Ra Capital Management, L.P. Top Holdings and 13F Report (2026) About Ra Capital Management, L.P.Investment ActivityRa Capital Management, L.P. has $11.51 billion in total holdings as of June 30, 2026.Ra Capital Management, L.P. owns shares of 84 different stocks, but just 23 companies or ETFs make up 80% of its holdings.Approximately 40.53% of the portfolio was purchased this quarter.About 30.16% of the portfolio was sold this quarter.This quarter, Ra Capital Management, L.P. has purchased 85 new stocks and bought additional shares in 10 stocks.Ra Capital Management, L.P. sold shares of 10 stocks and completely divested from 18 stocks this quarter.Largest Holdings ASCENDIS PHARMA A/S $2,742,280,613PARABILIS MEDICINES INC $791,906,364Rhythm Pharmaceuticals $740,218,912Vaxcyte $667,018,440SIONNA THERAPEUTICS INC $435,722,930 Largest New Holdings this Quarter K08588103 - ASCENDIS PHARMA A/S $2,742,280,613 Holding698955101 - PARABILIS MEDICINES INC $791,906,364 Holding423494103 - HEMAB THERAPEUTICS HOLDINGS $286,810,870 Holding00370M103 - ABIVAX SA-ADR $150,924,546 Holding687604108 - ORUKA THERAPEUTICS INC $147,950,996 Holding Largest Purchases this Quarter ASCENDIS PHARMA A/S 10,281,496 shares (about $2.74B)PARABILIS MEDICINES INC 28,933,371 shares (about $791.91M)HEMAB THERAPEUTICS HOLDINGS 7,808,627 shares (about $286.81M)ABIVAX SA-ADR 1,132,557 shares (about $150.92M)ORUKA THERAPEUTICS INC 1,554,597 shares (about $147.95M) Largest Sales this Quarter Nuvalent 1,287,689 shares (about $159.03M)Edgewise Therapeutics 2,035,707 shares (about $82.71M)VOR BIOPHARMA INC 3,002,903 shares (about $55.28M)Geron 20,961,615 shares (about $26.83M)AKTIS ONCOLOGY INC 188,679 shares (about $6.08M) Sector Allocation Over TimeMap of 500 Largest Holdings ofRa Capital Management, L.P. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorASCENDIS PHARMA A/S$2,742,280,613$2,742,280,613 â–²New Holding10,281,49623.8%Common StockPARABILIS MEDICINES INC$791,906,364$791,906,364 â–²New Holding28,933,3716.9%Common StockRYTMRhythm Pharmaceuticals$740,218,9120.0%6,666,8376.4%HealthcarePCVXVaxcyte$667,018,4400.0%11,474,5995.8%HealthcareSIONNA THERAPEUTICS INC$435,722,9300.0%9,905,0453.8%Common StockTYRATyra Biosciences$389,624,0830.0%12,198,6253.4%HealthcareEWTXEdgewise Therapeutics$340,996,620$82,710,775 â–¼-19.5%8,392,7303.0%HealthcareNAMSNewAmsterdam Pharma$323,655,9730.0%9,550,1912.8%HealthcareHEMAB THERAPEUTICS HOLDINGS$286,810,870$286,810,870 â–²New Holding7,808,6272.5%Common StockSEPTERNA INC$234,291,2840.0%6,995,8582.0%Common StockBICARA THERAPEUTICS INC$215,430,4320.0%7,255,9931.9%Common StockMLYSMineralys Therapeutics$207,550,3950.0%7,692,7501.8%HealthcareGHRSGH Research$205,277,533$1,072,082 â–¼-0.5%7,636,8131.8%HealthcareIRONDisc Medicine$179,209,1640.0%2,450,2211.6%HealthcareSPYGLASS PHARMA INC$178,550,0640.0%8,021,1171.6%Common StockARTIVA BIOTHERAPEUTICS INC$174,169,727$78,592,698 â–²82.2%17,955,6421.5%Common StockJANXJanux Therapeutics$171,873,6840.0%11,189,6931.5%HealthcareTSHATaysha Gene Therapies$160,413,9630.0%23,555,6481.4%HealthcareBCRXBioCryst Pharmaceuticals$158,271,8600.0%15,827,1861.4%HealthcareWVEWAVE Life Sciences$156,727,6840.0%26,975,5051.4%HealthcareNUVLNuvalent$153,937,316$159,029,592 â–¼-50.8%1,246,4561.3%HealthcareABIVAX SA-ADR$150,924,546$150,924,546 â–²New Holding1,132,5571.3%ADRORUKA THERAPEUTICS INC$147,950,996$147,950,996 â–²New Holding1,554,5971.3%Common StockELYMEliem Therapeutics$147,364,2450.0%11,300,9391.3%HealthcareSLDBSolid Biosciences$120,240,899$26,934,519 â–²28.9%12,036,1261.0%HealthcareZLABZai Lab$109,127,127$689,149 â–²0.6%5,743,5330.9%HealthcareSPRYARS Pharmaceuticals$86,996,4260.0%10,860,9770.8%HealthcareXNCRXencor$84,915,811$6,070,296 â–²7.7%5,274,2740.7%HealthcareJADE BIOSCIENCES INC$81,571,4640.0%3,671,0830.7%Common StockNTLAIntellia Therapeutics$76,595,588$76,595,588 â–²New Holding4,526,9260.7%HealthcareLB PHARMACEUTICALS INC$71,680,2430.0%2,208,6040.6%Common StockDEFINIUM THERAPEUTICS INC$70,560,000$70,560,000 â–²New Holding1,500,0000.6%Common StockACRSAclaris Therapeutics$67,304,808$31,311,267 â–²87.0%12,723,0260.6%HealthcareFDMT4D Molecular Therapeutics$67,162,0610.0%5,049,7790.6%HealthcareSANASana Biotechnology$65,437,500$65,437,500 â–²New Holding18,750,0000.6%HealthcareDAMORA THERAPEUTICS INC$62,416,249$10,196 â–²0.0%2,399,7020.5%Common StockMONOPAR THERAPEUTICS INC$61,776,6960.0%667,2070.5%Common StockABOSAcumen Pharmaceuticals$56,050,4260.0%20,992,6690.5%HealthcareGERNGeron$54,796,481$26,830,867 â–¼-32.9%42,809,7510.5%HealthcareRZLTRezolute$49,114,203$1,378,203 â–²2.9%9,445,0390.4%HealthcareEVOMMUNE INC$46,443,7390.0%3,494,6380.4%Common StockVOR BIOPHARMA INC$44,222,569$55,283,444 â–¼-55.6%2,402,0950.4%Common StockIPSCCentury Therapeutics$43,498,3540.0%17,754,4300.4%HealthcareAKTIS ONCOLOGY INC$42,363,273$6,081,124 â–¼-12.6%1,314,4050.4%Common StockBIOAGE LABS INC$40,972,092$514,710 â–²1.3%1,671,6480.4%Common StockCCCCC4 Therapeutics$37,360,0000.0%8,000,0000.3%HealthcareMIRMMirum Pharmaceuticals$37,293,1170.0%318,5540.3%HealthcareCAPRCapricor Therapeutics$36,308,8840.0%1,507,8440.3%HealthcarePEPGPepGen$36,116,1810.0%20,064,5450.3%HealthcarePRLDPrelude Therapeutics$34,516,451$34,516,451 â–²New Holding6,475,8820.3%HealthcareNKTXNkarta$30,578,5150.0%10,805,1290.3%HealthcareQ32 BIO INC$29,715,502$29,715,502 â–²New Holding2,332,4570.3%Common StockANTERIS TECHNOLOGIES GLOBAL$29,550,0000.0%3,000,0000.3%Common StockEDITEditas Medicine$28,800,360$28,800,360 â–²New Holding8,889,0000.3%HealthcareOVIDOvid Therapeutics$28,247,604$573,056 â–¼-2.0%10,500,9680.2%HealthcareASSEMBLY BIOSCIENCES INC$28,040,8670.0%1,020,4100.2%Common StockALXOALX Oncology$26,934,5270.0%13,011,8490.2%HealthcareBENITEC BIOPHARMA INC$24,753,0000.0%1,850,0000.2%Common StockLENZ THERAPEUTICS INC$23,735,7150.0%4,178,8230.2%Common StockLEXEO THERAPEUTICS INC$23,275,0000.0%5,000,0000.2%Common StockACRVAcrivon Therapeutics$21,768,325$6,922,221 â–²46.6%12,229,3960.2%HealthcareALTAltimmune$19,760,000$19,760,000 â–²New Holding6,500,0000.2%HealthcareKARYOPHARM THERAPEUTICS INC$18,732,5490.0%1,917,3540.2%Common StockBRIGHT MINDS BIOSCIENCES INC$18,603,0000.0%265,0000.2%Common StockAVALO THERAPEUTICS INC$18,480,000$6,228,351 â–²50.8%1,000,0000.2%Common StockONKURE THERAPEUTICS INC-A$18,232,3980.0%3,998,3330.2%Common StockFAETH THERAPEUTICS INC$18,050,500$18,050,500 â–²New Holding722,0200.2%Common StockAURAAura Biosciences$17,750,000$17,750,000 â–²New Holding2,500,0000.2%HealthcareSAB BIOTHERAPEUTICS INC$17,165,8500.0%4,401,5000.1%Common StockSEAPORT THERAPEUTICS INC$15,204,000$15,204,000 â–²New Holding700,0000.1%Common StockPALISADE BIO INC$14,889,4020.0%7,124,1160.1%Common StockHELIX ACQUISITION CORP-CL A$13,300,0000.0%1,250,0000.1%Common StockWAYSTAR HOLDING CORP$10,868,5820.0%529,4000.1%Common StockEQEquillium$9,908,2750.0%3,096,3360.1%HealthcareMGNXMacroGenics$8,612,4930.0%1,864,1760.1%HealthcarePERCEPTIVE CAPITAL SOLUTIONS$8,160,0000.0%750,0000.1%Common StockADICET BIO INC$8,057,871$2,160,000 â–¼-21.1%932,6240.1%Common StockNAMSWNewAmsterdam Pharma$7,123,3260.0%333,3330.1%HealthcareCRVSCorvus Pharmaceuticals$6,723,0000.0%450,0000.1%HealthcareRANIRani Therapeutics$6,463,4000.0%8,500,0000.1%HealthcareJATT II ACQUISITION CORP$5,680,000$5,680,000 â–²New Holding500,0000.0%Common StockAMANAT ACQUISITION CORP CL A$3,810,000$3,810,000 â–²New Holding375,0000.0%Common StockHOWLWerewolf Therapeutics$859,349$1,545,253 â–¼-64.3%2,387,7440.0%HealthcarePALATIN TECHNOLOGIES INC$670,318$84,982 â–¼-11.3%62,1240.0%Common StockASNDAscendis Pharma A/S$0$2,351,686,580 â–¼-100.0%00.0%HealthcareDIANTHUS THERAPEUTICS INC$0$219,176,633 â–¼-100.0%00.0%COMMON STOCKPRAXIS PRECISION MEDICINES I$0$120,430,434 â–¼-100.0%00.0%COMMON STOCKSRPTSarepta Therapeutics$0$84,920,489 â–¼-100.0%00.0%HealthcareSPYRE THERAPEUTICS INC$0$81,794,513 â–¼-100.0%00.0%COMMON STOCKFULCFulcrum Therapeutics$0$46,433,873 â–¼-100.0%00.0%HealthcareOLMAOlema Pharmaceuticals$0$38,766,000 â–¼-100.0%00.0%HealthcareDSGNDesign Therapeutics$0$31,632,433 â–¼-100.0%00.0%HealthcareTVTXTravere Therapeutics$0$22,188,646 â–¼-100.0%00.0%HealthcareGRAIL INC$0$22,132,787 â–¼-100.0%00.0%COMMON STOCKRLMDRelmada Therapeutics$0$20,513,688 â–¼-100.0%00.0%HealthcareSUTRO BIOPHARMA INC$0$17,818,297 â–¼-100.0%00.0%COMMON STOCKCONTINEUM THERAPEUTICS INC-A$0$16,925,917 â–¼-100.0%00.0%COMMON STOCKINSPInspire Medical Systems$0$16,797,698 â–¼-100.0%00.0%HealthcareHINGE HEALTH INC-A$0$14,059,477 â–¼-100.0%00.0%COMMON STOCKWGSGeneDx$0$13,478,943 â–¼-100.0%00.0%HealthcareShowing largest 100 holdings. 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