Ra Capital Management, L.P. Top Holdings and 13F Report (2026) About Ra Capital Management, L.P.Investment ActivityRa Capital Management, L.P. has $9.44 billion in total holdings as of March 31, 2026.Ra Capital Management, L.P. owns shares of 85 different stocks, but just 23 companies or ETFs make up 80% of its holdings.Approximately 13.47% of the portfolio was purchased this quarter.About 16.96% of the portfolio was sold this quarter.This quarter, Ra Capital Management, L.P. has purchased 71 new stocks and bought additional shares in 17 stocks.Ra Capital Management, L.P. sold shares of 2 stocks and completely divested from 10 stocks this quarter.Largest Holdings Ascendis Pharma A/S $2,351,686,580Vaxcyte $666,788,948Rhythm Pharmaceuticals $579,814,814Tyra Biosciences $467,207,338SIONNA THERAPEUTICS INC $397,093,254 Largest New Holdings this Quarter 85220G109 - SPYGLASS PHARMA INC $207,827,141 Holding98887Q104 - Zai Lab $107,353,598 Holding803607100 - Sarepta Therapeutics $84,920,489 Holding36322Q206 - DAMORA THERAPEUTICS INC $62,142,129 Holding98401F105 - Xencor $59,060,678 Holding Largest Purchases this Quarter SPYGLASS PHARMA INC 8,021,117 shares (about $207.83M)Zai Lab 5,707,262 shares (about $107.35M)Sarepta Therapeutics 3,902,596 shares (about $84.92M)DIANTHUS THERAPEUTICS INC 1,000,000 shares (about $83.92M)Nuvalent 654,088 shares (about $67.01M) Largest Sales this Quarter CONTINEUM THERAPEUTICS INC-A 883,699 shares (about $11.54M)4D Molecular Therapeutics 603,432 shares (about $5.62M) Sector Allocation Over TimeMap of 500 Largest Holdings ofRa Capital Management, L.P. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorASNDAscendis Pharma A/S$2,351,686,5800.0%10,281,49624.9%MedicalPCVXVaxcyte$666,788,948$43,582,500 â–²7.0%11,474,5997.1%MedicalRYTMRhythm Pharmaceuticals$579,814,8140.0%6,666,8376.1%MedicalTYRATyra Biosciences$467,207,3380.0%12,198,6255.0%MedicalSIONNA THERAPEUTICS INC$397,093,2540.0%9,905,0454.2%COMMON STOCKEWTXEdgewise Therapeutics$328,495,7660.0%10,428,4373.5%MedicalNAMSNewAmsterdam Pharma$305,701,6140.0%9,550,1913.2%MedicalNUVLNuvalent$259,623,155$67,011,316 â–²34.8%2,534,1452.8%MedicalDIANTHUS THERAPEUTICS INC$219,176,633$83,920,000 â–²62.0%2,611,7332.3%COMMON STOCKMLYSMineralys Therapeutics$208,396,598$9,996,210 â–²5.0%7,692,7502.2%MedicalSPYGLASS PHARMA INC$207,827,141$207,827,141 â–²New Holding8,021,1172.2%COMMON STOCKWVEWAVE Life Sciences$195,572,411$63,600,596 â–²48.2%26,975,5052.1%MedicalSEPTERNA INC$168,110,4680.0%6,995,8581.8%COMMON STOCKIRONDisc Medicine$156,667,131$30,313,251 â–²24.0%2,450,2211.7%MedicalJANXJanux Therapeutics$155,536,7330.0%11,189,6931.6%MedicalBCRXBioCryst Pharmaceuticals$150,674,8110.0%15,827,1861.6%MedicalBICARA THERAPEUTICS INC$144,321,701$5,967,000 â–²4.3%7,255,9931.5%COMMON STOCKPRAXIS PRECISION MEDICINES I$120,430,4340.0%373,7871.3%COMMON STOCKGHRSGH Research$107,934,3600.0%7,676,6971.1%MedicalZLABZai Lab$107,353,598$107,353,598 â–²New Holding5,707,2621.1%MedicalTSHATaysha Gene Therapies$105,293,7470.0%23,555,6481.1%MedicalVOR BIOPHARMA INC$96,425,1640.0%5,404,9981.0%COMMON STOCKGERNGeron$95,019,3350.0%63,771,3661.0%MedicalSPRYARS Pharmaceuticals$87,213,6450.0%10,860,9770.9%MedicalSRPTSarepta Therapeutics$84,920,489$84,920,489 â–²New Holding3,902,5960.9%MedicalSPYRE THERAPEUTICS INC$81,794,5130.0%1,621,6200.9%COMMON STOCKEVOMMUNE INC$80,341,728$824,605 â–²1.0%3,494,6380.9%COMMON STOCKELYMEliem Therapeutics$77,411,432$48,710 â–²0.1%11,300,9390.8%MedicalSLDBSolid Biosciences$67,247,842$25,405,596 â–²60.7%9,339,9780.7%MedicalARTIVA BIOTHERAPEUTICS INC$63,455,2650.0%9,853,3020.7%COMMON STOCKDAMORA THERAPEUTICS INC$62,142,129$62,142,129 â–²New Holding2,399,3100.7%COMMON STOCKXNCRXencor$59,060,678$59,060,678 â–²New Holding4,897,2370.6%MedicalLB PHARMACEUTICALS INC$54,464,1750.0%2,208,6040.6%COMMON STOCKJADE BIOSCIENCES INC$51,578,7160.0%3,671,0830.5%COMMON STOCKABOSAcumen Pharmaceuticals$49,542,699$14,303,030 â–²40.6%20,992,6690.5%MedicalFDMT4D Molecular Therapeutics$47,013,442$5,617,952 â–¼-10.7%5,049,7790.5%MedicalFULCFulcrum Therapeutics$46,433,8730.0%6,053,9600.5%MedicalCAPRCapricor Therapeutics$45,838,4580.0%1,507,8440.5%MedicalIPSCCentury Therapeutics$40,125,012$40,125,012 â–²New Holding17,754,4300.4%MedicalOLMAOlema Pharmaceuticals$38,766,0000.0%2,600,0000.4%MedicalLENZ THERAPEUTICS INC$38,236,2300.0%4,178,8230.4%COMMON STOCKMONOPAR THERAPEUTICS INC$36,556,2720.0%667,2070.4%COMMON STOCKPEPGPepGen$35,514,2450.0%20,064,5450.4%MedicalDSGNDesign Therapeutics$31,632,433$16,083,339 â–²103.4%2,972,9730.3%MedicalMIRMMirum Pharmaceuticals$29,428,019$29,428,019 â–²New Holding318,5540.3%MedicalBIOAGE LABS INC$28,869,834$28,869,834 â–²New Holding1,650,6480.3%COMMON STOCKLEXEO THERAPEUTICS INC$28,700,0000.0%5,000,0000.3%COMMON STOCKASSEMBLY BIOSCIENCES INC$28,316,3780.0%1,020,4100.3%COMMON STOCKRZLTRezolute$27,999,0000.0%9,180,0000.3%MedicalAKTIS ONCOLOGY INC$26,890,173$26,890,173 â–²New Holding1,503,0840.3%COMMON STOCKALXOALX Oncology$26,088,757$26,088,757 â–²New Holding13,011,8490.3%MedicalACRSAclaris Therapeutics$25,515,270$25,515,270 â–²New Holding6,804,0720.3%MedicalOVIDOvid Therapeutics$23,785,0800.0%10,714,0000.3%MedicalNKTXNkarta$22,798,8220.0%10,805,1290.2%MedicalTVTXTravere Therapeutics$22,188,646$22,188,646 â–²New Holding746,8410.2%MedicalGRAIL INC$22,132,7870.0%428,2660.2%COMMON STOCKCCCCC4 Therapeutics$21,040,0000.0%8,000,0000.2%MedicalRLMDRelmada Therapeutics$20,513,688$20,513,688 â–²New Holding2,947,3690.2%MedicalBENITEC BIOPHARMA INC$19,702,5000.0%1,850,0000.2%COMMON STOCKBRIGHT MINDS BIOSCIENCES INC$19,337,050$19,337,050 â–²New Holding265,0000.2%COMMON STOCKSUTRO BIOPHARMA INC$17,818,297$17,818,297 â–²New Holding715,3070.2%COMMON STOCKCONTINEUM THERAPEUTICS INC-A$16,925,917$11,541,109 â–¼-40.5%1,296,0120.2%COMMON STOCKSAB BIOTHERAPEUTICS INC$16,857,7450.0%4,401,5000.2%COMMON STOCKINSPInspire Medical Systems$16,797,698$9,475,195 â–²129.4%325,6630.2%MedicalANTERIS TECHNOLOGIES GLOBAL$16,650,000$16,650,000 â–²New Holding3,000,0000.2%COMMON STOCKONKURE THERAPEUTICS INC-A$16,553,099$16,553,099 â–²New Holding3,998,3330.2%COMMON STOCKHINGE HEALTH INC-A$14,059,477$10,970,320 â–²355.1%364,6130.1%COMMON STOCKWGSGeneDx$13,478,943$9,751,357 â–²261.6%209,8870.1%MedicalWAYSTAR HOLDING CORP$12,763,834$9,282,350 â–²266.6%529,4000.1%COMMON STOCKHELIX ACQUISITION CORP-CL A$12,700,000$12,700,000 â–²New Holding1,250,0000.1%COMMON STOCKPALISADE BIO INC$12,467,2030.0%7,124,1160.1%COMMON STOCKACRVAcrivon Therapeutics$11,593,3060.0%8,340,5080.1%MedicalATRIUM THERAPEUTICS INC$11,553,044$11,553,044 â–²New Holding864,1020.1%COMMON STOCKKARYOPHARM THERAPEUTICS INC$10,679,662$10,679,662 â–²New Holding1,917,3540.1%COMMON STOCKAVALO THERAPEUTICS INC$9,898,1120.0%662,9680.1%COMMON STOCKPERCEPTIVE CAPITAL SOLUTIONS$8,227,5000.0%750,0000.1%COMMON STOCKADICET BIO INC$8,053,669$1,596,094 â–²24.7%1,182,6240.1%COMMON STOCKNAMSWNewAmsterdam Pharma$6,679,9930.0%333,3330.1%MedicalCRVSCorvus Pharmaceuticals$6,583,500$6,583,500 â–²New Holding450,0000.1%MedicalRANIRani Therapeutics$6,245,8000.0%8,500,0000.1%MedicalEQEquillium$6,192,672$6,192,672 â–²New Holding3,096,3360.1%MedicalHOWLWerewolf Therapeutics$5,562,8560.0%6,681,3070.1%MedicalMGNXMacroGenics$5,387,469$5,387,469 â–²New Holding1,864,1760.1%MedicalMAPLIGHT THERAPEUTICS INC$5,047,817$5,047,817 â–²New Holding248,2940.1%COMMON STOCKPALATIN TECHNOLOGIES INC$1,219,4000.0%70,0000.0%COMMON STOCKCIDARA THERAPEUTICS INC$0$743,410,375 â–¼-100.0%00.0%SHRNAAvidity Biosciences$0$623,277,566 â–¼-100.0%00.0%MedicalACLXArcellx$0$82,618,571 â–¼-100.0%00.0%MedicalBLTEBelite Bio$0$69,180,141 â–¼-100.0%00.0%MedicalIVVDInvivyd$0$42,284,167 â–¼-100.0%00.0%MedicalMEDLINE INC-CL A$0$14,070,000 â–¼-100.0%00.0%SHPGNYProgyny$0$2,481,407 â–¼-100.0%00.0%MedicalQIAGEN N.V.$0$2,081,683 â–¼-100.0%00.0%SHKIDSOrthoPediatrics$0$1,952,872 â–¼-100.0%00.0%MedicalHCATHealth Catalyst$0$1,897,060 â–¼-100.0%00.0%MedicalShowing largest 100 holdings. 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