.0%
Health Care Services
1.8%
Life Sciences Tools & Services
1.7%
Health Care Equipment
0.8%
Pharmaceuticals
0.7%
Renewable Energy Equipment
0.3%
Health Care Supplies
0.1%

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MarketBeat tracks SPDR S&P Biotech ETF holdings and portfolio composition, last updated on 9/24/2026.

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SPDR S&P Biotech ETF (XBI) Holdings List